Hannu Maaheimo

20012019
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Research Output 2001 2019

2019
4 Citations (Scopus)

Effect of hydrothermal pretreatment severity on lignin inhibition in enzymatic hydrolysis

Kellock, M., Maaheimo, H., Marjamaa, K., Rahikainen, J., Zhang, H., Holopainen-Mantila, U., Ralph, J., Tamminen, T., Felby, C. & Kruus, K., 2019, In : Bioresource Technology. 280, p. 303-312 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Enzyme inhibition
Enzymatic hydrolysis
Lignin
lignin
hydrolysis

In vitro reconstitution and characterisation of the oxidative d-xylose pathway for production of organic acids and alcohols

Boer, H., Andberg, M., Pylkkänen, R., Maaheimo, H. & Koivula, A., 2019, In : AMB Express. 9, 1, 48.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Xylose
glycolic acid
Alcohols
Acids
Enzymes

Methyljasmonate Elicitation Increases Terpenoid Indole Alkaloid Accumulation in Rhazya stricta Hairy Root Cultures

Akhgari, A., Laakso, I., Maaheimo, H., Choi, Y. H., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 22 Nov 2019, In : Plants. 8, 12, 534.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Rhazya stricta
indole alkaloids
alkaloid
methyl jasmonate
terpenoids
2018
6 Citations (Scopus)

Enzymatic synthesis of fucose-containing galacto-oligosaccharides using β-galactosidase and identification of novel disaccharide structures

Usvalampi, A., Maaheimo, H., Tossavainen, O. & Frey, A. D., 2018, In : Glycoconjugate Journal. 35, 1, p. 31-40 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Galactosidases
Fucose
Disaccharides
Oligosaccharides
Monosaccharides
7 Citations (Scopus)

Structural and functional insights into lysostaphin-substrate interaction

Tossavainen, H., Raulinaitis, V., Kauppinen, L., Pentikäinen, U., Maaheimo, H. & Permi, P., 3 Jul 2018, In : Frontiers in Molecular Biosciences. 5, JUL, 60.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Lysostaphin
Substrates
Molecular Dynamics Simulation
Cell Wall
Molecular dynamics
2017
8 Citations (Scopus)

13C metabolic flux profiling of Pichia pastoris grown in aerobic batch cultures on glucose revealed high relative anabolic use of TCA cycle and limited incorporation of provided precursors of branched-chain amino acids

Zhang, M., Yu, X-W., Xu, Y., Jouhten, P., Swapna, G. V. T., Glaser, R. W., Hunt, J. F., Montelione, G. T., Maaheimo, H. & Szyperski, T., 2017, In : FEBS Journal. 284, 18, p. 3100-3113 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Branched Chain Amino Acids
Batch Cell Culture Techniques
Pichia
Yeast
Threonine Dehydratase
5 Citations (Scopus)

Functional comparison of versatile carbohydrate esterases from families CE1, CE6 and CE16 on acetyl-4-O-methylglucuronoxylan and acetyl-galactoglucomannan

Mai-Gisondi, G., Maaheimo, H., Chong, S-L., Hinz, S., Tenkanen, M. & Master, E., 1 Sep 2017, In : Biochimica et Biophysica Acta: General Subjects. 1861, 9, p. 2398-2405 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Esterases
Carbohydrates
Enzymes
Biocompatible Materials
Polysaccharides
5 Citations (Scopus)

New insight on the structural features of the cytotoxic auristatins MMAE and MMAF revealed by combined NMR spectroscopy and quantum chemical modelling

Johansson, M. P., Maaheimo, H. & Ekholm, F. S., 21 Nov 2017, In : Scientific Reports. 7, 1, p. 15920 15920.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Nuclear magnetic resonance spectroscopy
Pharmaceutical Preparations
Nuclear magnetic resonance
Molecules
Antibodies
4 Citations (Scopus)

Reaction pathways during oxidation of cereal β-glucans

Mäkelä, N., Sontag-Strohm, T., Schiehser, S., Potthast, A., Maaheimo, H. & Maina, N. H., 10 Feb 2017, In : Carbohydrate Polymers. 157, p. 1769-1776 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Glucans
Oxidation
formic acid
Ascorbic acid
Degradation
2016
8 Citations (Scopus)

Carbon 13-Metabolic Flux Analysis derived constraint-based metabolic modelling of Clostridium acetobutylicum in stressed chemostat conditions

Wallenius, J., Maaheimo, H. & Eerikäinen, T., 2016, In : Bioresource Technology. 219, p. 378-386

Research output: Contribution to journalArticleScientificpeer-review

Chemostats
Clostridium
Butanols
chemostat
Butenes
2 Citations (Scopus)

Characterization of a unique Caulobacter crescentus aldose-aldose oxidoreductase having dual activities

Andberg, M., Maaheimo, H., Kumpula, E-P., Boer, H., Toivari, M., Penttilä, M. & Koivula, A., 2016, In : Applied Microbiology and Biotechnology. 100, 2, p. 673-685

Research output: Contribution to journalArticleScientificpeer-review

Caulobacter crescentus
Oxidoreductases
Arabinose
Monosaccharides
Xylose
15 Citations (Scopus)

Lactose- and cellobiose-derived branched trisaccharides and a sucrose-containing trisaccharide produced by acceptor reactions of Weissella confusa dextransucrase

Shi, Q., Juvonen, M., Hou, Y., Kajala, I., Nyyssölä, A., Maina, N. H., Maaheimo, H., Virkki, L. & Tenkanen, M., 2016, In : Food Chemistry. 190, p. 226-236

Research output: Contribution to journalArticleScientificpeer-review

dextransucrase
Weissella
Weissella confusa
trisaccharides
Trisaccharides
6 Citations (Scopus)

Optimization of Isomaltooligosaccharide Size Distribution by Acceptor Reaction of Weissella confusa Dextransucrase and Characterization of Novel [alpha]-(1->2)-Branched Isomaltooligosaccharides

Shi, Q., Hou, Y., Juvonen, M., Tuomainen, P., Kajala, I., Shukla, S., Goyal, A., Maaheimo, H., Katina, K. & Tenkanen, M., 2016, In : Journal of Agricultural and Food Chemistry. 64, 16, p. 3276-3286

Research output: Contribution to journalArticleScientificpeer-review

dextransucrase
Weissella
Weissella confusa
Maltose
maltose
8 Citations (Scopus)

The introduction of the fungal D-galacturonate pathway enables the consumption of D-galacturonic acid by Saccharomyces cerevisiae

Biz, A., Sugai-Guérios, M. H., Kuivanen, J., Maaheimo, H., Krieger, N., Mitchell, D. A. & Richard, P., 2016, In : Microbial Cell Factories. 15, 144

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Yeast
Saccharomyces cerevisiae
Pulp
Acids
Sugar beets
2015
33 Citations (Scopus)

The impact of fermentation with exopolysaccharide producing lactic acid bacteria on rheological, chemical and sensory properties of pureed carrots (Daucus carota L.)

Juvonen, R., Honkapää, K., Maina, N. H., Shi, Q., Viljanen, K., Maaheimo, H., Virkki, L., Tenkanen, M. & Lantto, R., 2015, In : International Journal of Food Microbiology. 207, p. 109-118

Research output: Contribution to journalArticleScientificpeer-review

Daucus carota
exopolysaccharides
rheological properties
carrots
Fermentation
2014
15 Citations (Scopus)

Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway

Ritala, A., Dong, L., Imseng, N., Seppänen-Laakso, T., Vasilev, N., van der Krol, S., Rischer, H., Maaheimo, H., Virkki, A., Brändli, J., Schillerberg, S., Eibl, R., Bouwmeester, H. & Oksman-Caldentey, K-M., 2014, In : Journal of Biotechnology. 176, p. 20-28 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Secologanin Tryptamine Alkaloids
Alkaloids
Tobacco
Fragrances
Glycosides
28 Citations (Scopus)

Impact of steam explosion on the wheat straw lignin structure studied by solution-state nuclear magnetic resonance and density functional methods

Heikkinen, H., Elder, T., Maaheimo, H., Rovio, S., Rahikainen, J., Kruus, K. & Tamminen, T., 2014, In : Journal of Agricultural and Food Chemistry. 62, 43, p. 10437-10444 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Explosions
Lignin
explosions
Steam
Straw
6 Citations (Scopus)

l-Arabinose/d-galactose 1-dehydrogenase of Rhizobium leguminosarum bv. trifolii characterised and applied for bioconversion of l-arabinose to l-arabonate with Saccharomyces cerevisiae

Aro-Kärkkäinen, N., Toivari, M., Maaheimo, H., Ylilauri, M., Pentikäinen, O. T., Andberg, M., Oja, M., Penttilä, M., Wiebe, M. G., Ruohonen, L. & Koivula, A., 1 Jan 2014, In : Applied Microbiology and Biotechnology. 98, 23, p. 9653-9665 13 p.

Research output: Contribution to journalArticleScientificpeer-review

galactose dehydrogenase
Rhizobium leguminosarum
Arabinose
Saccharomyces cerevisiae
Yeasts
24 Citations (Scopus)

O-Acetylation of glucuronoxylan in Arabidopsis thaliana wild type and its change in xylan biosynthesis mutants

Chong, S. L., Virkki, L., Maaheimo, H., Juvonen, M., Derba-Maceluch, M., Koutaniemi, S., Roach, M., Sundberg, B., Tuomainen, P., Mellerowicz, E. J. & Tenkanen, M., 2014, In : Glycobiology. 24, 6, p. 494-506 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Xylans
Acetylation
Biosynthesis
Arabidopsis
Glycosyltransferases
13 Citations (Scopus)

Single cell and in vivo analyses elucidate the effect of xylC lactonase during production of D-xylonate in Saccharomyces cerevisiae

Nygård, Y., Maaheimo, H., Mojzita, D., Toivari, M., Wiebe, M., Resnekov, O., Gustavo Pesce, C., Ruohonen, L. & Penttilä, M., 1 Jan 2014, In : Metabolic Engineering. 25, p. 238-247

Research output: Contribution to journalArticleScientificpeer-review

Xylose
Lactones
Yeast
Saccharomyces cerevisiae
Fluorescence
2013
9 Citations (Scopus)

Characterization of the Ashbya gossypii secreted N-glycome and genomic insights into its N-glycosylation pathway

Aguiar, T. Q., Maaheimo, H., Heiskanen, A., Wiebe, M. G., Penttilä, M. & Domingues, L., 1 Jan 2013, In : Carbohydrate Research. 381, p. 19-27

Research output: Contribution to journalArticleScientificpeer-review

Glycosylation
Polysaccharides
Yeast
Saccharomyces cerevisiae
Genes

Diverse bioconversion of wood-derived diterpene by Nicotianatabacum and Catharanthusroseus cells

Häkkinen, S. T., Lackman, P., Nygrén, H., Oksman-Caldentey, K-M., Maaheimo, H. & Rischer, H., 2013, TERPNET 2013: Book of Abstracts. Aristotle University of Thessaloniki, p. 235 P105

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Expression of two early genes of the terpenoid biosynthetic pathway in tobacco results in major suppression of the pathway and profound changes in non-target metabolites in a differentation state dependent manner

Miralpeix, B., Choi, Y. H., Ritala, A., Maaheimo, H., Seppänen, T., Capell, T., Oksman-Caldentey, K-M., Verpoorte, R. & Christou, P., 2013, Terpnet 2013: Book of Abstracts. 255

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access
32 Citations (Scopus)

Hydrolysis of konjac glucomannan by Trichoderma reesei mannanase and endoglucanases Cel7B and Cel5A for the production of glucomannooligosaccharides

Mikkelson, A., Maaheimo, H. & Hakala, T., 2013, In : Carbohydrate Research. 372, p. 60-68 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Trichoderma
Oligosaccharides
Hydrolysis
Enzymes
Amorphophallus

Identification and characterization of enzymes involved in the oxidative D-galacturonic acid pathway

Koivula, A., Andberg, M., Maaheimo, H., Boer, H., Mojzita, D., Wiebe, M., Richard, P., Parkkinen, T., Taberman, H., Rouvinen, J. & Penttilä, M., 2013.

Research output: Contribution to conferenceConference AbstractScientific

2012
24 Citations (Scopus)
Agrobacterium tumefaciens
uronate dehydrogenase
Lactones
mandelate racemase
Enzymes
11 Citations (Scopus)

Differential patterns of dehydroabietic acid biotransformation by Nicotiana tabacum and Catharanthus roseus cells

Häkkinen, S. T., Lackman, P., Nygren, H., Oksman-Caldentey, K-M., Maaheimo, H. & Rischer, H., 2012, In : Journal of Biotechnology. 157, 2, p. 287-294 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Catharanthus
Biotransformation
Tobacco
Acids
Bioconversion
16 Citations (Scopus)
Aspergillus niger
Galactitol
Galactose
Oxidoreductases
Xylose
44 Citations (Scopus)

Metabolic engineering of Saccharomyces cerevisiae for bioconversion of d-xylose to d-xylonate

Toivari, M., Nygård, Y., Kumpula, E. P., Vehkomäki, M. L., Benčina, M., Valkonen, M., Maaheimo, H., Andberg, M., Koivula, A., Ruohonen, L., Penttilä, M. & Wiebe, M. G., 1 Jul 2012, In : Metabolic Engineering. 14, 4, p. 427-436

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Metabolic engineering
Metabolic Engineering
Bioconversion
Xylose
Xylitol
68 Citations (Scopus)

Metabolic flux profiling of recombinant protein secreting Pichia pastoris growing on glucose:methanol mixtures

Jordà, J., Jouhten, P., Cámara, E., Maaheimo, H., Albiol, J. & Ferrer, P., 2012, In : Microbial Cell Factories. 11, 14 p., 57.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Recombinant proteins
Pichia
Recombinant Proteins
Glucose
Methanol
2011
122 Citations (Scopus)

Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco

Lackman, P., González-Guzmán, M., Tilleman, S., Carqueijeiro, I., Cuéllar Pérez, A., Moses, T., Seo, M., Kanno, Y., Häkkinen, S. T., Van Montagu, M. C. E., Thevelein, J. M., Maaheimo, H., Oksman-Caldentey, K-M., Rodriguez, P. L., Rischer, H. & Goossens, A., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 14, p. 5891-5896

Research output: Contribution to journalArticleScientificpeer-review

abscisic acid
tobacco
Arabidopsis
receptors
alkaloids

Metabolism of Saccharomyces cerevisiae in sudden oxygen depletion

Jouhten, P., Rintala, E., Wiebe, M., Maaheimo, H., Ruohonen, L. & Penttilä, M., 2011, 12the International Conference on Systems Biology 2011 (ICSB 2011). Curran Associates Inc.

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

31 Citations (Scopus)

Structural Analysis of Enzyme-Resistant Isomaltooligosaccharides Reveals the Elongation of α-(1→3)-Linked Branches in Weissella confusa Dextran

Maina, N. H., Virkki, L., Pynnönen, H., Maaheimo, H. & Tenkanen, M., 2011, In : Biomacromolecules. 12, 2, p. 409-418 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Dextran
Dextrans
Structural analysis
Oligosaccharides
Elongation
21 Citations (Scopus)

Transcriptional responses of saccharomyces cerevisiae to shift from respiratory and respirofermentative to fully fermentative metabolism

Rintala, E., Jouhten, P., Toivari, M., Wiebe, M. G., Maaheimo, H., Penttilä, M. & Ruohonen, L., 1 Jul 2011, In : OMICS: A Journal of Integrative Biology. 15, 7-8, p. 461-476

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Metabolism
Yeast
Saccharomyces cerevisiae
Oxygen
Pentoses
2010
11 Citations (Scopus)

13C isotope effects on 1H chemical shifts: NMR spectral analysis of 13C-labelled D-glucose and some 13C-labelled amino acids

Tiainen, M., Maaheimo, H., Soininen, P. & Laatikainen, R., 2010, In : Magnetic Resonance in Chemistry. 48, 2, p. 117-122 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Chemical shift
Isotopes
Spectrum analysis
Glucose
Amino acids

1H NMR metabolic profiling of A. thaliana expressing Vitreoscilla hemoglobin (VHb) under oxygen deprivation and NO treatment

Lackman, P., Blokhina, O., Maaheimo, H., Fagerstedt, K. & Rischer, H., 2010, Metabolomics 2010, abstract book: Breakthroughs in plant, microbial and human biology, clinical and nutritional research, and biomarker discovery . 146

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access
98 Citations (Scopus)

A multi-level study of recombinant Pichia pastoris in different oxygen conditions

Baumann, K., Carnicer, M., Dragosits, M., Graf, A. B., Stadlmann, J., Jouhten, P., Maaheimo, H., Gasser, B., Albiol, J., Mattanovich, D. & Ferrer, P., 2010, In : BMC Systems Biology. 4, 141

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Pichia
Yeast
Oxygen
Hypoxia
Secretion
17 Citations (Scopus)
Ribitol
Pentose Phosphate Pathway
Ribose
Saccharomyces cerevisiae
Glucose
35 Citations (Scopus)

Identification in Agrobacterium tumefaciens of the D-galacturonic acid dehydrogenase gene

Boer, H., Maaheimo, H., Koivula, A., Penttilä, M. & Richard, P., 1 Apr 2010, In : Applied Microbiology and Biotechnology. 86, 3, p. 901-909

Research output: Contribution to journalArticleScientificpeer-review

Agrobacterium tumefaciens
Oxidoreductases
NAD
uronate dehydrogenase
Lactones
2009
18 Citations (Scopus)
Open Access
Trichoderma
Glucose
Pathway
Carbon
Yeast
2008
49 Citations (Scopus)

Acyl group migration and cleavage in selectively protected β-d-galactopyranosides as studied by NMR spectroscopy and kinetic calculations

Roslund, M. U., Aitio, O., Wärnå, J., Maaheimo, H., Murzin, D. Y. & Leino, R., 2008, In : Journal of the American Chemical Society. 130, 27, p. 8769-8772 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Galactose
Nuclear magnetic resonance spectroscopy
Esters
Magnetic Resonance Spectroscopy
Kinetics
37 Citations (Scopus)

An analytic and systematic framework for estimating metabolic flux ratios from 13C tracer experiments

Rantanen, A., Rousu, J., Jouhten, P., Zamboni, N., Maaheimo, H. & Ukkonen, E., 2008, In : BMC Bioinformatics. 2008, 9, 266.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Metabolic Flux Analysis
Fluxes
Glucose
Metabolic Networks and Pathways
Bacillus subtilis
57 Citations (Scopus)

Central carbon metabolism of Saccharomyces cerevisiae in anaerobic, oxygen-limited and fully aerobic steady-state conditions and following a shift to anaerobic conditions

Wiebe, M. G., Rintala, E., Tamminen, A., Simolin, H., Salusjärvi, L., Toivari, M., Kokkonen, J. T., Kiuru, J., Ketola, R. A., Jouhten, P., Huuskonen, A., Maaheimo, H., Ruohonen, L. & Penttilä, M., 1 Feb 2008, In : FEMS Yeast Research. 8, 1, p. 140-154

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Saccharomyces cerevisiae
Carbon
Oxygen
Citric Acid Cycle
Glycolysis
116 Citations (Scopus)

NMR spectroscopic analysis of exopolysaccharides produced by Leuconostoc citreum and Weissella confusa

Maina, N. H., Tenkanen, M., Maaheimo, H., Juvonen, R. & Virkki, L., 2008, In : Carbohydrate Research. 343, 9, p. 1446-1455 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Weissella
Leuconostoc
Spectroscopic analysis
Dextrans
Nuclear magnetic resonance
75 Citations (Scopus)

Oxygen dependence of metabolic fluxes and energy generation of Saccharomyces cerevisiae CEN.PK113-1A

Jouhten, P., Rintala, E., Huuskonen, A., Tamminen, A., Toivari, M., Wiebe, M., Ruohonen, L., Penttilä, M. & Maaheimo, H., 9 Jul 2008, In : BMC Systems Biology. 2, 60.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Saccharomyces Cerevisiae
Yeast
Saccharomyces cerevisiae
Oxygen
Fluxes
14 Citations (Scopus)

Spectral analysis of 1H coupled 13C spectra of the amino acids: Adaptive spectral library of amino acid 13C isotopomers and positional fractional 13C enrichments

Tiainen, M., Maaheimo, H., Niemitz, M., Soininen, P. & Laatikainen, R., 2008, In : Magnetic Resonance in Chemistry. 46, 2, p. 125 - 137 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Spectrum analysis
Amino acids
Amino Acids
Glucose
Nuclear magnetic resonance
2007
12 Citations (Scopus)

1H NMR at 800 MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins

Soininen, P., Öörni, K., Maaheimo, H., Laatikainen, R., Kovanen, P. T., Kaski, K. & Ala-Korpela, M., 2007, In : Biochemical and Biophysical Research Communications. 360, 1, p. 290-294

Research output: Contribution to journalArticleScientificpeer-review

LDL Lipoproteins
Phospholipids
Lysophosphatidylcholines
Nuclear magnetic resonance
1-Alkyl-2-acetylglycerophosphocholine Esterase
68 Citations (Scopus)

Metabolic flux profiling of Pichia pastoris grown on glycerol/methanol mixtures in chemostat cultures at low and high dilution rates

Solà, A., Jouhten, P., Maaheimo, H., Sánchez-Ferrando, F., Szyperski, T. & Ferrer, P., 2007, In : Microbiology. 153, 1, p. 281-290

Research output: Contribution to journalArticleScientificpeer-review

Responses of Saccharomyces cerevisiae to changing oxygen level

Wiebe, M., Rintala, E., Toivari, M., Tamminen, A., Salusjärvi, L., Jouhten, P., Huuskonen, A., Simolin, H., Kokkonen, J., Kiuru, J., Maaheimo, H., Ruohonen, L. & Penttilä, M., 2007, 3rd European Federation of Biotechnology Conference: Physiology of Yeasts and Filamentous Fungi PYFF3. Espoo: VTT Technical Research Centre of Finland, p. 114 P60. (VTT Symposium; No. 245).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access
Saccharomyces cerevisiae
metabolites
oxygen
gases
transcriptome