Hannu Maaheimo

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Research output per year

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Research Output

13C-constrained metabolic flux balancing analysis of Pichia pastoris grown on different carbon sources

Santos, S., Jouhten, P., Maaheimo, H., Albiol, J. & Ferrer, P., 2006, International Specialised Symposium on Yeasts ISSY25: Systems Biology of Yeasts - from Models to Applications. Espoo: VTT Technical Research Centre of Finland, p. 118-119 P63. (VTT Symposium; No. 242).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

13C isotope effects on 1H chemical shifts: NMR spectral analysis of 13C-labelled D-glucose and some 13C-labelled amino acids

Tiainen, M., Maaheimo, H., Soininen, P. & Laatikainen, R., 2010, In : Magnetic Resonance in Chemistry. 48, 2, p. 117-122 6 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

13C metabolic flux profiling of Pichia pastoris grown in aerobic batch cultures on glucose revealed high relative anabolic use of TCA cycle and limited incorporation of provided precursors of branched-chain amino acids

Zhang, M., Yu, X-W., Xu, Y., Jouhten, P., Swapna, G. V. T., Glaser, R. W., Hunt, J. F., Montelione, G. T., Maaheimo, H. & Szyperski, T., 2017, In : FEBS Journal. 284, 18, p. 3100-3113 14 p.

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)
Open Access
19 Citations (Scopus)

13C-NMR flux ratio analysis of Saccharomyces cerevisiae growing on glucose or xylose in chemostat cultivations

Maaheimo, H., Pitkänen, J-P., Szyperski, T., Aristidou, A. & Penttilä, M., 2002.

Research output: Contribution to conferenceConference PosterScientific

13NMR flux ratio analysis of Saccharomyces cerevisiae growing on glucose or xylose in chemostat cultivations

Maaheimo, H., Pitkänen, J-P., Szyperski, T., Salusjärvi, L., Aristidou, A. & Penttilä, M., 2002.

Research output: Contribution to conferenceConference articleScientific

1H NMR at 800 MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins

Soininen, P., Öörni, K., Maaheimo, H., Laatikainen, R., Kovanen, P. T., Kaski, K. & Ala-Korpela, M., 2007, In : Biochemical and Biophysical Research Communications. 360, 1, p. 290-294

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)

1H NMR metabolic profiling of A. thaliana expressing Vitreoscilla hemoglobin (VHb) under oxygen deprivation and NO treatment

Lackman, P., Blokhina, O., Maaheimo, H., Fagerstedt, K. & Rischer, H., 2010, Metabolomics 2010, abstract book: Breakthroughs in plant, microbial and human biology, clinical and nutritional research, and biomarker discovery . 146

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

2D Assignment and quantitative analysis of cellulose and oxidized celluloses using solution-state NMR spectroscopy

Koso, T., Rico del Cerro, D., Heikkinen, S., Nypelö, T., Buffiere, J., Perea-Buceta, J. E., Potthast, A., Rosenau, T., Heikkinen, H., Maaheimo, H., Isogai, A., Kilpeläinen, I. & King, A. W. T., 1 Sep 2020, In : Cellulose. 27, 14, p. 7929-7953 25 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Acyl group migration and cleavage in selectively protected β-d-galactopyranosides as studied by NMR spectroscopy and kinetic calculations

Roslund, M. U., Aitio, O., Wärnå, J., Maaheimo, H., Murzin, D. Y. & Leino, R., 2008, In : Journal of the American Chemical Society. 130, 27, p. 8769-8772 4 p.

Research output: Contribution to journalArticleScientificpeer-review

60 Citations (Scopus)

A framework for direct metabolic flux estimation

Rantanen, A., Rousu, J., Pitkänen, E., Maaheimo, H., Mielikäinen, T. & Ukkonen, E., 2006, International Specialised Symposium on Yeasts ISSY25: Systems Biology of Yeasts - from Models to Applications. Espoo: VTT Technical Research Centre of Finland, p. 117 P62. (VTT Symposium; No. 242).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

A method for estimating metabolic fluxes from incomplete isotopomer information

Rousu, J., Rantanen, A., Maaheimo, H., Pitkänen, E., Saarela, K. & Ukkonen, E., 2003, Computational Methods in Systems Biology. Springer, Vol. Part II. p. 88-103 (Lecture Notes in Computer Science, Vol. 2602).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

9 Citations (Scopus)

Amino acid biosynthesis and metabolic flux profiling of Pichia pastoris

Solà, A., Maaheimo, H., Ylönen, K., Ferrer, P. & Szyperski, T., 2004, In : European Journal of Biochemistry. 271, 12, p. 2462 - 2470 9 p.

Research output: Contribution to journalArticleScientificpeer-review

78 Citations (Scopus)

A multi-level study of recombinant Pichia pastoris in different oxygen conditions

Baumann, K., Carnicer, M., Dragosits, M., Graf, A. B., Stadlmann, J., Jouhten, P., Maaheimo, H., Gasser, B., Albiol, J., Mattanovich, D. & Ferrer, P., 2010, In : BMC Systems Biology. 4, 141

Research output: Contribution to journalArticleScientificpeer-review

Open Access
104 Citations (Scopus)

An analytic and systematic framework for estimating metabolic flux ratios from 13C tracer experiments

Rantanen, A., Rousu, J., Jouhten, P., Zamboni, N., Maaheimo, H. & Ukkonen, E., 2008, In : BMC Bioinformatics. 2008, 9, 266.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
36 Citations (Scopus)

Anatalline and other methyl jasmonate-inducible nicotine alkaloids from Nicotiana tabacum cv. BY-2 cell cultures

Häkkinen, S. T., Rischer, H., Laakso, I., Maaheimo, H., Seppänen-Laakso, T. & Oksman-Caldentey, K-M., 2004, In : Planta Medica. 70, 10, p. 936 - 941 6 p.

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)

Carbon 13-Metabolic Flux Analysis derived constraint-based metabolic modelling of Clostridium acetobutylicum in stressed chemostat conditions

Wallenius, J., Maaheimo, H. & Eerikäinen, T., 2016, In : Bioresource Technology. 219, p. 378-386

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)

Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional 13C labeling of common amino acids

Maaheimo, H., Fiaux, J., Cakar, Z. P., Bailey, J. E., Sauer, U. & Szyperski, T., 2001, In : FEBS Journal. 268, 8, p. 2464-2479 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
138 Citations (Scopus)

Central carbon metabolism of Saccharomyces cerevisiae in anaerobic, oxygen-limited and fully aerobic steady-state conditions and following a shift to anaerobic conditions

Wiebe, M. G., Rintala, E., Tamminen, A., Simolin, H., Salusjärvi, L., Toivari, M., Kokkonen, J. T., Kiuru, J., Ketola, R. A., Jouhten, P., Huuskonen, A., Maaheimo, H., Ruohonen, L. & Penttilä, M., 1 Feb 2008, In : FEMS Yeast Research. 8, 1, p. 140-154

Research output: Contribution to journalArticleScientificpeer-review

Open Access
60 Citations (Scopus)

Characterisation of fractions obtained by isoamylolysis and ion-exchange chromatography of cationic waxy maize starch

Manelius, R., Maaheimo, H., Nurmi, K. & Bertoft, E., 2002, In : Stärke. 54, 2, p. 58-65

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)
24 Citations (Scopus)

Characterization of a unique Caulobacter crescentus aldose-aldose oxidoreductase having dual activities

Andberg, M., Maaheimo, H., Kumpula, E-P., Boer, H., Toivari, M., Penttilä, M. & Koivula, A., 2016, In : Applied Microbiology and Biotechnology. 100, 2, p. 673-685

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Characterization of the Ashbya gossypii secreted N-glycome and genomic insights into its N-glycosylation pathway

Aguiar, T. Q., Maaheimo, H., Heiskanen, A., Wiebe, M. G., Penttilä, M. & Domingues, L., 1 Jan 2013, In : Carbohydrate Research. 381, p. 19-27

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Cloning and functional expression of a novel GDP-6-deoxy-D-talose synthetase from Actinobacillus actinomycetemcomitans

Mäki, M., Järvinen, N., Räbinä, J., Maaheimo, H., Mattila, P. & Renkonen, R., 2003, In : Glycobiology. 13, 4, p. 295-303 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
15 Citations (Scopus)

Differential patterns of dehydroabietic acid biotransformation by Nicotiana tabacum and Catharanthus roseus cells

Häkkinen, S. T., Lackman, P., Nygren, H., Oksman-Caldentey, K-M., Maaheimo, H. & Rischer, H., 2012, In : Journal of Biotechnology. 157, 2, p. 287-294 8 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Diverse bioconversion of wood-derived diterpene by Nicotianatabacum and Catharanthusroseus cells

Häkkinen, S. T., Lackman, P., Nygrén, H., Oksman-Caldentey, K-M., Maaheimo, H. & Rischer, H., 2013, TERPNET 2013: Book of Abstracts. Aristotle University of Thessaloniki, p. 235 P105

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Effect of hydrothermal pretreatment severity on lignin inhibition in enzymatic hydrolysis

Kellock, M., Maaheimo, H., Marjamaa, K., Rahikainen, J., Zhang, H., Holopainen-Mantila, U., Ralph, J., Tamminen, T., Felby, C. & Kruus, K., 2019, In : Bioresource Technology. 280, p. 303-312 10 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Effect of oxygen level metabolic fluxes and metabolite levels of yeast studied by NMR spectroscopy

Jouhten, P., Perälä, M., Rintala, E., Ruohonen, L., Penttilä, M. & Maaheimo, H., 2005.

Research output: Contribution to conferenceConference articleScientific

19 Citations (Scopus)

Enzymatic synthesis of fucose-containing galacto-oligosaccharides using β-galactosidase and identification of novel disaccharide structures

Usvalampi, A., Maaheimo, H., Tossavainen, O. & Frey, A. D., 2018, In : Glycoconjugate Journal. 35, 1, p. 31-40 10 p.

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)

Equivalence of metabolite fragments and flow analysis of isotopomer distributions for flux estimation

Rantanen, A., Maaheimo, H., Pitkänen, E., Rousu, J. & Ukkonen, E., 2006, Transactions on Computational Systems Biology VI. Priami, C. & Plotkin, G. (eds.). Berlin - Heidelberg: Springer, p. 198-220 (Transactions on Computational Systems Biology, Vol. VI). (Lecture Notes in Computer Science, Vol. 4420).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

1 Citation (Scopus)

Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway

Ritala, A., Dong, L., Imseng, N., Seppänen-Laakso, T., Vasilev, N., van der Krol, S., Rischer, H., Maaheimo, H., Virkki, A., Brändli, J., Schillerberg, S., Eibl, R., Bouwmeester, H. & Oksman-Caldentey, K-M., 2014, In : Journal of Biotechnology. 176, p. 20-28 8 p.

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)

Expression of two early genes of the terpenoid biosynthetic pathway in tobacco results in major suppression of the pathway and profound changes in non-target metabolites in a differentation state dependent manner

Miralpeix, B., Choi, Y. H., Ritala, A., Maaheimo, H., Seppänen, T., Capell, T., Oksman-Caldentey, K-M., Verpoorte, R. & Christou, P., 2013, Terpnet 2013: Book of Abstracts. 255

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Flow analysis of metabolite fragments for flux estimation

Rantanen, A., Rousu, J., Pitkänen, E., Maaheimo, H. & Ukkonen, E., 2005, Proceedings of CMSB 2005.

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Functional comparison of versatile carbohydrate esterases from families CE1, CE6 and CE16 on acetyl-4-O-methylglucuronoxylan and acetyl-galactoglucomannan

Mai-Gisondi, G., Maaheimo, H., Chong, S-L., Hinz, S., Tenkanen, M. & Master, E., 1 Sep 2017, In : Biochimica et Biophysica Acta: General Subjects. 1861, 9, p. 2398-2405 8 p.

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)

Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose

Mäki, M., Järvinen, N., Räbinä, J., Roos, C., Maaheimo, H., Mattila, P. & Renkonen, R., 2002, In : European Journal of Biochemistry. 269, 2, p. 593-601

Research output: Contribution to journalArticleScientificpeer-review

25 Citations (Scopus)

Human alfa3-fucosyltransferases convert chitin oligosaccharides to products containing a GlcNacbeta1-4(Fucalfa1-3)GlcNAc beta1-4R determinant at the nonreducing terminus

Natunen, J., Aitio, O., Helin, J., Maaheimo, H., Niemelä, R., Heikkinen, S. & Renkonen, O., 2001, In : Glycobiology. 11, 3, p. 209-216 8 p.

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Hydrolysis of konjac glucomannan by Trichoderma reesei mannanase and endoglucanases Cel7B and Cel5A for the production of glucomannooligosaccharides

Mikkelson, A., Maaheimo, H. & Hakala, T., 2013, In : Carbohydrate Research. 372, p. 60-68 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
35 Citations (Scopus)

Identification and characterization of enzymes involved in the oxidative D-galacturonic acid pathway

Koivula, A., Andberg, M., Maaheimo, H., Boer, H., Mojzita, D., Wiebe, M., Richard, P., Parkkinen, T., Taberman, H., Rouvinen, J. & Penttilä, M., 2013.

Research output: Contribution to conferenceConference AbstractScientific

Identification in Agrobacterium tumefaciens of the D-galacturonic acid dehydrogenase gene

Boer, H., Maaheimo, H., Koivula, A., Penttilä, M. & Richard, P., 1 Apr 2010, In : Applied Microbiology and Biotechnology. 86, 3, p. 901-909

Research output: Contribution to journalArticleScientificpeer-review

37 Citations (Scopus)
18 Citations (Scopus)

Impact of steam explosion on the wheat straw lignin structure studied by solution-state nuclear magnetic resonance and density functional methods

Heikkinen, H., Elder, T., Maaheimo, H., Rovio, S., Rahikainen, J., Kruus, K. & Tamminen, T., 2014, In : Journal of Agricultural and Food Chemistry. 62, 43, p. 10437-10444

Research output: Contribution to journalArticleScientificpeer-review

31 Citations (Scopus)

Integrative approaches for studying pentose metabolism in Saccharomyces cerevisiae

Salusjärvi, L., Oresic, M., Maaheimo, H., Rintala, E., Simolin, H., Ruohonen, L. & Penttilä, M., 2004.

Research output: Contribution to conferenceConference articleScientific

Integrative approaches for studying pentose metabolism in Saccharomyces cerevisiae

Ruohonen, L., Salusjärvi, L., Oresic, M., Maaheimo, H., Rintala, E., Simolin, H. & Penttilä, M., 2004.

Research output: Contribution to conferenceConference articleScientific

In vitro reconstitution and characterisation of the oxidative d-xylose pathway for production of organic acids and alcohols

Boer, H., Andberg, M., Pylkkänen, R., Maaheimo, H. & Koivula, A., 2019, In : AMB Express. 9, 1, 48.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2 Citations (Scopus)

Isotopomer analysis by mass spectrometry and mathematical algorithm

Kokkonen, J., Tarkiainen, V., Ketola, R. A., Rantanen, A., Rousu, J. & Maaheimo, H., 2003. 1 p.

Research output: Contribution to conferenceConference articleScientific

Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco

Lackman, P., González-Guzmán, M., Tilleman, S., Carqueijeiro, I., Cuéllar Pérez, A., Moses, T., Seo, M., Kanno, Y., Häkkinen, S. T., Van Montagu, M. C. E., Thevelein, J. M., Maaheimo, H., Oksman-Caldentey, K-M., Rodriguez, P. L., Rischer, H. & Goossens, A., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 14, p. 5891-5896

Research output: Contribution to journalArticleScientificpeer-review

137 Citations (Scopus)

Labelling analysis for 13C MFA using NMR spectroscopy

Jouhten, P. & Maaheimo, H., 12 Jul 2014, Metabolic Flux Analysis. Krömer, J., Nielsen, L. & Blank, L. (eds.). Springer, p. 143-164 22 p. (Methods in Molecular Biology, Vol. 1191).

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

3 Citations (Scopus)

Lactose- and cellobiose-derived branched trisaccharides and a sucrose-containing trisaccharide produced by acceptor reactions of Weissella confusa dextransucrase

Shi, Q., Juvonen, M., Hou, Y., Kajala, I., Nyyssölä, A., Maina, N. H., Maaheimo, H., Virkki, L. & Tenkanen, M., 2016, In : Food Chemistry. 190, p. 226-236

Research output: Contribution to journalArticleScientificpeer-review

17 Citations (Scopus)