TY - JOUR
T1 - A smart hospital-driven approach to precision pharmacovigilance
AU - De Pretis, Francesco
AU - van Gils, Mark
AU - Forsberg, Markus M.
N1 - Funding Information:
Research reported in this publication was supported by the European Research Consortium for Informatics and Mathematics . We thank Dr Ewen MacDonald for valuable comments and revising the language.
PY - 2022/6
Y1 - 2022/6
N2 - Researchers, regulatory agencies, and the pharmaceutical industry are moving towards precision pharmacovigilance as a comprehensive framework for drug safety assessment, at the service of the individual patient, by clustering specific risk groups in different databases. This article explores its implementation by focusing on: (i) designing a new data collection infrastructure, (ii) exploring new computational methods suitable for drug safety data, and (iii) providing a computer-aided framework for distributed clinical decisions with the aim of compiling a personalized information leaflet with specific reference to a drug's risks and adverse drug reactions. These goals can be achieved by using ‘smart hospitals’ as the principal data sources and by employing methods of precision medicine and medical statistics to supplement current public health decisions.
AB - Researchers, regulatory agencies, and the pharmaceutical industry are moving towards precision pharmacovigilance as a comprehensive framework for drug safety assessment, at the service of the individual patient, by clustering specific risk groups in different databases. This article explores its implementation by focusing on: (i) designing a new data collection infrastructure, (ii) exploring new computational methods suitable for drug safety data, and (iii) providing a computer-aided framework for distributed clinical decisions with the aim of compiling a personalized information leaflet with specific reference to a drug's risks and adverse drug reactions. These goals can be achieved by using ‘smart hospitals’ as the principal data sources and by employing methods of precision medicine and medical statistics to supplement current public health decisions.
KW - drug safety
KW - personalized information leaflet
KW - pharmacosurveillance
KW - pharmacovigilance
KW - precision medicine
KW - smart hospital
UR - http://www.scopus.com/inward/record.url?scp=85128995212&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2022.03.009
DO - 10.1016/j.tips.2022.03.009
M3 - Review Article
C2 - 35490032
AN - SCOPUS:85128995212
VL - 43
SP - 473
EP - 481
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
SN - 0165-6147
IS - 6
ER -
