Research Output

2009

Improved fermentation performance of a lager yeast after repair of its AGT1 maltose and maltotriose transporter genes

Vidgren, V., Huuskonen, A., Virtanen, H., Ruohonen, L. & Londesborough, J., 2009, In : Applied and Environmental Microbiology. 75, 8, p. 2333-2345 13 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Low oxygen levels as a trigger for enhancement of respiratory metabolism in Saccharomyces cerevisiae

Rintala, E., Toivari, M., Pitkänen, J. P., Wiebe, M. G., Ruohonen, L. & Penttilä, M., 5 Sep 2009, In : BMC Genomics. 10, 1 p., 1471.

Research output: Contribution to journalArticle

Open Access
34 Citations (Scopus)

Toward understanding of carbohydrate binding and substrate specificity of a glycosyl hydrolase 18 family (GH-18) chitinase from Trichoderma harzianum

Lienemann, M., Boer, H., Paananen, A., Cottaz, S. & Koivula, A., 13 Jul 2009, In : Glycobiology. 19, 10, p. 1116 - 1126

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)
2008

Catalytic pre-treatment of lignocellulosic raw materials

Lahtinen, P., von Weymarn, N., Lankinen, E., Repo, T., Leskelä, M., Kallioinen, A., Uusitalo, J., Siika-aho, M. & Tamminen, T., 2008, Proceedings: 10th European Workshop on Lignocellulosics and Pulp.

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Cellular responses to protein production in the filamentous fungus Trichoderma reesei

Pakula, T., Arvas, M., Rautio, J., Smit, B., Wiebe, M., Koivistoinen, H., Saloheimo, M. & Penttilä, M., 2008.

Research output: Contribution to conferenceConference AbstractScientific

Open Access
57 Citations (Scopus)
Open Access
75 Citations (Scopus)

Production of bioethanol from spruce bark

Uusitalo, J. & Nakari-Setälä, T., 2008, NWBC 2008: 2008 Nordic Wood Biorefinery Conference: Proceedings. p. 238-239

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

Regulation of xylose metabolism in recombinant Saccharomyces cerevisiae

Salusjärvi, L., Kankainen, M., Soliymani, R., Pitkänen, J. P., Penttilä, M. & Ruohonen, L., 4 Jun 2008, In : Microbial Cell Factories. 7, 18.

Research output: Contribution to journalArticle

Open Access
77 Citations (Scopus)

Transcription of hexose transporters of Saccharomyces cerevisiae is affected by change in oxygen provision

Rintala, E., Wiebe, M. G., Tamminen, A., Ruohonen, L. & Penttilä, M., 29 Apr 2008, In : BMC Microbiology. 8, 53.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)
2007

A TRAC study of gene expression in wort fermentations reveals novel aspects of the regulation of sugar transport and membrane synthesis

Rautio, J., Vidgren, V., Londesborough, J. & Huuskonen, A., 2007, 3rd European Federation of Biotechnology Conference: Physiology of Yeasts and Filamentous Fungi PYFF3. Espoo: VTT Technical Research Centre of Finland, p. 102 P49. (VTT Symposium; No. 245).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Geenien ilmentymisen mittaus vahvavierrekäymisten aikana TRAC-menetelmällä

Translated title of the contribution: Measure of gene expression with TRAC during fermentation in high gravity wortRautio, J., Huuskonen, A., Vidgren, V. & Londesborough, J., 2007, In : Mallas ja Olut. 1 , p. 14-19

Research output: Contribution to journalArticle

Monitoring yeast physiology during very high gravity wort fermentations by frequent analysis of gene expression

Rautio, J., Huuskonen, A., Vuokko, H., Vidgren, V. & Londesborough, J., 2007, In : Yeast. 24, 9, p. 741-760

Research output: Contribution to journalArticle

41 Citations (Scopus)

Phosphate-limited continuous flow cultures of Fusarium venenatum A3/5 and production of acid phosphatase

Hidayat, B. J., Wiebe, M. & Eriksen, N. T., 2007, In : Enzyme and Microbial Technology. 40, 4, p. 902-907

Research output: Contribution to journalArticle

1 Citation (Scopus)

Production of bio-ethanol from barley straw and reed canary grass: A raw material study

Pahkala, K., Kontturi, M., Kallioinen, A., Myllymäki, O., Uusitalo, J., Siika-aho, M. & von Weymarn, N., 2007, Proceedings of the 15th European Biomass Conference and Exhibition . p. 154-157

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Open Access

Production of Fusarium solani f. sp. pisi cutinase in Fusarium venenatum A3/5

Sorensen, J. D., Petersen, E. I. & Wiebe, M., 2007, In : Biotechnology Letters. 29, 8, p. 1227-1232

Research output: Contribution to journalArticle

5 Citations (Scopus)

Response of Saccharomyces cerevisiae to change in oxygen provision

Rintala, E., Toivari, M., Wiebe, M., Tamminen, A., Salusjärvi, L., Huuskonen, A., Simolin, H., Kokkonen, J., Kiuru, J., Ruohonen, L. & Penttilä, M., 2007, In : Yeast. 24, S1, p. 137 13-26.

Research output: Contribution to journalOther journal contribution

Open Access

Responses of Saccharomyces cerevisiae to changing oxygen level

Wiebe, M., Rintala, E., Toivari, M., Tamminen, A., Salusjärvi, L., Jouhten, P., Huuskonen, A., Simolin, H., Kokkonen, J., Kiuru, J., Maaheimo, H., Ruohonen, L. & Penttilä, M., 2007, 3rd European Federation of Biotechnology Conference: Physiology of Yeasts and Filamentous Fungi PYFF3. Espoo: VTT Technical Research Centre of Finland, p. 114 P60. (VTT Symposium; No. 245).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

The effect of external oxygen conditions on the metabolic flux distribution of Saccharomyces cerevisiae

Jouhten, P., Rintala, E., Huuskonen, A., Tamminen, A., Toivari, M., Wiebe, M., Rantanen, A., Ruohonen, L., Penttilä, M. & Maaheimo, H., 2007, 3rd European Federation of Biotechnology Conference : Physiology of Yeasts and Filamentous Fungi PYFF3. Espoo: VTT Technical Research Centre of Finland, p. 117 P63. (VTT Symposium; No. 245).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

The ORF YNL274c (GOR1) codes for glyoxylate reductase in Saccharomyces cerevisiae

Rintala, E., Pitkänen, J. P., Vehkomäki, M. L., Penttilä, M. & Ruohonen, L., 1 Feb 2007, In : Yeast. 24, 2, p. 129-136

Research output: Contribution to journalArticle

12 Citations (Scopus)

The response of anaerobically grown Saccharomyces cerevisiae to low and high oxygen in glucose-limited chemostat cultures

Wiebe, M., Rintala, E., Tamminen, A., Simolin, H., Salusjärvi, L., Toivari, M., Jouhten, P., Huuskonen, A., Maaheimo, H., Ruohonen, L. & Penttilä, M., 2007, 3rd European Federation of Biotechnology Conference: Physiology of Yeasts and Filamentous Fungi PYFF3. Espoo: VTT Technical Research Centre of Finland, p. 116 P69. (VTT Symposium; No. 245).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access
2006

Accumulation of phycocyanin in heterotrophic and mixotrophic cultures of the acidophilic red alga Galdieria sulphuraria

Sloth, J. K., Wiebe, M. & Eriksen, N. T., 2006, In : Enzyme and Microbial Technology. 38, 1-2, p. 168-175 8 p.

Research output: Contribution to journalArticleScientificpeer-review

60 Citations (Scopus)

Acid phosphatase production by Aspergillus niger N402A in continuous flow culture

Hidayat, B. J., Eriksen, N. T. & Wiebe, M., 2006, In : FEMS Microbiology Letters. 254, 2, p. 324 - 331

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Monitoring gene expression by TRAC through very high gravity brewing fermentations

Rautio, J., Huuskonen, A., Vuokko, H., Vidgren, V. & Londesborough, J., 2006, International Specialised Symposium on Yeasts ISSY25: Systems Biology of Yeasts - from Models to Applications. Espoo: VTT Technical Research Centre of Finland, p. 135 P79. (VTT Symposium; No. 242).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Physiological response of Saccharomyces cerevisiae to change in oxygen provision

Rintala, E., Toivari, M., Wiebe, M., Tamminen, A., Salusjärvi, L., Huuskonen, A., Simolin, H., Kokkonen, J., Kiuru, J., Maaheimo, H., Ruohonen, L. & Penttilä, M., 2006, International Specialised Symposium on Yeasts ISSY25: Systems Biology of Yeasts - from Models to Applications. Espoo: VTT Technical Research Centre of Finland, p. 39 T24. (VTT Symposium; No. 242).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Studies on the protein-carbohydrate interaction of the Trichoderma harzianum chitinase Chit42

Lienemann, M., Boer, H., Paananen, A. & Koivula, A., 2006. 1 p.

Research output: Contribution to conferenceConference AbstractScientific

Systems biology of yeast: Genome-wide analysis of pentose metabolism in Saccharomyces cerevisiae

Salusjärvi, L., Pitkänen, J-P., Koivistoinen, H., Ruohonen, L. & Penttilä, M., 2006, International Specialised Symposium on Yeasts ISSY25: Systems Biology of Yeasts - from Models to Applications. Espoo: VTT Technical Research Centre of Finland, p. 149 P93. (VTT Symposium; No. 242).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

The effect of oxygen level on metabolic flux distribution of Saccharomyces cerevisoae

Jouhten, P., Rintala, E., Tamminen, A., Huuskonen, A., Wiebe, M., Salusjärvi, L., Toivari, M., Ruohonen, L., Penttilä, M. & Maaheimo, H., 2006, International Specialised Symposium on Yeasts ISSY25: Systems Biology of Yeasts - from Models to Applications. VTT Technical Research Centre of Finland, p. 79 P27. (VTT Symposium; No. 242).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access
Open Access
31 Citations (Scopus)

Transcription analysis of recombinant Saccharomyces cerevisiae reveals novel responses to xylose

Salusjärvi, L., Pitkänen, J. P., Aristidou, A., Ruohonen, L. & Penttilä, M., 1 Jun 2006, In : Applied Biochemistry and Biotechnology. 128, 3, p. 237 - 274

Research output: Contribution to journalArticle

39 Citations (Scopus)
2005

Characterization and functional analysis of the MAL and MPH loci for maltose utilization in some ale and lager yeast strains

Vidgren, V., Ruohonen, L. & Londesborough, J., 2005, In : Applied and Environmental Microbiology. 71, 12, p. 7846 - 7857 12 p.

Research output: Contribution to journalArticleScientificpeer-review

47 Citations (Scopus)
46 Citations (Scopus)

Fysiologialtaan erilaiset hiivapopulaatiot jatkuvatoimisessa, kaksivaiheisessa, immobilisoidussa hiivareaktorissa oluen valmistuksessa

Translated title of the contribution: Different physiological states of yeast in a continuous, two-stage, immobilized yeast reactor making beerHuuskonen, A., Vidgren, V. & Londesborough, J., 2005, In : Mallas ja Olut. 4, p. 101-111

Research output: Contribution to journalArticle

The effect of specific growth rate on protein synthesis and secretion in the filamentous fungus Trichoderma reesei

Pakula, T. M., Salonen, K., Uusitalo, J. & Penttilä, M., 1 Jan 2005, In : Microbiology. 151, 1, p. 135-143 9 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Xylose chemostat isolates of Saccharomyces cerevisiae show altered metabolite and enzyme levels compared with xylose, glucose, and ethanol metabolism of the original strain

Pitkänen, J. P., Rintala, E., Aristidou, A., Ruohonen, L. & Penttilä, M., 1 Jun 2005, In : Applied Microbiology and Biotechnology. 67, 6, p. 827-837 11 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
2004

Evolution of recombinant (t-PA) Trichoderma reesei in chemostats selects mutants down-regulated in cellulase production

Lanthaler, K., Uusitalo, J., Pakula, T., Penttilä, M. & Robson, G. D., 2004, Poster Abstracts. p. 189 VIIIp-5

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Integrative approaches for studying pentose metabolism in Saccharomyces cerevisiae

Salusjärvi, L., Oresic, M., Pitkänen, J-P., Rintala, E., Koivistoinen, H., Ruohonen, L. & Penttilä, M., 2004.

Research output: Contribution to conferenceConference articleScientific

Proteome analysis in Trichoderma reesei

Pakula, T., Riipi, T., Koivistoinen, H., Lanthaler, K., Uusitalo, J., Saloheimo, M., Valmu, L., Kalkkinen, N., Robson, G. & Penttilä, M., 2004.

Research output: Contribution to conferenceConference articleScientific

Quorn™ myco-protein: Overview of a successful fungal product

Wiebe, M., 2004, In : Mycologist. 18, 1, p. 17 - 20 4 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Study of the Pgi deletion in Trichoderma reesei

Limon, C., Uusitalo, J., Saloheimo, M. & Penttilä, M., 2004, Posters Abstracts. VIIIp-36

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Transcriptional and proteomic changes in Trichoderma reesei expressing a heterologous bacterial xynB gene from the thermophile Dictyoglomus thermophilum

Nevalainen, H., Hekelaar, J., Uusitalo, J., Te o, J., Jonkers, I., Bergquist, P. & Penttilä, M., 2004, Poster Abstracts. p. 201 VIIIp-30

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access
2003

Efficient cellulase production by Trichoderma reesei in continuous cultivation on lactose medium with a computer-controlled feeding strategy

Bailey, M. & Tähtiharju, J., 2003, In : Applied Microbiology and Biotechnology. 62, 2-3, p. 156-162 7 p.

Research output: Contribution to journalArticleScientificpeer-review

84 Citations (Scopus)

Investigation of the pentose phosphate pathway in Trichoderma reesei: disruption of the phosphoglucose isomerase gene

Limon, C., Uusitalo, J., Pakula, T., Saloheimo, M. & Penttilä, M., 2003, 22nd Fungal Genetics Conference at Asilomar: Abstracts from the 2003 Fungal Genetics Conference at Asilomar. 30. (Fungal Genetics Reports; No. Article 18, Vol. 50).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Metabolic flux analysis of xylose metabolism in recombinant Saccharomyces cerevisiae using continuous culture

Pitkänen, J. P., Aristidou, A., Salusjärvi, L., Ruohonen, L. & Penttilä, M., 1 Jan 2003, In : Metabolic Engineering. 5, 1, p. 16-31 16 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Proteome analysis of recombinant xylose-fermenting Saccharomyces cerevisiae

Salusjärvi, L., Poutanen, M., Pitkänen, J. P., Koivistoinen, H., Aristidou, A., Kalkkinen, N., Ruohonen, L. & Penttilä, M., 1 Mar 2003, In : Yeast. 20, 4, p. 295-314 20 p.

Research output: Contribution to journalArticleScientificpeer-review

47 Citations (Scopus)

Stable production of recombinant proteins in filamentous fungi: Problems and improvements

Wiebe, M., 2003, In : Mycologist. 17, 3, p. 140-144 5 p.

Research output: Contribution to journalArticleScientificpeer-review

21 Citations (Scopus)
103 Citations (Scopus)
2002

13C-NMR flux ratio analysis of Saccharomyces cerevisiae growing on glucose or xylose in chemostat cultivations

Maaheimo, H., Pitkänen, J-P., Szyperski, T., Aristidou, A. & Penttilä, M., 2002.

Research output: Contribution to conferenceConference PosterScientific