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Research Output 1996 2019

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2019

Methyljasmonate Elicitation Increases Terpenoid Indole Alkaloid Accumulation in Rhazya stricta Hairy Root Cultures

Akhgari, A., Laakso, I., Maaheimo, H., Choi, Y. H., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 22 Nov 2019, In : Plants. 8, 12, 534.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Rhazya stricta
indole alkaloids
alkaloid
methyl jasmonate
terpenoids
2018

Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells

Häkkinen, S. T., Nygren, H., Maiorova, N., Haavikko, R., Alakurtti, S., Yli-Kauhaluoma, J., Rischer, H. & Oksman-Caldentey, K. M., 1 Jul 2018, In : Planta Medica. 84, 9-10, p. 743-748 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Plant Cells
Biotransformation
Catharanthus
Derivatives
Pentoses
3 Citations (Scopus)

Euglena gracilis growth and cell composition under different temperature, light and trophic conditions

Wang, Y., Seppänen-Laakso, T., Rischer, H. & Wiebe, M. G., 1 Apr 2018, In : PLoS ONE. 13, 4, e0195329.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Euglena gracilis
Light
Biomass
Temperature
Cells
5 Citations (Scopus)

Marine Microalgae: Promising source for new bioactive compounds

de Vera, C. R., Crespín, G. D., Daranas, A. H., Looga, S. M., Lillsunde, K. E., Tammela, P., Perälä, M., Hongisto, V., Virtanen, J., Rischer, H., Muller, C. D., Norte, M., Fernández, J. J. & Souto, M. L., 6 Sep 2018, In : Marine Drugs. 16, 9, 317.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Microalgae
Biodiversity
European Union
Biological Products
Oceans and Seas
3 Citations (Scopus)
Open Access
Plant Cells
Food
Vaccinium vitis-idaea
Fruit
Hydrolysis
3 Citations (Scopus)

Tobacco BY-2 Media Component Optimization for a Cost-Efficient Recombinant Protein Production

Häkkinen, S., Reuter, L., Nuorti, N., Joensuu, J., Rischer, H. & Ritala, A., Jan 2018, In : Frontiers in Plant Science. 9, 45.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
recombinant proteins
tobacco
culture media
industrial applications
cells
2017

Liquid chromatography-mass spectrometry (LC-MS)-based analysis of molecular lipids in algae samples

Nygren, H., Seppänen-Laakso, T. & Rischer, H., 21 Nov 2017, In : Methods in Molecular Biology. p. 1-8

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Metabolite profiling of the carnivorous pitcher plants Darlingtonia and Sarracenia

Hotti, H., Gopalacharyulu, P., Seppänen-Laakso, T. & Rischer, H., 1 Feb 2017, In : PLoS ONE. 12, 2, 21 p., e0171078.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Sarraceniaceae
Sarracenia
Metabolites
metabolites
Biosynthesis

Polyketide-derived alkaloids and anthraquinones in Aloe plants and cell cultures

Hotti, H., Häkkinen, S., Rischer, H. & Seppänen-Laakso, T., 2017, In : Journal of Plant Biotechnology Research. 1, 1, p. 1-15 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
polyketides
Aloe
anthraquinones
plant cultural practices
alkaloids
Sterols
Nonesterified Fatty Acids
Esters
Fatty Acids
Phytol
10 Citations (Scopus)

Variability in the production of tannins and other polyphenols in cell cultures of 12 Nordic plant species

Suvanto, J., Nohynek, L., Seppänen-Laakso, T., Rischer, H., Salminen, J-P. & Puupponen-Pimiä, R., Aug 2017, In : Planta. 246, 2, p. 227-241 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Tannins
Polyphenols
tannins
polyphenols
cell culture
2015
5 Citations (Scopus)

Analysis of indole alkaloids from Rhazya stricta hairy roots by ultra-performance liquid chromatography-mass spectrometry

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Molecules. 20, 12, p. 22621-22634

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Secologanin Tryptamine Alkaloids
Apocynaceae
Indole Alkaloids
alkaloids
Liquid chromatography
2 Citations (Scopus)

Bioconversion to Raspberry Ketone is Achieved by Several Non-related Plant Cell Cultures

Häkkinen, S., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 24 Nov 2015, In : Frontiers in Plant Science. 6, p. 1-9 9 p., 1035.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
raspberries
biotransformation
ketones
cell culture
flavor compounds
8 Citations (Scopus)

Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Phytochemical Analysis. 26, 5, p. 331-338

Research output: Contribution to journalArticleScientificpeer-review

Rhazya stricta
Secologanin Tryptamine Alkaloids
Apocynaceae
indole alkaloids
Rhazya
10 Citations (Scopus)

Elicitation of furanocoumarins in poison hemlock (Conium maculatum L.) cell culture

Meier, P., Hotti, H. & Rischer, H., 2015, In : Plant Cell, Tissue and Organ Culture. 123, 3, p. 443-453

Research output: Contribution to journalArticleScientificpeer-review

Conium maculatum
psoralens
cell culture
bergapten
psoralen
9 Citations (Scopus)

Establishment of transgenic Rhazya stricta hairy roots to modulate terpenoid indole alkaloid production

Akhgari, A., Yrjönen, T., Laakso, I., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Plant Cell Reports. 34, 11, p. 1939-1952

Research output: Contribution to journalArticleScientificpeer-review

Rhazya stricta
indole alkaloids
terpenoids
genetically modified organisms
alkaloids
10 Citations (Scopus)

Nile Red staining of phytoplankton neutral lipids: species-specific fluorescence kinetics in various solvents

Natunen, K., Seppälä, J., Schwenk, D., Rischer, H., Spilling, K. & Tamminen, T., 2015, In : Journal of Applied Phycology. 27, 3, p. 1161-1168

Research output: Contribution to journalArticleScientificpeer-review

Open Access
fluorescence
lipid
phytoplankton
triacylglycerols
kinetics
11 Citations (Scopus)

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development

Härmä, V., Haavikko, R., Virtanen, J., Ahonen, I., Schukov, H-P., Alakurtti, S., Purev, E., Rischer, H., Yli-Kauhaluoma, J., Moreira, V. M., Nees, M. & Oksman-Caldentey, K-M., 2015, In : PLoS ONE. 10, 5, 22 p., e0126111.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
betulin
prostatic neoplasms
Prostatic Neoplasms
chemical derivatives
Castration
6 Citations (Scopus)

Polyketide synthases from poison hemlock (Conium maculatum L.)

Hotti, H., Seppänen-Laakso, T., Arvas, M., Teeri, T. H. & Rischer, H., 2015, In : FEBS Journal. 282, 21, p. 4141-4156

Research output: Contribution to journalArticleScientificpeer-review

Conium
Polyketide Synthases
Poisons
Starters
Biosynthesis
80 Citations (Scopus)

Standards for plant synthetic biology: A common syntax for exchange of DNA parts

Patron, N. J., Orzaez, D. ., Marillonnet, S., Warzecha, H., Matthewman, C., Youles, M., Raitskin, O., Leveau, Farré, G., Rogers, C., Smith, A., Hibberd, J., Webb, A. A. R., Locke, J., Schornack, S., Ajioka, J., Baulcombe, D. C., Zipfel, C., Kamoun, S., Jones, J. D. G. & 30 others, Kuhn, H., Robatzek, S., Van Esse, H. P., Sanders, D., Oldroyd, G., Martin, C., Field, R., O'Connor, S., Fox, S., Wulff, B., Miller, B., Breakspear, A., Radhakrishnan, G., Delaux, P-M., Loqué, D., Granell, A., Tissier, A., Shih, P., Brutnell, T. P., Quick, W. P., Rischer, H., Fraser, P. D., Aharoni, A., Raines, C., South, P. F., Ané, J-M., Hamberger, B. R., Langdale, J., Stougaard, J. & Bouwmeester, H., 2015, In : New Phytologist. 208, 1, p. 13-19

Research output: Contribution to journalArticleScientificpeer-review

Synthetic Biology
synthetic biology
plant biology
engineering
Inventors
68 Citations (Scopus)

The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

Van Moerkercke, A., Steensma, P., Schweizer, F., Pollier, J., Gariboldi, I., Payne, R., Vanden Bossche, R., Miettinen, K., Espoz, J., Purnama, P. C., Kellner, F., Seppänen-Laakso, T., O'Connor, S. E., Rischer, H., Memelink, J. & Goossens, A., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 26, p. 8130-8135

Research output: Contribution to journalArticleScientificpeer-review

Open Access
basic helix-loop-helix transcription factors
indole alkaloids
Catharanthus roseus
monoterpenoids
Catharanthus
2014
17 Citations (Scopus)

Algae-bacteria association inferred by 16S rDNA similarity in established microalgae cultures

Schwenk, D., Nohynek, L. & Rischer, H., 2014, In : MicrobiologyOpen. 3, 3, p. 356-368

Research output: Contribution to journalArticleScientificpeer-review

Microalgae
Haptophyta
Ribosomal DNA
Rhodobacteraceae
Bacteria
8 Citations (Scopus)
Open Access
15 Citations (Scopus)

Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway

Ritala, A., Dong, L., Imseng, N., Seppänen-Laakso, T., Vasilev, N., van der Krol, S., Rischer, H., Maaheimo, H., Virkki, A., Brändli, J., Schillerberg, S., Eibl, R., Bouwmeester, H. & Oksman-Caldentey, K-M., 2014, In : Journal of Biotechnology. 176, p. 20-28 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Secologanin Tryptamine Alkaloids
Alkaloids
Tobacco
Fragrances
Glycosides

Rational design of plant systems for sustainable generation of value-added industrial products (SmartCell)

Oksman-Caldentey, K-M., Ritala, A., Rischer, H., Häkkinen, S. & Christou, P., 2014, In : Dosis. 30, 3

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)

Selection and validation of reference genes for transcript normalization in gene expression studies in Catharanthus roseus

Pollier, J., Vanden Bossche, R., Rischer, H. & Goossens, A., 2014, In : Plant Physiology and Biochemistry. 83, p. 20-25 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Catharanthus
Catharanthus roseus
Gene Expression
gene expression
Genes
2013
74 Citations (Scopus)

CathaCyc, a metabolic pathway database built from catharanthus roseus RNA-seq data

Van Moerkercke, A., Fabris, M., Pollier, J., Baart, G. J. E., Rombauts, S., Hasnain, G., Rischer, H., Memelink, J., Oksman-Caldentey, K-M. & Goossens, A., 2013, In : Plant and Cell Physiology. 54, 5, p. 673-685 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Catharanthus
Catharanthus roseus
Secologanin Tryptamine Alkaloids
Metabolic Networks and Pathways
indole alkaloids
17 Citations (Scopus)

Lipid content in 19 brackish and marine microalgae: Influence of growth phase, salinity and temperature

Schwenk, D., Seppälä, J., Spilling, K., Virkki, A., Tamminen, T., Oksman-Caldentey, K-M. & Rischer, H., 2013, In : Aquatic Ecology. 47, 4, p. 415-424 9 p.

Research output: Contribution to journalArticleScientificpeer-review

microalgae
lipid
lipid content
salinity
fatty acid
25 Citations (Scopus)

Metabolic engineering of plant secondary products: Which way forward?

Miralpeix, B., Rischer, H., Häkkinen, S., Ritala, A., Seppänen-Laakso, T., Oksman-Caldentey, K-M., Capell, T. & Christou, P., 2013, In : Current Pharmaceutical Design. 19, 31, p. 5622-5639 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Metabolic Engineering
Herbivory
Organ Culture Techniques
Plant Cells
Genetic Association Studies
25 Citations (Scopus)

Mixotrophic continuous flow cultivation of Chlorella protothecoides for lipids

Wang, Y., Rischer, H., Eriksen, N. T. & Wiebe, M., 2013, In : Bioresource Technology. 144, p. 608-614 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipids
lipid
Biomass
biomass
Nitrogen
33 Citations (Scopus)

Plant cells as pharmaceutical factories

Rischer, H., Häkkinen, S., Ritala, A., Seppänen-Laakso, T., Miralpeix, B., Capell, T., Christou, P. & Oksman-Caldentey, K-M., 2013, In : Current Pharmaceutical Design. 19, 31, p. 5640-5660 20 p.

Research output: Contribution to journalArticleScientificpeer-review

Plant Cells
Pharmaceutical Preparations
Secologanin Tryptamine Alkaloids
Tropanes
Viridiplantae
13 Citations (Scopus)

The effect of high pH on structural lipids in diatoms

Spilling, K., Brynjólfsdóttir, A., Enss, D., Rischer, H. & Svavarsson, H. G., 2013, In : Journal of Applied Phycology. 25, 5, p. 1435-1439 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Bacillariophyceae
diatom
lipid
Phaeodactylum tricornutum
lipids
9 Citations (Scopus)

Wave-mixed and orbitally shaken single-use photobioreactors for diatom algae propagation

Lehmann, N., Rischer, H., Eibl, D. & Eibl, R., 2013, In : Chemie-Ingenieur-Technik. 85, 1-2, p. 197-201 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Photobioreactors
Algae
Bioreactors
Bubble columns
Biomass
2012
11 Citations (Scopus)

Differential patterns of dehydroabietic acid biotransformation by Nicotiana tabacum and Catharanthus roseus cells

Häkkinen, S. T., Lackman, P., Nygren, H., Oksman-Caldentey, K-M., Maaheimo, H. & Rischer, H., 2012, In : Journal of Biotechnology. 157, 2, p. 287-294 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Catharanthus
Biotransformation
Tobacco
Acids
Bioconversion
22 Citations (Scopus)

In-depth proteome mining of cultured Catharanthus roseus cells identifies candidate proteins involved in the synthesis and transport of secondary metabolites

Champagne, A., Rischer, H., Oksman-Caldentey, K-M. & Boutry, M., 2012, In : Proteomics. 12, 23-24, p. 3536-3547 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Catharanthus
Proteome
Metabolites
Secologanin Tryptamine Alkaloids
Metabolism
2011
122 Citations (Scopus)

Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco

Lackman, P., González-Guzmán, M., Tilleman, S., Carqueijeiro, I., Cuéllar Pérez, A., Moses, T., Seo, M., Kanno, Y., Häkkinen, S. T., Van Montagu, M. C. E., Thevelein, J. M., Maaheimo, H., Oksman-Caldentey, K-M., Rodriguez, P. L., Rischer, H. & Goossens, A., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 14, p. 5891-5896

Research output: Contribution to journalArticleScientificpeer-review

abscisic acid
tobacco
Arabidopsis
receptors
alkaloids
2010
13 Citations (Scopus)

Evidence for species differentiation within the Ancistrocladus tectorius complex (Ancistrocladaceae) in Southeast Asia: A molecular approach

Meimberg, H., Rischer, H., Turini, F. G., Chamchumroon, V., Dreyer, M., Sommaro, M., Bringmann, G. & Heubl, G., 2010, In : Plant Systematics and Evolution. 284, 1-2, p. 77-98 22 p.

Research output: Contribution to journalArticleScientificpeer-review

Ancistrocladaceae
South East Asia
alkaloids
alkaloid
phytopharmaceuticals

Propagation of Triphyophyllum peltatum (Dioncophyllaceae) and observations on its carnivory

Rembold, K., Irmer, A., Poppinga, S., Rischer, H. & Bringmann, G., 2010, In : Carnivorous Plant Newsletter. 39, 3, p. 71-77 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Dioncophyllaceae
Triphyophyllum peltatum
carnivores
carnivorous plants
botanical gardens
2009
135 Citations (Scopus)

Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion (MATE) transporter in Nicotiana tabacum

Morita, M., Shitan, N., Sawada, K., Van Montagu, M. C. E., Inzé, D., Rischer, H., Goossens, A., Oksman-Caldentey, K-M., Moriyama, Y. & Yazaki, K., 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 7, p. 2447-2452 6 p.

Research output: Contribution to journalArticleScientificpeer-review

nicotine
toxic substances
extrusion
Nicotiana tabacum
transporters
2007
38 Citations (Scopus)

Functional characterisation of genes involved in pyridine alkaloid biosynthesis in tobacco

Häkkinen, S. T., Tilleman, S., Swiatek, S., De Sutter, V., Rischer, H., Vanhoutte, I., Van Onckelen, H., Hilson, P., Inzé, D., Oksman-Caldentey, K-M. & Goossens, A., 2007, In : Phytochemistry. 68, 22-24, p. 2773-2785

Research output: Contribution to journalArticleScientificpeer-review

pyridine alkaloids
Tobacco
Biosynthesis
Alkaloids
tobacco
22 Citations (Scopus)

Implementation of functional genomics for gene discovery in alkaloid producing plants

Goossens, A. & Rischer, H., 2007, In : Phytochemistry Reviews. 6, 1, p. 35-49

Research output: Contribution to journalArticleScientificpeer-review

Genetic Association Studies
Genomics
Alkaloids
alkaloids
genomics
2006
12 Citations (Scopus)

Development of in vitro techniques for the important medicinal plant Veratrum californicum

Ma, R., Ritala, A., Oksman-Caldentey, K-M. & Rischer, H., 2006, In : Planta Medica. 72, 12, p. 1142-1148 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Veratrum
Bony Callus
Medicinal Plants
Suspensions
Viridiplantae
232 Citations (Scopus)

Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells

Rischer, H., Oresic, M., Seppänen-Laakso, T., Katajamaa, M., Lammertyn, F., Ardiles-Diaz, W., Van Montagu, M. C. E., Inzé, D., Oksman-Caldentey, K-M. & Goossens, A., 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 14, p. 5614-5619 6 p.

Research output: Contribution to journalArticleScientificpeer-review

indole alkaloids
Catharanthus roseus
terpenoids
biosynthesis
metabolites
73 Citations (Scopus)

Unintended effects in genetically modified crops: Revealed by metabolomics?

Rischer, H. & Oksman-Caldentey, K-M., 2006, In : Trends in Biotechnology. 24, 3, p. 102-104 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Metabolomics
Metabolites
Crops
Genetically modified plants
Metabolome
2005
14 Citations (Scopus)

Ancistrocladus benomensis (Ancistrocladaceae): A new species from Peninsular Malaysia

Rischer, H., Heubl, G., Meimberg, H., Dreyer, M., Hadi, H. A. & Bringmann, G., 2005, In : Blumea: Journal of Plant Taxonomy and Plant Geography. 50, 2, p. 357 - 365 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Ancistrocladaceae
isoquinoline alkaloids
alkaloid
Malaysia
new species
2 Citations (Scopus)
plant genetic resources
phytopharmaceuticals
drugs
Pharmaceutical Preparations
Endangered Species
13 Citations (Scopus)

Carnivorous plant chemistry

Schlauer, J., Nerz, J. & Rischer, H., 2005, In : Acta Botanica Gallica. 152, 2, p. 187 - 195 9 p.

Research output: Contribution to journalArticleScientificpeer-review

carnivorous plants
plant biochemistry
Nepenthales
Cephalotaceae
Byblidaceae
32 Citations (Scopus)

ent-dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the “new” plant species Ancistrocladus benomensis

Bringmann, G., Dreyer, M., Kopff, H., Rischer, H., Wohlfarth, M., Hadi, H., Brun, R., Meimberg, H. & Heubl, G., 2005, In : Journal of Natural Products. 68, 5, p. 686 - 690 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Dioncophyllaceae
Alkaloids
Bioactivity
Parasites
Oxygen
2004
20 Citations (Scopus)

Anatalline and other methyl jasmonate-inducible nicotine alkaloids from Nicotiana tabacum cv. BY-2 cell cultures

Häkkinen, S. T., Rischer, H., Laakso, I., Maaheimo, H., Seppänen-Laakso, T. & Oksman-Caldentey, K-M., 2004, In : Planta Medica. 70, 10, p. 936 - 941 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Nicotine
Cell culture
Alkaloids
Tobacco
Cell Culture Techniques
22 Citations (Scopus)

Ancistrobenomine A, the first naphthylisoquinoline oxygenated at Me-3, and related 5,1'-coupled alkaloids, from the "new" plant species Ancistrocladus benomensis

Bringmann, G., Dreyer, M., Rischer, H., Wolf, K., Hadi, H. A., Brun, R., Meimberg, H. & Heubl, G., 2004, In : Journal of Natural Products. 67, 12, p. 2058 - 2062 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Alkaloids
Malaysia
Pathogens
Bioactivity
Oxygen