A dosimetric study on the use of bolus materials for treatment of superficial tumors with BNCT

Tiina Seppälä, Juhani Collan, Iiro Auterinen, Tom Serén, Eero Salli, Petri Kotiluoto, Mika Kortesniemi, Koen Van Leemput, Leena Kankaanranta, Heikki Joensuu, Sauli Savolainen

    Research output: Contribution to journalArticleScientificpeer-review

    8 Citations (Scopus)

    Abstract

    For treatment of superficially located tumors, such as head and neck cancers that invade the skin, the tumor dose may remain low on the skin when such tumors are treated with epithermal neutrons in boron neutron capture therapy (BNCT). The goal of this study was to examine the effects of bolus material for BNCT of superficial tumors, to verify the calculated 55Mn(n,γ) and the 197Au(n,γ) activation reaction rates and the neutron and the gamma doses in a phantom irradiated with a bolus, to measure the neutron activation of the bolus materials after irradiation, and according to depth dose distribution, to estimate when it is advantageous to use a bolus in BNCT. The present data show that both paraffin and water gel can be used as a bolus material for BNCT. However, we recommend paraffin for clinical use, since it is durable and can be easily shaped. A 5mm paraffin bolus increases the surface dose approximately 50%, and its use may be advantageous for treatment of superficial tumors where the planning target volume (PTV) reaches to 6cm or less in tissue depth.

    Original languageEnglish
    Pages (from-to)787-791
    Number of pages5
    JournalApplied Radiation and Isotopes
    Volume61
    Issue number5
    DOIs
    Publication statusPublished - 1 Nov 2004
    MoE publication typeA1 Journal article-refereed

    Fingerprint

    therapy
    boron
    tumors
    neutrons
    paraffins
    dosage
    activation
    planning
    reaction kinetics
    cancer
    gels
    irradiation
    estimates
    water

    Keywords

    • BNCT
    • Bolus
    • Dosimetry
    • Epithermal neutrons
    • Paraffin
    • Water gel

    Cite this

    Seppälä, Tiina ; Collan, Juhani ; Auterinen, Iiro ; Serén, Tom ; Salli, Eero ; Kotiluoto, Petri ; Kortesniemi, Mika ; Van Leemput, Koen ; Kankaanranta, Leena ; Joensuu, Heikki ; Savolainen, Sauli. / A dosimetric study on the use of bolus materials for treatment of superficial tumors with BNCT. In: Applied Radiation and Isotopes. 2004 ; Vol. 61, No. 5. pp. 787-791.
    @article{b292a088c5834a59b9559eabf5c7c185,
    title = "A dosimetric study on the use of bolus materials for treatment of superficial tumors with BNCT",
    abstract = "For treatment of superficially located tumors, such as head and neck cancers that invade the skin, the tumor dose may remain low on the skin when such tumors are treated with epithermal neutrons in boron neutron capture therapy (BNCT). The goal of this study was to examine the effects of bolus material for BNCT of superficial tumors, to verify the calculated 55Mn(n,γ) and the 197Au(n,γ) activation reaction rates and the neutron and the gamma doses in a phantom irradiated with a bolus, to measure the neutron activation of the bolus materials after irradiation, and according to depth dose distribution, to estimate when it is advantageous to use a bolus in BNCT. The present data show that both paraffin and water gel can be used as a bolus material for BNCT. However, we recommend paraffin for clinical use, since it is durable and can be easily shaped. A 5mm paraffin bolus increases the surface dose approximately 50{\%}, and its use may be advantageous for treatment of superficial tumors where the planning target volume (PTV) reaches to 6cm or less in tissue depth.",
    keywords = "BNCT, Bolus, Dosimetry, Epithermal neutrons, Paraffin, Water gel",
    author = "Tiina Sepp{\"a}l{\"a} and Juhani Collan and Iiro Auterinen and Tom Ser{\'e}n and Eero Salli and Petri Kotiluoto and Mika Kortesniemi and {Van Leemput}, Koen and Leena Kankaanranta and Heikki Joensuu and Sauli Savolainen",
    year = "2004",
    month = "11",
    day = "1",
    doi = "10.1016/j.apradiso.2004.05.054",
    language = "English",
    volume = "61",
    pages = "787--791",
    journal = "Applied Radiation and Isotopes",
    issn = "0969-8043",
    publisher = "Elsevier",
    number = "5",

    }

    Seppälä, T, Collan, J, Auterinen, I, Serén, T, Salli, E, Kotiluoto, P, Kortesniemi, M, Van Leemput, K, Kankaanranta, L, Joensuu, H & Savolainen, S 2004, 'A dosimetric study on the use of bolus materials for treatment of superficial tumors with BNCT', Applied Radiation and Isotopes, vol. 61, no. 5, pp. 787-791. https://doi.org/10.1016/j.apradiso.2004.05.054

    A dosimetric study on the use of bolus materials for treatment of superficial tumors with BNCT. / Seppälä, Tiina; Collan, Juhani; Auterinen, Iiro; Serén, Tom; Salli, Eero; Kotiluoto, Petri; Kortesniemi, Mika; Van Leemput, Koen; Kankaanranta, Leena; Joensuu, Heikki; Savolainen, Sauli.

    In: Applied Radiation and Isotopes, Vol. 61, No. 5, 01.11.2004, p. 787-791.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - A dosimetric study on the use of bolus materials for treatment of superficial tumors with BNCT

    AU - Seppälä, Tiina

    AU - Collan, Juhani

    AU - Auterinen, Iiro

    AU - Serén, Tom

    AU - Salli, Eero

    AU - Kotiluoto, Petri

    AU - Kortesniemi, Mika

    AU - Van Leemput, Koen

    AU - Kankaanranta, Leena

    AU - Joensuu, Heikki

    AU - Savolainen, Sauli

    PY - 2004/11/1

    Y1 - 2004/11/1

    N2 - For treatment of superficially located tumors, such as head and neck cancers that invade the skin, the tumor dose may remain low on the skin when such tumors are treated with epithermal neutrons in boron neutron capture therapy (BNCT). The goal of this study was to examine the effects of bolus material for BNCT of superficial tumors, to verify the calculated 55Mn(n,γ) and the 197Au(n,γ) activation reaction rates and the neutron and the gamma doses in a phantom irradiated with a bolus, to measure the neutron activation of the bolus materials after irradiation, and according to depth dose distribution, to estimate when it is advantageous to use a bolus in BNCT. The present data show that both paraffin and water gel can be used as a bolus material for BNCT. However, we recommend paraffin for clinical use, since it is durable and can be easily shaped. A 5mm paraffin bolus increases the surface dose approximately 50%, and its use may be advantageous for treatment of superficial tumors where the planning target volume (PTV) reaches to 6cm or less in tissue depth.

    AB - For treatment of superficially located tumors, such as head and neck cancers that invade the skin, the tumor dose may remain low on the skin when such tumors are treated with epithermal neutrons in boron neutron capture therapy (BNCT). The goal of this study was to examine the effects of bolus material for BNCT of superficial tumors, to verify the calculated 55Mn(n,γ) and the 197Au(n,γ) activation reaction rates and the neutron and the gamma doses in a phantom irradiated with a bolus, to measure the neutron activation of the bolus materials after irradiation, and according to depth dose distribution, to estimate when it is advantageous to use a bolus in BNCT. The present data show that both paraffin and water gel can be used as a bolus material for BNCT. However, we recommend paraffin for clinical use, since it is durable and can be easily shaped. A 5mm paraffin bolus increases the surface dose approximately 50%, and its use may be advantageous for treatment of superficial tumors where the planning target volume (PTV) reaches to 6cm or less in tissue depth.

    KW - BNCT

    KW - Bolus

    KW - Dosimetry

    KW - Epithermal neutrons

    KW - Paraffin

    KW - Water gel

    UR - http://www.scopus.com/inward/record.url?scp=4143141002&partnerID=8YFLogxK

    U2 - 10.1016/j.apradiso.2004.05.054

    DO - 10.1016/j.apradiso.2004.05.054

    M3 - Article

    C2 - 15308145

    AN - SCOPUS:4143141002

    VL - 61

    SP - 787

    EP - 791

    JO - Applied Radiation and Isotopes

    JF - Applied Radiation and Isotopes

    SN - 0969-8043

    IS - 5

    ER -