19962019
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Research Output 1996 2019

2019

Methyljasmonate Elicitation Increases Terpenoid Indole Alkaloid Accumulation in Rhazya stricta Hairy Root Cultures

Akhgari, A., Laakso, I., Maaheimo, H., Choi, Y. H., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 22 Nov 2019, In : Plants. 8, 12, 534.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Rhazya stricta
indole alkaloids
alkaloid
methyl jasmonate
terpenoids
2018

Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells

Häkkinen, S. T., Nygren, H., Maiorova, N., Haavikko, R., Alakurtti, S., Yli-Kauhaluoma, J., Rischer, H. & Oksman-Caldentey, K. M., 1 Jul 2018, In : Planta Medica. 84, 9-10, p. 743-748 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Plant Cells
Biotransformation
Catharanthus
Derivatives
Pentoses
3 Citations (Scopus)

Euglena gracilis growth and cell composition under different temperature, light and trophic conditions

Wang, Y., Seppänen-Laakso, T., Rischer, H. & Wiebe, M. G., 1 Apr 2018, In : PLoS ONE. 13, 4, e0195329.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Euglena gracilis
Light
Biomass
Temperature
Cells
5 Citations (Scopus)

Marine Microalgae: Promising source for new bioactive compounds

de Vera, C. R., Crespín, G. D., Daranas, A. H., Looga, S. M., Lillsunde, K. E., Tammela, P., Perälä, M., Hongisto, V., Virtanen, J., Rischer, H., Muller, C. D., Norte, M., Fernández, J. J. & Souto, M. L., 6 Sep 2018, In : Marine Drugs. 16, 9, 317.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Microalgae
Biodiversity
European Union
Biological Products
Oceans and Seas
3 Citations (Scopus)
Open Access
Plant Cells
Food
Vaccinium vitis-idaea
Fruit
Hydrolysis
3 Citations (Scopus)

Tobacco BY-2 Media Component Optimization for a Cost-Efficient Recombinant Protein Production

Häkkinen, S., Reuter, L., Nuorti, N., Joensuu, J., Rischer, H. & Ritala, A., Jan 2018, In : Frontiers in Plant Science. 9, 45.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
recombinant proteins
tobacco
culture media
industrial applications
cells
2017

Bioconversion to raspberry ketone is achieved by several non-related plant cell cultures

Häkkinen, S., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 2017, Frontiers Research Topic: Engineering the plant factory for the production of biologics and small-molecule medicines. De Martinis, D., Franconi, R., Benvenuto, E., Rybicki, E. P. & Fujiyama, K. (eds.). Frontiers Media, p. 334-342

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

Open Access
3 Citations (Scopus)

Biotechnology of the medicinal plant Rhazya stricta: A little investigated member of the Apocynaceae family

Akhgari, A., Oksman-Caldentey, K-M. & Rischer, H., 2017, In : Biotechnology Letters. 39, 6, p. 829-840 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Secologanin Tryptamine Alkaloids
Apocynaceae
Medicinal Plants
Biotechnology
Metabolic Engineering

Biotechnology of unique wild berries and their commercial application potential

Oksman-Caldentey, K-M., Nohynek, L., Häkkinen, S. T., Smolander, M., Rischer, H. & Puupponen-Pimiä, R., 2017, Fisiología Vegetal FVc2017: Libro de Abstracts. p. 2-3

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Food without fields: Plant cell technology for a sustainable food supply

Rischer, H., 2017.

Research output: Contribution to conferenceConference AbstractScientific

Liquid chromatography-mass spectrometry (LC-MS)-based analysis of molecular lipids in algae samples

Nygren, H., Seppänen-Laakso, T. & Rischer, H., 21 Nov 2017, In : Methods in Molecular Biology. p. 1-8

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Metabolite profiling of the carnivorous pitcher plants Darlingtonia and Sarracenia

Hotti, H., Gopalacharyulu, P., Seppänen-Laakso, T. & Rischer, H., 1 Feb 2017, In : PLoS ONE. 12, 2, 21 p., e0171078.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Sarraceniaceae
Sarracenia
Metabolites
metabolites
Biosynthesis

Polyketide-derived alkaloids and anthraquinones in Aloe plants and cell cultures

Hotti, H., Häkkinen, S., Rischer, H. & Seppänen-Laakso, T., 2017, In : Journal of Plant Biotechnology Research. 1, 1, p. 1-15 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
polyketides
Aloe
anthraquinones
plant cultural practices
alkaloids
cosmetics
skin (animal)
small fruits
ingredients
cells
3 Citations (Scopus)

The killer of socrates: Coniine and related alkaloids in the plant Kingdom

Hotti, H. & Rischer, H., 14 Nov 2017, In : Molecules. 22, 11, 1962.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
alkaloids
Alkaloids
poisons
Conium
Poisons
Sterols
Nonesterified Fatty Acids
Esters
Fatty Acids
Phytol
11 Citations (Scopus)

Variability in the production of tannins and other polyphenols in cell cultures of 12 Nordic plant species

Suvanto, J., Nohynek, L., Seppänen-Laakso, T., Rischer, H., Salminen, J-P. & Puupponen-Pimiä, R., Aug 2017, In : Planta. 246, 2, p. 227-241 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Tannins
Polyphenols
tannins
polyphenols
cell culture
2016

A berry good story: berry cells as active ingredients for skin care products

Oksman-Caldentey, K-M., Virtanen, V., Nohynek, L., Rischer, H. & Puupponen-Pimiä, R., 2016, Abstract book. Phytochemical Society of Europe PSE , 40

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Biosynthesis and distribution of polyketide-derived piperidines in plants

Rischer, H., Hotti, H. & Teerinen, T., 2016, Abstract book. Phytochemical Society of Europe PSE , 62

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

In vitro grown plant cells as food: A simple bioreactor for decentralised food

Ahtinen, J., Reuter, L., Pitkänen, J-P. & Rischer, H., 2016, Food Factor I Conference 2016: Book of Abstracts. Formatex Research Center

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

bioreactors
food production
cell culture
health promotion
kitchens
2015
5 Citations (Scopus)

Analysis of indole alkaloids from Rhazya stricta hairy roots by ultra-performance liquid chromatography-mass spectrometry

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Molecules. 20, 12, p. 22621-22634

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Secologanin Tryptamine Alkaloids
Apocynaceae
Indole Alkaloids
alkaloids
Liquid chromatography

Betulins as novel lead compounds for cancer

Oksman-Caldentey, K-M., Lämsä, M., Härmä, V., Haavikko, R., Alakurtti, S., Nygren, H., Häkkinen, S., Yli-Kauhaluoma, J., Nees, M. & Rischer, H., 2015, Book of Abstracts. 102

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

2 Citations (Scopus)

Bioconversion to Raspberry Ketone is Achieved by Several Non-related Plant Cell Cultures

Häkkinen, S., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 24 Nov 2015, In : Frontiers in Plant Science. 6, p. 1-9 9 p., 1035.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
raspberries
biotransformation
ketones
cell culture
flavor compounds
8 Citations (Scopus)

Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Phytochemical Analysis. 26, 5, p. 331-338

Research output: Contribution to journalArticleScientificpeer-review

Rhazya stricta
Secologanin Tryptamine Alkaloids
Apocynaceae
indole alkaloids
Rhazya
10 Citations (Scopus)

Elicitation of furanocoumarins in poison hemlock (Conium maculatum L.) cell culture

Meier, P., Hotti, H. & Rischer, H., 2015, In : Plant Cell, Tissue and Organ Culture. 123, 3, p. 443-453

Research output: Contribution to journalArticleScientificpeer-review

Conium maculatum
psoralens
cell culture
bergapten
psoralen
9 Citations (Scopus)

Establishment of transgenic Rhazya stricta hairy roots to modulate terpenoid indole alkaloid production

Akhgari, A., Yrjönen, T., Laakso, I., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Plant Cell Reports. 34, 11, p. 1939-1952

Research output: Contribution to journalArticleScientificpeer-review

Rhazya stricta
indole alkaloids
terpenoids
genetically modified organisms
alkaloids

Metabolic engineering of secondary biosynthetic pathways in plants

Fräbel, S., Seppänen-Laakso, T., Rischer, H. & Heribert, W., 2015, Book of Abstracts: Challenges and prospects in PNP metabolic engineering and production: Final Conference,. 96

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Natural raspberry ketone production via bioconversion using plant cell cultures

Häkkinen, S. T., Seppänen-Laakso, T. & Rischer, H., 2015, Book of Abstracts: Bioflavour 2015. 99

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

10 Citations (Scopus)

Nile Red staining of phytoplankton neutral lipids: species-specific fluorescence kinetics in various solvents

Natunen, K., Seppälä, J., Schwenk, D., Rischer, H., Spilling, K. & Tamminen, T., 2015, In : Journal of Applied Phycology. 27, 3, p. 1161-1168

Research output: Contribution to journalArticleScientificpeer-review

Open Access
fluorescence
lipid
phytoplankton
triacylglycerols
kinetics
11 Citations (Scopus)

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development

Härmä, V., Haavikko, R., Virtanen, J., Ahonen, I., Schukov, H-P., Alakurtti, S., Purev, E., Rischer, H., Yli-Kauhaluoma, J., Moreira, V. M., Nees, M. & Oksman-Caldentey, K-M., 2015, In : PLoS ONE. 10, 5, 22 p., e0126111.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
betulin
prostatic neoplasms
Prostatic Neoplasms
chemical derivatives
Castration

Phenolic composition of cloudberry and arctic bramble cell suspension cultures

Puupponen-Pimiä, R., Nohynek, L., Salminen, J-P., Rischer, H. & Oksman-Caldentey, K-M., 2015, Book of Abstracts. p. 30 P-1

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

6 Citations (Scopus)

Polyketide synthases from poison hemlock (Conium maculatum L.)

Hotti, H., Seppänen-Laakso, T., Arvas, M., Teeri, T. H. & Rischer, H., 2015, In : FEBS Journal. 282, 21, p. 4141-4156

Research output: Contribution to journalArticleScientificpeer-review

Conium
Polyketide Synthases
Poisons
Starters
Biosynthesis
80 Citations (Scopus)

Standards for plant synthetic biology: A common syntax for exchange of DNA parts

Patron, N. J., Orzaez, D. ., Marillonnet, S., Warzecha, H., Matthewman, C., Youles, M., Raitskin, O., Leveau, Farré, G., Rogers, C., Smith, A., Hibberd, J., Webb, A. A. R., Locke, J., Schornack, S., Ajioka, J., Baulcombe, D. C., Zipfel, C., Kamoun, S., Jones, J. D. G. & 30 others, Kuhn, H., Robatzek, S., Van Esse, H. P., Sanders, D., Oldroyd, G., Martin, C., Field, R., O'Connor, S., Fox, S., Wulff, B., Miller, B., Breakspear, A., Radhakrishnan, G., Delaux, P-M., Loqué, D., Granell, A., Tissier, A., Shih, P., Brutnell, T. P., Quick, W. P., Rischer, H., Fraser, P. D., Aharoni, A., Raines, C., South, P. F., Ané, J-M., Hamberger, B. R., Langdale, J., Stougaard, J. & Bouwmeester, H., 2015, In : New Phytologist. 208, 1, p. 13-19

Research output: Contribution to journalArticleScientificpeer-review

Synthetic Biology
synthetic biology
plant biology
engineering
Inventors
68 Citations (Scopus)

The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

Van Moerkercke, A., Steensma, P., Schweizer, F., Pollier, J., Gariboldi, I., Payne, R., Vanden Bossche, R., Miettinen, K., Espoz, J., Purnama, P. C., Kellner, F., Seppänen-Laakso, T., O'Connor, S. E., Rischer, H., Memelink, J. & Goossens, A., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 26, p. 8130-8135

Research output: Contribution to journalArticleScientificpeer-review

Open Access
basic helix-loop-helix transcription factors
indole alkaloids
Catharanthus roseus
monoterpenoids
Catharanthus

Type III polyketide synthases from poison hemlock

Hotti, H., Teeri, T. & Rischer, H., 2015, Book of Abstracts. 63

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

2014
17 Citations (Scopus)

Algae-bacteria association inferred by 16S rDNA similarity in established microalgae cultures

Schwenk, D., Nohynek, L. & Rischer, H., 2014, In : MicrobiologyOpen. 3, 3, p. 356-368

Research output: Contribution to journalArticleScientificpeer-review

Microalgae
Haptophyta
Ribosomal DNA
Rhodobacteraceae
Bacteria
7 Citations (Scopus)

Disposable bioreactors for cultivation of plant cell cultures

Lehmann, N., Dittler, I., Lämsä, M., Ritala, A., Rischer, H., Eibl, D., Oksman-Caldentey, K-M. & Eibl, R., 2014, Production of Biomass and Bioactive Compounds Using Bioreactor Technology. Paek, K-Y., Hosakatte, N. M. & Zhong, J-J. (eds.). Springer, p. 17-46

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleProfessional

bioreactors
plant cultural practices
cell culture
cells
biopharmaceuticals
15 Citations (Scopus)

Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway

Ritala, A., Dong, L., Imseng, N., Seppänen-Laakso, T., Vasilev, N., van der Krol, S., Rischer, H., Maaheimo, H., Virkki, A., Brändli, J., Schillerberg, S., Eibl, R., Bouwmeester, H. & Oksman-Caldentey, K-M., 2014, In : Journal of Biotechnology. 176, p. 20-28 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Secologanin Tryptamine Alkaloids
Alkaloids
Tobacco
Fragrances
Glycosides

Metabolic engineering of terpenoid indole alkaloid pathway in Catharanthus roseus

Oksman-Caldentey, K-M. & Rischer, H., 2014, International Association for Plant Biotechnology Congress 2014: Book of Abstracts. 24

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Rational design of plant systems for sustainable generation of value-added industrial products (SmartCell)

Oksman-Caldentey, K-M., Ritala, A., Rischer, H., Häkkinen, S. & Christou, P., 2014, In : Dosis. 30, 3

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)

Selection and validation of reference genes for transcript normalization in gene expression studies in Catharanthus roseus

Pollier, J., Vanden Bossche, R., Rischer, H. & Goossens, A., 2014, In : Plant Physiology and Biochemistry. 83, p. 20-25 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Catharanthus
Catharanthus roseus
Gene Expression
gene expression
Genes

Type III polyketide synthases from poison hemlock

Hotti, H., Teeri, T. & Rischer, H., 2014.

Research output: Contribution to conferenceConference AbstractScientific

2013
10 Citations (Scopus)

Analysis of the Interface between Primary and Secondary Metabolism in Catharanthus roseus Cell Cultures Using 13C-Stable Isotope Feeding and Coupled Mass Spectrometry: Letter to the Editor

Antonio, C., Mustafa, N. R., Osorio, S., Tohge, T., Giavalisco, P., Willmitzer, L., Rischer, H., Oksman-Caldentey, K-M., Verpoorte, R. & Fernie, A. R., 2013, In : Molecular Plant. 6, 2, p. 581-584 4 p.

Research output: Contribution to journalOther journal contributionScientific

Open Access

Arctic vitality from berry cell culture technology

Nohynek, L., Rischer, H., Oksman-Caldentey, K-M. & Puupponen-Pimiä, R., 2013.

Research output: Contribution to conferenceConference articleScientific

74 Citations (Scopus)

CathaCyc, a metabolic pathway database built from catharanthus roseus RNA-seq data

Van Moerkercke, A., Fabris, M., Pollier, J., Baart, G. J. E., Rombauts, S., Hasnain, G., Rischer, H., Memelink, J., Oksman-Caldentey, K-M. & Goossens, A., 2013, In : Plant and Cell Physiology. 54, 5, p. 673-685 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Catharanthus
Catharanthus roseus
Secologanin Tryptamine Alkaloids
Metabolic Networks and Pathways
indole alkaloids

Cell-based functional screening of modified betulins, abietanes and resin acids as lead compounds for anti-cancer drugs (BARC)

Nees, M., Haavikko, R., Moreira, V., Alakurtti, S., Yli-Kauhaluoma, J., Rischer, H., Purev, E., Virtanen, J. & Oksman-Caldentey, K-M., 2013, TERPNET 2013: Book of Abstracts. Aristotle University of Thessaloniki, p. 88 1 p. O53

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Diverse bioconversion of wood-derived diterpene by Nicotianatabacum and Catharanthusroseus cells

Häkkinen, S. T., Lackman, P., Nygrén, H., Oksman-Caldentey, K-M., Maaheimo, H. & Rischer, H., 2013, TERPNET 2013: Book of Abstracts. Aristotle University of Thessaloniki, p. 235 P105

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

17 Citations (Scopus)

Lipid content in 19 brackish and marine microalgae: Influence of growth phase, salinity and temperature

Schwenk, D., Seppälä, J., Spilling, K., Virkki, A., Tamminen, T., Oksman-Caldentey, K-M. & Rischer, H., 2013, In : Aquatic Ecology. 47, 4, p. 415-424 9 p.

Research output: Contribution to journalArticleScientificpeer-review

microalgae
lipid
lipid content
salinity
fatty acid