Abstract
For treatment of superficially located tumors, such as head and neck cancers that invade the skin, the tumor dose may remain low on the skin when such tumors are treated with epithermal neutrons in boron neutron capture therapy (BNCT). The goal of this study was to examine the effects of bolus material for BNCT of superficial tumors, to verify the calculated 55Mn(n,γ) and the 197Au(n,γ) activation reaction rates and the neutron and the gamma doses in a phantom irradiated with a bolus, to measure the neutron activation of the bolus materials after irradiation, and according to depth dose distribution, to estimate when it is advantageous to use a bolus in BNCT. The present data show that both paraffin and water gel can be used as a bolus material for BNCT. However, we recommend paraffin for clinical use, since it is durable and can be easily shaped. A 5mm paraffin bolus increases the surface dose approximately 50%, and its use may be advantageous for treatment of superficial tumors where the planning target volume (PTV) reaches to 6cm or less in tissue depth.
| Original language | English |
|---|---|
| Pages (from-to) | 787-791 |
| Number of pages | 5 |
| Journal | Applied Radiation and Isotopes |
| Volume | 61 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 Nov 2004 |
| MoE publication type | A1 Journal article-refereed |
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Keywords
- BNCT
- Bolus
- Dosimetry
- Epithermal neutrons
- Paraffin
- Water gel
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A dosimetric study on the use of bolus materials for treatment of superficial tumors with BNCT. / Seppälä, Tiina; Collan, Juhani; Auterinen, Iiro; Serén, Tom; Salli, Eero; Kotiluoto, Petri; Kortesniemi, Mika; Van Leemput, Koen; Kankaanranta, Leena; Joensuu, Heikki; Savolainen, Sauli.
In: Applied Radiation and Isotopes, Vol. 61, No. 5, 01.11.2004, p. 787-791.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - A dosimetric study on the use of bolus materials for treatment of superficial tumors with BNCT
AU - Seppälä, Tiina
AU - Collan, Juhani
AU - Auterinen, Iiro
AU - Serén, Tom
AU - Salli, Eero
AU - Kotiluoto, Petri
AU - Kortesniemi, Mika
AU - Van Leemput, Koen
AU - Kankaanranta, Leena
AU - Joensuu, Heikki
AU - Savolainen, Sauli
PY - 2004/11/1
Y1 - 2004/11/1
N2 - For treatment of superficially located tumors, such as head and neck cancers that invade the skin, the tumor dose may remain low on the skin when such tumors are treated with epithermal neutrons in boron neutron capture therapy (BNCT). The goal of this study was to examine the effects of bolus material for BNCT of superficial tumors, to verify the calculated 55Mn(n,γ) and the 197Au(n,γ) activation reaction rates and the neutron and the gamma doses in a phantom irradiated with a bolus, to measure the neutron activation of the bolus materials after irradiation, and according to depth dose distribution, to estimate when it is advantageous to use a bolus in BNCT. The present data show that both paraffin and water gel can be used as a bolus material for BNCT. However, we recommend paraffin for clinical use, since it is durable and can be easily shaped. A 5mm paraffin bolus increases the surface dose approximately 50%, and its use may be advantageous for treatment of superficial tumors where the planning target volume (PTV) reaches to 6cm or less in tissue depth.
AB - For treatment of superficially located tumors, such as head and neck cancers that invade the skin, the tumor dose may remain low on the skin when such tumors are treated with epithermal neutrons in boron neutron capture therapy (BNCT). The goal of this study was to examine the effects of bolus material for BNCT of superficial tumors, to verify the calculated 55Mn(n,γ) and the 197Au(n,γ) activation reaction rates and the neutron and the gamma doses in a phantom irradiated with a bolus, to measure the neutron activation of the bolus materials after irradiation, and according to depth dose distribution, to estimate when it is advantageous to use a bolus in BNCT. The present data show that both paraffin and water gel can be used as a bolus material for BNCT. However, we recommend paraffin for clinical use, since it is durable and can be easily shaped. A 5mm paraffin bolus increases the surface dose approximately 50%, and its use may be advantageous for treatment of superficial tumors where the planning target volume (PTV) reaches to 6cm or less in tissue depth.
KW - BNCT
KW - Bolus
KW - Dosimetry
KW - Epithermal neutrons
KW - Paraffin
KW - Water gel
UR - http://www.scopus.com/inward/record.url?scp=4143141002&partnerID=8YFLogxK
U2 - 10.1016/j.apradiso.2004.05.054
DO - 10.1016/j.apradiso.2004.05.054
M3 - Article
VL - 61
SP - 787
EP - 791
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
IS - 5
ER -