Personal profile
Expertise area
PhD in Computational Physics. I model, engineer, and design biological macromolecules (enzymes, receptors, structural proteins, lipids, carbohydrates) at difference scale using existing and developing new methods in AI/ML, computational chemistry and molecular simulations.
Education/Academic qualification
Natural sciences, Doctorate, Computational Physics, University of Helsinki
Award Date: 29 Aug 2024
External positions
Visiting Researcher, University of Helsinki
17 May 2024 → 31 Dec 2025
Skills and expertise
- Molecular Modelling
- Protein engineering
- Machine Learning
- Computational Chemistry
- Quantum Chemistry
- Biophysics
- Biopolymers
- Molecular Simulations
- Structural Bioinformatics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 9 Industry, Innovation, and Infrastructure -
SDG 12 Responsible Consumption and Production
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Collaborations and top research areas from the last five years
Projects
- 3 Active
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BIOCOLL: Producing Collagen peptides in Trichoderma Reesei using precision fermentation technology
Pietiäinen, M. (Manager), Healy-Rehn, M. (PI), Nakari-Setälä, T. (Owner), Aalto, A. (Participant), Casteleijn, M. (Participant), Tal, R. (Participant) & Girych, M. (Participant)
1/09/25 → 28/02/27
Project: Business Finland project
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FinBioFAB: Finnish BioFoundry for Advanced Biomanufacturing
Barth, D. (Manager), Nygård, Y. (PI), Koponen, T. (Participant), Girych, M. (Participant), Castillo, S. (Participant), Åkerman, M. (Participant), Lehtinen, S. (Participant), Nakari-Setälä, T. (Owner), Jäntti, J. (Participant), Healy-Rehn, M. (Participant), Laukkanen, A. (Participant), Aro, N. (Participant), Hentula, M. (Participant), Tenkanen, T. (Participant), Choo, H. (Participant) & Nguyen, T. (Participant)
1/01/25 → 31/12/29
Project: Business Finland project
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FoodID: NSF Food Innovation and Diversification to Advance the Bioeconomy
Honkapää, K. (Manager), Sözer, N. (Owner), Nordström, E. (Owner), Ollila, S. (Manager), Aalto, A. (Participant), Uusitalo, J. (Participant), Småros, F. (Participant), Troullier, M. (Participant), Pietiäinen, M. (Participant), Juvonen, R. (Participant), Aisala, H. (Participant), Tsitko, I. (Participant), Kortekangas, A. (Participant), Lille, M. (Participant), Alakomi, H.-L. (Participant), Castillo, S. (Participant), Alaraasakka, R.-M. (Participant), Tiainen, V. (Participant), Nisov, A. (Participant) & Girych, M. (Participant)
Funded by Research Council of Finland, Business Finland
1/01/25 → 31/12/27
Project: Business Finland project
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Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting
Clubb, J. H. A., Kudling, T. V., Girych, M., Haybout, L., Pakola, S., Hamdan, F., Cervera-Carrascon, V., Hemmes, A., Grönberg-Vähä-Koskela, S., Santos, J. M., Quixabeira, D. C. A., Basnet, S., Heiniö, C., Arias, V., Jirovec, E., Kaptan, S., Havunen, R., Sorsa, S., Erikat, A. & Schwartz, J. & 7 others, , 3 Feb 2023, In: Frontiers in Immunology. 14Research output: Contribution to journal › Article › Scientific › peer-review
Open Access11 Link opens in a new tab Citations (Scopus) -
How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)
Girych, M., Kulig, W., Enkavi, G. & Vattulainen, I., Oct 2023, In: Cold Spring Harbor perspectives in biology. 15, a041419.Research output: Contribution to journal › Review Article › peer-review
15 Link opens in a new tab Citations (Scopus) -
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
Moliner, R., Girych, M., Brunello, C. A., Kovaleva, V., Biojone, C., Enkavi, G., Antenucci, L., Kot, E., Goncharuk, S., Kaurinkoski, K., Kuutti, M., Fred, S. M., Elsilä, L., Sakson, S., Cannarozzo, C., Diniz, C. R. A. F., Seiffert, N., Rubiolo, A., Haapaniemi, H. & Mesi, E. & 13 others, , Jun 2023, In: Nature Neuroscience. 26, p. 1032–1041Research output: Contribution to journal › Article › Scientific › peer-review
Open Access364 Link opens in a new tab Citations (Scopus) -
Maturation of the SARS-CoV-2 virus is regulated by dimerization of its main protease
Kaptan, S., Girych, M., Enkavi, G., Kulig, W., Sharma, V., Vuorio, J., Rog, T. & Vattulainen, I. T., 2022, In: Computational and Structural Biotechnology Journal. 20, p. 3336-3346 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access13 Link opens in a new tab Citations (Scopus) -
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
Casarotto, P., Girych, M., Fred, S. M., Kovaleva, V., Moliner, R., Enkavi, G., Biojone, C., Cannarozzo, C., Sahu, M. P., Kaurinkoski, K., Brunello, C. A., Steinzeig, A., Winkel, F., Patil, S., Vestring, S., Serchov, T., Diniz, C. R. A. F., Laukkanen, L., Cardon, I. & Antila, H. P. & 8 others, , Mar 2021, In: Cell. 184, 5, p. 1299-1313.e19Research output: Contribution to journal › Article › Scientific › peer-review
Open Access541 Link opens in a new tab Citations (Scopus)