A novel gas phase method for the combined synthesis and coating of pharmaceutical particles

Janne Raula, Anna Lähde, Esko I. Kauppinen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

28 Citations (Scopus)

Abstract

Purpose

A novel aerosol flow reactor method for the combined gas phase synthesis and coating of particles for drug delivery has been developed.

Materials and Methods

As an example, micron-sized salbutamol sulfate particles were produced via droplet-to-particle conversion and in-situ coated by the physical vapor deposition (PVD) of l-leucine vapor.

Results

During the deposition, l-leucine vapor crystallized on the surfaces of amorphous salbutamol particles. The size of l-leucine crystallites increased with increasing vapor concentration of l-leucine. The salbutamol particles with rough l-leucine surfaces exhibited good flowability enabling to them to be dispersed into air flow without the delivery aid of coarse lactose carriers.

Conclusions

The fraction of particles smaller than 5 micrometers varied between 0.35 and 0.48 when dispersed into 60 l/min air flow having a jet Reynolds number of 30700. When the coated fine particles were blended with lactose carriers, the fine particle fraction was as high as 90%. The l-leucine coating also improved the stability of salbutamol particles when stored at 45% relative humidity atmosphere.

Original languageEnglish
Pages (from-to)242-245
JournalPharmaceutical Research
Volume25
Issue number1
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

Fingerprint

Leucine
Albuterol
Gases
Coatings
Pharmaceutical Preparations
Vapors
Lactose
Air
Physical vapor deposition
Humidity
Aerosols
Atmosphere
Drug delivery
Crystallites
Sulfates
Atmospheric humidity
Reynolds number

Keywords

  • aerosol
  • coating
  • evaporation
  • gas phase deposition
  • inhalation
  • L-leucine
  • pharmaceutical
  • powder production
  • salbutamol sulfate
  • surface modification
  • vapor

Cite this

Raula, Janne ; Lähde, Anna ; Kauppinen, Esko I. / A novel gas phase method for the combined synthesis and coating of pharmaceutical particles. In: Pharmaceutical Research. 2008 ; Vol. 25, No. 1. pp. 242-245.
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abstract = "PurposeA novel aerosol flow reactor method for the combined gas phase synthesis and coating of particles for drug delivery has been developed.Materials and MethodsAs an example, micron-sized salbutamol sulfate particles were produced via droplet-to-particle conversion and in-situ coated by the physical vapor deposition (PVD) of l-leucine vapor.ResultsDuring the deposition, l-leucine vapor crystallized on the surfaces of amorphous salbutamol particles. The size of l-leucine crystallites increased with increasing vapor concentration of l-leucine. The salbutamol particles with rough l-leucine surfaces exhibited good flowability enabling to them to be dispersed into air flow without the delivery aid of coarse lactose carriers.ConclusionsThe fraction of particles smaller than 5 micrometers varied between 0.35 and 0.48 when dispersed into 60 l/min air flow having a jet Reynolds number of 30700. When the coated fine particles were blended with lactose carriers, the fine particle fraction was as high as 90{\%}. The l-leucine coating also improved the stability of salbutamol particles when stored at 45{\%} relative humidity atmosphere.",
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A novel gas phase method for the combined synthesis and coating of pharmaceutical particles. / Raula, Janne; Lähde, Anna; Kauppinen, Esko I. (Corresponding Author).

In: Pharmaceutical Research, Vol. 25, No. 1, 2008, p. 242-245.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - A novel gas phase method for the combined synthesis and coating of pharmaceutical particles

AU - Raula, Janne

AU - Lähde, Anna

AU - Kauppinen, Esko I.

PY - 2008

Y1 - 2008

N2 - PurposeA novel aerosol flow reactor method for the combined gas phase synthesis and coating of particles for drug delivery has been developed.Materials and MethodsAs an example, micron-sized salbutamol sulfate particles were produced via droplet-to-particle conversion and in-situ coated by the physical vapor deposition (PVD) of l-leucine vapor.ResultsDuring the deposition, l-leucine vapor crystallized on the surfaces of amorphous salbutamol particles. The size of l-leucine crystallites increased with increasing vapor concentration of l-leucine. The salbutamol particles with rough l-leucine surfaces exhibited good flowability enabling to them to be dispersed into air flow without the delivery aid of coarse lactose carriers.ConclusionsThe fraction of particles smaller than 5 micrometers varied between 0.35 and 0.48 when dispersed into 60 l/min air flow having a jet Reynolds number of 30700. When the coated fine particles were blended with lactose carriers, the fine particle fraction was as high as 90%. The l-leucine coating also improved the stability of salbutamol particles when stored at 45% relative humidity atmosphere.

AB - PurposeA novel aerosol flow reactor method for the combined gas phase synthesis and coating of particles for drug delivery has been developed.Materials and MethodsAs an example, micron-sized salbutamol sulfate particles were produced via droplet-to-particle conversion and in-situ coated by the physical vapor deposition (PVD) of l-leucine vapor.ResultsDuring the deposition, l-leucine vapor crystallized on the surfaces of amorphous salbutamol particles. The size of l-leucine crystallites increased with increasing vapor concentration of l-leucine. The salbutamol particles with rough l-leucine surfaces exhibited good flowability enabling to them to be dispersed into air flow without the delivery aid of coarse lactose carriers.ConclusionsThe fraction of particles smaller than 5 micrometers varied between 0.35 and 0.48 when dispersed into 60 l/min air flow having a jet Reynolds number of 30700. When the coated fine particles were blended with lactose carriers, the fine particle fraction was as high as 90%. The l-leucine coating also improved the stability of salbutamol particles when stored at 45% relative humidity atmosphere.

KW - aerosol

KW - coating

KW - evaporation

KW - gas phase deposition

KW - inhalation

KW - L-leucine

KW - pharmaceutical

KW - powder production

KW - salbutamol sulfate

KW - surface modification

KW - vapor

U2 - 10.1007/s11095-007-9464-4

DO - 10.1007/s11095-007-9464-4

M3 - Article

VL - 25

SP - 242

EP - 245

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 1

ER -