A decade of cancer gene profiling: From molecular portraits to molecular function

Henri Sara, Olli Kallioniemi, Matthias Nees

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

11 Citations (Scopus)

Abstract

Cancer gene profiling has greatly profited from the progress in high-throughput technologies including microarray-, sequencing-, and bioinformatics-based methods. The flood of data generated during the last decade has provoked a panel of “-omics” fields that significantly changed our understanding of malignant diseases. However, while the terms “-omics” and “-ome” in principle refer to the completeness of a genetic approach, we are in fact far from a complete understanding of cancer progression. We may understand gene expression patterns better and successfully use gene signatures for outcome prediction and prognosis, but truly promising molecular targets still have to find their way into novel therapeutic concepts. In this chapter, we will show how more comprehensive strategies, integrating multiple layers of genetic information, might in the future provide a more profound functional understanding of cancer.
Original languageEnglish
Title of host publicationCancer Gene Profiling
Subtitle of host publicationMethods and Protocols
EditorsRobert Grützmann, Christian Pilarsky
PublisherHumana Press
Pages61-87
ISBN (Electronic)978-1-59745-545-9
ISBN (Print)978-1-934115-76-3, 978-1-61779-659-3
DOIs
Publication statusPublished - 2010
MoE publication typeA3 Part of a book or another research book

Publication series

SeriesMethods in Molecular Biology
Volume576
ISSN1064-3745

Keywords

  • Microarray
  • Expression
  • CGH
  • Comparative genomic hybridization
  • Sequencing

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