Heiko Rischer

Dr. rer. nat.

  • Phone+358407206834
19962020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Agrobacterium-mediated genetic transformation of the medicinal plant veratrum dahuricum

Ma, R., Yu, Z., Cai, Q., Li, H., Dong, Y., Oksman-Caldentey, K. M. & Rischer, H., 4 Feb 2020, In : Plants. 9, 2, 191.

Research output: Contribution to journalArticle

Open Access

Cellular agriculture: Industrial biotechnology for food and materials

Rischer, H., Szilvay, G. R. & Oksman-Caldentey, K-M., Feb 2020, In : Current Opinion in Biotechnology. 61, p. 128-134 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
1 Citation (Scopus)

Liquid chromatography-mass spectrometry (LC-MS)-based analysis of molecular lipids in algae samples

Nygren, H., Seppänen-Laakso, T. & Rischer, H., 1 Jan 2020, Methods in Molecular Biology: Methods and Protocols. Spilling, K. (ed.). Humana Press, p. 215-222 8 p. (Methods in Molecular Biology, Vol. 1980).

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

2 Citations (Scopus)
2019

Methyljasmonate Elicitation Increases Terpenoid Indole Alkaloid Accumulation in Rhazya stricta Hairy Root Cultures

Akhgari, A., Laakso, I., Maaheimo, H., Choi, Y. H., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 22 Nov 2019, In : Plants. 8, 12, 534.

Research output: Contribution to journalArticle

Open Access
2018

Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells

Häkkinen, S. T., Nygren, H., Maiorova, N., Haavikko, R., Alakurtti, S., Yli-Kauhaluoma, J., Rischer, H. & Oksman-Caldentey, K. M., 1 Jul 2018, In : Planta Medica. 84, 9-10, p. 743-748 6 p.

Research output: Contribution to journalArticle

Euglena gracilis growth and cell composition under different temperature, light and trophic conditions

Wang, Y., Seppänen-Laakso, T., Rischer, H. & Wiebe, M. G., 1 Apr 2018, In : PLoS ONE. 13, 4, e0195329.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
5 Citations (Scopus)

Marine Microalgae: Promising source for new bioactive compounds

de Vera, C. R., Crespín, G. D., Daranas, A. H., Looga, S. M., Lillsunde, K. E., Tammela, P., Perälä, M., Hongisto, V., Virtanen, J., Rischer, H., Muller, C. D., Norte, M., Fernández, J. J. & Souto, M. L., 6 Sep 2018, In : Marine Drugs. 16, 9, 317.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Plant cells as food: A concept taking shape

Nordlund, E., Lille, M., Silventoinen, P., Nygren, H., Seppänen-Laakso, T., Mikkelson, A., Aura, A-M., Heiniö, R-L., Nohynek, L., Puupponen-Pimiä, R. & Rischer, H., 2018, In : Food Research International. 107, p. 297–305 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
5 Citations (Scopus)

Tobacco BY-2 Media Component Optimization for a Cost-Efficient Recombinant Protein Production

Häkkinen, S., Reuter, L., Nuorti, N., Joensuu, J., Rischer, H. & Ritala, A., Jan 2018, In : Frontiers in Plant Science. 9, 45.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
4 Citations (Scopus)
2017

Bioconversion to raspberry ketone is achieved by several non-related plant cell cultures

Häkkinen, S., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 2017, Frontiers Research Topic: Engineering the plant factory for the production of biologics and small-molecule medicines. De Martinis, D., Franconi, R., Benvenuto, E., Rybicki, E. P. & Fujiyama, K. (eds.). Frontiers Media, p. 334-342

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

Open Access

Biotechnology of the medicinal plant Rhazya stricta: A little investigated member of the Apocynaceae family

Akhgari, A., Oksman-Caldentey, K-M. & Rischer, H., 2017, In : Biotechnology Letters. 39, 6, p. 829-840 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

4 Citations (Scopus)

Biotechnology of unique wild berries and their commercial application potential

Oksman-Caldentey, K-M., Nohynek, L., Häkkinen, S. T., Smolander, M., Rischer, H. & Puupponen-Pimiä, R., 2017, Fisiología Vegetal FVc2017: Libro de Abstracts. p. 2-3

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Food without fields: Plant cell technology for a sustainable food supply

Rischer, H., 2017.

Research output: Contribution to conferenceConference AbstractScientific

Metabolite profiling of the carnivorous pitcher plants Darlingtonia and Sarracenia

Hotti, H., Gopalacharyulu, P., Seppänen-Laakso, T. & Rischer, H., 1 Feb 2017, In : PLoS ONE. 12, 2, 21 p., e0171078.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2 Citations (Scopus)
Open Access

The killer of socrates: Coniine and related alkaloids in the plant Kingdom

Hotti, H. & Rischer, H., 14 Nov 2017, In : Molecules. 22, 11, 1962.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
5 Citations (Scopus)

Variability in the production of tannins and other polyphenols in cell cultures of 12 Nordic plant species

Suvanto, J., Nohynek, L., Seppänen-Laakso, T., Rischer, H., Salminen, J-P. & Puupponen-Pimiä, R., Aug 2017, In : Planta. 246, 2, p. 227-241 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
13 Citations (Scopus)
2016

A berry good story: berry cells as active ingredients for skin care products

Oksman-Caldentey, K-M., Virtanen, V., Nohynek, L., Rischer, H. & Puupponen-Pimiä, R., 2016, Abstract book. Phytochemical Society of Europe PSE , 40

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Biosynthesis and distribution of polyketide-derived piperidines in plants

Rischer, H., Hotti, H. & Teerinen, T., 2016, Abstract book. Phytochemical Society of Europe PSE , 62

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

In vitro grown plant cells as food: A simple bioreactor for decentralised food

Ahtinen, J., Reuter, L., Pitkänen, J-P. & Rischer, H., 2016, Food Factor I Conference 2016: Book of Abstracts. Formatex Research Center

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

2015

Analysis of indole alkaloids from Rhazya stricta hairy roots by ultra-performance liquid chromatography-mass spectrometry

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Molecules. 20, 12, p. 22621-22634

Research output: Contribution to journalArticleScientificpeer-review

Open Access
6 Citations (Scopus)

Betulins as novel lead compounds for cancer

Oksman-Caldentey, K-M., Lämsä, M., Härmä, V., Haavikko, R., Alakurtti, S., Nygren, H., Häkkinen, S., Yli-Kauhaluoma, J., Nees, M. & Rischer, H., 2015, Book of Abstracts. 102

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access
2 Citations (Scopus)

Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Phytochemical Analysis. 26, 5, p. 331-338

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)

Elicitation of furanocoumarins in poison hemlock (Conium maculatum L.) cell culture

Meier, P., Hotti, H. & Rischer, H., 2015, In : Plant Cell, Tissue and Organ Culture. 123, 3, p. 443-453

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Establishment of transgenic Rhazya stricta hairy roots to modulate terpenoid indole alkaloid production

Akhgari, A., Yrjönen, T., Laakso, I., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Plant Cell Reports. 34, 11, p. 1939-1952

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)

Metabolic engineering of secondary biosynthetic pathways in plants

Fräbel, S., Seppänen-Laakso, T., Rischer, H. & Heribert, W., 2015, Book of Abstracts: Challenges and prospects in PNP metabolic engineering and production: Final Conference,. 96

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Natural raspberry ketone production via bioconversion using plant cell cultures

Häkkinen, S. T., Seppänen-Laakso, T. & Rischer, H., 2015, Book of Abstracts: Bioflavour 2015. 99

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Nile Red staining of phytoplankton neutral lipids: species-specific fluorescence kinetics in various solvents

Natunen, K., Seppälä, J., Schwenk, D., Rischer, H., Spilling, K. & Tamminen, T., 2015, In : Journal of Applied Phycology. 27, 3, p. 1161-1168

Research output: Contribution to journalArticleScientificpeer-review

Open Access
14 Citations (Scopus)

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development

Härmä, V., Haavikko, R., Virtanen, J., Ahonen, I., Schukov, H-P., Alakurtti, S., Purev, E., Rischer, H., Yli-Kauhaluoma, J., Moreira, V. M., Nees, M. & Oksman-Caldentey, K-M., 2015, In : PLoS ONE. 10, 5, 22 p., e0126111.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Phenolic composition of cloudberry and arctic bramble cell suspension cultures

Puupponen-Pimiä, R., Nohynek, L., Salminen, J-P., Rischer, H. & Oksman-Caldentey, K-M., 2015, Book of Abstracts. p. 30 P-1

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

Polyketide synthases from poison hemlock (Conium maculatum L.)

Hotti, H., Seppänen-Laakso, T., Arvas, M., Teeri, T. H. & Rischer, H., 2015, In : FEBS Journal. 282, 21, p. 4141-4156

Research output: Contribution to journalArticleScientificpeer-review

6 Citations (Scopus)

Standards for plant synthetic biology: A common syntax for exchange of DNA parts

Patron, N. J., Orzaez, D. ., Marillonnet, S., Warzecha, H., Matthewman, C., Youles, M., Raitskin, O., Leveau, Farré, G., Rogers, C., Smith, A., Hibberd, J., Webb, A. A. R., Locke, J., Schornack, S., Ajioka, J., Baulcombe, D. C., Zipfel, C., Kamoun, S., Jones, J. D. G. & 30 others, Kuhn, H., Robatzek, S., Van Esse, H. P., Sanders, D., Oldroyd, G., Martin, C., Field, R., O'Connor, S., Fox, S., Wulff, B., Miller, B., Breakspear, A., Radhakrishnan, G., Delaux, P-M., Loqué, D., Granell, A., Tissier, A., Shih, P., Brutnell, T. P., Quick, W. P., Rischer, H., Fraser, P. D., Aharoni, A., Raines, C., South, P. F., Ané, J-M., Hamberger, B. R., Langdale, J., Stougaard, J. & Bouwmeester, H., 2015, In : New Phytologist. 208, 1, p. 13-19

Research output: Contribution to journalArticleScientificpeer-review

86 Citations (Scopus)

The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

Van Moerkercke, A., Steensma, P., Schweizer, F., Pollier, J., Gariboldi, I., Payne, R., Vanden Bossche, R., Miettinen, K., Espoz, J., Purnama, P. C., Kellner, F., Seppänen-Laakso, T., O'Connor, S. E., Rischer, H., Memelink, J. & Goossens, A., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 26, p. 8130-8135

Research output: Contribution to journalArticle

Open Access
75 Citations (Scopus)

Type III polyketide synthases from poison hemlock

Hotti, H., Teeri, T. & Rischer, H., 2015, Book of Abstracts. 63

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

2014

Algae-bacteria association inferred by 16S rDNA similarity in established microalgae cultures

Schwenk, D., Nohynek, L. & Rischer, H., 2014, In : MicrobiologyOpen. 3, 3, p. 356-368

Research output: Contribution to journalArticle

20 Citations (Scopus)

Disposable bioreactors for cultivation of plant cell cultures

Lehmann, N., Dittler, I., Lämsä, M., Ritala, A., Rischer, H., Eibl, D., Oksman-Caldentey, K-M. & Eibl, R., 2014, Production of Biomass and Bioactive Compounds Using Bioreactor Technology. Paek, K-Y., Hosakatte, N. M. & Zhong, J-J. (eds.). Springer, p. 17-46

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleProfessional

8 Citations (Scopus)

Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway

Ritala, A., Dong, L., Imseng, N., Seppänen-Laakso, T., Vasilev, N., van der Krol, S., Rischer, H., Maaheimo, H., Virkki, A., Brändli, J., Schillerberg, S., Eibl, R., Bouwmeester, H. & Oksman-Caldentey, K-M., 2014, In : Journal of Biotechnology. 176, p. 20-28 8 p.

Research output: Contribution to journalArticleScientificpeer-review

17 Citations (Scopus)

Metabolic engineering of terpenoid indole alkaloid pathway in Catharanthus roseus

Oksman-Caldentey, K-M. & Rischer, H., 2014, International Association for Plant Biotechnology Congress 2014: Book of Abstracts. 24

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Selection and validation of reference genes for transcript normalization in gene expression studies in Catharanthus roseus

Pollier, J., Vanden Bossche, R., Rischer, H. & Goossens, A., 2014, In : Plant Physiology and Biochemistry. 83, p. 20-25 6 p.

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)

Type III polyketide synthases from poison hemlock

Hotti, H., Teeri, T. & Rischer, H., 2014.

Research output: Contribution to conferenceConference AbstractScientific

2013

Analysis of the Interface between Primary and Secondary Metabolism in Catharanthus roseus Cell Cultures Using 13C-Stable Isotope Feeding and Coupled Mass Spectrometry: Letter to the Editor

Antonio, C., Mustafa, N. R., Osorio, S., Tohge, T., Giavalisco, P., Willmitzer, L., Rischer, H., Oksman-Caldentey, K-M., Verpoorte, R. & Fernie, A. R., 2013, In : Molecular Plant. 6, 2, p. 581-584 4 p.

Research output: Contribution to journalOther journal contribution

Open Access
10 Citations (Scopus)

Arctic vitality from berry cell culture technology

Nohynek, L., Rischer, H., Oksman-Caldentey, K-M. & Puupponen-Pimiä, R., 2013.

Research output: Contribution to conferenceConference articleScientific

CathaCyc, a metabolic pathway database built from catharanthus roseus RNA-seq data

Van Moerkercke, A., Fabris, M., Pollier, J., Baart, G. J. E., Rombauts, S., Hasnain, G., Rischer, H., Memelink, J., Oksman-Caldentey, K-M. & Goossens, A., 2013, In : Plant and Cell Physiology. 54, 5, p. 673-685 13 p.

Research output: Contribution to journalArticle

Open Access
76 Citations (Scopus)

Cell-based functional screening of modified betulins, abietanes and resin acids as lead compounds for anti-cancer drugs (BARC)

Nees, M., Haavikko, R., Moreira, V., Alakurtti, S., Yli-Kauhaluoma, J., Rischer, H., Purev, E., Virtanen, J. & Oksman-Caldentey, K-M., 2013, TERPNET 2013: Book of Abstracts. Aristotle University of Thessaloniki, p. 88 1 p. O53

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access