Heiko Rischer

Dr. rer. nat.

  • Phone+358407206834
19962020

Research output per year

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Research Output

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Agrobacterium-mediated genetic transformation of the medicinal plant veratrum dahuricum

Ma, R., Yu, Z., Cai, Q., Li, H., Dong, Y., Oksman-Caldentey, K. M. & Rischer, H., 4 Feb 2020, In : Plants. 9, 2, 191.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
1 Citation (Scopus)

Algae-bacteria association inferred by 16S rDNA similarity in established microalgae cultures

Schwenk, D., Nohynek, L. & Rischer, H., 2014, In : MicrobiologyOpen. 3, 3, p. 356-368

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)

Analysis of indole alkaloids from Rhazya stricta hairy roots by ultra-performance liquid chromatography-mass spectrometry

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Molecules. 20, 12, p. 22621-22634

Research output: Contribution to journalArticleScientificpeer-review

Open Access
6 Citations (Scopus)

Anatalline and other methyl jasmonate-inducible nicotine alkaloids from Nicotiana tabacum cv. BY-2 cell cultures

Häkkinen, S. T., Rischer, H., Laakso, I., Maaheimo, H., Seppänen-Laakso, T. & Oksman-Caldentey, K-M., 2004, In : Planta Medica. 70, 10, p. 936 - 941 6 p.

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)

Ancistrobenomine A, the first naphthylisoquinoline oxygenated at Me-3, and related 5,1'-coupled alkaloids, from the "new" plant species Ancistrocladus benomensis

Bringmann, G., Dreyer, M., Rischer, H., Wolf, K., Hadi, H. A., Brun, R., Meimberg, H. & Heubl, G., 2004, In : Journal of Natural Products. 67, 12, p. 2058 - 2062 5 p.

Research output: Contribution to journalArticleScientificpeer-review

23 Citations (Scopus)

Ancistrocladus benomensis (Ancistrocladaceae): A new species from Peninsular Malaysia

Rischer, H., Heubl, G., Meimberg, H., Dreyer, M., Hadi, H. A. & Bringmann, G., 2005, In : Blumea: Journal of Plant Taxonomy and Plant Geography. 50, 2, p. 357 - 365 9 p.

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

A new biosynthetic pathway to alkaloids in plants: Acetogenic isoquinolines

Bringmann, G., Wohlfarth, M., Rischer, H., Grüne, M. & Schlauer, J., 2000, In : Angewandte Chemie: International Edition. 39, 8, p. 1464-1466 3 p.

Research output: Contribution to journalArticleScientificpeer-review

72 Citations (Scopus)

Antidesmone, a novel antitrypanosomal alkaloid

Bringmann, G., Schlauer, J., Rischer, H., Wohlfarth, M., Haller, R., Bär, S. & Brun, R., 2001, In : Pharmaceutical and pharmacological letters. 11, 2, p. 47-48 2 p.

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)

A photometric screening method for dimeric naphthylisoquinoline alkaloids and complete on-line structural eludication of a dimer in crude plant extracts, by the LC−MS/LC−NMR/LC−CD Triad

Bringmann, G., Wohlfarth, M., Rischer, H., Heubes, M., Saeb, W., Diem, S., Herderich, M. & Schlauer, J., 2001, In : Analytical Chemistry. 73, 11, p. 2571-2577 7 p.

Research output: Contribution to journalArticleScientificpeer-review

42 Citations (Scopus)

Bioconversion to Raspberry Ketone is Achieved by Several Non-related Plant Cell Cultures

Häkkinen, S., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 24 Nov 2015, In : Frontiers in Plant Science. 6, p. 1-9 9 p., 1035.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
4 Citations (Scopus)

Biosynthesis of antidesmone in cell cultures of Antidesma membranaceum (Euphorbiaceae): An unprecedented class of glycine-derived alkaloids

Bringmann, G., Rischer, H., Wohlfarth, M. & Schlauer, J., 2000, In : Journal of the American Chemical Society. 122, 41, p. 9905-9910 6 p.

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)
2 Citations (Scopus)

Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells

Häkkinen, S. T., Nygren, H., Maiorova, N., Haavikko, R., Alakurtti, S., Yli-Kauhaluoma, J., Rischer, H. & Oksman-Caldentey, K. M., 1 Jul 2018, In : Planta Medica. 84, 9-10, p. 743-748 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Carnivorous plant chemistry

Schlauer, J., Nerz, J. & Rischer, H., 2005, In : Acta Botanica Gallica. 152, 2, p. 187 - 195 9 p.

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

CathaCyc, a metabolic pathway database built from catharanthus roseus RNA-seq data

Van Moerkercke, A., Fabris, M., Pollier, J., Baart, G. J. E., Rombauts, S., Hasnain, G., Rischer, H., Memelink, J., Oksman-Caldentey, K-M. & Goossens, A., 2013, In : Plant and Cell Physiology. 54, 5, p. 673-685 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
81 Citations (Scopus)
Open Access
11 Citations (Scopus)

Cultivation of Triphyophyllum peltatum (Dioncophyllaceae), the part-time carnivorous plant

Bringmann, G., Schlauer, J., Wolf, K., Rischer, H., Buschbom, U., Kreiner, A., Thiele, F., Duschek, M. & Aké Assi, L., 1999, In : Carnivorous Plant Newsletter. 28, p. 7-13 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Phytochemical Analysis. 26, 5, p. 331-338

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)

Development of in vitro techniques for the important medicinal plant Veratrum californicum

Ma, R., Ritala, A., Oksman-Caldentey, K-M. & Rischer, H., 2006, In : Planta Medica. 72, 12, p. 1142-1148 7 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Differential patterns of dehydroabietic acid biotransformation by Nicotiana tabacum and Catharanthus roseus cells

Häkkinen, S. T., Lackman, P., Nygren, H., Oksman-Caldentey, K-M., Maaheimo, H. & Rischer, H., 2012, In : Journal of Biotechnology. 157, 2, p. 287-294 8 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Droserone from cell cultures of Triphyophyllum peltatum (Dioncophyllaceae) and its biosynthetic origin

Bringmann, G., Rischer, H., Wohlfarth, M., Schlauer, J. & Aké Assi, L., 2000, In : Phytochemistry. 53, 3, p. 339-343 5 p.

Research output: Contribution to journalArticleScientificpeer-review

34 Citations (Scopus)

Elicitation of furanocoumarins in poison hemlock (Conium maculatum L.) cell culture

Meier, P., Hotti, H. & Rischer, H., 2015, In : Plant Cell, Tissue and Organ Culture. 123, 3, p. 443-453

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)

ent-dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the “new” plant species Ancistrocladus benomensis

Bringmann, G., Dreyer, M., Kopff, H., Rischer, H., Wohlfarth, M., Hadi, H., Brun, R., Meimberg, H. & Heubl, G., 2005, In : Journal of Natural Products. 68, 5, p. 686 - 690 5 p.

Research output: Contribution to journalArticleScientificpeer-review

33 Citations (Scopus)

Establishment of transgenic Rhazya stricta hairy roots to modulate terpenoid indole alkaloid production

Akhgari, A., Yrjönen, T., Laakso, I., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Plant Cell Reports. 34, 11, p. 1939-1952

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Euglena gracilis growth and cell composition under different temperature, light and trophic conditions

Wang, Y., Seppänen-Laakso, T., Rischer, H. & Wiebe, M. G., 1 Apr 2018, In : PLoS ONE. 13, 4, e0195329.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
6 Citations (Scopus)

Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway

Ritala, A., Dong, L., Imseng, N., Seppänen-Laakso, T., Vasilev, N., van der Krol, S., Rischer, H., Maaheimo, H., Virkki, A., Brändli, J., Schillerberg, S., Eibl, R., Bouwmeester, H. & Oksman-Caldentey, K-M., 2014, In : Journal of Biotechnology. 176, p. 20-28 8 p.

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)

Evidence for species differentiation within the Ancistrocladus tectorius complex (Ancistrocladaceae) in Southeast Asia: A molecular approach

Meimberg, H., Rischer, H., Turini, F. G., Chamchumroon, V., Dreyer, M., Sommaro, M., Bringmann, G. & Heubl, G., 2010, In : Plant Systematics and Evolution. 284, 1-2, p. 77-98 22 p.

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

Extract screening by HPLC coupled to MS-MS, NMR, and CD: A dimeric and three monomeric naphthylisoquinoline alkaloids from Ancistrocladus griffithii

Bringmann, G., Wohlfarth, M., Rischer, H., Schlauer, J. & Brun, R., 2002, In : Phytochemistry. 61, 2, p. 195-204

Research output: Contribution to journalArticleScientificpeer-review

54 Citations (Scopus)

Functional characterisation of genes involved in pyridine alkaloid biosynthesis in tobacco

Häkkinen, S. T., Tilleman, S., Swiatek, S., De Sutter, V., Rischer, H., Vanhoutte, I., Van Onckelen, H., Hilson, P., Inzé, D., Oksman-Caldentey, K-M. & Goossens, A., 2007, In : Phytochemistry. 68, 22-24, p. 2773-2785

Research output: Contribution to journalArticleScientificpeer-review

41 Citations (Scopus)

Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells

Rischer, H., Oresic, M., Seppänen-Laakso, T., Katajamaa, M., Lammertyn, F., Ardiles-Diaz, W., Van Montagu, M. C. E., Inzé, D., Oksman-Caldentey, K-M. & Goossens, A., 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 14, p. 5614-5619 6 p.

Research output: Contribution to journalArticleScientificpeer-review

239 Citations (Scopus)

Implementation of functional genomics for gene discovery in alkaloid producing plants

Goossens, A. & Rischer, H., 2007, In : Phytochemistry Reviews. 6, 1, p. 35-49

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)

In-depth proteome mining of cultured Catharanthus roseus cells identifies candidate proteins involved in the synthesis and transport of secondary metabolites

Champagne, A., Rischer, H., Oksman-Caldentey, K-M. & Boutry, M., 2012, In : Proteomics. 12, 23-24, p. 3536-3547 11 p.

Research output: Contribution to journalArticleScientificpeer-review

23 Citations (Scopus)

In vitro germination and establishment of tissue cultures of Bulbine caulescens and of two Kniphofia species (Asphodelaceae)

Bringmann, G., Noll, T. & Rischer, H., 2002, In : Plant Cell Reports. 21, 2, p. 125-129

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

In vitro propagation of Ancistrocladus abbreviatus airy shaw (Ancistrocladaceae)

Bringmann, G., Rischer, H., Schlauer, J. & Aké Assi, L., 1999, In : Plant Cell, Tissue and Organ Culture. 57, 1, p. 71-73 3 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco

Lackman, P., González-Guzmán, M., Tilleman, S., Carqueijeiro, I., Cuéllar Pérez, A., Moses, T., Seo, M., Kanno, Y., Häkkinen, S. T., Van Montagu, M. C. E., Thevelein, J. M., Maaheimo, H., Oksman-Caldentey, K-M., Rodriguez, P. L., Rischer, H. & Goossens, A., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 14, p. 5891-5896

Research output: Contribution to journalArticleScientificpeer-review

133 Citations (Scopus)

Lipid content in 19 brackish and marine microalgae: Influence of growth phase, salinity and temperature

Schwenk, D., Seppälä, J., Spilling, K., Virkki, A., Tamminen, T., Oksman-Caldentey, K-M. & Rischer, H., 2013, In : Aquatic Ecology. 47, 4, p. 415-424 9 p.

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)

Marine Microalgae: Promising source for new bioactive compounds

de Vera, C. R., Crespín, G. D., Daranas, A. H., Looga, S. M., Lillsunde, K. E., Tammela, P., Perälä, M., Hongisto, V., Virtanen, J., Rischer, H., Muller, C. D., Norte, M., Fernández, J. J. & Souto, M. L., 6 Sep 2018, In : Marine Drugs. 16, 9, 317.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
8 Citations (Scopus)

Metabolic engineering of plant secondary products: Which way forward?

Miralpeix, B., Rischer, H., Häkkinen, S., Ritala, A., Seppänen-Laakso, T., Oksman-Caldentey, K-M., Capell, T. & Christou, P., 2013, In : Current Pharmaceutical Design. 19, 31, p. 5622-5639 17 p.

Research output: Contribution to journalArticleScientificpeer-review

28 Citations (Scopus)

Metabolite profiling of the carnivorous pitcher plants Darlingtonia and Sarracenia

Hotti, H., Gopalacharyulu, P., Seppänen-Laakso, T. & Rischer, H., 1 Feb 2017, In : PLoS ONE. 12, 2, 21 p., e0171078.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
4 Citations (Scopus)

Methyljasmonate Elicitation Increases Terpenoid Indole Alkaloid Accumulation in Rhazya stricta Hairy Root Cultures

Akhgari, A., Laakso, I., Maaheimo, H., Choi, Y. H., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 22 Nov 2019, In : Plants. 8, 12, 534.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Mixotrophic continuous flow cultivation of Chlorella protothecoides for lipids

Wang, Y., Rischer, H., Eriksen, N. T. & Wiebe, M., 2013, In : Bioresource Technology. 144, p. 608-614 6 p.

Research output: Contribution to journalArticleScientificpeer-review

33 Citations (Scopus)

Nepenthes insignis uses a C2-portion of the carbon skeleton of L-alanine acquired via its carnivorous organs, to build up the allelochemical plumbagin

Rischer, H., Hamm, A. & Bringmann, G., 2002, In : Phytochemistry. 59, 6, p. 603-609

Research output: Contribution to journalArticleScientificpeer-review

55 Citations (Scopus)

Nepenthes lavicola, a new species of Nepenthaceae from the Aceh Province in the North of Sumatra

Wistuba, A. & Rischer, H., 1996, In : Carnivorous Plant Newsletter. 25, 4, p. 106-111 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Nile Red staining of phytoplankton neutral lipids: species-specific fluorescence kinetics in various solvents

Natunen, K., Seppälä, J., Schwenk, D., Rischer, H., Spilling, K. & Tamminen, T., 2015, In : Journal of Applied Phycology. 27, 3, p. 1161-1168

Research output: Contribution to journalArticleScientificpeer-review

Open Access
16 Citations (Scopus)

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development

Härmä, V., Haavikko, R., Virtanen, J., Ahonen, I., Schukov, H-P., Alakurtti, S., Purev, E., Rischer, H., Yli-Kauhaluoma, J., Moreira, V. M., Nees, M. & Oksman-Caldentey, K-M., 2015, In : PLoS ONE. 10, 5, 22 p., e0126111.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
13 Citations (Scopus)

Plant cells as food: A concept taking shape

Nordlund, E., Lille, M., Silventoinen, P., Nygren, H., Seppänen-Laakso, T., Mikkelson, A., Aura, A-M., Heiniö, R-L., Nohynek, L., Puupponen-Pimiä, R. & Rischer, H., 2018, In : Food Research International. 107, p. 297–305 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
9 Citations (Scopus)

Plant cells as pharmaceutical factories

Rischer, H., Häkkinen, S., Ritala, A., Seppänen-Laakso, T., Miralpeix, B., Capell, T., Christou, P. & Oksman-Caldentey, K-M., 2013, In : Current Pharmaceutical Design. 19, 31, p. 5640-5660 20 p.

Research output: Contribution to journalArticleScientificpeer-review

34 Citations (Scopus)

Polyketide-derived alkaloids and anthraquinones in Aloe plants and cell cultures

Hotti, H., Häkkinen, S., Rischer, H. & Seppänen-Laakso, T., 2017, In : Journal of Plant Biotechnology Research. 1, 1, p. 1-15 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Polyketide synthases from poison hemlock (Conium maculatum L.)

Hotti, H., Seppänen-Laakso, T., Arvas, M., Teeri, T. H. & Rischer, H., 2015, In : FEBS Journal. 282, 21, p. 4141-4156

Research output: Contribution to journalArticleScientificpeer-review

7 Citations (Scopus)

Propagation of Triphyophyllum peltatum (Dioncophyllaceae) and observations on its carnivory

Rembold, K., Irmer, A., Poppinga, S., Rischer, H. & Bringmann, G., 2010, In : Carnivorous Plant Newsletter. 39, 3, p. 71-77 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access