Heiko Rischer

Dr. rer. nat.

  • Phone+358407206834
19962020

Research output per year

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Research Output

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Article
1996

Nepenthes lavicola, a new species of Nepenthaceae from the Aceh Province in the North of Sumatra

Wistuba, A. & Rischer, H., 1996, In : Carnivorous Plant Newsletter. 25, 4, p. 106-111 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
1998

The polyketide folding mode in the biogenesis of isoshinanolone and plumbagin from Ancistrocladus heyneanus (Ancistrocladaceae)

Bringmann, G., Wohlfarth, M., Rischer, H., Rückert, M. & Schlauer, J., 1998, In : Tetrahedron Letters. 39, 46, p. 8445-8448

Research output: Contribution to journalArticleScientificpeer-review

31 Citations (Scopus)
1999

Cultivation of Triphyophyllum peltatum (Dioncophyllaceae), the part-time carnivorous plant

Bringmann, G., Schlauer, J., Wolf, K., Rischer, H., Buschbom, U., Kreiner, A., Thiele, F., Duschek, M. & Aké Assi, L., 1999, In : Carnivorous Plant Newsletter. 28, p. 7-13 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

In vitro propagation of Ancistrocladus abbreviatus airy shaw (Ancistrocladaceae)

Bringmann, G., Rischer, H., Schlauer, J. & Aké Assi, L., 1999, In : Plant Cell, Tissue and Organ Culture. 57, 1, p. 71-73 3 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)
2000

A new biosynthetic pathway to alkaloids in plants: Acetogenic isoquinolines

Bringmann, G., Wohlfarth, M., Rischer, H., Grüne, M. & Schlauer, J., 2000, In : Angewandte Chemie: International Edition. 39, 8, p. 1464-1466 3 p.

Research output: Contribution to journalArticleScientificpeer-review

72 Citations (Scopus)

Biosynthesis of antidesmone in cell cultures of Antidesma membranaceum (Euphorbiaceae): An unprecedented class of glycine-derived alkaloids

Bringmann, G., Rischer, H., Wohlfarth, M. & Schlauer, J., 2000, In : Journal of the American Chemical Society. 122, 41, p. 9905-9910 6 p.

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Droserone from cell cultures of Triphyophyllum peltatum (Dioncophyllaceae) and its biosynthetic origin

Bringmann, G., Rischer, H., Wohlfarth, M., Schlauer, J. & Aké Assi, L., 2000, In : Phytochemistry. 53, 3, p. 339-343 5 p.

Research output: Contribution to journalArticleScientificpeer-review

34 Citations (Scopus)

Revised structure of antidesmone, an unusual alkaloid from tropical Antidesma plants (Euphorbiaceae)

Bringmann, G., Schlauer, J., Rischer, H., Wohlfarth, M., Mühlbacher, J., Buske, A., Porzel, A., Schmidt, J. & Adam, G., 2000, In : Tetrahedron. 56, 23, p. 3691-3695 5 p.

Research output: Contribution to journalArticleScientificpeer-review

31 Citations (Scopus)
2001

Antidesmone, a novel antitrypanosomal alkaloid

Bringmann, G., Schlauer, J., Rischer, H., Wohlfarth, M., Haller, R., Bär, S. & Brun, R., 2001, In : Pharmaceutical and pharmacological letters. 11, 2, p. 47-48 2 p.

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)

A photometric screening method for dimeric naphthylisoquinoline alkaloids and complete on-line structural eludication of a dimer in crude plant extracts, by the LC−MS/LC−NMR/LC−CD Triad

Bringmann, G., Wohlfarth, M., Rischer, H., Heubes, M., Saeb, W., Diem, S., Herderich, M. & Schlauer, J., 2001, In : Analytical Chemistry. 73, 11, p. 2571-2577 7 p.

Research output: Contribution to journalArticleScientificpeer-review

42 Citations (Scopus)
2002

Extract screening by HPLC coupled to MS-MS, NMR, and CD: A dimeric and three monomeric naphthylisoquinoline alkaloids from Ancistrocladus griffithii

Bringmann, G., Wohlfarth, M., Rischer, H., Schlauer, J. & Brun, R., 2002, In : Phytochemistry. 61, 2, p. 195-204

Research output: Contribution to journalArticleScientificpeer-review

54 Citations (Scopus)

In vitro germination and establishment of tissue cultures of Bulbine caulescens and of two Kniphofia species (Asphodelaceae)

Bringmann, G., Noll, T. & Rischer, H., 2002, In : Plant Cell Reports. 21, 2, p. 125-129

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Nepenthes insignis uses a C2-portion of the carbon skeleton of L-alanine acquired via its carnivorous organs, to build up the allelochemical plumbagin

Rischer, H., Hamm, A. & Bringmann, G., 2002, In : Phytochemistry. 59, 6, p. 603-609

Research output: Contribution to journalArticleScientificpeer-review

55 Citations (Scopus)
2004

Anatalline and other methyl jasmonate-inducible nicotine alkaloids from Nicotiana tabacum cv. BY-2 cell cultures

Häkkinen, S. T., Rischer, H., Laakso, I., Maaheimo, H., Seppänen-Laakso, T. & Oksman-Caldentey, K-M., 2004, In : Planta Medica. 70, 10, p. 936 - 941 6 p.

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)

Ancistrobenomine A, the first naphthylisoquinoline oxygenated at Me-3, and related 5,1'-coupled alkaloids, from the "new" plant species Ancistrocladus benomensis

Bringmann, G., Dreyer, M., Rischer, H., Wolf, K., Hadi, H. A., Brun, R., Meimberg, H. & Heubl, G., 2004, In : Journal of Natural Products. 67, 12, p. 2058 - 2062 5 p.

Research output: Contribution to journalArticleScientificpeer-review

23 Citations (Scopus)
2005

Ancistrocladus benomensis (Ancistrocladaceae): A new species from Peninsular Malaysia

Rischer, H., Heubl, G., Meimberg, H., Dreyer, M., Hadi, H. A. & Bringmann, G., 2005, In : Blumea: Journal of Plant Taxonomy and Plant Geography. 50, 2, p. 357 - 365 9 p.

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)
2 Citations (Scopus)

Carnivorous plant chemistry

Schlauer, J., Nerz, J. & Rischer, H., 2005, In : Acta Botanica Gallica. 152, 2, p. 187 - 195 9 p.

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

ent-dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the “new” plant species Ancistrocladus benomensis

Bringmann, G., Dreyer, M., Kopff, H., Rischer, H., Wohlfarth, M., Hadi, H., Brun, R., Meimberg, H. & Heubl, G., 2005, In : Journal of Natural Products. 68, 5, p. 686 - 690 5 p.

Research output: Contribution to journalArticleScientificpeer-review

33 Citations (Scopus)
2006

Development of in vitro techniques for the important medicinal plant Veratrum californicum

Ma, R., Ritala, A., Oksman-Caldentey, K-M. & Rischer, H., 2006, In : Planta Medica. 72, 12, p. 1142-1148 7 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells

Rischer, H., Oresic, M., Seppänen-Laakso, T., Katajamaa, M., Lammertyn, F., Ardiles-Diaz, W., Van Montagu, M. C. E., Inzé, D., Oksman-Caldentey, K-M. & Goossens, A., 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 14, p. 5614-5619 6 p.

Research output: Contribution to journalArticleScientificpeer-review

239 Citations (Scopus)

Unintended effects in genetically modified crops: Revealed by metabolomics?

Rischer, H. & Oksman-Caldentey, K-M., 2006, In : Trends in Biotechnology. 24, 3, p. 102-104 3 p.

Research output: Contribution to journalArticleScientificpeer-review

74 Citations (Scopus)
2007

Functional characterisation of genes involved in pyridine alkaloid biosynthesis in tobacco

Häkkinen, S. T., Tilleman, S., Swiatek, S., De Sutter, V., Rischer, H., Vanhoutte, I., Van Onckelen, H., Hilson, P., Inzé, D., Oksman-Caldentey, K-M. & Goossens, A., 2007, In : Phytochemistry. 68, 22-24, p. 2773-2785

Research output: Contribution to journalArticleScientificpeer-review

41 Citations (Scopus)

Implementation of functional genomics for gene discovery in alkaloid producing plants

Goossens, A. & Rischer, H., 2007, In : Phytochemistry Reviews. 6, 1, p. 35-49

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)
2009

Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion (MATE) transporter in Nicotiana tabacum

Morita, M., Shitan, N., Sawada, K., Van Montagu, M. C. E., Inzé, D., Rischer, H., Goossens, A., Oksman-Caldentey, K-M., Moriyama, Y. & Yazaki, K., 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 7, p. 2447-2452 6 p.

Research output: Contribution to journalArticleScientificpeer-review

146 Citations (Scopus)
2010

Evidence for species differentiation within the Ancistrocladus tectorius complex (Ancistrocladaceae) in Southeast Asia: A molecular approach

Meimberg, H., Rischer, H., Turini, F. G., Chamchumroon, V., Dreyer, M., Sommaro, M., Bringmann, G. & Heubl, G., 2010, In : Plant Systematics and Evolution. 284, 1-2, p. 77-98 22 p.

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

Propagation of Triphyophyllum peltatum (Dioncophyllaceae) and observations on its carnivory

Rembold, K., Irmer, A., Poppinga, S., Rischer, H. & Bringmann, G., 2010, In : Carnivorous Plant Newsletter. 39, 3, p. 71-77 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2011

Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco

Lackman, P., González-Guzmán, M., Tilleman, S., Carqueijeiro, I., Cuéllar Pérez, A., Moses, T., Seo, M., Kanno, Y., Häkkinen, S. T., Van Montagu, M. C. E., Thevelein, J. M., Maaheimo, H., Oksman-Caldentey, K-M., Rodriguez, P. L., Rischer, H. & Goossens, A., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 14, p. 5891-5896

Research output: Contribution to journalArticleScientificpeer-review

133 Citations (Scopus)
2012

Differential patterns of dehydroabietic acid biotransformation by Nicotiana tabacum and Catharanthus roseus cells

Häkkinen, S. T., Lackman, P., Nygren, H., Oksman-Caldentey, K-M., Maaheimo, H. & Rischer, H., 2012, In : Journal of Biotechnology. 157, 2, p. 287-294 8 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

In-depth proteome mining of cultured Catharanthus roseus cells identifies candidate proteins involved in the synthesis and transport of secondary metabolites

Champagne, A., Rischer, H., Oksman-Caldentey, K-M. & Boutry, M., 2012, In : Proteomics. 12, 23-24, p. 3536-3547 11 p.

Research output: Contribution to journalArticleScientificpeer-review

23 Citations (Scopus)
2013

CathaCyc, a metabolic pathway database built from catharanthus roseus RNA-seq data

Van Moerkercke, A., Fabris, M., Pollier, J., Baart, G. J. E., Rombauts, S., Hasnain, G., Rischer, H., Memelink, J., Oksman-Caldentey, K-M. & Goossens, A., 2013, In : Plant and Cell Physiology. 54, 5, p. 673-685 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
81 Citations (Scopus)

Lipid content in 19 brackish and marine microalgae: Influence of growth phase, salinity and temperature

Schwenk, D., Seppälä, J., Spilling, K., Virkki, A., Tamminen, T., Oksman-Caldentey, K-M. & Rischer, H., 2013, In : Aquatic Ecology. 47, 4, p. 415-424 9 p.

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)

Metabolic engineering of plant secondary products: Which way forward?

Miralpeix, B., Rischer, H., Häkkinen, S., Ritala, A., Seppänen-Laakso, T., Oksman-Caldentey, K-M., Capell, T. & Christou, P., 2013, In : Current Pharmaceutical Design. 19, 31, p. 5622-5639 17 p.

Research output: Contribution to journalArticleScientificpeer-review

28 Citations (Scopus)

Mixotrophic continuous flow cultivation of Chlorella protothecoides for lipids

Wang, Y., Rischer, H., Eriksen, N. T. & Wiebe, M., 2013, In : Bioresource Technology. 144, p. 608-614 6 p.

Research output: Contribution to journalArticleScientificpeer-review

33 Citations (Scopus)

Plant cells as pharmaceutical factories

Rischer, H., Häkkinen, S., Ritala, A., Seppänen-Laakso, T., Miralpeix, B., Capell, T., Christou, P. & Oksman-Caldentey, K-M., 2013, In : Current Pharmaceutical Design. 19, 31, p. 5640-5660 20 p.

Research output: Contribution to journalArticleScientificpeer-review

34 Citations (Scopus)

The effect of high pH on structural lipids in diatoms

Spilling, K., Brynjólfsdóttir, A., Enss, D., Rischer, H. & Svavarsson, H. G., 2013, In : Journal of Applied Phycology. 25, 5, p. 1435-1439 5 p.

Research output: Contribution to journalArticleScientificpeer-review

16 Citations (Scopus)

Wave-mixed and orbitally shaken single-use photobioreactors for diatom algae propagation

Lehmann, N., Rischer, H., Eibl, D. & Eibl, R., 2013, In : Chemie-Ingenieur-Technik. 85, 1-2, p. 197-201 5 p.

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)
2014

Algae-bacteria association inferred by 16S rDNA similarity in established microalgae cultures

Schwenk, D., Nohynek, L. & Rischer, H., 2014, In : MicrobiologyOpen. 3, 3, p. 356-368

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)
Open Access
11 Citations (Scopus)

Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway

Ritala, A., Dong, L., Imseng, N., Seppänen-Laakso, T., Vasilev, N., van der Krol, S., Rischer, H., Maaheimo, H., Virkki, A., Brändli, J., Schillerberg, S., Eibl, R., Bouwmeester, H. & Oksman-Caldentey, K-M., 2014, In : Journal of Biotechnology. 176, p. 20-28 8 p.

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)

Rational design of plant systems for sustainable generation of value-added industrial products (SmartCell)

Oksman-Caldentey, K-M., Ritala, A., Rischer, H., Häkkinen, S. & Christou, P., 2014, In : Dosis. 30, 3

Research output: Contribution to journalArticleScientificpeer-review

Selection and validation of reference genes for transcript normalization in gene expression studies in Catharanthus roseus

Pollier, J., Vanden Bossche, R., Rischer, H. & Goossens, A., 2014, In : Plant Physiology and Biochemistry. 83, p. 20-25 6 p.

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)
2015

Analysis of indole alkaloids from Rhazya stricta hairy roots by ultra-performance liquid chromatography-mass spectrometry

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Molecules. 20, 12, p. 22621-22634

Research output: Contribution to journalArticleScientificpeer-review

Open Access
6 Citations (Scopus)

Bioconversion to Raspberry Ketone is Achieved by Several Non-related Plant Cell Cultures

Häkkinen, S., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 24 Nov 2015, In : Frontiers in Plant Science. 6, p. 1-9 9 p., 1035.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
4 Citations (Scopus)

Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Phytochemical Analysis. 26, 5, p. 331-338

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)

Elicitation of furanocoumarins in poison hemlock (Conium maculatum L.) cell culture

Meier, P., Hotti, H. & Rischer, H., 2015, In : Plant Cell, Tissue and Organ Culture. 123, 3, p. 443-453

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)

Establishment of transgenic Rhazya stricta hairy roots to modulate terpenoid indole alkaloid production

Akhgari, A., Yrjönen, T., Laakso, I., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Plant Cell Reports. 34, 11, p. 1939-1952

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Nile Red staining of phytoplankton neutral lipids: species-specific fluorescence kinetics in various solvents

Natunen, K., Seppälä, J., Schwenk, D., Rischer, H., Spilling, K. & Tamminen, T., 2015, In : Journal of Applied Phycology. 27, 3, p. 1161-1168

Research output: Contribution to journalArticleScientificpeer-review

Open Access
16 Citations (Scopus)

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development

Härmä, V., Haavikko, R., Virtanen, J., Ahonen, I., Schukov, H-P., Alakurtti, S., Purev, E., Rischer, H., Yli-Kauhaluoma, J., Moreira, V. M., Nees, M. & Oksman-Caldentey, K-M., 2015, In : PLoS ONE. 10, 5, 22 p., e0126111.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
13 Citations (Scopus)

Polyketide synthases from poison hemlock (Conium maculatum L.)

Hotti, H., Seppänen-Laakso, T., Arvas, M., Teeri, T. H. & Rischer, H., 2015, In : FEBS Journal. 282, 21, p. 4141-4156

Research output: Contribution to journalArticleScientificpeer-review

7 Citations (Scopus)