Heiko Rischer

Dr. rer. nat.

  • Phone+358407206834
19962020

Research output per year

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Research Output

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Article
2020

Agrobacterium-mediated genetic transformation of the medicinal plant veratrum dahuricum

Ma, R., Yu, Z., Cai, Q., Li, H., Dong, Y., Oksman-Caldentey, K. M. & Rischer, H., 4 Feb 2020, In : Plants. 9, 2, 191.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2 Citations (Scopus)
2019

Methyljasmonate Elicitation Increases Terpenoid Indole Alkaloid Accumulation in Rhazya stricta Hairy Root Cultures

Akhgari, A., Laakso, I., Maaheimo, H., Choi, Y. H., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 22 Nov 2019, In : Plants. 8, 12, 534.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2018

Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells

Häkkinen, S. T., Nygren, H., Maiorova, N., Haavikko, R., Alakurtti, S., Yli-Kauhaluoma, J., Rischer, H. & Oksman-Caldentey, K. M., 1 Jul 2018, In : Planta Medica. 84, 9-10, p. 743-748 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Euglena gracilis growth and cell composition under different temperature, light and trophic conditions

Wang, Y., Seppänen-Laakso, T., Rischer, H. & Wiebe, M. G., 1 Apr 2018, In : PLoS ONE. 13, 4, e0195329.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
6 Citations (Scopus)

Marine Microalgae: Promising source for new bioactive compounds

de Vera, C. R., Crespín, G. D., Daranas, A. H., Looga, S. M., Lillsunde, K. E., Tammela, P., Perälä, M., Hongisto, V., Virtanen, J., Rischer, H., Muller, C. D., Norte, M., Fernández, J. J. & Souto, M. L., 6 Sep 2018, In : Marine Drugs. 16, 9, 317.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
7 Citations (Scopus)

Plant cells as food: A concept taking shape

Nordlund, E., Lille, M., Silventoinen, P., Nygren, H., Seppänen-Laakso, T., Mikkelson, A., Aura, A-M., Heiniö, R-L., Nohynek, L., Puupponen-Pimiä, R. & Rischer, H., 2018, In : Food Research International. 107, p. 297–305 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
8 Citations (Scopus)

Tobacco BY-2 Media Component Optimization for a Cost-Efficient Recombinant Protein Production

Häkkinen, S., Reuter, L., Nuorti, N., Joensuu, J., Rischer, H. & Ritala, A., Jan 2018, In : Frontiers in Plant Science. 9, 45.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
6 Citations (Scopus)
2017

Metabolite profiling of the carnivorous pitcher plants Darlingtonia and Sarracenia

Hotti, H., Gopalacharyulu, P., Seppänen-Laakso, T. & Rischer, H., 1 Feb 2017, In : PLoS ONE. 12, 2, 21 p., e0171078.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
3 Citations (Scopus)

Polyketide-derived alkaloids and anthraquinones in Aloe plants and cell cultures

Hotti, H., Häkkinen, S., Rischer, H. & Seppänen-Laakso, T., 2017, In : Journal of Plant Biotechnology Research. 1, 1, p. 1-15 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Variability in the production of tannins and other polyphenols in cell cultures of 12 Nordic plant species

Suvanto, J., Nohynek, L., Seppänen-Laakso, T., Rischer, H., Salminen, J-P. & Puupponen-Pimiä, R., Aug 2017, In : Planta. 246, 2, p. 227-241 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
14 Citations (Scopus)
2015

Analysis of indole alkaloids from Rhazya stricta hairy roots by ultra-performance liquid chromatography-mass spectrometry

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Molecules. 20, 12, p. 22621-22634

Research output: Contribution to journalArticleScientificpeer-review

Open Access
6 Citations (Scopus)

Bioconversion to Raspberry Ketone is Achieved by Several Non-related Plant Cell Cultures

Häkkinen, S., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 24 Nov 2015, In : Frontiers in Plant Science. 6, p. 1-9 9 p., 1035.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
4 Citations (Scopus)

Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Phytochemical Analysis. 26, 5, p. 331-338

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)

Elicitation of furanocoumarins in poison hemlock (Conium maculatum L.) cell culture

Meier, P., Hotti, H. & Rischer, H., 2015, In : Plant Cell, Tissue and Organ Culture. 123, 3, p. 443-453

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Establishment of transgenic Rhazya stricta hairy roots to modulate terpenoid indole alkaloid production

Akhgari, A., Yrjönen, T., Laakso, I., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Plant Cell Reports. 34, 11, p. 1939-1952

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Nile Red staining of phytoplankton neutral lipids: species-specific fluorescence kinetics in various solvents

Natunen, K., Seppälä, J., Schwenk, D., Rischer, H., Spilling, K. & Tamminen, T., 2015, In : Journal of Applied Phycology. 27, 3, p. 1161-1168

Research output: Contribution to journalArticleScientificpeer-review

Open Access
15 Citations (Scopus)

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development

Härmä, V., Haavikko, R., Virtanen, J., Ahonen, I., Schukov, H-P., Alakurtti, S., Purev, E., Rischer, H., Yli-Kauhaluoma, J., Moreira, V. M., Nees, M. & Oksman-Caldentey, K-M., 2015, In : PLoS ONE. 10, 5, 22 p., e0126111.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
13 Citations (Scopus)

Polyketide synthases from poison hemlock (Conium maculatum L.)

Hotti, H., Seppänen-Laakso, T., Arvas, M., Teeri, T. H. & Rischer, H., 2015, In : FEBS Journal. 282, 21, p. 4141-4156

Research output: Contribution to journalArticleScientificpeer-review

7 Citations (Scopus)

Standards for plant synthetic biology: A common syntax for exchange of DNA parts

Patron, N. J., Orzaez, D. ., Marillonnet, S., Warzecha, H., Matthewman, C., Youles, M., Raitskin, O., Leveau, Farré, G., Rogers, C., Smith, A., Hibberd, J., Webb, A. A. R., Locke, J., Schornack, S., Ajioka, J., Baulcombe, D. C., Zipfel, C., Kamoun, S., Jones, J. D. G. & 30 others, Kuhn, H., Robatzek, S., Van Esse, H. P., Sanders, D., Oldroyd, G., Martin, C., Field, R., O'Connor, S., Fox, S., Wulff, B., Miller, B., Breakspear, A., Radhakrishnan, G., Delaux, P-M., Loqué, D., Granell, A., Tissier, A., Shih, P., Brutnell, T. P., Quick, W. P., Rischer, H., Fraser, P. D., Aharoni, A., Raines, C., South, P. F., Ané, J-M., Hamberger, B. R., Langdale, J., Stougaard, J. & Bouwmeester, H., 2015, In : New Phytologist. 208, 1, p. 13-19

Research output: Contribution to journalArticleScientificpeer-review

98 Citations (Scopus)

The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

Van Moerkercke, A., Steensma, P., Schweizer, F., Pollier, J., Gariboldi, I., Payne, R., Vanden Bossche, R., Miettinen, K., Espoz, J., Purnama, P. C., Kellner, F., Seppänen-Laakso, T., O'Connor, S. E., Rischer, H., Memelink, J. & Goossens, A., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 26, p. 8130-8135

Research output: Contribution to journalArticleScientificpeer-review

Open Access
81 Citations (Scopus)
2014

Algae-bacteria association inferred by 16S rDNA similarity in established microalgae cultures

Schwenk, D., Nohynek, L. & Rischer, H., 2014, In : MicrobiologyOpen. 3, 3, p. 356-368

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)
Open Access
11 Citations (Scopus)

Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway

Ritala, A., Dong, L., Imseng, N., Seppänen-Laakso, T., Vasilev, N., van der Krol, S., Rischer, H., Maaheimo, H., Virkki, A., Brändli, J., Schillerberg, S., Eibl, R., Bouwmeester, H. & Oksman-Caldentey, K-M., 2014, In : Journal of Biotechnology. 176, p. 20-28 8 p.

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)

Rational design of plant systems for sustainable generation of value-added industrial products (SmartCell)

Oksman-Caldentey, K-M., Ritala, A., Rischer, H., Häkkinen, S. & Christou, P., 2014, In : Dosis. 30, 3

Research output: Contribution to journalArticleScientificpeer-review

Selection and validation of reference genes for transcript normalization in gene expression studies in Catharanthus roseus

Pollier, J., Vanden Bossche, R., Rischer, H. & Goossens, A., 2014, In : Plant Physiology and Biochemistry. 83, p. 20-25 6 p.

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)
2013

CathaCyc, a metabolic pathway database built from catharanthus roseus RNA-seq data

Van Moerkercke, A., Fabris, M., Pollier, J., Baart, G. J. E., Rombauts, S., Hasnain, G., Rischer, H., Memelink, J., Oksman-Caldentey, K-M. & Goossens, A., 2013, In : Plant and Cell Physiology. 54, 5, p. 673-685 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
81 Citations (Scopus)

Lipid content in 19 brackish and marine microalgae: Influence of growth phase, salinity and temperature

Schwenk, D., Seppälä, J., Spilling, K., Virkki, A., Tamminen, T., Oksman-Caldentey, K-M. & Rischer, H., 2013, In : Aquatic Ecology. 47, 4, p. 415-424 9 p.

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)

Metabolic engineering of plant secondary products: Which way forward?

Miralpeix, B., Rischer, H., Häkkinen, S., Ritala, A., Seppänen-Laakso, T., Oksman-Caldentey, K-M., Capell, T. & Christou, P., 2013, In : Current Pharmaceutical Design. 19, 31, p. 5622-5639 17 p.

Research output: Contribution to journalArticleScientificpeer-review

28 Citations (Scopus)

Mixotrophic continuous flow cultivation of Chlorella protothecoides for lipids

Wang, Y., Rischer, H., Eriksen, N. T. & Wiebe, M., 2013, In : Bioresource Technology. 144, p. 608-614 6 p.

Research output: Contribution to journalArticleScientificpeer-review

32 Citations (Scopus)

Plant cells as pharmaceutical factories

Rischer, H., Häkkinen, S., Ritala, A., Seppänen-Laakso, T., Miralpeix, B., Capell, T., Christou, P. & Oksman-Caldentey, K-M., 2013, In : Current Pharmaceutical Design. 19, 31, p. 5640-5660 20 p.

Research output: Contribution to journalArticleScientificpeer-review

34 Citations (Scopus)

The effect of high pH on structural lipids in diatoms

Spilling, K., Brynjólfsdóttir, A., Enss, D., Rischer, H. & Svavarsson, H. G., 2013, In : Journal of Applied Phycology. 25, 5, p. 1435-1439 5 p.

Research output: Contribution to journalArticleScientificpeer-review

16 Citations (Scopus)

Wave-mixed and orbitally shaken single-use photobioreactors for diatom algae propagation

Lehmann, N., Rischer, H., Eibl, D. & Eibl, R., 2013, In : Chemie-Ingenieur-Technik. 85, 1-2, p. 197-201 5 p.

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)
2012

Differential patterns of dehydroabietic acid biotransformation by Nicotiana tabacum and Catharanthus roseus cells

Häkkinen, S. T., Lackman, P., Nygren, H., Oksman-Caldentey, K-M., Maaheimo, H. & Rischer, H., 2012, In : Journal of Biotechnology. 157, 2, p. 287-294 8 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

In-depth proteome mining of cultured Catharanthus roseus cells identifies candidate proteins involved in the synthesis and transport of secondary metabolites

Champagne, A., Rischer, H., Oksman-Caldentey, K-M. & Boutry, M., 2012, In : Proteomics. 12, 23-24, p. 3536-3547 11 p.

Research output: Contribution to journalArticleScientificpeer-review

23 Citations (Scopus)
2011

Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco

Lackman, P., González-Guzmán, M., Tilleman, S., Carqueijeiro, I., Cuéllar Pérez, A., Moses, T., Seo, M., Kanno, Y., Häkkinen, S. T., Van Montagu, M. C. E., Thevelein, J. M., Maaheimo, H., Oksman-Caldentey, K-M., Rodriguez, P. L., Rischer, H. & Goossens, A., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 14, p. 5891-5896

Research output: Contribution to journalArticleScientificpeer-review

132 Citations (Scopus)
2010

Evidence for species differentiation within the Ancistrocladus tectorius complex (Ancistrocladaceae) in Southeast Asia: A molecular approach

Meimberg, H., Rischer, H., Turini, F. G., Chamchumroon, V., Dreyer, M., Sommaro, M., Bringmann, G. & Heubl, G., 2010, In : Plant Systematics and Evolution. 284, 1-2, p. 77-98 22 p.

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

Propagation of Triphyophyllum peltatum (Dioncophyllaceae) and observations on its carnivory

Rembold, K., Irmer, A., Poppinga, S., Rischer, H. & Bringmann, G., 2010, In : Carnivorous Plant Newsletter. 39, 3, p. 71-77 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2009

Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion (MATE) transporter in Nicotiana tabacum

Morita, M., Shitan, N., Sawada, K., Van Montagu, M. C. E., Inzé, D., Rischer, H., Goossens, A., Oksman-Caldentey, K-M., Moriyama, Y. & Yazaki, K., 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 7, p. 2447-2452 6 p.

Research output: Contribution to journalArticleScientificpeer-review

144 Citations (Scopus)
2007

Functional characterisation of genes involved in pyridine alkaloid biosynthesis in tobacco

Häkkinen, S. T., Tilleman, S., Swiatek, S., De Sutter, V., Rischer, H., Vanhoutte, I., Van Onckelen, H., Hilson, P., Inzé, D., Oksman-Caldentey, K-M. & Goossens, A., 2007, In : Phytochemistry. 68, 22-24, p. 2773-2785

Research output: Contribution to journalArticleScientificpeer-review

41 Citations (Scopus)

Implementation of functional genomics for gene discovery in alkaloid producing plants

Goossens, A. & Rischer, H., 2007, In : Phytochemistry Reviews. 6, 1, p. 35-49

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)
2006

Development of in vitro techniques for the important medicinal plant Veratrum californicum

Ma, R., Ritala, A., Oksman-Caldentey, K-M. & Rischer, H., 2006, In : Planta Medica. 72, 12, p. 1142-1148 7 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells

Rischer, H., Oresic, M., Seppänen-Laakso, T., Katajamaa, M., Lammertyn, F., Ardiles-Diaz, W., Van Montagu, M. C. E., Inzé, D., Oksman-Caldentey, K-M. & Goossens, A., 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 14, p. 5614-5619 6 p.

Research output: Contribution to journalArticleScientificpeer-review

239 Citations (Scopus)

Unintended effects in genetically modified crops: Revealed by metabolomics?

Rischer, H. & Oksman-Caldentey, K-M., 2006, In : Trends in Biotechnology. 24, 3, p. 102-104 3 p.

Research output: Contribution to journalArticleScientificpeer-review

74 Citations (Scopus)
2005

Ancistrocladus benomensis (Ancistrocladaceae): A new species from Peninsular Malaysia

Rischer, H., Heubl, G., Meimberg, H., Dreyer, M., Hadi, H. A. & Bringmann, G., 2005, In : Blumea: Journal of Plant Taxonomy and Plant Geography. 50, 2, p. 357 - 365 9 p.

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)
2 Citations (Scopus)

Carnivorous plant chemistry

Schlauer, J., Nerz, J. & Rischer, H., 2005, In : Acta Botanica Gallica. 152, 2, p. 187 - 195 9 p.

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

ent-dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the “new” plant species Ancistrocladus benomensis

Bringmann, G., Dreyer, M., Kopff, H., Rischer, H., Wohlfarth, M., Hadi, H., Brun, R., Meimberg, H. & Heubl, G., 2005, In : Journal of Natural Products. 68, 5, p. 686 - 690 5 p.

Research output: Contribution to journalArticleScientificpeer-review

33 Citations (Scopus)
2004

Anatalline and other methyl jasmonate-inducible nicotine alkaloids from Nicotiana tabacum cv. BY-2 cell cultures

Häkkinen, S. T., Rischer, H., Laakso, I., Maaheimo, H., Seppänen-Laakso, T. & Oksman-Caldentey, K-M., 2004, In : Planta Medica. 70, 10, p. 936 - 941 6 p.

Research output: Contribution to journalArticleScientificpeer-review

21 Citations (Scopus)

Ancistrobenomine A, the first naphthylisoquinoline oxygenated at Me-3, and related 5,1'-coupled alkaloids, from the "new" plant species Ancistrocladus benomensis

Bringmann, G., Dreyer, M., Rischer, H., Wolf, K., Hadi, H. A., Brun, R., Meimberg, H. & Heubl, G., 2004, In : Journal of Natural Products. 67, 12, p. 2058 - 2062 5 p.

Research output: Contribution to journalArticleScientificpeer-review

23 Citations (Scopus)