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Research Output 1988 2019

2019

European Court of Justice delivers no justice to Europe on genome‐edited crops

Schulman, A. H., Oksman-Caldentey, K-M. & Teeri, T., Jun 2019, In : Plant Biotechnology Journal. p. 1-3

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2018

Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells

Häkkinen, S. T., Nygren, H., Maiorova, N., Haavikko, R., Alakurtti, S., Yli-Kauhaluoma, J., Rischer, H. & Oksman-Caldentey, K. M., 1 Jul 2018, In : Planta Medica. 84, 9-10, p. 743-748 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Plant Cells
Biotransformation
Catharanthus
Derivatives
Pentoses

Progress and Prospects of Hairy Root Research

Häkkinen, S. & Oksman-Caldentey, K-M., 2018, Hairy Roots. Srivastava, V., Mehrotra, S. & Mishra, S. (eds.). Springer, p. 3 - 19

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

biotechnology
Rhizobium rhizogenes
bioremediation
engineers
recombinant proteins

Skopolamiinia tuottavien karvajuurien metabolinen stabiilisuus: 16 vuoden ylläpidon jälkeen

Häkkinen, S. & Oksman-Caldentey, K-M., 2018, In : Dosis. 34, 4, p. 277-287

Research output: Contribution to journalReview ArticleScientific

2017

Bioconversion to raspberry ketone is achieved by several non-related plant cell cultures

Häkkinen, S., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 2017, Frontiers Research Topic: Engineering the plant factory for the production of biologics and small-molecule medicines. De Martinis, D., Franconi, R., Benvenuto, E., Rybicki, E. P. & Fujiyama, K. (eds.). Frontiers Media, p. 334-342

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

Open Access
3 Citations (Scopus)

Biotechnology of the medicinal plant Rhazya stricta: A little investigated member of the Apocynaceae family

Akhgari, A., Oksman-Caldentey, K-M. & Rischer, H., 2017, In : Biotechnology Letters. 39, 6, p. 829-840 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Secologanin Tryptamine Alkaloids
Apocynaceae
Medicinal Plants
Biotechnology
Metabolic Engineering

Biotechnology of unique wild berries and their commercial application potential

Oksman-Caldentey, K-M., Nohynek, L., Häkkinen, S. T., Smolander, M., Rischer, H. & Puupponen-Pimiä, R., 2017, Fisiología Vegetal FVc2017: Libro de Abstracts. p. 2-3

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

4 Citations (Scopus)

Genetically engineered hairy root cultures of Hyoscyamus senecionis and H. muticus: ploidy as a promising parameter in the metabolic engineering of tropane alkaloids

Dehghan, E., Reed, D. W., Covello, P. S., Hasanpour, Z., Palazon, J., Oksman-Caldentey, K-M. & Ahmadi, F. S., 1 Oct 2017, In : Plant Cell Reports. 36, 10, p. 1615-1626 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Hyoscyamus
Hyoscyamus muticus
tropane alkaloids
metabolic engineering
ploidy
cosmetics
skin (animal)
small fruits
ingredients
cells
2016

A berry good story: berry cells as active ingredients for skin care products

Oksman-Caldentey, K-M., Virtanen, V., Nohynek, L., Rischer, H. & Puupponen-Pimiä, R., 2016, Abstract book. Phytochemical Society of Europe PSE , 40

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

18 Citations (Scopus)

Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi

Pirttimaa, M., Nasereddin, A., Kopelyanskiy, D., Kaiser, M., Yli-Kauhaluoma, J., Oksman-Caldentey, K-M., Brun, R., Jaffe, C. L., Moreira, V. M. & Alakurtti, S., 2016, In : Journal of Natural Products. 79, 2, p. 362-368

Research output: Contribution to journalArticleScientificpeer-review

Abietane Diterpenes
Leishmania donovani
Diterpenes
Trypanosoma cruzi
Amides
11 Citations (Scopus)

Exploring the metabolic stability of engineered hairy roots after 16 years maintenance

Häkkinen, S. T., Moyano, E., Cusidó, R. M. & Oksman-Caldentey, K-M., 2016, In : Frontiers in Plant Science. 3, 1486.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
secondary metabolites
cell culture
Hyoscyamus muticus
tropane alkaloids
paclitaxel
7 Citations (Scopus)

Fermantation and dry fractionation increase bioactivity of cloudberry (Rubus chamaemorus)

Puupponen-Pimiä, R., Nohynek, L., Juvonen, R., Kössö, T., Truchado, P., Westerlund-Wikström, B., Leppänen, T., Moilanen, E. & Oksman-Caldentey, K-M., 2016, In : Food Chemistry. 197, Part A, p. 950-958

Research output: Contribution to journalArticleScientificpeer-review

Rubus chamaemorus
Fractionation
Bioactivity
Fermentation
Ellagic Acid

Novel berry-based antimicrobials in cosmetics

Nohynek, L., Honkapää, K., Oksman-Caldentey, K-M. & Puupponen-Pimiä, R., 2016.

Research output: Contribution to conferenceConference PosterScientific

2015
4 Citations (Scopus)

Analysis of indole alkaloids from Rhazya stricta hairy roots by ultra-performance liquid chromatography-mass spectrometry

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Molecules. 20, 12, p. 22621-22634

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Secologanin Tryptamine Alkaloids
Apocynaceae
Indole Alkaloids
alkaloids
Liquid chromatography

Betulins as novel lead compounds for cancer

Oksman-Caldentey, K-M., Lämsä, M., Härmä, V., Haavikko, R., Alakurtti, S., Nygren, H., Häkkinen, S., Yli-Kauhaluoma, J., Nees, M. & Rischer, H., 2015, Book of Abstracts. 102

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

2 Citations (Scopus)

Bioconversion to Raspberry Ketone is Achieved by Several Non-related Plant Cell Cultures

Häkkinen, S., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 24 Nov 2015, In : Frontiers in Plant Science. 6, p. 1-9 9 p., 1035.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
raspberries
biotransformation
ketones
cell culture
flavor compounds
7 Citations (Scopus)

Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Phytochemical Analysis. 26, 5, p. 331-338

Research output: Contribution to journalArticleScientificpeer-review

Rhazya stricta
Secologanin Tryptamine Alkaloids
Apocynaceae
indole alkaloids
Rhazya

Discovery of missing steps of secoiridoid pathway in Catharanthus roseus

Oksman-Caldentey, K-M., 2015.

Research output: Contribution to conferenceConference articleScientific

Catharanthus roseus
factories
biochemical pathways
taxanes
genomics

Effects of ellagitannin rich berries on blood lipid profiles, gut microbiota and metabolism of phenolic compounds in metabolic syndrome

Puupponen-Pimiä, R., Seppänen-Laakso, T., Maukonen, J., Nohynek, L., Tómas-Barberán, F. A., Törrönen, R., Kolehmainen, M., Kankainen, M., Espín, J. C., Aura, A-M., Poutanen, K., Leppänen, T., Moilanen, E. & Oksman-Caldentey, K-M., 2015, In : Dosis. 33, 3, p. 55-76

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Fruit
Lipids
Hydrolyzable Tannins
8-epi-prostaglandin F2alpha
Blood Pressure
7 Citations (Scopus)

Establishment of transgenic Rhazya stricta hairy roots to modulate terpenoid indole alkaloid production

Akhgari, A., Yrjönen, T., Laakso, I., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Plant Cell Reports. 34, 11, p. 1939-1952

Research output: Contribution to journalArticleScientificpeer-review

Rhazya stricta
indole alkaloids
terpenoids
genetically modified organisms
alkaloids

Harvinaisten ja vaikeasti syntetisoitavien lääkeyhdisteiden tuottaminen kasvibiotekniikan keinoin

Häkkinen, S., Oksman-Caldentey, K-M. & Ritala, A., 2015, In : Dosis. 31, 3, p. 162-169

Research output: Contribution to journalArticleScientificpeer-review

value added
Olla
10 Citations (Scopus)

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development

Härmä, V., Haavikko, R., Virtanen, J., Ahonen, I., Schukov, H-P., Alakurtti, S., Purev, E., Rischer, H., Yli-Kauhaluoma, J., Moreira, V. M., Nees, M. & Oksman-Caldentey, K-M., 2015, In : PLoS ONE. 10, 5, 22 p., e0126111.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
betulin
prostatic neoplasms
Prostatic Neoplasms
chemical derivatives
Castration

Phenolic composition of cloudberry and arctic bramble cell suspension cultures

Puupponen-Pimiä, R., Nohynek, L., Salminen, J-P., Rischer, H. & Oksman-Caldentey, K-M., 2015, Book of Abstracts. p. 30 P-1

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

2014
8 Citations (Scopus)
Open Access
16 Citations (Scopus)

Comparison of plant-based expression platforms for the heterologous production of geraniol

Vasilev, N., Schmitz, C., Dong, L., Ritala, A., Imseng, N., Häkkinen, S., van der Krol, S., Eibl, R., Oksman-Caldentey, K-M., Bouwmeester, H., Fischer, R. & Schillberg, S., 2014, In : Plant Cell, Tissue and Organ Culture. 117, 3, p. 373-380

Research output: Contribution to journalArticleScientificpeer-review

geraniol
cell suspension culture
agroinfiltration
transgenic plants
biomass

Contained molecular farming: Controllable contained systems for high yield and consistency (CoMoFarm)

Ritala, A., Häkkinen, S., Oksman-Caldentey, K-M., Raven, N., Schillberg, S., Henquet, M. & Bosch, D., 2014, In : Dosis. 30, 3

Research output: Contribution to journalArticleScientificpeer-review

7 Citations (Scopus)

Disposable bioreactors for cultivation of plant cell cultures

Lehmann, N., Dittler, I., Lämsä, M., Ritala, A., Rischer, H., Eibl, D., Oksman-Caldentey, K-M. & Eibl, R., 2014, Production of Biomass and Bioactive Compounds Using Bioreactor Technology. Paek, K-Y., Hosakatte, N. M. & Zhong, J-J. (eds.). Springer, p. 17-46

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleProfessional

bioreactors
plant cultural practices
cell culture
cells
biopharmaceuticals

Dosiksen kolme vuosikymmentä - Farmaseuttinen tutkimus eilen, tänään ja huomenna

Oksman-Caldentey, K-M., 2014.

Research output: Contribution to conferenceOther conference contributionProfessional

15 Citations (Scopus)

Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway

Ritala, A., Dong, L., Imseng, N., Seppänen-Laakso, T., Vasilev, N., van der Krol, S., Rischer, H., Maaheimo, H., Virkki, A., Brändli, J., Schillerberg, S., Eibl, R., Bouwmeester, H. & Oksman-Caldentey, K-M., 2014, In : Journal of Biotechnology. 176, p. 20-28 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Secologanin Tryptamine Alkaloids
Alkaloids
Tobacco
Fragrances
Glycosides

Luonnon monimuotoisuuden merkitys uusien lääkeaineiden löytämisessä: kasveista saatavat lääkeaineet

Oksman-Caldentey, K-M., 2014.

Research output: Contribution to conferenceOther conference contributionProfessional

Luonnon monimuotoisuuden merkitys uusien lääkeaineiden löytämisessä: kasveista saatavat lääkeaineet

Oksman-Caldentey, K-M., 2014.

Research output: Contribution to conferenceOther conference contributionProfessional

Metabolic engineering of terpenoid indole alkaloid pathway in Catharanthus roseus

Oksman-Caldentey, K-M. & Rischer, H., 2014, International Association for Plant Biotechnology Congress 2014: Book of Abstracts. 24

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

20 Citations (Scopus)

Metabolic flux phenotype of tobacco hairy roots engineered for increased geraniol production

Masakapalli, S. K., Ritala, A., Dong, L., van der Krol, A. R., Oksman-Caldentey, K-M., Ratcliffe, R. G. & Sweetlove, L. J., 2014, In : Phytochemistry. 99, p. 73-85 13 p.

Research output: Contribution to journalArticleScientificpeer-review

geraniol
Tobacco
tobacco
Fluxes
Phenotype
28 Citations (Scopus)

Molecular farming in tobacco hairy roots by triggering the secretion of a pharmaceutical antibody

Häkkinen, S. T., Raven, N., Henquet, M., Laukkanen, M-L., Anderlei, T., Pitkänen, J-P., Twyman, R. M., Bosch, D., Oksman-Caldentey, K-M., Schillberg, S. & Ritala, A., 2014, In : Biotechnology and Bioengineering. 111, 2, p. 336-346

Research output: Contribution to journalArticleScientificpeer-review

Molecular Farming
Tobacco
Antibodies
Drug products
Pharmaceutical Preparations

Production of cosmetic ingredients by cell cultures of Nordic berry species

Puupponen-Pimiä, R., Nohynek, H. R. & Oksman-Caldentey, K-M., 2014.

Research output: Contribution to conferenceConference articleScientificpeer-review

Rational design of plant systems for sustainable generation of value-added industrial products (SmartCell)

Oksman-Caldentey, K-M., Ritala, A., Rischer, H., Häkkinen, S. & Christou, P., 2014, In : Dosis. 30, 3

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)

Recombinant barley-produced antibody for detection and immunoprecipitation of the major bovine milk allergen, ß-lactoglobulin

Ritala, A., Leelavathi, S., Oksman-Caldentey, K-M., Reddy, V. S. & Laukkanen, M-L., 2014, In : Transgenic Research. 23, 3, p. 477-487 11 p.

Research output: Contribution to journalArticleScientificpeer-review

lactoglobulins
Lactoglobulins
antibody detection
Hordeum
allergens

Therapeutically active berry compounds, BERRYDRUG

Puupponen-Pimiä, R., Nohynek, L., Törrönen, R., Kolehmainen, M., Moilanen, E., Leppänen, T., Westerlund-Wikström, B., Heinonen, M. & Oksman-Caldentey, K-M., 2014, In : Dosis. 30, 3

Research output: Contribution to journalArticleScientificpeer-review

183 Citations (Scopus)

The seco-iridoid pathway from Catharanthus roseus

Miettinen, K., Dong, L., Navrot, N., Schneider, T., Burlat, V., Pollier, J., Woittiez, L., van der Krol, S., Lugan, R., Ilc, T., Verpoorte, R., Oksman-Caldentey, K-M., Martinoia, E., Bouwmeester, H., Goossens, A., Memelink, J. & Werck-Reichhart, D., 2014, In : Nature Communications. 5, 3606.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Secologanin Tryptamine Alkaloids
Catharanthus
alkaloids
Biosynthesis
Iridoids
2013
10 Citations (Scopus)

Analysis of the Interface between Primary and Secondary Metabolism in Catharanthus roseus Cell Cultures Using 13C-Stable Isotope Feeding and Coupled Mass Spectrometry: Letter to the Editor

Antonio, C., Mustafa, N. R., Osorio, S., Tohge, T., Giavalisco, P., Willmitzer, L., Rischer, H., Oksman-Caldentey, K-M., Verpoorte, R. & Fernie, A. R., 2013, In : Molecular Plant. 6, 2, p. 581-584 4 p.

Research output: Contribution to journalOther journal contributionScientific

Open Access

Arctic vitality from berry cell culture technology

Nohynek, L., Rischer, H., Oksman-Caldentey, K-M. & Puupponen-Pimiä, R., 2013.

Research output: Contribution to conferenceConference articleScientific

74 Citations (Scopus)

CathaCyc, a metabolic pathway database built from catharanthus roseus RNA-seq data

Van Moerkercke, A., Fabris, M., Pollier, J., Baart, G. J. E., Rombauts, S., Hasnain, G., Rischer, H., Memelink, J., Oksman-Caldentey, K-M. & Goossens, A., 2013, In : Plant and Cell Physiology. 54, 5, p. 673-685 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Catharanthus
Catharanthus roseus
Secologanin Tryptamine Alkaloids
Metabolic Networks and Pathways
indole alkaloids

Cell-based functional screening of modified betulins, abietanes and resin acids as lead compounds for anti-cancer drugs (BARC)

Nees, M., Haavikko, R., Moreira, V., Alakurtti, S., Yli-Kauhaluoma, J., Rischer, H., Purev, E., Virtanen, J. & Oksman-Caldentey, K-M., 2013, TERPNET 2013: Book of Abstracts. Aristotle University of Thessaloniki, p. 88 1 p. O53

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Diverse bioconversion of wood-derived diterpene by Nicotianatabacum and Catharanthusroseus cells

Häkkinen, S. T., Lackman, P., Nygrén, H., Oksman-Caldentey, K-M., Maaheimo, H. & Rischer, H., 2013, TERPNET 2013: Book of Abstracts. Aristotle University of Thessaloniki, p. 235 P105

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

39 Citations (Scopus)

Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

Puupponen-Pimiä, R., Seppänen-Laakso, T., Kankainen, M., Maukonen, J., Törrönen, R., Kolehmainen, M., Leppänen, T., Moilanen, E., Nohynek, L., Aura, A-M., Poutanen, K., Tómas-Barberán, F. A., Espín, J. C. & Oksman-Caldentey, K-M., 2013, In : Molecular Nutrition and Food Research. 57, 12, p. 2258-2263 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Hydrolyzable Tannins
metabolic syndrome
intestinal microorganisms
blood lipids
signs and symptoms (animals and humans)

Expression of two early genes of the terpenoid biosynthetic pathway in tobacco results in major suppression of the pathway and profound changes in non-target metabolites in a differentation state dependent manner

Miralpeix, B., Choi, Y. H., Ritala, A., Maaheimo, H., Seppänen, T., Capell, T., Oksman-Caldentey, K-M., Verpoorte, R. & Christou, P., 2013, Terpnet 2013: Book of Abstracts. 255

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access
16 Citations (Scopus)

Lipid content in 19 brackish and marine microalgae: Influence of growth phase, salinity and temperature

Schwenk, D., Seppälä, J., Spilling, K., Virkki, A., Tamminen, T., Oksman-Caldentey, K-M. & Rischer, H., 2013, In : Aquatic Ecology. 47, 4, p. 415-424 9 p.

Research output: Contribution to journalArticleScientificpeer-review

microalgae
lipid
lipid content
salinity
fatty acid

Metabolic engineering and elicitation of pharmaceutically active metabolites in Rhazya stricta (Apocynaceau)

Akhgari, A., Laakso, I., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2013, In : Planta Medica. 79, 13, PM1.

Research output: Contribution to journalOther journal contributionScientific

Secologanin Tryptamine Alkaloids
Apocynaceae
Metabolic engineering
Metabolic Engineering
Metabolites