Hannu Maaheimo

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20012020

Research output per year

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Research Output

2007

1H NMR at 800 MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins

Soininen, P., Öörni, K., Maaheimo, H., Laatikainen, R., Kovanen, P. T., Kaski, K. & Ala-Korpela, M., 2007, In : Biochemical and Biophysical Research Communications. 360, 1, p. 290-294

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)

Metabolic flux profiling of Pichia pastoris grown on glycerol/methanol mixtures in chemostat cultures at low and high dilution rates

Solà, A., Jouhten, P., Maaheimo, H., Sánchez-Ferrando, F., Szyperski, T. & Ferrer, P., 2007, In : Microbiology. 153, 1, p. 281-290

Research output: Contribution to journalArticleScientificpeer-review

70 Citations (Scopus)

Responses of Saccharomyces cerevisiae to changing oxygen level

Wiebe, M., Rintala, E., Toivari, M., Tamminen, A., Salusjärvi, L., Jouhten, P., Huuskonen, A., Simolin, H., Kokkonen, J., Kiuru, J., Maaheimo, H., Ruohonen, L. & Penttilä, M., 2007, 3rd European Federation of Biotechnology Conference: Physiology of Yeasts and Filamentous Fungi PYFF3. Espoo: VTT Technical Research Centre of Finland, p. 114 P60. (VTT Symposium; No. 245).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

The effect of external oxygen conditions on the metabolic flux distribution of Saccharomyces cerevisiae

Jouhten, P., Rintala, E., Huuskonen, A., Tamminen, A., Toivari, M., Wiebe, M., Rantanen, A., Ruohonen, L., Penttilä, M. & Maaheimo, H., 2007, 3rd European Federation of Biotechnology Conference : Physiology of Yeasts and Filamentous Fungi PYFF3. Espoo: VTT Technical Research Centre of Finland, p. 117 P63. (VTT Symposium; No. 245).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

The response of anaerobically grown Saccharomyces cerevisiae to low and high oxygen in glucose-limited chemostat cultures

Wiebe, M., Rintala, E., Tamminen, A., Simolin, H., Salusjärvi, L., Toivari, M., Jouhten, P., Huuskonen, A., Maaheimo, H., Ruohonen, L. & Penttilä, M., 2007, 3rd European Federation of Biotechnology Conference: Physiology of Yeasts and Filamentous Fungi PYFF3. Espoo: VTT Technical Research Centre of Finland, p. 116 P69. (VTT Symposium; No. 245).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access
2006

13C-constrained metabolic flux balancing analysis of Pichia pastoris grown on different carbon sources

Santos, S., Jouhten, P., Maaheimo, H., Albiol, J. & Ferrer, P., 2006, International Specialised Symposium on Yeasts ISSY25: Systems Biology of Yeasts - from Models to Applications. Espoo: VTT Technical Research Centre of Finland, p. 118-119 P63. (VTT Symposium; No. 242).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

A framework for direct metabolic flux estimation

Rantanen, A., Rousu, J., Pitkänen, E., Maaheimo, H., Mielikäinen, T. & Ukkonen, E., 2006, International Specialised Symposium on Yeasts ISSY25: Systems Biology of Yeasts - from Models to Applications. Espoo: VTT Technical Research Centre of Finland, p. 117 P62. (VTT Symposium; No. 242).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Equivalence of metabolite fragments and flow analysis of isotopomer distributions for flux estimation

Rantanen, A., Maaheimo, H., Pitkänen, E., Rousu, J. & Ukkonen, E., 2006, Transactions on Computational Systems Biology VI. Priami, C. & Plotkin, G. (eds.). Berlin - Heidelberg: Springer, p. 198-220 (Transactions on Computational Systems Biology, Vol. VI). (Lecture Notes in Computer Science, Vol. 4420).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

1 Citation (Scopus)

L-galactonate dehydratase is part of the fungal path for D-galacturonic acid catabolism

Kuorelahti, S., Jouhten, P., Maaheimo, H., Penttilä, M. & Richard, P., 1 Aug 2006, In : Molecular Microbiology. 61, 4, p. 1060-1068 9 p.

Research output: Contribution to journalArticleScientificpeer-review

33 Citations (Scopus)

Physiological response of Saccharomyces cerevisiae to change in oxygen provision

Rintala, E., Toivari, M., Wiebe, M., Tamminen, A., Salusjärvi, L., Huuskonen, A., Simolin, H., Kokkonen, J., Kiuru, J., Maaheimo, H., Ruohonen, L. & Penttilä, M., 2006, International Specialised Symposium on Yeasts ISSY25: Systems Biology of Yeasts - from Models to Applications. Espoo: VTT Technical Research Centre of Finland, p. 39 T24. (VTT Symposium; No. 242).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Planning optimal measurements of isotopomer distributions for estimation of metabolic fluxes

Rantanen, A., Mielikäinen, T., Rousu, J., Maaheimo, H. & Ukkonen, E., 2006, In : Bioinformatics. 22, 10, p. 1198-1206 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
23 Citations (Scopus)

The effect of oxygen level on metabolic flux distribution of Saccharomyces cerevisoae

Jouhten, P., Rintala, E., Tamminen, A., Huuskonen, A., Wiebe, M., Salusjärvi, L., Toivari, M., Ruohonen, L., Penttilä, M. & Maaheimo, H., 2006, International Specialised Symposium on Yeasts ISSY25: Systems Biology of Yeasts - from Models to Applications. VTT Technical Research Centre of Finland, p. 79 P27. (VTT Symposium; No. 242).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access
2005

Effect of oxygen level metabolic fluxes and metabolite levels of yeast studied by NMR spectroscopy

Jouhten, P., Perälä, M., Rintala, E., Ruohonen, L., Penttilä, M. & Maaheimo, H., 2005.

Research output: Contribution to conferenceConference articleScientific

Flow analysis of metabolite fragments for flux estimation

Rantanen, A., Rousu, J., Pitkänen, E., Maaheimo, H. & Ukkonen, E., 2005, Proceedings of CMSB 2005.

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

NMR spectroscopy in systems biology: Methods for metabolomics and fluxomics

Jouhten, P., Perälä, M., Rintala, E., Permi, P., Ruohonen, L., Penttilä, M. & Maaheimo, H., 2005.

Research output: Contribution to conferenceConference PosterScientific

NMR spectroscopy in systems biology: Methods for metabolomics and fluxomics

Jouhten, P., Perälä, M., Rintala, E., Permi, P., Ruohonen, L., Penttilä, M. & Maaheimo, H., 2005.

Research output: Contribution to conferenceOther conference contributionScientific

Protein-oligosaccharide interaction mechanisms in chitinases engineered towards neolectins

Munck, N., Tappura, K., Aitio, O., Maaheimo, H., Boer, H. & Koivula, A., 2005, In : European Biophysics Journal. 34, 6, p. 741 1 p., P-626.

Research output: Contribution to journalOther journal contributionScientificpeer-review

2004

Amino acid biosynthesis and metabolic flux profiling of Pichia pastoris

Solà, A., Maaheimo, H., Ylönen, K., Ferrer, P. & Szyperski, T., 2004, In : European Journal of Biochemistry. 271, 12, p. 2462 - 2470 9 p.

Research output: Contribution to journalArticleScientificpeer-review

78 Citations (Scopus)

Anatalline and other methyl jasmonate-inducible nicotine alkaloids from Nicotiana tabacum cv. BY-2 cell cultures

Häkkinen, S. T., Rischer, H., Laakso, I., Maaheimo, H., Seppänen-Laakso, T. & Oksman-Caldentey, K-M., 2004, In : Planta Medica. 70, 10, p. 936 - 941 6 p.

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)

Integrative approaches for studying pentose metabolism in Saccharomyces cerevisiae

Salusjärvi, L., Oresic, M., Maaheimo, H., Rintala, E., Simolin, H., Ruohonen, L. & Penttilä, M., 2004.

Research output: Contribution to conferenceConference articleScientific

Integrative approaches for studying pentose metabolism in Saccharomyces cerevisiae

Ruohonen, L., Salusjärvi, L., Oresic, M., Maaheimo, H., Rintala, E., Simolin, H. & Penttilä, M., 2004.

Research output: Contribution to conferenceConference articleScientific

Mitochondrial metabolomics in Saccharomyces cerevisiae

Rintala, E., Oresic, M., Simolin, H., Mattila, I., Maaheimo, H., Ruohonen, L. & Penttilä, M., 2004.

Research output: Contribution to conferenceConference articleScientific

Molecular dynamics study of protein-oligosaccharide interaction mechanisms in chitinases engineered towards neolectins

Munck, N., Tappura, K., Aitio, O., Maaheimo, H., Boer, H. & Koivula, A., 2004, p. A01-025.

Research output: Contribution to conferenceConference AbstractScientific

Open Access

Molecular dynamics study of protein-oligosaccharide interaction mechanisms in chitinases engineered towards neolectins

Munck, N., Tappura, K., Aitio, O., Maaheimo, H., Boer, H. & Koivula, A., 2004.

Research output: Contribution to conferenceOther conference contributionScientific

NMR in systems biology research: Mmthods for metabolomics and fluxomics

Jouhten, P., Perälä, M., Rintala, E., Ruohonen, L., Permi, P., Penttilä, M. & Maaheimo, H., 2004.

Research output: Contribution to conferenceConference articleScientific

The phosphoenolpyruvate carboxykinase also catalyzes C3 carboxylation at the interface of glycolysis and the TCA cycle of Bacillus subtilis

Zamboni, N., Maaheimo, H., Szyperski, T., Hohmann, H-P. & Sauer, U., 2004, In : Metabolic Engineering. 6, 4, p. 277-284 8 p.

Research output: Contribution to journalArticleScientificpeer-review

40 Citations (Scopus)

Towards mitochondrial metabolomics

Oresic, M., Maaheimo, H., Mattila, I., Rintala, E., Salusjärvi, L., Simolin, H., Ruohonen, L. & Penttilä, M., 2004.

Research output: Contribution to conferenceConference PosterScientific

2003

A method for estimating metabolic fluxes from incomplete isotopomer information

Rousu, J., Rantanen, A., Maaheimo, H., Pitkänen, E., Saarela, K. & Ukkonen, E., 2003, Computational Methods in Systems Biology. Springer, Vol. Part II. p. 88-103 (Lecture Notes in Computer Science, Vol. 2602).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

9 Citations (Scopus)

Cloning and functional expression of a novel GDP-6-deoxy-D-talose synthetase from Actinobacillus actinomycetemcomitans

Mäki, M., Järvinen, N., Räbinä, J., Maaheimo, H., Mattila, P. & Renkonen, R., 2003, In : Glycobiology. 13, 4, p. 295-303 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
15 Citations (Scopus)

Isotopomer analysis by mass spectrometry and mathematical algorithm

Kokkonen, J., Tarkiainen, V., Ketola, R. A., Rantanen, A., Rousu, J. & Maaheimo, H., 2003. 1 p.

Research output: Contribution to conferenceConference articleScientific

Molecular dynamics study of protein-oligosaccharide interaction mechanisms in chitinases

Munck, N., Tappura, K., Maaheimo, H., Boer, H., Mattinen, M. & Koivula, A., 2003, In : European Biophysics Journal. 34, 3, p. 250 1 p.

Research output: Contribution to journalOther journal contributionScientific

2002

13C-NMR flux ratio analysis of Saccharomyces cerevisiae growing on glucose or xylose in chemostat cultivations

Maaheimo, H., Pitkänen, J-P., Szyperski, T., Aristidou, A. & Penttilä, M., 2002.

Research output: Contribution to conferenceConference PosterScientific

13NMR flux ratio analysis of Saccharomyces cerevisiae growing on glucose or xylose in chemostat cultivations

Maaheimo, H., Pitkänen, J-P., Szyperski, T., Salusjärvi, L., Aristidou, A. & Penttilä, M., 2002.

Research output: Contribution to conferenceConference articleScientific

Characterisation of fractions obtained by isoamylolysis and ion-exchange chromatography of cationic waxy maize starch

Manelius, R., Maaheimo, H., Nurmi, K. & Bertoft, E., 2002, In : Stärke. 54, 2, p. 58-65

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)

Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose

Mäki, M., Järvinen, N., Räbinä, J., Roos, C., Maaheimo, H., Mattila, P. & Renkonen, R., 2002, In : European Journal of Biochemistry. 269, 2, p. 593-601

Research output: Contribution to journalArticleScientificpeer-review

25 Citations (Scopus)
2001

Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional 13C labeling of common amino acids

Maaheimo, H., Fiaux, J., Cakar, Z. P., Bailey, J. E., Sauer, U. & Szyperski, T., 2001, In : FEBS Journal. 268, 8, p. 2464-2479 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
138 Citations (Scopus)

Human alfa3-fucosyltransferases convert chitin oligosaccharides to products containing a GlcNacbeta1-4(Fucalfa1-3)GlcNAc beta1-4R determinant at the nonreducing terminus

Natunen, J., Aitio, O., Helin, J., Maaheimo, H., Niemelä, R., Heikkinen, S. & Renkonen, O., 2001, In : Glycobiology. 11, 3, p. 209-216 8 p.

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)