Heli Nygren

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20102020

Research output per year

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Research Output

2020

Examining safety of biocolourants from fungal and plant sources-examples from Cortinarius and Tapinella, Salix and Tanacetum spp. and dyed woollen fabrics

Räisänen, R., Primetta, A., Nikunen, S., Honkalampi, U., Nygren, H., Pihlava, J. M., Berghe, I. V. & von Wright, A., May 2020, In : Antibiotics. 9, 5, 266.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Liquid chromatography-mass spectrometry (LC-MS)-based analysis of molecular lipids in algae samples

Nygren, H., Seppänen-Laakso, T. & Rischer, H., 1 Jan 2020, Methods in Molecular Biology: Methods and Protocols. Spilling, K. (ed.). Humana Press, p. 215-222 8 p. (Methods in Molecular Biology, Vol. 1980).

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

2 Citations (Scopus)
2018

Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells

Häkkinen, S. T., Nygren, H., Maiorova, N., Haavikko, R., Alakurtti, S., Yli-Kauhaluoma, J., Rischer, H. & Oksman-Caldentey, K. M., 1 Jul 2018, In : Planta Medica. 84, 9-10, p. 743-748 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Enzymatic Interesterification of Heterotrophic Microalgal Oil with Rapeseed Oil to Decrease the Levels of Tripalmitin

Bogevik, A. S., Nygren, H., Balle, T., Haugsgjerd, B. O. & Kousoulaki, K., 1 Jul 2018, In : European Journal of Lipid Science and Technology. 120, 7, 1800063.

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Plant cells as food: A concept taking shape

Nordlund, E., Lille, M., Silventoinen, P., Nygren, H., Seppänen-Laakso, T., Mikkelson, A., Aura, A-M., Heiniö, R-L., Nohynek, L., Puupponen-Pimiä, R. & Rischer, H., 2018, In : Food Research International. 107, p. 297–305 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
8 Citations (Scopus)
2017

Characterization of feather-degrading bacterial populations from birds' nests - Potential strains for biomass production for animal feed

Saarela, M., Berlin, M., Nygren, H., Lahtinen, P., Honkapää, K., Lantto, R. & Maukonen, J., 2017, In : International Biodeterioration and Biodegradation. 123, p. 262-268 7 p.

Research output: Contribution to journalArticleScientificpeer-review

6 Citations (Scopus)

High Yield Protein Extraction from Brewer's Spent Grainwith Novel Carboxylate Salt: Urea Aqueous Deep Eutectic Solvents

Wahlström, R., Rommi, K., Willberg-Keyriläinen, P., Ercili-Cura, D., Holopainen-Mantila, U., Hiltunen, J., Mäkinen, O., Nygren, H., Mikkelson, A. & Kuutti, L., 1 Jan 2017, In : ChemistrySelect. 2, 29, p. 9355-9363 9 p.

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)
2016

A healthy Nordic diet alters the plasma lipidomic profile in adults with features of metabolic syndrome in a multicenter randomized dietary intervention

Lankinen, M. A., Schwab, U. S., Kolehmainen, M., Paananen, J., Nygrén, H., Seppänen-Laakso, T. E., Poutanen, K. S., Hyötyläinen, T., Risérus, U., Savolainen, M. J., Hukkanen, J. & Brader, L., 2016, In : Journal of Nutrition. 146, 4, p. 662-672

Research output: Contribution to journalArticleScientificpeer-review

36 Citations (Scopus)

Genome wide analysis of protein production load in Trichoderma reesei

Pakula, T., Nygrén, H., Barth, D., Heinonen, M., Castillo, S. D., Penttilä, M. E. & Arvas, M., 2016, In : Biotechnology for Biofuels. 9, 26 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
11 Citations (Scopus)

Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI)

Kurko, J., Tringham, M., Tanner, L., Näntö-Salonen, K., Vähä-Mäkilä, M., Nygren, H., Pöhö, P., Lietzen, N., Mattila, I., Olkku, A., Hyötyläinen, T., Oresic, M., Simell, O., Niinikoski, H. & Mykkänen, J., 2016, In : Metabolism: Clinical and Experimental. 65, 9, p. 1361-1375

Research output: Contribution to journalArticleScientificpeer-review

7 Citations (Scopus)

Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism

Caesar, R., Nygrén, H., Oresic, M. & Bäckhed, F., 2016, In : Journal of Lipid Research. 57, 3, p. 474-781

Research output: Contribution to journalArticleScientificpeer-review

36 Citations (Scopus)

Whole-genome metabolic model of Trichoderma reesei built by comparative reconstruction

Castillo, S., Barth, D., Arvas, M., Pakula, T. M., Pitkänen, E., Blomberg, P., Seppänen-Laakso, T., Nygren, H., Sivasiddarthan, D., Penttilä, M. & Oja, M., 2016, In : Biotechnology for Biofuels. 9, 252, 20 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
5 Citations (Scopus)
2015

Betulins as novel lead compounds for cancer

Oksman-Caldentey, K-M., Lämsä, M., Härmä, V., Haavikko, R., Alakurtti, S., Nygren, H., Häkkinen, S., Yli-Kauhaluoma, J., Nees, M. & Rischer, H., 2015, Book of Abstracts. 102

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function

Barbarroja, N., Rodriguez-Cuenca, S., Nygren, H., Camargo, A., Pirraco, A., Relat, J., Cuadrado, I., Pellegrinelli, V., Medina-Gomez, G., Lopez-Pedrera, C., Tinahones, F. J., Symons, J. D., Summers, S. A., Oresic, M. & Vidal-Puig, A., 2015, In : Diabetes. 64, 4, p. 1180-1192

Research output: Contribution to journalArticleScientificpeer-review

28 Citations (Scopus)

Serum lipid and serum metabolite components in relation to anthropometric parameters in EPIC-Potsdam participants

Foerster, J., Hyötyläinen, T., Oresic, M., Nygren, H. & Boeing, H., 2015, In : Metabolism: Clinical and Experimental. 64, 10, p. 1348-1358

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)
2014

In-vitro co-culture for matching Diabetes Type II changes with adipocyte lipidome

Kolari, K., Virtanen, J., Aura, A-M., Nygren, H. & Nees, M., 2014.

Research output: Contribution to conferenceOther conference contributionScientific

Overexpression of PPAR{\gamma} Specifically in Pancreatic {\beta}-Cells Exacerbates Obesity-Induced Glucose Intolerance, Reduces {\beta}-Cell Mass, and Alters Islet Lipid Metabolism in Male Mice

Hogh, K-L. N., Craig, M. N., Uy, C. E., Nygren, H., Asadi, A., Speck, M., Fraser, J. D., Rudecki, A. P., Baker, R. K., Oresic, M. & Gray, S. L., 2014, In : Endocrinology. 155, 10, p. 3843-3852 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
6 Citations (Scopus)

Quantitative profiling of bile acids in blood, adipose tissue, intestine, and gall bladder samples using ultra high performance liquid chromatography-tandem mass spectrometry

Jäntti, S. E., Kivilompolo, M., Öhrnberg, L., Pietiläinen, K. H., Nygren, H., Oresic, M. & Hyötyläinen, T., 2014, In : Analytical and Bioanalytical Chemistry. 406, 30, p. 7799 -7815 16 p.

Research output: Contribution to journalArticleScientificpeer-review

21 Citations (Scopus)

Ultrahigh-performance liquid chromatography-mass spectrometry in Lipidomics

Nygren, H., Pöhö, P., Seppänen-Laakso, T., Lahtinen, U., Oresic, M. & Hyötyläinen, T., 2014, In : LC-GC North America. 32, 4, p. 286-293 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes

Orešič, M., Gopalacharyulu, P., Mykkänen, J., Lietzen, N., Mäkinen, M., Nygren, H., Simell, S., Simell, V., Hyöty, H., Veijola, R., Ilonen, J., Sysi-Aho, M., Knip, M., Hyötyläinen, T. & Simell, O., 1 Sep 2013, In : Diabetes. 62, 9, p. 3268-3274 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
42 Citations (Scopus)

Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids

Orešič, M., Hyötyläinen, T., Kotronen, A., Gopalacharyulu, P., Nygren, H., Arola, J., Castillo, S., Mattila, I., Hakkarainen, A., Borra, R. J. H., Honka, M. J., Verrijken, A., Francque, S., Iozzo, P., Leivonen, M., Jaser, N., Juuti, A., Sørensen, T. I. A., Nuutila, P., Van Gaal, L. & 1 others, Yki-Järvinen, H., 1 Oct 2013, In : Diabetologia. 56, 10, p. 2266-2274 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
59 Citations (Scopus)

Steroid and steroid glucuronide profiles in urine during pregnancy determined by liquid chromatography-electrospray ionization-tandem mass spectrometry

Jäntti, S., Hartonen, M., Hilvo, M., Nygren, H., Hyötyläinen, T., Ketola, R. A. & Kostiainen, R., 2013, In : Analytica Chimica Acta. 802, p. 56-66 10 p.

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)
2012

Differential patterns of dehydroabietic acid biotransformation by Nicotiana tabacum and Catharanthus roseus cells

Häkkinen, S. T., Lackman, P., Nygren, H., Oksman-Caldentey, K-M., Maaheimo, H. & Rischer, H., 2012, In : Journal of Biotechnology. 157, 2, p. 287-294 8 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)
2011

Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans

Pietiläinen, K. H., Róg, T., Seppänen-Laakso, T., Virtue, S., Gopalacharyulu, P., Tang, J., Rodriguez-Cuenca, S., Maciejewski, A., Naukkarinen, J., Ruskeepää, A-L., Niemelä, P., Yetukuri, L., Tan, C. Y., Velagapudi, V., Castillo, S., Nygren, H., Hyötyläinen, T., Rissanen, A., Kaprio, J., Yki-Järvinen, H. & 3 others, Vattulainen, I., Vidal-Puig, A. & Orešič, M., 2011, In : PLoS Biology. 9, 6, 14 p., e1000623.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
143 Citations (Scopus)

Discovery of diagnostic biomarkers for non-alcoholic fatty liver disease (NAFLD)

Gopalacharyulu, P., Castillo, S., Nygren, H., Hyötyläinen, T., Seppänen-Laakso, T., Kotronen, A., Yki-Järvinen, H. & Oresic, M., 2011, Metabomeeting 2011. p. 51

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

High Density Lipoprotein structural changes and drug response in lipidomic profiles following the long-term fenofibrate therapy in the FIELD substudy

Yetukuri, L., Huopaniemi, I., Koivuniemi, A., Maranghi, M., Hiukka, A., Nygren, H., Kaski, S., Taskinen, M-R., Vattulainen, I., Jauhiainen, M. & Orešič, M., 2011, In : PLoS ONE. 6, 8, 12 p., e23589.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
31 Citations (Scopus)

Impact of surface lipid fluidity to the distribution of lipids in high density lipoprotein particles: Implications to high density fraction profiles

Koivuniemi, A., Nygren, H., Hyötyläinen, T., Sysi-Aho, M. & Oresic, M., 2011, Metabomeeting 2011. p. 142

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

Lipid profiles in breast cancer samples: Characterization of glycosylated ceramides associated to estrogen receptor negative tumors

Nygren, H., Hilvo, M., Seppänen-Laakso, T., Hyötyläinen, T. & Oresic, M., 2011, Metabomeeting 2011. p. 76

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

Liquid Chromatography-Mass Spectrometry (LC-MS)-Based Lipidomics for Studies of Body Fluids and Tissues

Nygren, H., Seppänen-Laakso, T., Castillo, S., Hyötyläinen, T. & Oresic, M., 2011, Metabolic Profiling: Methods and Protocols. Metz, T. O. (ed.). Springer, p. 247-257

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

89 Citations (Scopus)

Metabolic profiling of serum and adipose tissue of monozygotic twins after high-fat meal

Jäntti, S., Kivilompolo, M., Mattila, I., Seppänen-Laakso, T., Nygren, H., Ruskeepää, A-L., Lahtinen, U., Kaprio, J., Tang, J., Pietiläinen, K., Hyötyläinen, T. & Oresic, M., 2011, Metabomeeting 2011. p. 141

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression

Hilvo, M., Denkert, C., Lehtinen, L., Muller, B., Brockmoller, S., Seppänen-Laakso, T., Budczies, J., Bucher, E., Yetukuri, L., Castillo, S., Berg, E., Nygren, H., Sysi-Aho, M., Griffin, J. L., Fiehn, O., Loibl, S., Richter-Ehrenstein, C., Radke, C., Hyötyläinen, T., Kallioniemi, O. & 2 others, Iljin, K. & Oresic, M., 2011, In : Cancer Research. 71, 9, p. 3236-3245 10 p.

Research output: Contribution to journalArticleScientificpeer-review

276 Citations (Scopus)

Rasvasolujen solukalvo mukautuu ylimääräiseen rasvaan

Pietiläinen, K. H., Róg, T., Seppänen-Laakso, T., Virtue, S., Gopalacharyulu, P., Tang, J., Rodriguez-Cuenca, S., Maciejewski, A., Naukkarinen, J., Ruskeepää, A-L., Niemelä, P., Yetukuri, L., Tan, C. Y., Velagapudi, V., Castillo, S., Nygren, H., Hyötyläinen, T., Rissanen, A., Kaptio, J., Yki-Järvinen, H. & 3 others, Vattulainen, I., Vidal-Puig, A. & Oresic, M., 2011, In : Duodecim. 127, 14, 1493.

Research output: Contribution to journalArticleScientific

Open Access
2010

Discovery and validation of plasma markers of liver fat content: Metabolomics approach

Nygren, H., Seppänen-Laakso, T., Mattila, I., Hyötyläinen, T., Kotronen, A., Oresic, M. & Yki-Järvinen, H., 2010, Metabolomics 2010, abstract book: Breakthroughs in plant, microbial and human biology, clinical and nutritional research, and biomarker discovery. p. 119

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Discovery and validation of plasma markers of liver fat content: Metabolomics approach

Nygren, H., Seppänen-Laakso, T., Mattila, I., Tang, J., Hyötyläinen, T., Kotronen, A., Oresic, M. & Yki-Järvinen, H., 2010.

Research output: Contribution to conferenceConference articleScientific

Statistical modeling for the prediction of non-alcoholic fatty liver disease

Gopalacharyulu, P., Seppänen-Laakso, T., Nygren, H., Kotronen, A. & Hyötyläinen, T., 2010.

Research output: Contribution to conferenceConference articleScientific