Hannu Maaheimo

  • Phone+358505229978
20012020

Research output per year

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Research Output

Article

13C isotope effects on 1H chemical shifts: NMR spectral analysis of 13C-labelled D-glucose and some 13C-labelled amino acids

Tiainen, M., Maaheimo, H., Soininen, P. & Laatikainen, R., 2010, In : Magnetic Resonance in Chemistry. 48, 2, p. 117-122 6 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

13C metabolic flux profiling of Pichia pastoris grown in aerobic batch cultures on glucose revealed high relative anabolic use of TCA cycle and limited incorporation of provided precursors of branched-chain amino acids

Zhang, M., Yu, X-W., Xu, Y., Jouhten, P., Swapna, G. V. T., Glaser, R. W., Hunt, J. F., Montelione, G. T., Maaheimo, H. & Szyperski, T., 2017, In : FEBS Journal. 284, 18, p. 3100-3113 14 p.

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)
Open Access
19 Citations (Scopus)

1H NMR at 800 MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins

Soininen, P., Öörni, K., Maaheimo, H., Laatikainen, R., Kovanen, P. T., Kaski, K. & Ala-Korpela, M., 2007, In : Biochemical and Biophysical Research Communications. 360, 1, p. 290-294

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)

2D Assignment and quantitative analysis of cellulose and oxidized celluloses using solution-state NMR spectroscopy

Koso, T., Rico del Cerro, D., Heikkinen, S., Nypelö, T., Buffiere, J., Perea-Buceta, J. E., Potthast, A., Rosenau, T., Heikkinen, H., Maaheimo, H., Isogai, A., Kilpeläinen, I. & King, A. W. T., 1 Sep 2020, In : Cellulose. 27, 14, p. 7929-7953 25 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Acyl group migration and cleavage in selectively protected β-d-galactopyranosides as studied by NMR spectroscopy and kinetic calculations

Roslund, M. U., Aitio, O., Wärnå, J., Maaheimo, H., Murzin, D. Y. & Leino, R., 2008, In : Journal of the American Chemical Society. 130, 27, p. 8769-8772 4 p.

Research output: Contribution to journalArticleScientificpeer-review

60 Citations (Scopus)

Amino acid biosynthesis and metabolic flux profiling of Pichia pastoris

Solà, A., Maaheimo, H., Ylönen, K., Ferrer, P. & Szyperski, T., 2004, In : European Journal of Biochemistry. 271, 12, p. 2462 - 2470 9 p.

Research output: Contribution to journalArticleScientificpeer-review

78 Citations (Scopus)

A multi-level study of recombinant Pichia pastoris in different oxygen conditions

Baumann, K., Carnicer, M., Dragosits, M., Graf, A. B., Stadlmann, J., Jouhten, P., Maaheimo, H., Gasser, B., Albiol, J., Mattanovich, D. & Ferrer, P., 2010, In : BMC Systems Biology. 4, 141

Research output: Contribution to journalArticleScientificpeer-review

Open Access
104 Citations (Scopus)

An analytic and systematic framework for estimating metabolic flux ratios from 13C tracer experiments

Rantanen, A., Rousu, J., Jouhten, P., Zamboni, N., Maaheimo, H. & Ukkonen, E., 2008, In : BMC Bioinformatics. 2008, 9, 266.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
36 Citations (Scopus)

Anatalline and other methyl jasmonate-inducible nicotine alkaloids from Nicotiana tabacum cv. BY-2 cell cultures

Häkkinen, S. T., Rischer, H., Laakso, I., Maaheimo, H., Seppänen-Laakso, T. & Oksman-Caldentey, K-M., 2004, In : Planta Medica. 70, 10, p. 936 - 941 6 p.

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)

Carbon 13-Metabolic Flux Analysis derived constraint-based metabolic modelling of Clostridium acetobutylicum in stressed chemostat conditions

Wallenius, J., Maaheimo, H. & Eerikäinen, T., 2016, In : Bioresource Technology. 219, p. 378-386

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)

Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional 13C labeling of common amino acids

Maaheimo, H., Fiaux, J., Cakar, Z. P., Bailey, J. E., Sauer, U. & Szyperski, T., 2001, In : FEBS Journal. 268, 8, p. 2464-2479 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
138 Citations (Scopus)

Central carbon metabolism of Saccharomyces cerevisiae in anaerobic, oxygen-limited and fully aerobic steady-state conditions and following a shift to anaerobic conditions

Wiebe, M. G., Rintala, E., Tamminen, A., Simolin, H., Salusjärvi, L., Toivari, M., Kokkonen, J. T., Kiuru, J., Ketola, R. A., Jouhten, P., Huuskonen, A., Maaheimo, H., Ruohonen, L. & Penttilä, M., 1 Feb 2008, In : FEMS Yeast Research. 8, 1, p. 140-154

Research output: Contribution to journalArticleScientificpeer-review

Open Access
60 Citations (Scopus)

Characterisation of fractions obtained by isoamylolysis and ion-exchange chromatography of cationic waxy maize starch

Manelius, R., Maaheimo, H., Nurmi, K. & Bertoft, E., 2002, In : Stärke. 54, 2, p. 58-65

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)
24 Citations (Scopus)

Characterization of a unique Caulobacter crescentus aldose-aldose oxidoreductase having dual activities

Andberg, M., Maaheimo, H., Kumpula, E-P., Boer, H., Toivari, M., Penttilä, M. & Koivula, A., 2016, In : Applied Microbiology and Biotechnology. 100, 2, p. 673-685

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Characterization of the Ashbya gossypii secreted N-glycome and genomic insights into its N-glycosylation pathway

Aguiar, T. Q., Maaheimo, H., Heiskanen, A., Wiebe, M. G., Penttilä, M. & Domingues, L., 1 Jan 2013, In : Carbohydrate Research. 381, p. 19-27

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Cloning and functional expression of a novel GDP-6-deoxy-D-talose synthetase from Actinobacillus actinomycetemcomitans

Mäki, M., Järvinen, N., Räbinä, J., Maaheimo, H., Mattila, P. & Renkonen, R., 2003, In : Glycobiology. 13, 4, p. 295-303 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
15 Citations (Scopus)

Differential patterns of dehydroabietic acid biotransformation by Nicotiana tabacum and Catharanthus roseus cells

Häkkinen, S. T., Lackman, P., Nygren, H., Oksman-Caldentey, K-M., Maaheimo, H. & Rischer, H., 2012, In : Journal of Biotechnology. 157, 2, p. 287-294 8 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Effect of hydrothermal pretreatment severity on lignin inhibition in enzymatic hydrolysis

Kellock, M., Maaheimo, H., Marjamaa, K., Rahikainen, J., Zhang, H., Holopainen-Mantila, U., Ralph, J., Tamminen, T., Felby, C. & Kruus, K., 2019, In : Bioresource Technology. 280, p. 303-312 10 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)
19 Citations (Scopus)

Enzymatic synthesis of fucose-containing galacto-oligosaccharides using β-galactosidase and identification of novel disaccharide structures

Usvalampi, A., Maaheimo, H., Tossavainen, O. & Frey, A. D., 2018, In : Glycoconjugate Journal. 35, 1, p. 31-40 10 p.

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)

Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway

Ritala, A., Dong, L., Imseng, N., Seppänen-Laakso, T., Vasilev, N., van der Krol, S., Rischer, H., Maaheimo, H., Virkki, A., Brändli, J., Schillerberg, S., Eibl, R., Bouwmeester, H. & Oksman-Caldentey, K-M., 2014, In : Journal of Biotechnology. 176, p. 20-28 8 p.

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)

Functional comparison of versatile carbohydrate esterases from families CE1, CE6 and CE16 on acetyl-4-O-methylglucuronoxylan and acetyl-galactoglucomannan

Mai-Gisondi, G., Maaheimo, H., Chong, S-L., Hinz, S., Tenkanen, M. & Master, E., 1 Sep 2017, In : Biochimica et Biophysica Acta: General Subjects. 1861, 9, p. 2398-2405 8 p.

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)

Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose

Mäki, M., Järvinen, N., Räbinä, J., Roos, C., Maaheimo, H., Mattila, P. & Renkonen, R., 2002, In : European Journal of Biochemistry. 269, 2, p. 593-601

Research output: Contribution to journalArticleScientificpeer-review

25 Citations (Scopus)

Human alfa3-fucosyltransferases convert chitin oligosaccharides to products containing a GlcNacbeta1-4(Fucalfa1-3)GlcNAc beta1-4R determinant at the nonreducing terminus

Natunen, J., Aitio, O., Helin, J., Maaheimo, H., Niemelä, R., Heikkinen, S. & Renkonen, O., 2001, In : Glycobiology. 11, 3, p. 209-216 8 p.

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Hydrolysis of konjac glucomannan by Trichoderma reesei mannanase and endoglucanases Cel7B and Cel5A for the production of glucomannooligosaccharides

Mikkelson, A., Maaheimo, H. & Hakala, T., 2013, In : Carbohydrate Research. 372, p. 60-68 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
35 Citations (Scopus)

Identification in Agrobacterium tumefaciens of the D-galacturonic acid dehydrogenase gene

Boer, H., Maaheimo, H., Koivula, A., Penttilä, M. & Richard, P., 1 Apr 2010, In : Applied Microbiology and Biotechnology. 86, 3, p. 901-909

Research output: Contribution to journalArticleScientificpeer-review

37 Citations (Scopus)
18 Citations (Scopus)

Impact of steam explosion on the wheat straw lignin structure studied by solution-state nuclear magnetic resonance and density functional methods

Heikkinen, H., Elder, T., Maaheimo, H., Rovio, S., Rahikainen, J., Kruus, K. & Tamminen, T., 2014, In : Journal of Agricultural and Food Chemistry. 62, 43, p. 10437-10444

Research output: Contribution to journalArticleScientificpeer-review

31 Citations (Scopus)

In vitro reconstitution and characterisation of the oxidative d-xylose pathway for production of organic acids and alcohols

Boer, H., Andberg, M., Pylkkänen, R., Maaheimo, H. & Koivula, A., 2019, In : AMB Express. 9, 1, 48.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2 Citations (Scopus)

Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco

Lackman, P., González-Guzmán, M., Tilleman, S., Carqueijeiro, I., Cuéllar Pérez, A., Moses, T., Seo, M., Kanno, Y., Häkkinen, S. T., Van Montagu, M. C. E., Thevelein, J. M., Maaheimo, H., Oksman-Caldentey, K-M., Rodriguez, P. L., Rischer, H. & Goossens, A., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 14, p. 5891-5896

Research output: Contribution to journalArticleScientificpeer-review

137 Citations (Scopus)

Lactose- and cellobiose-derived branched trisaccharides and a sucrose-containing trisaccharide produced by acceptor reactions of Weissella confusa dextransucrase

Shi, Q., Juvonen, M., Hou, Y., Kajala, I., Nyyssölä, A., Maina, N. H., Maaheimo, H., Virkki, L. & Tenkanen, M., 2016, In : Food Chemistry. 190, p. 226-236

Research output: Contribution to journalArticleScientificpeer-review

17 Citations (Scopus)

l-Arabinose/d-galactose 1-dehydrogenase of Rhizobium leguminosarum bv. trifolii characterised and applied for bioconversion of l-arabinose to l-arabonate with Saccharomyces cerevisiae

Aro-Kärkkäinen, N., Toivari, M., Maaheimo, H., Ylilauri, M., Pentikäinen, O. T., Andberg, M., Oja, M., Penttilä, M., Wiebe, M. G., Ruohonen, L. & Koivula, A., 1 Jan 2014, In : Applied Microbiology and Biotechnology. 98, 23, p. 9653-9665 13 p.

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)

L-galactonate dehydratase is part of the fungal path for D-galacturonic acid catabolism

Kuorelahti, S., Jouhten, P., Maaheimo, H., Penttilä, M. & Richard, P., 1 Aug 2006, In : Molecular Microbiology. 61, 4, p. 1060-1068 9 p.

Research output: Contribution to journalArticleScientificpeer-review

33 Citations (Scopus)

Metabolic engineering of Saccharomyces cerevisiae for bioconversion of d-xylose to d-xylonate

Toivari, M., Nygård, Y., Kumpula, E. P., Vehkomäki, M. L., Benčina, M., Valkonen, M., Maaheimo, H., Andberg, M., Koivula, A., Ruohonen, L., Penttilä, M. & Wiebe, M. G., 1 Jul 2012, In : Metabolic Engineering. 14, 4, p. 427-436

Research output: Contribution to journalArticleScientificpeer-review

Open Access
53 Citations (Scopus)

Metabolic flux profiling of Pichia pastoris grown on glycerol/methanol mixtures in chemostat cultures at low and high dilution rates

Solà, A., Jouhten, P., Maaheimo, H., Sánchez-Ferrando, F., Szyperski, T. & Ferrer, P., 2007, In : Microbiology. 153, 1, p. 281-290

Research output: Contribution to journalArticleScientificpeer-review

70 Citations (Scopus)

Metabolic flux profiling of recombinant protein secreting Pichia pastoris growing on glucose:methanol mixtures

Jordà, J., Jouhten, P., Cámara, E., Maaheimo, H., Albiol, J. & Ferrer, P., 2012, In : Microbial Cell Factories. 11, 14 p., 57.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
74 Citations (Scopus)

Methyljasmonate Elicitation Increases Terpenoid Indole Alkaloid Accumulation in Rhazya stricta Hairy Root Cultures

Akhgari, A., Laakso, I., Maaheimo, H., Choi, Y. H., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 22 Nov 2019, In : Plants. 8, 12, 534.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

New insight on the structural features of the cytotoxic auristatins MMAE and MMAF revealed by combined NMR spectroscopy and quantum chemical modelling

Johansson, M. P., Maaheimo, H. & Ekholm, F. S., 21 Nov 2017, In : Scientific Reports. 7, 1, p. 15920 15920.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
7 Citations (Scopus)

NMR spectroscopic analysis of exopolysaccharides produced by Leuconostoc citreum and Weissella confusa

Maina, N. H., Tenkanen, M., Maaheimo, H., Juvonen, R. & Virkki, L., 2008, In : Carbohydrate Research. 343, 9, p. 1446-1455 10 p.

Research output: Contribution to journalArticleScientificpeer-review

126 Citations (Scopus)

O-Acetylation of glucuronoxylan in Arabidopsis thaliana wild type and its change in xylan biosynthesis mutants

Chong, S. L., Virkki, L., Maaheimo, H., Juvonen, M., Derba-Maceluch, M., Koutaniemi, S., Roach, M., Sundberg, B., Tuomainen, P., Mellerowicz, E. J. & Tenkanen, M., 2014, In : Glycobiology. 24, 6, p. 494-506 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
30 Citations (Scopus)

Optimization of Isomaltooligosaccharide Size Distribution by Acceptor Reaction of Weissella confusa Dextransucrase and Characterization of Novel [alpha]-(1->2)-Branched Isomaltooligosaccharides

Shi, Q., Hou, Y., Juvonen, M., Tuomainen, P., Kajala, I., Shukla, S., Goyal, A., Maaheimo, H., Katina, K. & Tenkanen, M., 2016, In : Journal of Agricultural and Food Chemistry. 64, 16, p. 3276-3286

Research output: Contribution to journalArticleScientificpeer-review

7 Citations (Scopus)

Oxygen dependence of metabolic fluxes and energy generation of Saccharomyces cerevisiae CEN.PK113-1A

Jouhten, P., Rintala, E., Huuskonen, A., Tamminen, A., Toivari, M., Wiebe, M., Ruohonen, L., Penttilä, M. & Maaheimo, H., 9 Jul 2008, In : BMC Systems Biology. 2, 60.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
80 Citations (Scopus)

Planning optimal measurements of isotopomer distributions for estimation of metabolic fluxes

Rantanen, A., Mielikäinen, T., Rousu, J., Maaheimo, H. & Ukkonen, E., 2006, In : Bioinformatics. 22, 10, p. 1198-1206 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
23 Citations (Scopus)

Production and characterization of Aspergillus niger GH29 family α-fucosidase and production of a novel non-reducing 1-fucosyllactose

Usvalampi, A., Ruvalcaba Medrano, M., Maaheimo, H., Salminen, H., Tossavainen, O. & Frey, A. D., Apr 2020, In : Glycoconjugate Journal. 37, 2, p. 221-229 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Reaction pathways during oxidation of cereal β-glucans

Mäkelä, N., Sontag-Strohm, T., Schiehser, S., Potthast, A., Maaheimo, H. & Maina, N. H., 10 Feb 2017, In : Carbohydrate Polymers. 157, p. 1769-1776 8 p.

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)

Single cell and in vivo analyses elucidate the effect of xylC lactonase during production of D-xylonate in Saccharomyces cerevisiae

Nygård, Y., Maaheimo, H., Mojzita, D., Toivari, M., Wiebe, M., Resnekov, O., Gustavo Pesce, C., Ruohonen, L. & Penttilä, M., 1 Jan 2014, In : Metabolic Engineering. 25, p. 238-247

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

Spectral analysis of 1H coupled 13C spectra of the amino acids: Adaptive spectral library of amino acid 13C isotopomers and positional fractional 13C enrichments

Tiainen, M., Maaheimo, H., Niemitz, M., Soininen, P. & Laatikainen, R., 2008, In : Magnetic Resonance in Chemistry. 46, 2, p. 125 - 137 13 p.

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)