Markku Saloheimo

  • Phone+358405760892
1987 …2020

Research output per year

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Research Output

2020

Modification of transcriptional factor ACE3 enhances protein production in Trichoderma reesei in the absence of cellulase gene inducer

Luo, Y., Valkonen, M., Jackson, R. E., Palmer, J. M., Bhalla, A., Nikolaev, I., Saloheimo, M. & Ward, M., Aug 2020, In : Biotechnology for Biofuels. 13, 1, 137.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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4 Downloads (Pure)
2018

A new crystal form of Aspergillus oryzae catechol oxidase and evaluation of copper site structures in coupled binuclear copper enzymes

Penttinen, L., Rutanen, C., Saloheimo, M., Kruus, K., Rouvinen, J. & Hakulinen, N., 1 May 2018, In : PLoS ONE. 13, 5, e0196691.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
3 Citations (Scopus)
2017

Development of a low-cost cellulase production process using Trichoderma reesei for Brazilian biorefineries

Ellilä, S., Fonseca, L., Uchima, C., Cota, J., Goldman, G. H., Saloheimo, M., Sacon, V. & Siika-Aho, M., 2017, In : Biotechnology for Biofuels. 10, 1, p. 30

Research output: Contribution to journalArticleScientificpeer-review

Open Access
52 Citations (Scopus)

Transient Silencing of DNA Repair Genes Improves Targeted Gene Integration in the Filamentous Fungus Trichoderma reesei

Chum, P. Y., Schmidt, G., Saloheimo, M. & Landowski, C. P., 2017, In : Applied and Environmental Microbiology. 83, 15, 11 p., e00535-17.

Research output: Contribution to journalArticleScientificpeer-review

6 Citations (Scopus)
2016

Enabling low cost biopharmaceuticals: high level interferon alpha-2b production in Trichoderma reesei

Landowski, C. P., Mustalahti, E., Wahl, R., Croute, L., Sivasiddarthan, D., Westerholm-Parvinen, A., Sommer, B., Ostermeier, C., Helk, B., Saarinen, J. & Saloheimo, M., 2016, In : Microbial Cell Factories. 15, 1, 104.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
13 Citations (Scopus)

Expression of Two Novel β-Glucosidases from Chaetomium atrobrunneum in Trichoderma reesei and Characterization of the Heterologous Protein Products

Colabardini, A. C., Valkonen, M., Huuskonen, A., Siika-aho, M., Koivula, A., Goldman, G. H. & Saloheimo, M., 1 Dec 2016, In : Molecular Biotechnology. 58, 12, p. 821-831 11 p.

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)

Quantitative site-specific phosphoproteomics of Trichoderma reesei signaling pathways upon induction of hydrolytic enzyme production

Nguyen, E. V., Imanishi, S. Y., Haapaniemi, P., Yadav, A., Saloheimo, M., Corthals, G. L. & Pakula, T. M., 2016, In : Journal of Proteome Research. 15, 2, p. 457-467

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)
2015

Enabling low cost biopharmaceuticals: A systematic approach to delete proteases from a well-known protein production host trichoderma reesei

Landowski, C. P., Huuskonen, A., Wahl, R., Westerholm-Parvinen, A., Kanerva, A., Hänninen, A-L., Salovuori, N., Penttilä, M., Natunen, J., Ostermeier, C., Helk, B., Saarinen, J. & Saloheimo, M., 2015, In : PLoS ONE. 10, 8, e0134723.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
29 Citations (Scopus)

Removing boundaries for therapeutic protein production in the filamentous fungus Trichoderma reesei: Reduction of the host protease load

Landowski, C., Huuskonen, A., Wahl, R., Westerholm-Parvinen, A., Sommer, B., Penttilä, M., Natunen, J., Ostermeier, C., Helk, B., Saarinen, J. & Saloheimo, M., 2015.

Research output: Contribution to conferenceConference AbstractScientific

43 Citations (Scopus)

The effects of extracellular pH and of the transcriptional regulator PACI on the transcriptome of Trichoderma reesei

Häkkinen, M., Sivasiddarthan, D., Aro, N., Saloheimo, M. & Pakula, T. M., 2015, In : Microbial Cell Factories. 14, 63.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
23 Citations (Scopus)
2014

Cloning and characterization of a novel acidic cutinase from Sirococcus conigenus

Nyyssölä, A., Pihlajaniemi, V., Häkkinen, M., Kontkanen, H., Saloheimo, M. & Nakari-Setälä, T., 1 Jan 2014, In : Applied Microbiology and Biotechnology. 98, 8, p. 3639-3650 12 p.

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)
Open Access
7 Citations (Scopus)

Protein production: ER Quality control and secretion stress responses in Trichoderma reesei

Saloheimo, M., Pakula, T., Aro, N. & Joensuu, J., 2014, Biotechnology and Biotechnology of Trichoderma. Elsevier, p. 81-88

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleProfessional

1 Citation (Scopus)
Open Access
112 Citations (Scopus)
2013

A fusion protein approach in directing enzymatic cross-linking functionality to the air-water interface

Paananen, A., Ercili-Cura, D., Saloheimo, M., Lantto, R. & LInder, M., 2013.

Research output: Contribution to conferenceConference PosterScientific

Directing enzymatic cross-linking activity to the air-water interface by a fusion protein approach

Paananen, A., Ercili Cura, D., Saloheimo, M., Lantto, R. & Linder, M., 2013, In : Soft Matter. 9, 5, p. 1612-1619 8 p.

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Experimental and bioinformatic investigation of the proteolytic degradation of the C-terminal domain of a fungal tyrosinase

Faccio, G., Arvas, M., Thöny-Meyer, L. & Saloheimo, M., 2013, In : Journal of Inorganic Biochemistry. 121, p. 37-45 9 p.

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)

Intracellular protein production in Trichoderma reesei (Hypocrea jecorina) with hydrophobin fusion technology

Mustalahti, E., Saloheimo, M. & Joensuu, J., 2013, In : New Biotechnology. 30, 2, p. 262-268 7 p.

Research output: Contribution to journalArticleScientificpeer-review

15 Citations (Scopus)

Swollenin aids in the amorphogenesis step during the enzymatic hydrolysis of pretreated biomass

Gourlay, K., Hu, J., Arantes, V., Andberg, M., Saloheimo, M., Penttilä, M. & Saddler, J., 1 Jan 2013, In : Bioresource Technology. 142, p. 498-503

Research output: Contribution to journalArticleScientificpeer-review

Open Access
61 Citations (Scopus)

Unconventional microbial systems for the cost-efficient production of high-quality protein therapeutics

Corchero, J. L., Gasser, B., Resina, D., Smith, W., Parrilli, E., Vázquez, F., Abasolo, I., Giuliani, M., Jäntti, J., Ferrer, P., Saloheimo, M., Mattanovich, D., Schwartz Jr, S., Tutino, M. L. & Villaverde, A., 2013, In : Biotechnology Advances. 31, 2, p. 140-153 14 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

79 Citations (Scopus)

Xylanase XYN IV from Trichoderma reesei showing exo- and endo-xylanase activity

Tenkanen, M., Vršanská, M., Siika-Aho, M., Wong, D. W., Puchart, V., Penttilä, M., Saloheimo, M. & Biely, P., 1 Jan 2013, In : FEBS Journal. 280, 1, p. 285-301

Research output: Contribution to journalArticleScientificpeer-review

43 Citations (Scopus)
2012

Bacterial tyrosinases and their applications

Faccio, G., Kruus, K., Saloheimo, M. & Thöny-Meyer, L., 2012, In : Process Biochemistry. 47, 12, p. 1749-1760 11 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

54 Citations (Scopus)

Correlation of gene expression and protein production rate: A system wide study

Arvas, M., Pakula, T., Smit, B., Rautio, J., Koivistoinen, H., Jouhten, P., Lindfors, E., Wiebe, M., Penttilä, M. & Saloheimo, M., 2012, Abstracts from the 11th European Conference on Fungal Genetics. New Prairie Press, p. 244 PR8.52. (Fungal Genetics Reports; No. 6, Vol. 59).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Hydrophobin fusions for high level intracellular protein production and purification in Trichoderma reesei

Mustalahti, E., Aro, N., Vitikainen, M., Saloheimo, M. & Joensuu, J., 2012, Abstracts from the 11th European Conference on Fungal Genetics. New Prairie Press, p. 223 PR8.9. (Fungal Genetics Reports; No. 6, Vol. 59).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Re-annotation of the CAZy genes of Trichoderma reesei and transcription in the presence of lignocellulosic substrates

Häkkinen, M., Arvas, M., Oja, M., Aro, N., Penttilä, M., Saloheimo, M. & Pakula, T. M., 4 Oct 2012, In : Microbial Cell Factories. 11, 134.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
98 Citations (Scopus)

Sulfhydryl oxidase enhances the effects of ascorbic acid in wheat dough

Faccio, G., Flander, L., Buchert, J., Saloheimo, M. & Nordlund, E., 2012, In : Journal of Cereal Science. 55, 1, p. 37-43 7 p.

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

The cargo and the transport system: Secreted proteins and protein secretion in Trichoderma reesei (Hypocrea jecorina)

Saloheimo, M. & Pakula, T., 2012, In : Microbiology. 158, 1, p. 46-57 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

78 Citations (Scopus)

Transcriptional analysis of Trichoderma reesei cultivated in the presence of different lignocellulose substrates

Häkkinen, M., Arvas, M., Oja, M., Aro, N., Penttilä, M., Saloheimo, M. & Pakula, T., 2012, Abstracts from the 11th European Conference on Fungal Genetics. New Prairie Press, p. 237 PR8.37. (Fungal Genetics Reports; No. 6, Vol. 59).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access
2011

Correlation of gene expression and protein production rate: A system wide study

Arvas, M., Pakula, T., Smit, B., Rautio, J., Jouhten, P., Koivistoinen, H., Lindfors, E., Wiebe, M., Penttilä, M. & Saloheimo, M., 2011, 26th Fungal Genetics Conference at Asilomar March 15-20, 2011. Genetics Society of America, p. 120 (Fungal Genetics Reports; No. Supplement, Vol. 58).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Correlation of gene expression and protein production rate: a system wide study

Arvas, M., Pakula, T., Smit, B., Rautio, J., Koivistoinen, H., Jouhten, P., Lindfors, E., Wiebe, M., Penttilä, M. & Saloheimo, M., 20 Dec 2011, In : BMC Genomics. 12, 616.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
45 Citations (Scopus)

Erratum: Discovery of a new tyrosinase-like enzyme family lacking a C-terminally processed domain: Production and characterization of an Aspergillus oryzae catechol oxidase

Gasparetti, C., Faccio, G., Arvas, M., Buchert, J., Saloheimo, M. & Kruus, K., 2011, In : Applied Microbiology and Biotechnology. 90, 1, 397.

Research output: Contribution to journalOther journal contributionScientific

Hydrophobin fusions for high level intracellular protein production and purification in plants and filamentous fungi

Joensuu, J., Conley, A., Mustalahti, E., Lienemann, M., Linder, M., Menassa, R. & Saloheimo, M., 2011, Conference on Recombinant Protein Production 6: Abstracts.

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Influence of growth temperature on the production of antibody Fab fragments in different microbes: A host comparative analysis

Dragosits, M., Frascotti, G., Bernard-Granger, L., Vázquez, F., Giuliani, M., Baumann, K., Rodríguez-Carmona, E., Tokkanen, J., Parrilli, E., Wiebe, M. G., Kunert, R., Maurer, M., Gasser, B., Sauer, M., Branduardi, P., Pakula, T., Saloheimo, M., Penttilä, M., Ferrer, P., Luisa Tutino, M. & 3 others, Villaverde, A., Porro, D. & Mattanovich, D., 1 Jan 2011, In : Biotechnology Progress. 27, 1, p. 38-46

Research output: Contribution to journalArticleScientificpeer-review

32 Citations (Scopus)

Production and characterisation of AoSOX2 from Aspergillus oryzae, a novel flavin-dependent sulfhydryl oxidase with good pH and temperature stability

Faccio, G., Kruus, K., Buchert, J. & Saloheimo, M., 2011, In : Applied Microbiology and Biotechnology. 90, 3, p. 941-949 9 p.

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)

Protein production in the filamentous fungus Trichoderma reesei in intracellular protein bodies with the help of hydrophobin fusions

Mustalahti, E., Joensuu, J. & Saloheimo, M., 2011, Conference on Recombinant Protein Production 6: Abstracts.

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Sulfhydryl oxidases: Sources, properties, production and applications

Faccio, G., Nivala, O., Kruus, K., Buchert, J. & Saloheimo, M., 2011, In : Applied Microbiology and Biotechnology. 91, 4, p. 957-966 10 p.

Research output: Contribution to journalArticleScientificpeer-review

16 Citations (Scopus)

The effects of disruption of phosphoglucose isomerase gene on carbon utilisation and cellulase production in Trichoderma reesei Rut-C30

Limón, M. C., Pakula, T., Saloheimo, M. & Penttilä, M., 24 May 2011, In : Microbial Cell Factories. 10, 40.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
8 Citations (Scopus)

Transcriptional analysis of Trichoderma reesei cultivated in the presence of different lignocellulose substrate

Häkkinen, M., Saloheimo, M., Penttilä, M. & Pakula, T., 2011, 26th Fungal Genetics Conference at Asilomar March 15-20, 2011. Genetics Society of America, p. 272 645. (Fungal Genetics Reports; No. Supplement, Vol. 58).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Transcriptional and genomic profiling of industrial Trichoderma reesei strains

Mäkinen, S., Paloheimo, M., Pakula, T., Arvas, M., Oja, M., Saloheimo, M., Penttilä, M., Kallio, J., Vehmaanperä, J. & Puranen, T., 2011, Fungal Genetics Conference: 26th Fungal Genetics Conference at Asilomar. New Prairie Press, p. 272 643. (Fungal Genetics Reports; No. 2, Vol. 58).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access

Transformation system for hypocrea jecorina (trichoderma reesei) that favors homologous integration and employs reusable bidirectionally selectable markers

Steiger, M. G., Vitikainen, M., Uskonen, P., Brunner, K., Adam, G., Pakula, T., Penttilä, M., Saloheimo, M., Mach, R. L. & Mach-Aigner, A. R., 1 Jan 2011, In : Applied and Environmental Microbiology. 77, 1, p. 114-121

Research output: Contribution to journalArticleScientificpeer-review

82 Citations (Scopus)
2010

Array comparative genomic hybridisation analysis of Trichoderma reesei high cellulase producing strains

Vitikainen, M., Arvas, M., Pakula, T., Oja, M., Penttilä, M. & Saloheimo, M., 2010.

Research output: Contribution to conferenceConference articleScientific

Array comparative genomic hybridization analysis of Trichoderma reesei strains with enhanced cellulase production properties

Vitikainen, M., Arvas, M., Pakula, T., Oja, M., Penttilä, M. & Saloheimo, M., 19 Jul 2010, In : BMC Genomics. 11, 441.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
62 Citations (Scopus)

Detecting novel genes with sparse arrays

Arvas, M., Haiminen, N., Smit, B., Rautio, J., Vitikainen, M., Wiebe, M., Martinez, D., Chee, C., Kunkel, J., Sanchez, C., Nelson, M. A., Pakula, T., Saloheimo, M., Penttilä, M. & Kivioja, T., 1 Nov 2010, In : Gene. 467, 1-2, p. 41-51

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)

Discovery of a new tyrosinase-like enzyme family lacking a C-terminally processed domain: Production and characterization of an Aspergillus oryzae catechol oxidase

Gasparetti, C., Faccio, G., Arvas, M., Buchert, J., Saloheimo, M. & Kruus, K., 2010, In : Applied Microbiology and Biotechnology. 86, 1, p. 213-226 14 p.

Research output: Contribution to journalArticleScientificpeer-review

30 Citations (Scopus)

Exploring laccase-like multicopper oxidase genes from the ascomycete Trichoderma reesei: A functional, phylogenetic and evolutionary study

Levasseur, A., Saloheimo, M., Navarro, D., Andberg, M., Pontarotti, P., Kruus, K. & Record, E., 2010, In : BMC biochemistry. 11, 32

Research output: Contribution to journalArticleScientificpeer-review

Open Access
34 Citations (Scopus)

Secreted fungal sulfhydryl oxidases: sequence analysis and characterisation of a representative flavin-dependent enzyme from Aspergillus oryzae

Faccio, G., Kruus, K., Buchert, J. & Saloheimo, M., 2010, In : FEBS Journal. 277, Supplement 1, p. 280 YSF-28.

Research output: Contribution to journalOther journal contributionScientific

Secreted fungal sulfhydryl oxidases: Sequence analysis and characterisation of a representative flavin-dependent enzyme from Aspergillus oryzae

Faccio, G., Kruus, K., Buchert, J. & Saloheimo, M., 2010, In : BMC biochemistry. 11, 11 p., 31.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
12 Citations (Scopus)

Transcriptional analysis of Trichoderma reesei cultivated in the presence of different lignocellulose substrates

Häkkinen, M., Saloheimo, M., Pakula, T. & Penttilä, M., 2010.

Research output: Contribution to conferenceConference PosterScientific

Transcriptome and proteome analysis of an antibody Fab fragment producing Trichoderma reesei strain and its parental strain at different cultivation temperatures

Pakula, T., Bernard-Granger, L., Toikkanen, J., Oja, M., Wiebe, M., Saloheimo, M. & Penttilä, M., 2010.

Research output: Contribution to conferenceConference PosterScientific