A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults

Leila Karhunen (Corresponding Author), Kristiina Juvonen, Sanna Flander, Kirsi-Helena Liukkonen, Liisa Lähteenmäki, Maritta Siloaho, David Laaksonen, Karl-Heinz Herzig, Matti Uusitupa, Kaisa Poutanen

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Abstract

Dietary fiber (DF) and protein are essential constituents of a healthy diet and are well known for their high satiety impact. However, little is known about their influence on postprandial gastrointestinal (GI) peptide release. Our aim in this single-blind, randomized, cross-over study was to investigate the effects of DF and/or protein enrichments on satiety-related metabolic and hormonal responses. Sixteen healthy, nonobese volunteers participated in the study and ingested 1 of 5 isoenergetic test meals in a randomized order on separate days. The test meals were as follows: 1) low in protein (2.8 g) and fiber (7.6 g); 2) low in protein (2.6 g) and high in soluble fiber (psyllium, 23.0 g); 3) high in protein (soy, 19.7 g) and low in fiber (6.2 g); 4) high in protein (18.4 g) and fiber (23.0 g); and 5) white wheat bread. Serum insulin and plasma glucose, ghrelin, glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) concentrations were determined for 2 h following the meals. In addition, hunger and satiety ratings were collected. Postprandial glucose, insulin, ghrelin, GLP-1, and PYY responses all differed among the meals (P ≤ 0.05). Fiber-enriched meals decreased glucose, insulin, ghrelin, and PYY responses; in addition, PYY secretion was prolonged compared with the other meals. The postprandial GLP-1 concentration was significantly suppressed after a fiber- and protein-rich meal, in contrast to the initial increases following the other meals. However, postprandial ratings of appetite were mostly similar after the test meals. In conclusion, solid meals enriched with psyllium fiber strongly modified postprandial signals arising from the GI tract.
Original languageEnglish
Pages (from-to)737-744
Number of pages8
JournalJournal of Nutrition
Volume140
Issue number4
DOIs
Publication statusPublished - 2010
MoE publication typeA1 Journal article-refereed

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Psyllium
Meals
Young Adult
Peptides
Peptide YY
Ghrelin
Glucagon-Like Peptide 1
Dietary Proteins
Dietary Fiber
Insulin
Glucose
Proteins
Soybean Proteins
Hunger
Bread
Appetite
Cross-Over Studies
Triticum
Gastrointestinal Tract
Healthy Volunteers

Cite this

Karhunen, Leila ; Juvonen, Kristiina ; Flander, Sanna ; Liukkonen, Kirsi-Helena ; Lähteenmäki, Liisa ; Siloaho, Maritta ; Laaksonen, David ; Herzig, Karl-Heinz ; Uusitupa, Matti ; Poutanen, Kaisa. / A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults. In: Journal of Nutrition. 2010 ; Vol. 140, No. 4. pp. 737-744.
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title = "A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults",
abstract = "Dietary fiber (DF) and protein are essential constituents of a healthy diet and are well known for their high satiety impact. However, little is known about their influence on postprandial gastrointestinal (GI) peptide release. Our aim in this single-blind, randomized, cross-over study was to investigate the effects of DF and/or protein enrichments on satiety-related metabolic and hormonal responses. Sixteen healthy, nonobese volunteers participated in the study and ingested 1 of 5 isoenergetic test meals in a randomized order on separate days. The test meals were as follows: 1) low in protein (2.8 g) and fiber (7.6 g); 2) low in protein (2.6 g) and high in soluble fiber (psyllium, 23.0 g); 3) high in protein (soy, 19.7 g) and low in fiber (6.2 g); 4) high in protein (18.4 g) and fiber (23.0 g); and 5) white wheat bread. Serum insulin and plasma glucose, ghrelin, glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) concentrations were determined for 2 h following the meals. In addition, hunger and satiety ratings were collected. Postprandial glucose, insulin, ghrelin, GLP-1, and PYY responses all differed among the meals (P ≤ 0.05). Fiber-enriched meals decreased glucose, insulin, ghrelin, and PYY responses; in addition, PYY secretion was prolonged compared with the other meals. The postprandial GLP-1 concentration was significantly suppressed after a fiber- and protein-rich meal, in contrast to the initial increases following the other meals. However, postprandial ratings of appetite were mostly similar after the test meals. In conclusion, solid meals enriched with psyllium fiber strongly modified postprandial signals arising from the GI tract.",
author = "Leila Karhunen and Kristiina Juvonen and Sanna Flander and Kirsi-Helena Liukkonen and Liisa L{\"a}hteenm{\"a}ki and Maritta Siloaho and David Laaksonen and Karl-Heinz Herzig and Matti Uusitupa and Kaisa Poutanen",
year = "2010",
doi = "10.3945/jn.109.115436",
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Karhunen, L, Juvonen, K, Flander, S, Liukkonen, K-H, Lähteenmäki, L, Siloaho, M, Laaksonen, D, Herzig, K-H, Uusitupa, M & Poutanen, K 2010, 'A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults', Journal of Nutrition, vol. 140, no. 4, pp. 737-744. https://doi.org/10.3945/jn.109.115436

A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults. / Karhunen, Leila (Corresponding Author); Juvonen, Kristiina; Flander, Sanna; Liukkonen, Kirsi-Helena; Lähteenmäki, Liisa; Siloaho, Maritta; Laaksonen, David; Herzig, Karl-Heinz; Uusitupa, Matti; Poutanen, Kaisa.

In: Journal of Nutrition, Vol. 140, No. 4, 2010, p. 737-744.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults

AU - Karhunen, Leila

AU - Juvonen, Kristiina

AU - Flander, Sanna

AU - Liukkonen, Kirsi-Helena

AU - Lähteenmäki, Liisa

AU - Siloaho, Maritta

AU - Laaksonen, David

AU - Herzig, Karl-Heinz

AU - Uusitupa, Matti

AU - Poutanen, Kaisa

PY - 2010

Y1 - 2010

N2 - Dietary fiber (DF) and protein are essential constituents of a healthy diet and are well known for their high satiety impact. However, little is known about their influence on postprandial gastrointestinal (GI) peptide release. Our aim in this single-blind, randomized, cross-over study was to investigate the effects of DF and/or protein enrichments on satiety-related metabolic and hormonal responses. Sixteen healthy, nonobese volunteers participated in the study and ingested 1 of 5 isoenergetic test meals in a randomized order on separate days. The test meals were as follows: 1) low in protein (2.8 g) and fiber (7.6 g); 2) low in protein (2.6 g) and high in soluble fiber (psyllium, 23.0 g); 3) high in protein (soy, 19.7 g) and low in fiber (6.2 g); 4) high in protein (18.4 g) and fiber (23.0 g); and 5) white wheat bread. Serum insulin and plasma glucose, ghrelin, glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) concentrations were determined for 2 h following the meals. In addition, hunger and satiety ratings were collected. Postprandial glucose, insulin, ghrelin, GLP-1, and PYY responses all differed among the meals (P ≤ 0.05). Fiber-enriched meals decreased glucose, insulin, ghrelin, and PYY responses; in addition, PYY secretion was prolonged compared with the other meals. The postprandial GLP-1 concentration was significantly suppressed after a fiber- and protein-rich meal, in contrast to the initial increases following the other meals. However, postprandial ratings of appetite were mostly similar after the test meals. In conclusion, solid meals enriched with psyllium fiber strongly modified postprandial signals arising from the GI tract.

AB - Dietary fiber (DF) and protein are essential constituents of a healthy diet and are well known for their high satiety impact. However, little is known about their influence on postprandial gastrointestinal (GI) peptide release. Our aim in this single-blind, randomized, cross-over study was to investigate the effects of DF and/or protein enrichments on satiety-related metabolic and hormonal responses. Sixteen healthy, nonobese volunteers participated in the study and ingested 1 of 5 isoenergetic test meals in a randomized order on separate days. The test meals were as follows: 1) low in protein (2.8 g) and fiber (7.6 g); 2) low in protein (2.6 g) and high in soluble fiber (psyllium, 23.0 g); 3) high in protein (soy, 19.7 g) and low in fiber (6.2 g); 4) high in protein (18.4 g) and fiber (23.0 g); and 5) white wheat bread. Serum insulin and plasma glucose, ghrelin, glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) concentrations were determined for 2 h following the meals. In addition, hunger and satiety ratings were collected. Postprandial glucose, insulin, ghrelin, GLP-1, and PYY responses all differed among the meals (P ≤ 0.05). Fiber-enriched meals decreased glucose, insulin, ghrelin, and PYY responses; in addition, PYY secretion was prolonged compared with the other meals. The postprandial GLP-1 concentration was significantly suppressed after a fiber- and protein-rich meal, in contrast to the initial increases following the other meals. However, postprandial ratings of appetite were mostly similar after the test meals. In conclusion, solid meals enriched with psyllium fiber strongly modified postprandial signals arising from the GI tract.

U2 - 10.3945/jn.109.115436

DO - 10.3945/jn.109.115436

M3 - Article

VL - 140

SP - 737

EP - 744

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 4

ER -