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Research Output 2010 2020

2020

Liquid chromatography-mass spectrometry (LC-MS)-based analysis of molecular lipids in algae samples

Nygren, H., Seppänen-Laakso, T. & Rischer, H., 1 Jan 2020, Methods in Molecular Biology: Methods and Protocols. Spilling, K. (ed.). Humana Press, p. 215-222 8 p. (Methods in Molecular Biology, Vol. 1980).

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

Liquid chromatography
Algae
Mass spectrometry
Lipids
Mass spectrometers
2 Citations (Scopus)
Sterols
Nonesterified Fatty Acids
Esters
Fatty Acids
Phytol
2018

Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells

Häkkinen, S. T., Nygren, H., Maiorova, N., Haavikko, R., Alakurtti, S., Yli-Kauhaluoma, J., Rischer, H. & Oksman-Caldentey, K. M., 1 Jul 2018, In : Planta Medica. 84, 9-10, p. 743-748 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Plant Cells
Biotransformation
Catharanthus
Derivatives
Pentoses

Enzymatic Interesterification of Heterotrophic Microalgal Oil with Rapeseed Oil to Decrease the Levels of Tripalmitin

Bogevik, A. S., Nygren, H., Balle, T., Haugsgjerd, B. O. & Kousoulaki, K., 1 Jul 2018, In : European Journal of Lipid Science and Technology. 120, 7, 1800063.

Research output: Contribution to journalArticleScientificpeer-review

enzymatic interesterification
tripalmitin
rapeseed oil
Microalgae
Oils
5 Citations (Scopus)

Plant cells as food: A concept taking shape

Nordlund, E., Lille, M., Silventoinen, P., Nygren, H., Seppänen-Laakso, T., Mikkelson, A., Aura, A-M., Heiniö, R-L., Nohynek, L., Puupponen-Pimiä, R. & Rischer, H., 2018, In : Food Research International. 107, p. 297–305 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Plant Cells
Food
Vaccinium vitis-idaea
Fruit
Hydrolysis
2017
3 Citations (Scopus)

Characterization of feather-degrading bacterial populations from birds' nests - Potential strains for biomass production for animal feed

Saarela, M., Berlin, M., Nygren, H., Lahtinen, P., Honkapää, K., Lantto, R. & Maukonen, J., 2017, In : International Biodeterioration and Biodegradation. 123, p. 262-268 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Feathers
Birds
feather
Biomass
Amino acids
3 Citations (Scopus)

High Yield Protein Extraction from Brewer's Spent Grainwith Novel Carboxylate Salt: Urea Aqueous Deep Eutectic Solvents

Wahlström, R., Rommi, K., Willberg-Keyriläinen, P., Ercili-Cura, D., Holopainen-Mantila, U., Hiltunen, J., Mäkinen, O., Nygren, H., Mikkelson, A. & Kuutti, L., 1 Jan 2017, In : ChemistrySelect. 2, 29, p. 9355-9363 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Eutectics
Urea
Salts
Proteins
Brewing
2016
36 Citations (Scopus)

A healthy Nordic diet alters the plasma lipidomic profile in adults with features of metabolic syndrome in a multicenter randomized dietary intervention

Lankinen, M. A., Schwab, U. S., Kolehmainen, M., Paananen, J., Nygrén, H., Seppänen-Laakso, T. E., Poutanen, K. S., Hyötyläinen, T., Risérus, U., Savolainen, M. J., Hukkanen, J. & Brader, L., 2016, In : Journal of Nutrition. 146, 4, p. 662-672

Research output: Contribution to journalArticleScientificpeer-review

Plasmalogens
Diet
Fruit
Lipids
Ceramides
9 Citations (Scopus)

Genome wide analysis of protein production load in Trichoderma reesei

Pakula, T., Nygrén, H., Barth, D., Heinonen, M., Castillo, S. D., Penttilä, M. E. & Arvas, M., 2016, In : Biotechnology for Biofuels. 9, 26 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Trichoderma
genome
Genes
Genome
Proteins
7 Citations (Scopus)

Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI)

Kurko, J., Tringham, M., Tanner, L., Näntö-Salonen, K., Vähä-Mäkilä, M., Nygren, H., Pöhö, P., Lietzen, N., Mattila, I., Olkku, A., Hyötyläinen, T., Oresic, M., Simell, O., Niinikoski, H. & Mykkänen, J., 2016, In : Metabolism: Clinical and Experimental. 65, 9, p. 1361-1375

Research output: Contribution to journalArticleScientificpeer-review

Chronic Renal Insufficiency
Lipids
Amino Acids
Triglycerides
Hyperammonemia
31 Citations (Scopus)

Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism

Caesar, R., Nygrén, H., Oresic, M. & Bäckhed, F., 2016, In : Journal of Lipid Research. 57, 3, p. 474-781

Research output: Contribution to journalArticleScientificpeer-review

Metabolism
Cholesterol Esters
Cholesterol
Lipids
Liver
4 Citations (Scopus)

Whole-genome metabolic model of Trichoderma reesei built by comparative reconstruction

Castillo, S., Barth, D., Arvas, M., Pakula, T. M., Pitkänen, E., Blomberg, P., Seppänen-Laakso, T., Nygren, H., Sivasiddarthan, D., Penttilä, M. & Oja, M., 2016, In : Biotechnology for Biofuels. 9, 252, 20 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2015

Betulins as novel lead compounds for cancer

Oksman-Caldentey, K-M., Lämsä, M., Härmä, V., Haavikko, R., Alakurtti, S., Nygren, H., Häkkinen, S., Yli-Kauhaluoma, J., Nees, M. & Rischer, H., 2015, Book of Abstracts. 102

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

25 Citations (Scopus)

Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function

Barbarroja, N., Rodriguez-Cuenca, S., Nygren, H., Camargo, A., Pirraco, A., Relat, J., Cuadrado, I., Pellegrinelli, V., Medina-Gomez, G., Lopez-Pedrera, C., Tinahones, F. J., Symons, J. D., Summers, S. A., Oresic, M. & Vidal-Puig, A., 2015, In : Diabetes. 64, 4, p. 1180-1192

Research output: Contribution to journalArticleScientificpeer-review

Ceramides
Adipocytes
Adipose Tissue
Obesity
Lipids
6 Citations (Scopus)

Serum lipid and serum metabolite components in relation to anthropometric parameters in EPIC-Potsdam participants

Foerster, J., Hyötyläinen, T., Oresic, M., Nygren, H. & Boeing, H., 2015, In : Metabolism: Clinical and Experimental. 64, 10, p. 1348-1358

Research output: Contribution to journalArticleScientificpeer-review

Principal Component Analysis
Lipids
Serum
Metabolomics
Obesity
2014

In-vitro co-culture for matching Diabetes Type II changes with adipocyte lipidome

Kolari, K., Virtanen, J., Aura, A-M., Nygren, H. & Nees, M., 2014.

Research output: Contribution to conferenceOther conference contributionScientific

6 Citations (Scopus)

Overexpression of PPAR{\gamma} Specifically in Pancreatic {\beta}-Cells Exacerbates Obesity-Induced Glucose Intolerance, Reduces {\beta}-Cell Mass, and Alters Islet Lipid Metabolism in Male Mice

Hogh, K-L. N., Craig, M. N., Uy, C. E., Nygren, H., Asadi, A., Speck, M., Fraser, J. D., Rudecki, A. P., Baker, R. K., Oresic, M. & Gray, S. L., 2014, In : Endocrinology. 155, 10, p. 3843-3852 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Glucose Intolerance
Insulin-Secreting Cells
Lipid Metabolism
Obesity
Obese Mice
20 Citations (Scopus)

Quantitative profiling of bile acids in blood, adipose tissue, intestine, and gall bladder samples using ultra high performance liquid chromatography-tandem mass spectrometry

Jäntti, S. E., Kivilompolo, M., Öhrnberg, L., Pietiläinen, K. H., Nygren, H., Oresic, M. & Hyötyläinen, T., 2014, In : Analytical and Bioanalytical Chemistry. 406, 30, p. 7799 -7815 16 p.

Research output: Contribution to journalArticleScientificpeer-review

High performance liquid chromatography
Bile Acids and Salts
Mass spectrometry
Blood
Tissue

Ultrahigh-performance liquid chromatography-mass spectrometry in Lipidomics

Nygren, H., Pöhö, P., Seppänen-Laakso, T., Lahtinen, U., Oresic, M. & Hyötyläinen, T., 2014, In : LC-GC North America. 32, 4, p. 286-293 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Liquid chromatography
Mass spectrometry
Lipids
Plasmalogens
2013
57 Citations (Scopus)

Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids

Orešič, M., Hyötyläinen, T., Kotronen, A., Gopalacharyulu, P., Nygren, H., Arola, J., Castillo, S., Mattila, I., Hakkarainen, A., Borra, R. J. H., Honka, M. J., Verrijken, A., Francque, S., Iozzo, P., Leivonen, M., Jaser, N., Juuti, A., Sørensen, T. I. A., Nuutila, P., Van Gaal, L. & 1 others, Yki-Järvinen, H., 1 Oct 2013, In : Diabetologia. 56, 10, p. 2266-2274 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Fats
Lipids
Liver
Serum
Biomarkers
9 Citations (Scopus)

Steroid and steroid glucuronide profiles in urine during pregnancy determined by liquid chromatography-electrospray ionization-tandem mass spectrometry

Jäntti, S., Hartonen, M., Hilvo, M., Nygren, H., Hyötyläinen, T., Ketola, R. A. & Kostiainen, R., 2013, In : Analytica Chimica Acta. 802, p. 56-66 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Electrospray ionization
Electrospray Ionization Mass Spectrometry
Glucuronides
Liquid chromatography
steroid
2012
11 Citations (Scopus)

Differential patterns of dehydroabietic acid biotransformation by Nicotiana tabacum and Catharanthus roseus cells

Häkkinen, S. T., Lackman, P., Nygren, H., Oksman-Caldentey, K-M., Maaheimo, H. & Rischer, H., 2012, In : Journal of Biotechnology. 157, 2, p. 287-294 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Catharanthus
Biotransformation
Tobacco
Acids
Bioconversion
2011
136 Citations (Scopus)

Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans

Pietiläinen, K. H., Róg, T., Seppänen-Laakso, T., Virtue, S., Gopalacharyulu, P., Tang, J., Rodriguez-Cuenca, S., Maciejewski, A., Naukkarinen, J., Ruskeepää, A-L., Niemelä, P., Yetukuri, L., Tan, C. Y., Velagapudi, V., Castillo, S., Nygren, H., Hyötyläinen, T., Rissanen, A., Kaprio, J., Yki-Järvinen, H. & 3 others, Vattulainen, I., Vidal-Puig, A. & Orešič, M., 2011, In : PLoS Biology. 9, 6, 14 p., e1000623.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
adipocytes
Adipocytes
adipose tissue
Adipose Tissue
obesity

Discovery of diagnostic biomarkers for non-alcoholic fatty liver disease (NAFLD)

Gopalacharyulu, P., Castillo, S., Nygren, H., Hyötyläinen, T., Seppänen-Laakso, T., Kotronen, A., Yki-Järvinen, H. & Oresic, M., 2011, Metabomeeting 2011. p. 51

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

30 Citations (Scopus)

High Density Lipoprotein structural changes and drug response in lipidomic profiles following the long-term fenofibrate therapy in the FIELD substudy

Yetukuri, L., Huopaniemi, I., Koivuniemi, A., Maranghi, M., Hiukka, A., Nygren, H., Kaski, S., Taskinen, M-R., Vattulainen, I., Jauhiainen, M. & Orešič, M., 2011, In : PLoS ONE. 6, 8, 12 p., e23589.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Fenofibrate
high density lipoprotein
HDL Lipoproteins
Apolipoprotein A-II
drugs

Impact of surface lipid fluidity to the distribution of lipids in high density lipoprotein particles: Implications to high density fraction profiles

Koivuniemi, A., Nygren, H., Hyötyläinen, T., Sysi-Aho, M. & Oresic, M., 2011, Metabomeeting 2011. p. 142

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

Lipid profiles in breast cancer samples: Characterization of glycosylated ceramides associated to estrogen receptor negative tumors

Nygren, H., Hilvo, M., Seppänen-Laakso, T., Hyötyläinen, T. & Oresic, M., 2011, Metabomeeting 2011. p. 76

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

85 Citations (Scopus)

Liquid Chromatography-Mass Spectrometry (LC-MS)-Based Lipidomics for Studies of Body Fluids and Tissues

Nygren, H., Seppänen-Laakso, T., Castillo, S., Hyötyläinen, T. & Oresic, M., 2011, Metabolic Profiling: Methods and Protocols. Metz, T. O. (ed.). Springer, p. 247-257

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

Body fluids
Liquid chromatography
Mass spectrometry
Tissue
Lipids

Metabolic profiling of serum and adipose tissue of monozygotic twins after high-fat meal

Jäntti, S., Kivilompolo, M., Mattila, I., Seppänen-Laakso, T., Nygren, H., Ruskeepää, A-L., Lahtinen, U., Kaprio, J., Tang, J., Pietiläinen, K., Hyötyläinen, T. & Oresic, M., 2011, Metabomeeting 2011. p. 141

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

267 Citations (Scopus)

Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression

Hilvo, M., Denkert, C., Lehtinen, L., Muller, B., Brockmoller, S., Seppänen-Laakso, T., Budczies, J., Bucher, E., Yetukuri, L., Castillo, S., Berg, E., Nygren, H., Sysi-Aho, M., Griffin, J. L., Fiehn, O., Loibl, S., Richter-Ehrenstein, C., Radke, C., Hyötyläinen, T., Kallioniemi, O. & 2 others, Iljin, K. & Oresic, M., 2011, In : Cancer Research. 71, 9, p. 3236-3245 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Membrane Lipids
Lipid Metabolism
Breast Neoplasms
Lipids
Genes

Rasvasolujen solukalvo mukautuu ylimääräiseen rasvaan

Pietiläinen, K. H., Róg, T., Seppänen-Laakso, T., Virtue, S., Gopalacharyulu, P., Tang, J., Rodriguez-Cuenca, S., Maciejewski, A., Naukkarinen, J., Ruskeepää, A-L., Niemelä, P., Yetukuri, L., Tan, C. Y., Velagapudi, V., Castillo, S., Nygren, H., Hyötyläinen, T., Rissanen, A., Kaptio, J., Yki-Järvinen, H. & 3 others, Vattulainen, I., Vidal-Puig, A. & Oresic, M., 2011, In : Duodecim. 127, 14, 1493.

Research output: Contribution to journalArticleScientific

Open Access
2010

Discovery and validation of plasma markers of liver fat content: Metabolomics approach

Nygren, H., Seppänen-Laakso, T., Mattila, I., Tang, J., Hyötyläinen, T., Kotronen, A., Oresic, M. & Yki-Järvinen, H., 2010.

Research output: Contribution to conferenceConference articleScientific

Discovery and validation of plasma markers of liver fat content: Metabolomics approach

Nygren, H., Seppänen-Laakso, T., Mattila, I., Hyötyläinen, T., Kotronen, A., Oresic, M. & Yki-Järvinen, H., 2010, Metabolomics 2010, abstract book: Breakthroughs in plant, microbial and human biology, clinical and nutritional research, and biomarker discovery. p. 119

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Statistical modeling for the prediction of non-alcoholic fatty liver disease

Gopalacharyulu, P., Seppänen-Laakso, T., Nygren, H., Kotronen, A. & Hyötyläinen, T., 2010.

Research output: Contribution to conferenceConference articleScientific