A smart hospital-driven approach to precision pharmacovigilance

Francesco De Pretis, Mark van Gils, Markus M. Forsberg

Research output: Contribution to journalReview ArticleScientificpeer-review

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Abstract

Researchers, regulatory agencies, and the pharmaceutical industry are moving towards precision pharmacovigilance as a comprehensive framework for drug safety assessment, at the service of the individual patient, by clustering specific risk groups in different databases. This article explores its implementation by focusing on: (i) designing a new data collection infrastructure, (ii) exploring new computational methods suitable for drug safety data, and (iii) providing a computer-aided framework for distributed clinical decisions with the aim of compiling a personalized information leaflet with specific reference to a drug's risks and adverse drug reactions. These goals can be achieved by using ‘smart hospitals’ as the principal data sources and by employing methods of precision medicine and medical statistics to supplement current public health decisions.

Original languageEnglish
Pages (from-to)473-481
Number of pages9
JournalTrends in Pharmacological Sciences
Volume43
Issue number6
DOIs
Publication statusPublished - Jun 2022
MoE publication typeA2 Review article in a scientific journal

Keywords

  • drug safety
  • personalized information leaflet
  • pharmacosurveillance
  • pharmacovigilance
  • precision medicine
  • smart hospital

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