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2019
1 Citation (Scopus)

A Decision Support System for Diagnostics and Treatment Planning in Traumatic Brain Injury

Umer, A., Mattila, J., Liedes, H., Koikkalainen, J., Lotjonen, J., Katila, A., Frantzen, J., Newcombe, V., Tenovuo, O., Menon, D. & van Gils, M., 1 May 2019, In : IEEE Journal of Biomedical and Health Informatics. 23, 3, p. 1261-1268 8370619.

Research output: Contribution to journalArticleScientificpeer-review

Decision support systems
Brain
Planning
Software Design
Validation Studies
1 Downloads (Pure)

A system dynamics model for evaluating the impact of public investments in a data-driven precision medicine ecosystem

Lähteenmäki, J., Ruutu, S., Ylén, P. & van Gils, M., 23 Jul 2019, p. ThPOS-33.40.

Research output: Contribution to conferenceConference AbstractScientificpeer-review

System dynamics model
Business activity
Ecosystem
Economic benefits
Healthcare
1 Citation (Scopus)

Automatically computed rating scales from MRI for patients with cognitive disorders

Koikkalainen, J. R., Rhodius-Meester, H. F. M., Frederiksen, K. S., Bruun, M., Hasselbalch, S. G., Baroni, M., Mecocci, P., Vanninen, R., Remes, A., Soininen, H., van Gils, M., van der Flier, W. M., Scheltens, P., Barkhof, F., Erkinjuntti, T. & Lötjönen, J. M. P., 1 Sep 2019, In : European Radiology. 29, 9, p. 4937-4947 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Atrophy
Temporal Lobe
Dementia
Biomarkers
Frontotemporal Lobar Degeneration
1 Citation (Scopus)

Correlation of blood biomarkers and biomarker panels with traumatic findings on computed tomography after traumatic brain injury

Posti, J. P., Takala, R. S. K., Lagerstedt, L., Dickens, A. M., Hossain, I., Mohammadian, M., Ala-Seppälä, H., Frantzén, J., van Gils, M., Hutchinson, P. J., Katila, A. J., Maanpaä, H. R., Menon, D. K., Newcombe, V. F., Tallus, J., Hrusovsky, K., Wilson, D. H., Gill, J., Sanchez, J. C., Tenovuo, O. & 2 others, Zetterberg, H. & Blennow, K., 15 Jul 2019, In : Journal of Neurotrauma. 36, 14, p. 2178-2189

Research output: Contribution to journalArticleScientificpeer-review

Biomarkers
Tomography
Glial Fibrillary Acidic Protein
Intermediate Filaments
Fatty Acid-Binding Proteins
3 Citations (Scopus)

Detecting frontotemporal dementia syndromes using MRI biomarkers

Bruun, M., Koikkalainen, J., Rhodius-Meester, H. F. M., Baroni, M., Gjerum, L., van Gils, M., Soininen, H., Remes, A., Hartikainen, P., Waldemar, G., Mecocci, P., Barkhof, F., Pijnenburg, Y., van der Flier, W. M., Hasselbalch, S. G., Lötjönen, J. & Frederiksen, K. S., 4 Feb 2019, In : NeuroImage: Clinical. 22, p. 101711 101711.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Frontotemporal Dementia
Biomarkers
Magnetic Resonance Imaging
Area Under Curve
Primary Progressive Aphasia

Early Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein in Predicting the Outcome of Mild Traumatic Brain Injury

Hossain, I., Mohammadian, M., Takala, R. S. K., Tenovuo, O., Lagerstedt, L., Ala-Seppälä, H. M., Frantzén, J., van Gils, M., Hutchinson, P. J., Katila, A. J., Maanpää, H-R., Menon, D., Newcombe, V., Tallus, J., Hrusovsky, K., Wilson, D., Blennow, K., Sanchez, J-C., Zetterberg, H. & Posti, J. P., 15 May 2019, In : Journal of Neurotrauma. 36, 10, p. 1551-1560

Research output: Contribution to journalArticleScientificpeer-review

Brain Concussion
Glial Fibrillary Acidic Protein
Glasgow Outcome Scale
Tomography
neurofilament protein L
1 Citation (Scopus)

Impact of a Clinical Decision Support Tool on Dementia Diagnostics in Memory Clinics: The PredictND Validation Study

Bruun, M., Frederiksen, K. S., Rhodius-Meester, H. F. M., Baroni, M., Gjerum, L., Koikkalainen, J., Urhemaa, T., Tolonen, A., van Gils, M., Tong, T., Guerrero, R., Rueckert, D., Dyremose, N., Bo Andersen, B., Simonsen, A. H., Lemstra, A. W., Hallikainen, M., Kurl, S., Herukka, S-K., Remes, A. M. & 6 others, Waldemar, G., Soininen, H., Mecocci, P., van der Flier, W. M., Lötjönen, J. & Hasselbalch, S. G., Feb 2019, In : Current Alzheimer Research. 16, 2, p. 91-101 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Clinical Decision Support Systems
Validation Studies
Dementia
Differential Diagnosis
Lewy Body Disease

Impact of a clinical decision support tool on prediction of progression in early-stage dementia: A prospective validation study

Bruun, M., Frederiksen, K. S., Rhodius-Meester, H. F. M., Baroni, M., Gjerum, L., Koikkalainen, J., Urhemaa, T., Tolonen, A., van Gils, M., Rueckert, D., Dyremose, N., Andersen, B. B., Lemstra, A. W., Hallikainen, M., Kurl, S., Herukka, S. K., Remes, A. M., Waldemar, G., Soininen, H., Mecocci, P. & 3 others, Van Der Flier, W. M., Lötjönen, J. & Hasselbalch, S. G., 20 Mar 2019, In : Alzheimer's Research and Therapy. 11, 1, 25.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Clinical Decision Support Systems
Validation Studies
Dementia
Prospective Studies
Cognitive Dysfunction

Multivariate prediction of Hippocampal atrophy in Alzheimer's disease

Liedes, H., Lötjönen, J., Kortelainen, J. M., Novak, G., van Gils, M. & Gordon, M. F., 23 Apr 2019, In : Journal of Alzheimer's Disease. 68, 4, p. 1453-1468

Research output: Contribution to journalArticleScientificpeer-review

Atrophy
Alzheimer Disease
Magnetic Resonance Spectroscopy
Biomarkers
Neuropsychological Tests

"OPTImAL": An ontology for patient adherence modeling in physical activity domain

Livitckaia, K., Koutkias, V., Kouidi, E., van Gils, M., Maglaveras, N. & Chouvarda, I., 25 Apr 2019, In : BMC Medical Informatics and Decision Making. 19, 1, 15 p., 92.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Patient Compliance
Exercise
Cardiovascular Diseases
Neon
Psychology
2 Citations (Scopus)

Prediction models for dementia and neuropathology in the oldest old: The Vantaa 85+ cohort study 11 Medical and Health Sciences 1109 Neurosciences

Hall, A., Pekkala, T., Polvikoski, T., van Gils, M., Kivipelto, M., Lötjönen, J., Mattila, J., Kero, M., Myllykangas, L., Mäkelä, M., Oinas, M., Paetau, A., Soininen, H., Tanskanen, M. & Solomon, A., 22 Jan 2019, In : Alzheimer's Research and Therapy. 11, 1, p. 11 11.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Neurosciences
Dementia
Cohort Studies
Health
Pathology
2018

Adherence to physical activity in patients with heart disease: Types, settings and evaluation instruments

Livitckaia, K., Koutkias, V., Maglaveras, N., Kouidi, E., van Gils, M. & Chouvarda, I., 1 Jan 2018, Precision Medicine Powered by pHealth and Connected Health: ICBHI 2017. Springer, p. 255-259 5 p. (IFMBE Proceedings, Vol. 66).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Patient rehabilitation
4 Citations (Scopus)

Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis

Cajanus, A., Hall, A., Koikkalainen, J., Solje, E., Tolonen, A., Urhemaa, T., Liu, Y., Haanpää, R. M., Hartikainen, P., Helisalmi, S., Korhonen, V., Rueckert, D., Hasselbalch, S., Waldemar, G., Mecocci, P., Vanninen, R., van Gils, M., Soininen, H., Lötjönen, J. & Remes, A. M., 3 Apr 2018, In : Dementia and Geriatric Cognitive Disorders Extra. 8, 1, p. 51-59 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Frontotemporal Dementia
Lewy Body Disease
Alzheimer Disease
Atrophy
Differential Diagnosis

Consistensy of Muistikko web-based cognitive test while performed at clinic and at home

Lötjönen, J., Paajanen, T., Bruun, M., Mahdiani, S., Baroni, M., Rhodius-Meester, H., Herukka, S-K., Lemstra, A. W., Pikkarainen, M., Hänninen, T., van Gils, M., Hasselbalch, S., Mecocci, P., Remes, A. M., van der Flier, W. M. & Soininen, H., 1 Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 418-418 P1-328.

Research output: Contribution to journalArticleScientificpeer-review

117 Downloads (Pure)
Open Access
File
medicine
stakeholder
ecosystem
genome
infrastructure

Detecting frontotemporal dementia using a novel MRI imaging biomarker: The anterior versus posterior index

Bruun, M., Koikkalainen, J., Rhodius-Meester, H. F. M., Baroni, M., Gjerum, L., van Gils, M., Soininen, H., Remes, A. M., Waldemar, G., Mecocci, P., van der Flier, W. M., Hasselbalch, S., Jyrki, L. & Frederiksen, K. S., 1 Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 821-822 P2-350.

Research output: Contribution to journalArticleScientific

Frontotemporal Dementia
Biomarkers
Atrophy
Dementia
Frontal Lobe

Different combinations of diagnostic tests discriminate specific subtypes of dementia

Rhodius-Meester, H. F. M., Bruun, M., Baroni, M., Gjerum, L., Remes, A. M., Urhemaa, T., Tolonen, A., Rueckert, D., van Gils, M., Lemstra, E., Barkhof, F., Frederiksen, K. S., Waldemar, G., Scheltens, P., Soininen, H., Mecocci, P., Koikkalainen, J., Lötjönen, J. & van der Flier, W. M., 1 Jul 2018, In : Alzheimer's and Dementia. 10, 7, p. 820-821 P2-349.

Research output: Contribution to journalArticleScientific

7 Citations (Scopus)

Disease-related determinants are associated with mortality in dementia due to Alzheimer's disease

Rhodius-Meester, H. F. M., Liedes, H., Koene, T., Lemstra, A. W., Teunissen, C. E., Barkhof, F., Scheltens, P., van Gils, M., Lötjönen, J. & van der Flier, W. M., 2018, In : Alzheimer's Research and Therapy. 10, 1, 23.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Dementia
Alzheimer Disease
Comorbidity
Mortality
Atrophy
4 Citations (Scopus)

Evaluating combinations of diagnostic tests to discriminate different dementia types

Bruun, M., Rhodius-Meester, H. F. M., Koikkalainen, J., Baroni, M., Gjerum, L., Lemstra, A. W., Barkhof, F., Remes, A. M., Urhemaa, T., Tolonen, A., Rueckert, D., van Gils, M., Frederiksen, K. S., Waldemar, G., Scheltens, P., Mecocci, P., Soininen, H., Lötjönen, J., Hasselbalch, S. G. & van der Flier, W. M., 1 Jan 2018, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 509-518 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Routine Diagnostic Tests
Dementia
Lewy Body Disease
Frontotemporal Dementia
Vascular Dementia
6 Citations (Scopus)

Platform for systems medicine research and diagnostic applications in psychotic disorders-The METSY project

Frank, E., Maier, D., Pajula, J., Suvitaival, T., Borgan, F., Butz-Ostendorf, M., Fischer, A., Hietala, J., Howes, O., Hyötyläinen, T., Janssen, J., Laurikainen, H., Moreno, C., Suvisaari, J., van Gils, M. & Orešič, M., 1 Apr 2018, In : European Psychiatry. 50, p. 40-46 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Systems Analysis
Psychotic Disorders
Research
Endocannabinoids
Lipid Metabolism
4 Citations (Scopus)

Quantitative EEG Parameters for Prediction of Outcome in Severe Traumatic Brain Injury: Development Study

Tolonen, A., Särkelä, M., Takala, R., Katila, A., Frantzén, J., Posti, J., Müller, M., van Gils, M. & Tenovuo, O., 2018, In : Clinical EEG and Neuroscience. 49, 4, p. 248-257 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Electroencephalography
Area Under Curve
Intensive Care Units
Traumatic Brain Injury
Glasgow Outcome Scale
1 Citation (Scopus)

Reproducibility of standardized fine motor control tasks and age effects in healthy adults

Smits, E. J., Tolonen, A. J., Cluitmans, L., van Gils, M., Zietsma, R. C., Tijssen, M. A. J. & Maurits, N. M., 1 Jan 2018, In : Measurement. 114, Jan, p. 177-184

Research output: Contribution to journalArticleScientificpeer-review

Monitoring
tracing
correlation coefficients
Parkinson disease
disorders

The potential of low-cost tests for decision support in neurodegenerative diseases

van Gils, M., Mahdiani, S., Pärkkä, J. & Lötjönen, J., 6 Jun 2018, 8th Kuopio Alzheimer Symposium: From translational research to biomarkers, treatment and prevention strategies. Malm, T. (ed.). University of Eastern Finland, p. 34 1 p. (Reports and Studies in Health Sciences; No. 26).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Open Access
Gait
Neurodegenerative Diseases
Dementia
Video Games
Costs and Cost Analysis
1 Citation (Scopus)

Validation of prognostic biomarker scores for predicting progression of dementia in patients with amnestic mild cognitive impairment

Moreland, J., Urhemaa, T., van Gils, M., Lötjönen, J., Wolber, J. & Buckley, C. J., 1 Jan 2018, In : Nuclear Medicine Communications. 39, 4, p. 297-303

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Dementia
Biomarkers
Amyloid
Alzheimer Disease
Psychometrics
2017

Detecting cognitive disorders using the Muistikkoweb-based cognitive test battery: Validation in three cohorts

Paajanen, T., Mahdiani, S., Bruun, M., Baroni, M., Rhodius-Meester, H. F. M., Lemstra, A. W., Herukka, S-K., Pikkarainen, M., Hänninen, T., Ngandu, T., Kivipelto, M., van Gils, M., Hasselbalch, S., Mecocci, P., van der Flier, W. M., Remes, A., Soininen, H. & Lötjönen, J., 2017, Alzheimers and Dementia, Abstract Supplement. Elsevier, p. 234-235

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific

Detection of cognitive disorders using web-based cognitive games: Validation against traditional methods

Mahdiani, S., Paajanen, T., Bruun, M., Baroni, M., Rhodius-Meester, H., Lemstra, A. W., Herukka, S-K., Pikkarainen, M., Hänninen, T., Ngandu, T., Kivipelto, M., van Gils, M., Hasselbach, S., Mecocci, P., van der Flier, W. M., Remes, A., Soininen, H. & Lötjönen, J., 2017.

Research output: Contribution to conferenceConference AbstractScientific

Detection of cognitive disorders using web-based cognitive test battery: Validation against traditional methods

Mahdiani, S., Paajanen, T., Bruun, M., Baroni, M., Rhodius-Meester, H., Lemstra, A. W., Herukka, S-K., Pikkarainen, M., Hänninen, T., Ngandu, T., Kivipelto, M., van Gils, M., Hasselbach, S., Mecocci, P., van der Flier, W. M., Remes, A., Soininen, H. & Lötjönen, J., 2017.

Research output: Contribution to conferenceConference AbstractScientific

Gait as predictor of dementia

Pärkkä, J., Mahdiani, S., Bruun, M., Baroni, M., Rhodius-Meester, H., Herukka, S-K., van Gils, M., Hasselbalch, S., Mecocci, P., van der Flier, W., Remes, A., Soininen, H. & Lötjönen, J., 2017.

Research output: Contribution to conferenceConference AbstractScientific

27 Citations (Scopus)

Glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 are not specific biomarkers for mild CT-negative traumatic brain injury

Posti, J. P., Hossain, I., Takala, R. S. K., Liedes, H., Newcombe, V., Outtrim, J., Katila, A. J., Frantzén, J., Ala-Seppälä, H., Coles, J. P., Kyllönen, A., Maanpää, H-R., Tallus, J., Hutchinson, P. J., van Gils, M., Menon, D. K. & Tenovuo, O., 1 Apr 2017, In : Journal of Neurotrauma. 34, 7, p. 1427-1438 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Ubiquitin Thiolesterase
Glial Fibrillary Acidic Protein
Brain Concussion
Protein C
Biomarkers
8 Citations (Scopus)

Graphical Tasks to Measure Upper Limb Function in Patients with Parkinson's Disease: Validity and Response to Dopaminergic Medication

Smits, E. J., Tolonen, A. J., Cluitmans, L., van Gils, M., Zietsma, R. C., Borgemeester, R. W. K., van Laar, T. & Maurits, N. M., 1 Jan 2017, In : IEEE Journal of Biomedical and Health Informatics. 21, 1, p. 283-289

Research output: Contribution to journalArticleScientificpeer-review

Upper Extremity
Parkinson Disease
Tremor

New measurement methods for early detection of cognitive decline

Mahdiani, S., Pärkkä, J., van Gils, M. & Lötjönen, J., 2017, Ikääntyminen ja teknologia. Leikas, J. (ed.). Helsinki: VTT Technical Research Centre of Finland, p. 12-17 (VTT Research Highlights; No. 14).

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleProfessional

Open Access
Dementia
Gait
Biomarkers
Costs and Cost Analysis
Cognitive Dysfunction
1 Citation (Scopus)

Overview of health behavior change interventions to promote physical-activity-related adherence in patients with heart disease

Livitckaia, K., Koutkias, V., Maglaveras, N., Kouidi, E., van Gils, M. & Chouvarda, I., 1 Jan 2017, EMBEC and NBC 2017 - Joint Conference of the European Medical and Biological Engineering Conference EMBEC 2017 and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2017. Eskola, H., Vaisanen, O., Viik, J. & Hyttinen, J. (eds.). Springer, Vol. 65. p. 286-289 4 p. (IFMBE Proceedings, Vol. 65).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Health
Patient rehabilitation
Decision making

Procedures for Evaluating the Adequacy of Anesthesia

van Gils, M., Korhonen, I. & Yli-Hankala, A., 1 Jan 2017, In : Critical Reviews in Biomedical Engineering. 45, 1-6, p. 187-218 32 p.

Research output: Contribution to journalArticleScientificpeer-review

Neurology
Bioelectric potentials
Electroencephalography
2016
3 Citations (Scopus)

Comparison of train-of-four ratios measured with Datex-Ohmeda's M-NMT MechanoSensor and M-NMT ElectroSensor

Salminen, J., van Gils, M., Paloheimo, M. & Yli-Hankala, A., 2016, In : Journal of Clinical Monitoring and Computing. 30, 3, p. 295-300

Research output: Contribution to journalArticleScientificpeer-review

Neuromuscular Blockade
Anesthesia
Propofol
Anesthetics
Equipment and Supplies
34 Citations (Scopus)

Glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 as outcome predictors in traumatic brain injury

Takala, R. S. K., Posti, J. P., Runtti, H., Newcombe, V. F., Outtrim, J., Katila, A. J., Frantzén, J., Ala-Seppälä, H., Kyllönen, A., Maanpää, H-R., Tallus, J., Hossain, M. I., Coles, J. P., Hutchinson, P., van Gils, M., Menon, D. K. & Tenovuo, O., 2016, In : World Neurosurgery. 87, p. 8-20

Research output: Contribution to journalArticleScientificpeer-review

Ubiquitin Thiolesterase
Glial Fibrillary Acidic Protein
Protein C
Glasgow Outcome Scale
Brain Injuries
2 Citations (Scopus)

Prediction of Outcome after Traumatic Brain Injury: Comparison of Disease State Index and IMPACT Calculator

Liedes, H., Mattila, J., Lingsma, H., Lötjönen, J., Menon, D., Tenovuo, O. & van Gils, M., 2016, pHealth 2016. Vol. 224. p. 175-180 (Studies in Health Technology and Informatics, Vol. 224).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Clinical Trials
Young Adult
Cause of Death
Decision Making
Traumatic Brain Injury
31 Citations (Scopus)

The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury: Correlations With Clinical and Imaging Findings

Posti, J., Takala, R. S. K., Runtti, H., Newcombe, V. F., Outtrim, J., Katila, A. J., Frantzén, J., Ala-Seppälä, H., Coles, J. P., Hossain, M. I., Kyllönen, A., Maanpää, H-R., Tallus, J., Hutchinson, P. J., van Gils, M., Menon, D. K. & Tenovuo, O., 2016, In : Neurosurgery. 79, 3, p. 456-464

Research output: Contribution to journalArticleScientificpeer-review

Ubiquitin Thiolesterase
Glial Fibrillary Acidic Protein
Protein C
Glasgow Coma Scale
Wounds and Injuries
2015
1 Citation (Scopus)

Distinguishing Parkinson's disease from other syndromes causing tremor using automatic analysis of writing and drawing tasks

Tolonen, A., Cluitmans, L., Smits, E., van Gils, M., Maurits, N. & Zietsma, R., 2015, Bioinformatics and Bioengineering (BIBE), 2015 IEEE 15th International Conference on. IEEE Institute of Electrical and Electronic Engineers , p. 1-4

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Tremor
Parkinson Disease
Essential Tremor
Motor Skills
Movement Disorders
40 Citations (Scopus)

Telemonitoring and mobile phone-based health coaching among finnish diabetic and heart disease patients: a randomized controlled trial

Karhula, T., Vuorinen, A-L., Rääpysjärvi, K., Pakanen, M., Itkonen, P., Tepponen, M., Junno, U-M., Jokinen, T., van Gils, M., Lähteenmäki, J., Kohtamäki, K. & Saranummi, N., 2015, In : Journal of Medical Internet Research. 17, 6, e153.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Cell Phones
Heart Diseases
Randomized Controlled Trials
Health
Mentoring

Wavelet Based Analysis of the Heart Rate during Recovery in a Guided Rehabilitation Exercise Program

Filos, D., Chouvarda, I., van Gils, M. & Maglaveras, N., 2015, 6th European Conference of the International Federation for Medical and Biological Engineering: IFMBE Proceedings. Springer, p. 281-284

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Exercise Therapy
Wavelet Analysis
Heart Rate
Exercise
Parasympathetic Nervous System