A dosimetric study on the use of bolus materials for treatment of superficial tumors with BNCT

Tiina Seppälä; Juhani Collan; Iiro Auterinen; Tom Serén; Eero Salli; Petri Kotiluoto; Mika Kortesniemi; Koen Van Leemput; Leena Kankaanranta; Heikki Joensuu; Sauli Savolainen

doi:10.1016/j.apradiso.2004.05.054

A dosimetric study on the use of bolus materials for treatment of superficial tumors with BNCT

Tiina Seppälä^*, Juhani Collan, Iiro Auterinen, Tom Serén, Eero Salli, Petri Kotiluoto, Mika Kortesniemi, Koen Van Leemput, Leena Kankaanranta, Heikki Joensuu, Sauli Savolainen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

18 Citations (Scopus)

Abstract

For treatment of superficially located tumors, such as head and neck cancers that invade the skin, the tumor dose may remain low on the skin when such tumors are treated with epithermal neutrons in boron neutron capture therapy (BNCT). The goal of this study was to examine the effects of bolus material for BNCT of superficial tumors, to verify the calculated ⁵⁵Mn(n,γ) and the ¹⁹⁷Au(n,γ) activation reaction rates and the neutron and the gamma doses in a phantom irradiated with a bolus, to measure the neutron activation of the bolus materials after irradiation, and according to depth dose distribution, to estimate when it is advantageous to use a bolus in BNCT. The present data show that both paraffin and water gel can be used as a bolus material for BNCT. However, we recommend paraffin for clinical use, since it is durable and can be easily shaped. A 5mm paraffin bolus increases the surface dose approximately 50%, and its use may be advantageous for treatment of superficial tumors where the planning target volume (PTV) reaches to 6cm or less in tissue depth.

Original language	English
Pages (from-to)	787-791
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	61
Issue number	5
DOIs	https://doi.org/10.1016/j.apradiso.2004.05.054
Publication status	Published - 1 Nov 2004
MoE publication type	A1 Journal article-refereed

Funding

This work was supported by the Academy of Finland and Helsinki University Central Hospital Research Funds.

Keywords

BNCT
Bolus
Dosimetry
Epithermal neutrons
Paraffin
Water gel

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.apradiso.2004.05.054

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title = "A dosimetric study on the use of bolus materials for treatment of superficial tumors with BNCT",

abstract = "For treatment of superficially located tumors, such as head and neck cancers that invade the skin, the tumor dose may remain low on the skin when such tumors are treated with epithermal neutrons in boron neutron capture therapy (BNCT). The goal of this study was to examine the effects of bolus material for BNCT of superficial tumors, to verify the calculated 55Mn(n,γ) and the 197Au(n,γ) activation reaction rates and the neutron and the gamma doses in a phantom irradiated with a bolus, to measure the neutron activation of the bolus materials after irradiation, and according to depth dose distribution, to estimate when it is advantageous to use a bolus in BNCT. The present data show that both paraffin and water gel can be used as a bolus material for BNCT. However, we recommend paraffin for clinical use, since it is durable and can be easily shaped. A 5mm paraffin bolus increases the surface dose approximately 50%, and its use may be advantageous for treatment of superficial tumors where the planning target volume (PTV) reaches to 6cm or less in tissue depth.",

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AU - Salli, Eero

AU - Kotiluoto, Petri

AU - Kortesniemi, Mika

AU - Van Leemput, Koen

AU - Kankaanranta, Leena

AU - Joensuu, Heikki

AU - Savolainen, Sauli

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AB - For treatment of superficially located tumors, such as head and neck cancers that invade the skin, the tumor dose may remain low on the skin when such tumors are treated with epithermal neutrons in boron neutron capture therapy (BNCT). The goal of this study was to examine the effects of bolus material for BNCT of superficial tumors, to verify the calculated 55Mn(n,γ) and the 197Au(n,γ) activation reaction rates and the neutron and the gamma doses in a phantom irradiated with a bolus, to measure the neutron activation of the bolus materials after irradiation, and according to depth dose distribution, to estimate when it is advantageous to use a bolus in BNCT. The present data show that both paraffin and water gel can be used as a bolus material for BNCT. However, we recommend paraffin for clinical use, since it is durable and can be easily shaped. A 5mm paraffin bolus increases the surface dose approximately 50%, and its use may be advantageous for treatment of superficial tumors where the planning target volume (PTV) reaches to 6cm or less in tissue depth.

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A dosimetric study on the use of bolus materials for treatment of superficial tumors with BNCT

Abstract

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Keywords

UN SDGs

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