A low-aspect-ratio, roll-to-roll hot embossed inertial microfluidic sorter

X. Wang; Christina Liedert; Ralph Liedert; I. Papautsky

A low-aspect-ratio, roll-to-roll hot embossed inertial microfluidic sorter

X. Wang, Christina Liedert, Ralph Liedert, I. Papautsky (Corresponding author)

University of Cincinnati

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

1 Citation (Scopus)

Abstract

This work presents a low-aspect-ratio (LAR) inertial microfluidic design compatible with roll-to-roll (R2R) hot embossing for size-based cell or microparticle separation in a low-cost and disposable format. The device consists of two segments of LAR channels in which inertial lift forces are used to differentiate lateral positions based on size for separation downstream. Separation of 18µm and 15µm diameter particles was first demonstrated in a conventional PDMS device, and further validated in a thin-film device mass-produced by R2R embossing. The described LAR inertial microfluidic separator is ideally suited as a low-cost, disposable device for point-of-care sample preparation.

Original language	English
Title of host publication	Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Pages	2447-2449
Publication status	Published - 2014
MoE publication type	A4 Article in a conference publication
Event	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: 26 Oct 2014 → 30 Oct 2014 Conference number: 18

Conference

Conference	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Abbreviated title	MicroTAS 2014
Country/Territory	United States
City	San Antonio
Period	26/10/14 → 30/10/14

Keywords

inertial microfluidics
microfluidic sorting
roll-to-roll hot embossing

Cite this

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title = "A low-aspect-ratio, roll-to-roll hot embossed inertial microfluidic sorter",

abstract = "This work presents a low-aspect-ratio (LAR) inertial microfluidic design compatible with roll-to-roll (R2R) hot embossing for size-based cell or microparticle separation in a low-cost and disposable format. The device consists of two segments of LAR channels in which inertial lift forces are used to differentiate lateral positions based on size for separation downstream. Separation of 18µm and 15µm diameter particles was first demonstrated in a conventional PDMS device, and further validated in a thin-film device mass-produced by R2R embossing. The described LAR inertial microfluidic separator is ideally suited as a low-cost, disposable device for point-of-care sample preparation.",

keywords = "inertial microfluidics, microfluidic sorting, roll-to-roll hot embossing",

author = "X. Wang and Christina Liedert and Ralph Liedert and I. Papautsky",

year = "2014",

language = "English",

isbn = "978-0-9798064-7-6",

pages = "2447--2449",

booktitle = "Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

note = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",

}

Wang, X, Liedert, C , Liedert, R & Papautsky, I 2014, A low-aspect-ratio, roll-to-roll hot embossed inertial microfluidic sorter. in Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. pp. 2447-2449, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, Texas, United States, 26/10/14.

A low-aspect-ratio, roll-to-roll hot embossed inertial microfluidic sorter. / Wang, X.; Liedert, Christina ; Liedert, Ralph et al.
Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 2014. p. 2447-2449.

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

TY - GEN

T1 - A low-aspect-ratio, roll-to-roll hot embossed inertial microfluidic sorter

AU - Wang, X.

AU - Liedert, Christina

AU - Liedert, Ralph

AU - Papautsky, I.

N1 - Conference code: 18

PY - 2014

Y1 - 2014

N2 - This work presents a low-aspect-ratio (LAR) inertial microfluidic design compatible with roll-to-roll (R2R) hot embossing for size-based cell or microparticle separation in a low-cost and disposable format. The device consists of two segments of LAR channels in which inertial lift forces are used to differentiate lateral positions based on size for separation downstream. Separation of 18µm and 15µm diameter particles was first demonstrated in a conventional PDMS device, and further validated in a thin-film device mass-produced by R2R embossing. The described LAR inertial microfluidic separator is ideally suited as a low-cost, disposable device for point-of-care sample preparation.

AB - This work presents a low-aspect-ratio (LAR) inertial microfluidic design compatible with roll-to-roll (R2R) hot embossing for size-based cell or microparticle separation in a low-cost and disposable format. The device consists of two segments of LAR channels in which inertial lift forces are used to differentiate lateral positions based on size for separation downstream. Separation of 18µm and 15µm diameter particles was first demonstrated in a conventional PDMS device, and further validated in a thin-film device mass-produced by R2R embossing. The described LAR inertial microfluidic separator is ideally suited as a low-cost, disposable device for point-of-care sample preparation.

KW - inertial microfluidics

KW - microfluidic sorting

KW - roll-to-roll hot embossing

M3 - Conference article in proceedings

SN - 978-0-9798064-7-6

SN - 978-1-63439-697-4

SP - 2447

EP - 2449

BT - Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Y2 - 26 October 2014 through 30 October 2014

ER -

A low-aspect-ratio, roll-to-roll hot embossed inertial microfluidic sorter

Abstract

Conference

Keywords

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