RI services to promote deep digitalization of Industrial Biotechnology - towards smart biomanufacturing

Project: EU project

Project Details


Industrial Biotechnology (IB) is a Key Enabling Technology for the circular bio-economy, industrial renewal and European manufacturing autonomy. Its development forms a vital part of EU’s strategy to become climate neutral in 2050. For IB to become a major manufacturing technology, it must widen its use of advanced digital technologies. These will improve R&D efficiency, reducing time-to-market and costs. Moreover, for manufacturing, advanced digital technologies will drive distributed, autonomous and highly adaptable production systems. To support digitalization of IB, BIOINDUSTRY 4.0 will create new services delivered by European research infrastructures (RI). These services will address several challenges, focusing on the acceleration of bio-process development pipelines. Drawing on the complementary skills of its consortium, BIOINDUSTRY 4.0 will develop data-driven approaches, exploiting AI to empower novel decision support systems and digital twins, the latter being to better design bio-processes and enable their real-time online control. To complete these services, BIOINDUSTRY 4.0 will also develop data and metadata standards to generate high quality, interoperable multi-scale bio-process data, the technical basis for trusted data networks and process analytical devices to provide real-time online monitoring of bio-processes. Once deployed, these RI services will provide Users with access to cutting-edge technologies that can be used singly or in an integrated way, covering whole R&D pipelines. Integrated services will be delivered by a distributed RI, conferring Europe with a unique R&D test-bed for bio-process development and a competitive advantage with respect to global competition. To succeed, BIOINDUSTRY 4.0 brings together 6 EU RIs, 1 global company, 2 innovative EU SMEs and several research teams around an ambitious 4-year workplan that will be implemented in consultation with IB stakeholders, using a co-design strategy to specify goals.
Effective start/end date1/01/2331/12/26

Collaborative partners

  • VTT Technical Research Centre of Finland
  • Flemish Institute for Technological Research (VITO)
  • LifeGlimmer GmbH
  • Biofaction KG
  • University of Manchester
  • Biobanks and Biomolecular Resources Research Infrastructure Consortium (BBMRI-ERIC)
  • RWTH Aachen University
  • National Technical University of Athens
  • Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V.
  • INRAE Transfert SAS
  • University of Valencia
  • SYMBIOLABS Circular Intelligence P.C.
  • Athena Research and Innovation Center In Information Communication & Knowledge Technologies
  • Institut National des Sciences Appliquées de Toulouse (INSAT)
  • Bioeconomy for Change (B4C)
  • Newcastle University
  • Timegate Instruments Oy
  • Siemens Process Systems Engineering Ltd
  • National Research Council (CNR)
  • Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures
  • Wageningen University & Research (WUR)
  • Autonomous University of Barcelona
  • University of Koblenz-Landau
  • National Research Institute for Agriculture, Food and Environment (INRAE) (lead)
  • Hubrecht Institute for Developmental Biology and Stem Cell Research

Funding category

  • Horizon Europe


  • HORIZON-INFRA-2022-TECH-01-01
  • industrial biotechnology
  • data networks
  • bioeconomy
  • PAT devices
  • online monitoring
  • digitalization
  • Raman
  • online microscope
  • S. cerevisiae