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    Kirsi-Marja Oksman-Caldentey
2019

European Court of Justice delivers no justice to Europe on genome‐edited crops

Schulman, A. H., Oksman-Caldentey, K-M. & Teeri, T., Jun 2019, In : Plant Biotechnology Journal. p. 1-3

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Methyljasmonate Elicitation Increases Terpenoid Indole Alkaloid Accumulation in Rhazya stricta Hairy Root Cultures

Akhgari, A., Laakso, I., Maaheimo, H., Choi, Y. H., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 22 Nov 2019, In : Plants. 8, 12, 534.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Rhazya stricta
indole alkaloids
alkaloid
methyl jasmonate
terpenoids
2018

Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells

Häkkinen, S. T., Nygren, H., Maiorova, N., Haavikko, R., Alakurtti, S., Yli-Kauhaluoma, J., Rischer, H. & Oksman-Caldentey, K. M., 1 Jul 2018, In : Planta Medica. 84, 9-10, p. 743-748 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Plant Cells
Biotransformation
Catharanthus
Derivatives
Pentoses

Progress and Prospects of Hairy Root Research

Häkkinen, S. & Oksman-Caldentey, K-M., 2018, Hairy Roots. Srivastava, V., Mehrotra, S. & Mishra, S. (eds.). Springer, p. 3 - 19

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

biotechnology
Rhizobium rhizogenes
bioremediation
engineers
recombinant proteins

Skopolamiinia tuottavien karvajuurien metabolinen stabiilisuus: 16 vuoden ylläpidon jälkeen

Häkkinen, S. & Oksman-Caldentey, K-M., 2018, In : Dosis. 34, 4, p. 277-287

Research output: Contribution to journalReview ArticleScientific

2017

Bioconversion to raspberry ketone is achieved by several non-related plant cell cultures

Häkkinen, S., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 2017, Frontiers Research Topic: Engineering the plant factory for the production of biologics and small-molecule medicines. De Martinis, D., Franconi, R., Benvenuto, E., Rybicki, E. P. & Fujiyama, K. (eds.). Frontiers Media, p. 334-342

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

Open Access
3 Citations (Scopus)

Biotechnology of the medicinal plant Rhazya stricta: A little investigated member of the Apocynaceae family

Akhgari, A., Oksman-Caldentey, K-M. & Rischer, H., 2017, In : Biotechnology Letters. 39, 6, p. 829-840 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Secologanin Tryptamine Alkaloids
Apocynaceae
Medicinal Plants
Biotechnology
Metabolic Engineering

Biotechnology of unique wild berries and their commercial application potential

Oksman-Caldentey, K-M., Nohynek, L., Häkkinen, S. T., Smolander, M., Rischer, H. & Puupponen-Pimiä, R., 2017, Fisiología Vegetal FVc2017: Libro de Abstracts. p. 2-3

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

4 Citations (Scopus)

Genetically engineered hairy root cultures of Hyoscyamus senecionis and H. muticus: ploidy as a promising parameter in the metabolic engineering of tropane alkaloids

Dehghan, E., Reed, D. W., Covello, P. S., Hasanpour, Z., Palazon, J., Oksman-Caldentey, K-M. & Ahmadi, F. S., 1 Oct 2017, In : Plant Cell Reports. 36, 10, p. 1615-1626 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Hyoscyamus
Hyoscyamus muticus
tropane alkaloids
metabolic engineering
ploidy
cosmetics
skin (animal)
small fruits
ingredients
cells
2016

A berry good story: berry cells as active ingredients for skin care products

Oksman-Caldentey, K-M., Virtanen, V., Nohynek, L., Rischer, H. & Puupponen-Pimiä, R., 2016, Abstract book. Phytochemical Society of Europe PSE , 40

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

18 Citations (Scopus)

Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi

Pirttimaa, M., Nasereddin, A., Kopelyanskiy, D., Kaiser, M., Yli-Kauhaluoma, J., Oksman-Caldentey, K-M., Brun, R., Jaffe, C. L., Moreira, V. M. & Alakurtti, S., 2016, In : Journal of Natural Products. 79, 2, p. 362-368

Research output: Contribution to journalArticleScientificpeer-review

Abietane Diterpenes
Leishmania donovani
Diterpenes
Trypanosoma cruzi
Amides
12 Citations (Scopus)

Exploring the metabolic stability of engineered hairy roots after 16 years maintenance

Häkkinen, S. T., Moyano, E., Cusidó, R. M. & Oksman-Caldentey, K-M., 2016, In : Frontiers in Plant Science. 3, 1486.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
secondary metabolites
cell culture
Hyoscyamus muticus
tropane alkaloids
paclitaxel
7 Citations (Scopus)

Fermantation and dry fractionation increase bioactivity of cloudberry (Rubus chamaemorus)

Puupponen-Pimiä, R., Nohynek, L., Juvonen, R., Kössö, T., Truchado, P., Westerlund-Wikström, B., Leppänen, T., Moilanen, E. & Oksman-Caldentey, K-M., 2016, In : Food Chemistry. 197, Part A, p. 950-958

Research output: Contribution to journalArticleScientificpeer-review

Rubus chamaemorus
Fractionation
Bioactivity
Fermentation
Ellagic Acid

Novel berry-based antimicrobials in cosmetics

Nohynek, L., Honkapää, K., Oksman-Caldentey, K-M. & Puupponen-Pimiä, R., 2016.

Research output: Contribution to conferenceConference PosterScientific

2015
5 Citations (Scopus)

Analysis of indole alkaloids from Rhazya stricta hairy roots by ultra-performance liquid chromatography-mass spectrometry

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Molecules. 20, 12, p. 22621-22634

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Secologanin Tryptamine Alkaloids
Apocynaceae
Indole Alkaloids
alkaloids
Liquid chromatography

Betulins as novel lead compounds for cancer

Oksman-Caldentey, K-M., Lämsä, M., Härmä, V., Haavikko, R., Alakurtti, S., Nygren, H., Häkkinen, S., Yli-Kauhaluoma, J., Nees, M. & Rischer, H., 2015, Book of Abstracts. 102

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

2 Citations (Scopus)

Bioconversion to Raspberry Ketone is Achieved by Several Non-related Plant Cell Cultures

Häkkinen, S., Seppänen-Laakso, T., Oksman-Caldentey, K-M. & Rischer, H., 24 Nov 2015, In : Frontiers in Plant Science. 6, p. 1-9 9 p., 1035.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
raspberries
biotransformation
ketones
cell culture
flavor compounds
8 Citations (Scopus)

Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS

Akhgari, A., Laakso, I., Seppänen-Laakso, T., Yrjönen, T., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Phytochemical Analysis. 26, 5, p. 331-338

Research output: Contribution to journalArticleScientificpeer-review

Rhazya stricta
Secologanin Tryptamine Alkaloids
Apocynaceae
indole alkaloids
Rhazya

Discovery of missing steps of secoiridoid pathway in Catharanthus roseus

Oksman-Caldentey, K-M., 2015.

Research output: Contribution to conferenceConference articleScientific

Catharanthus roseus
factories
biochemical pathways
taxanes
genomics

Effects of ellagitannin rich berries on blood lipid profiles, gut microbiota and metabolism of phenolic compounds in metabolic syndrome

Puupponen-Pimiä, R., Seppänen-Laakso, T., Maukonen, J., Nohynek, L., Tómas-Barberán, F. A., Törrönen, R., Kolehmainen, M., Kankainen, M., Espín, J. C., Aura, A-M., Poutanen, K., Leppänen, T., Moilanen, E. & Oksman-Caldentey, K-M., 2015, In : Dosis. 33, 3, p. 55-76

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Fruit
Lipids
Hydrolyzable Tannins
8-epi-prostaglandin F2alpha
Blood Pressure
9 Citations (Scopus)

Establishment of transgenic Rhazya stricta hairy roots to modulate terpenoid indole alkaloid production

Akhgari, A., Yrjönen, T., Laakso, I., Vuorela, H., Oksman-Caldentey, K-M. & Rischer, H., 2015, In : Plant Cell Reports. 34, 11, p. 1939-1952

Research output: Contribution to journalArticleScientificpeer-review

Rhazya stricta
indole alkaloids
terpenoids
genetically modified organisms
alkaloids

Harvinaisten ja vaikeasti syntetisoitavien lääkeyhdisteiden tuottaminen kasvibiotekniikan keinoin

Häkkinen, S., Oksman-Caldentey, K-M. & Ritala, A., 2015, In : Dosis. 31, 3, p. 162-169

Research output: Contribution to journalArticleScientificpeer-review

value added
Olla
11 Citations (Scopus)

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development

Härmä, V., Haavikko, R., Virtanen, J., Ahonen, I., Schukov, H-P., Alakurtti, S., Purev, E., Rischer, H., Yli-Kauhaluoma, J., Moreira, V. M., Nees, M. & Oksman-Caldentey, K-M., 2015, In : PLoS ONE. 10, 5, 22 p., e0126111.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
betulin
prostatic neoplasms
Prostatic Neoplasms
chemical derivatives
Castration

Phenolic composition of cloudberry and arctic bramble cell suspension cultures

Puupponen-Pimiä, R., Nohynek, L., Salminen, J-P., Rischer, H. & Oksman-Caldentey, K-M., 2015, Book of Abstracts. p. 30 P-1

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientific