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    2019
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    Author

    Tuulikki Seppänen-Laakso
2019

A Small In Vitro Fermentation Model for Screening the Gut Microbiota Effects of Different Fiber Preparations

Tsitko, I., Wiik-Miettinen, F., Mattila, O., Rosa-Sibakov, N., Seppänen-Laakso, T., Maukonen, J., Nordlund, E. & Saarela, M., 18 Apr 2019, In : International Journal of Molecular Sciences. 20, 8, 1925.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
fermentation
Fermentation
Screening
screening
Microbiota

Methyljasmonate Elicitation Increases Terpenoid Indole Alkaloid Accumulation in Rhazya stricta Hairy Root Cultures

Akhgari, A., Laakso, I., Maaheimo, H., Choi, Y. H., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 22 Nov 2019, In : Plants. 8, 12, 534.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Rhazya stricta
indole alkaloids
alkaloid
methyl jasmonate
terpenoids
2018
3 Citations (Scopus)

Euglena gracilis growth and cell composition under different temperature, light and trophic conditions

Wang, Y., Seppänen-Laakso, T., Rischer, H. & Wiebe, M. G., 1 Apr 2018, In : PLoS ONE. 13, 4, e0195329.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Euglena gracilis
Light
Biomass
Temperature
Cells
2 Citations (Scopus)

Interlaboratory coverage test on plant food bioactive compounds and their metabolites by mass spectrometry-based untargeted metabolomics

Koistinen, V. M., da Silva, A. B., Abrankó, L., Low, D., Villalba, R. G., Barberán, F. T., Landberg, R., Savolainen, O., Alvarez-Acero, I., de Pascual-Teresa, S., Van Poucke, C., Almeida, C., Petrásková, L., Valentová, K., Durand, S., Wiczkowski, W., Szawara-Nowak, D., González-Domínguez, R., Llorach, R., Andrés-Lacueva, C. & 5 others, Aura, A. M., Seppänen-Laakso, T., Hanhineva, K., Manach, C. & Bronze, M. R., 1 Sep 2018, In : Metabolites. 8, 3, 46.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Edible Plants
Metabolomics
Metabolites
Mass spectrometry
Mass Spectrometry
2 Citations (Scopus)

In Vitro Gut Metabolism of [U-13C]-Quinic Acid, The Other Hydrolysis Product of Chlorogenic Acid

Naranjo Pinta, M., Montoliu, I., Aura, A. M., Seppänen-Laakso, T., Barron, D. & Moco, S., 1 Nov 2018, In : Molecular Nutrition and Food Research. 62, 22, 1800396.

Research output: Contribution to journalArticleScientificpeer-review

Caffeic Acids
Quinic Acid
Chlorogenic Acid
quinic acid
chlorogenic acid
3 Citations (Scopus)
Open Access
Plant Cells
Food
Vaccinium vitis-idaea
Fruit
Hydrolysis

Prepartal high-energy feeding with grass silage-based diets does not disturb the hepatic adaptation of dairy cows during the periparturient period

Qin, N., Kokkonen, T., Salin, S., Seppänen-Laakso, T., Taponen, J., Vanhatalo, A. & Elo, K., 1 Oct 2018, In : Journal of Dairy Science. 101, 10, p. 8929-8943 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Silage
grass silage
Poaceae
dairy cows
Diet
2017

Bioconversion to raspberry ketone is achieved by several non-related plant cell cultures

Häkkinen, S., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 2017, Frontiers Research Topic: Engineering the plant factory for the production of biologics and small-molecule medicines. De Martinis, D., Franconi, R., Benvenuto, E., Rybicki, E. P. & Fujiyama, K. (eds.). Frontiers Media, p. 334-342

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

Open Access
1 Citation (Scopus)

Chemical profiling and bioactivity of body wall lipids from strongylocentrotus droebachiensis

Shikov, A. N., Laakso, I., Pozharitskaya, O. N., nen-Laakso, T. S., Krishtopina, A. S., Makarova, M. N., Vuorela, H. & Makarov, V., 24 Nov 2017, In : Marine Drugs. 15, 12, 365.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Strongylocentrotus
Lipids
Fatty Acids
Palmitic Acids
Monounsaturated Fatty Acids
17 Citations (Scopus)
Open Access
Brewing
Saccharomyces
Beer
Yeast
Flavors

Liquid chromatography-mass spectrometry (LC-MS)-based analysis of molecular lipids in algae samples

Nygren, H., Seppänen-Laakso, T. & Rischer, H., 21 Nov 2017, In : Methods in Molecular Biology. p. 1-8

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Metabolite profiling of the carnivorous pitcher plants Darlingtonia and Sarracenia

Hotti, H., Gopalacharyulu, P., Seppänen-Laakso, T. & Rischer, H., 1 Feb 2017, In : PLoS ONE. 12, 2, 21 p., e0171078.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Sarraceniaceae
Sarracenia
Metabolites
metabolites
Biosynthesis

Polyketide-derived alkaloids and anthraquinones in Aloe plants and cell cultures

Hotti, H., Häkkinen, S., Rischer, H. & Seppänen-Laakso, T., 2017, In : Journal of Plant Biotechnology Research. 1, 1, p. 1-15 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
polyketides
Aloe
anthraquinones
plant cultural practices
alkaloids
2 Citations (Scopus)

Prepartal overfeeding alters the lipidomic profiles in the liver and the adipose tissue of transition dairy cows

Qin, N., Kokkonen, T., Salin, S., Seppänen-Laakso, T., Taponen, J., Vanhatalo, A. & Elo, K., 1 Feb 2017, In : Metabolomics. 13, 2, 21.

Research output: Contribution to journalArticleScientificpeer-review

Dairies
Liver
Adipose Tissue
Tissue
Phosphatidylethanolamines
Sterols
Nonesterified Fatty Acids
Esters
Fatty Acids
Phytol
11 Citations (Scopus)

Variability in the production of tannins and other polyphenols in cell cultures of 12 Nordic plant species

Suvanto, J., Nohynek, L., Seppänen-Laakso, T., Rischer, H., Salminen, J-P. & Puupponen-Pimiä, R., Aug 2017, In : Planta. 246, 2, p. 227-241 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Tannins
Polyphenols
tannins
polyphenols
cell culture
2016
32 Citations (Scopus)

A healthy Nordic diet alters the plasma lipidomic profile in adults with features of metabolic syndrome in a multicenter randomized dietary intervention

Lankinen, M. A., Schwab, U. S., Kolehmainen, M., Paananen, J., Nygrén, H., Seppänen-Laakso, T. E., Poutanen, K. S., Hyötyläinen, T., Risérus, U., Savolainen, M. J., Hukkanen, J. & Brader, L., 2016, In : Journal of Nutrition. 146, 4, p. 662-672

Research output: Contribution to journalArticleScientificpeer-review

Plasmalogens
Diet
Fruit
Lipids
Ceramides
3 Citations (Scopus)

Whole-genome metabolic model of Trichoderma reesei built by comparative reconstruction

Castillo, S., Barth, D., Arvas, M., Pakula, T. M., Pitkänen, E., Blomberg, P., Seppänen-Laakso, T., Nygren, H., Sivasiddarthan, D., Penttilä, M. & Oja, M., 2016, In : Biotechnology for Biofuels. 9, 252, 20 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2015
4 Citations (Scopus)

Analysis of Beers from an 1840s’ Shipwreck

Londesborough, J., Dresel, M., Gibson, B., Juvonen, R., Holopainen, U., Mikkelson, A., Seppänen-Laakso, T., Viljanen, K., Virtanen, H., Wilpola, A., Hofmann, T. & Wilhelmson, A., 2015, In : Journal of Agricultural and Food Chemistry. 63, 9, p. 2525-2536

Research output: Contribution to journalArticleScientificpeer-review

Beer
beers
Acids
Humulus
Bottles
5 Citations (Scopus)

Analysis of indole alkaloids from Rhazya stricta hairy roots by ultra-performance liquid chromatography-mass spectrometry

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Molecules. 20, 12, p. 22621-22634

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Secologanin Tryptamine Alkaloids
Apocynaceae
Indole Alkaloids
alkaloids
Liquid chromatography
12 Citations (Scopus)

Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea

Pozharitskaya, O. N., Shikov, A. N., Laakso, I., Seppänen-Laakso, T., Makarenko, I. E., Faustova, N. M., Makarova, M. N. & Makarov, V. G., 2015, In : Journal of Functional Foods. 17, p. 227-234

Research output: Contribution to journalArticleScientificpeer-review

Strongylocentrotus
Strongylocentrotus nudus
Barents Sea
Sea Urchins
Gonads
2 Citations (Scopus)

Bioconversion to Raspberry Ketone is Achieved by Several Non-related Plant Cell Cultures

Häkkinen, S., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 24 Nov 2015, In : Frontiers in Plant Science. 6, p. 1-9 9 p., 1035.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
raspberries
biotransformation
ketones
cell culture
flavor compounds
8 Citations (Scopus)

Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Phytochemical Analysis. 26, 5, p. 331-338

Research output: Contribution to journalArticleScientificpeer-review

Rhazya stricta
Secologanin Tryptamine Alkaloids
Apocynaceae
indole alkaloids
Rhazya

Effects of ellagitannin rich berries on blood lipid profiles, gut microbiota and metabolism of phenolic compounds in metabolic syndrome

Puupponen-Pimiä, R., Seppänen-Laakso, T., Maukonen, J., Nohynek, L., Tómas-Barberán, F. A., Törrönen, R., Kolehmainen, M., Kankainen, M., Espín, J. C., Aura, A-M., Poutanen, K., Leppänen, T., Moilanen, E. & Oksman-Caldentey, K-M., 2015, In : Dosis. 33, 3, p. 55-76

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Fruit
Lipids
Hydrolyzable Tannins
8-epi-prostaglandin F2alpha
Blood Pressure

Metabolic engineering of secondary biosynthetic pathways in plants

Fräbel, S., Seppänen-Laakso, T., Rischer, H. & Heribert, W., 2015, Book of Abstracts: Challenges and prospects in PNP metabolic engineering and production: Final Conference,. 96

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

1 Citation (Scopus)

Physicochemical characterization of sahti, an 'ancient' beer style indigenous to Finland

Ekberg, J., Gibson, B., Joensuu, J. J., Krogerus, K., Magalhães, F., Mikkelson, A., Seppänen-Laakso, T. & Wilpola, A., 2015, In : Journal of the Institute of Brewing. 121, 4, p. 464-473

Research output: Contribution to journalArticleScientificpeer-review

Finland
beers
brewing
alcohols
Alcohols
6 Citations (Scopus)

Polyketide synthases from poison hemlock (Conium maculatum L.)

Hotti, H., Seppänen-Laakso, T., Arvas, M., Teeri, T. H. & Rischer, H., 2015, In : FEBS Journal. 282, 21, p. 4141-4156

Research output: Contribution to journalArticleScientificpeer-review

Conium
Polyketide Synthases
Poisons
Starters
Biosynthesis
68 Citations (Scopus)

The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

Van Moerkercke, A., Steensma, P., Schweizer, F., Pollier, J., Gariboldi, I., Payne, R., Vanden Bossche, R., Miettinen, K., Espoz, J., Purnama, P. C., Kellner, F., Seppänen-Laakso, T., O'Connor, S. E., Rischer, H., Memelink, J. & Goossens, A., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 26, p. 8130-8135

Research output: Contribution to journalArticleScientificpeer-review

Open Access
basic helix-loop-helix transcription factors
indole alkaloids
Catharanthus roseus
monoterpenoids
Catharanthus