Bioanalytics facilities

Our bioanalytics lab offers state-of-the-art techniques such as LC-MS (Liquid chromatography-mass spectrometry) and GC-MS (Gas chromatography-mass spectrometry) for the analysis of small and large molecules. We combine these facilities with extensive knowledge about ´omics´ and have several proven platforms ready for metabolite, protein and glycan analysis. Additionally, the development of tailor-made analytical methods for specific analytes and matrices is offered.  

 
Analytical services for small molecules: 
• Reversed Phase (UPLC)-UV-MS for majority of small molecules. UV and/or mass detection can be chosen based on need for selectivity and sensitivity. 
• HILIC (UPLC)-UV-MS method for determination of polar compounds. 
• Amino acid composition analysis by UPLC-UV and/or LC-MS 
• Quantitative and/or qualitative analysis of lipids by UPLC-ELSD, UPLC-(HR)MS and/or GC-MS (FAME & intact triglycerides) 
• Volatiles, GC techniques including headspace, SPME and liquid injection coupled with MS 
 
Analytical services for large biomolecules: 
• Intact mass (LC-MS) to measure the molecular mass of proteins in sample 
• Peptide mapping (LC-MS) to confirm the sequence of proteins and to study modifications and their locations 
• Released glycan analysis (LC-MS) to determine the identity of glycans (sugars) attached to protein 
• Quantitative analysis of target proteins within the provided biological matrix (LC-MS) 
 
Available Instrumentation: 
• Sciex ZenoTOF 7600 mass spectrometer with Acquity UPLC front-end 
• Waters Synapt G2-Si IMS QTOF mass spectrometer with Acquity UPLC front-end 
• Waters Xevo TQ-S triple quadrupole mass spectrometer with Acquity UPLC front-end 
• Waters Xevo XS-TQ-S triple quadrupole mass spectrometer with Acquity UPLC front-end 
• 2 x Agilent 6890/7890 + 5975/5977 GC-MS instruments 
• Waters Acquity UPLC-UV instruments 

• Waters Acquity UPLC-ELSD instrument 

• Dionex Ion Chromatography system with PAD and Conductivity detection 
• Possibility to collaborate internally at VTT for NMR, ICP-MS, Polymer analysis etc. 
 
Please get in contact if you have any questions or if you are interested in any of our bioanalytics services!