TY - JOUR
T1 - A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI
AU - Tirotta, I
AU - Mastropietro, A
AU - Gordiglieri, C
AU - Gazzera, L
AU - Baggi, F
AU - Baselli, G
AU - Grazia Bruzzone, M
AU - Zucca, I
AU - Cavallo, G
AU - Teraneo, G
AU - Baldelli Bombelli, F
AU - Metrangolo, Pierangelo
AU - Resnati, G
PY - 2014
Y1 - 2014
N2 - 19F-MRI offers unique opportunities to image diseases and
track cells and therapeutic agents in vivo. Herein we
report a superfluorinated molecular probe, herein called
PERFECTA, possessing excellent cellular compatibility,
and whose spectral properties, relaxation times, and
sensitivity are promising for in vivo 19F-MRI
applications. The molecule, which bears 36 equivalent 19F
atoms and shows a single intense resonance peak, is
easily synthesized via a simple one-step reaction and is
formulated in water with high stability using trivial
reagents and methods
AB - 19F-MRI offers unique opportunities to image diseases and
track cells and therapeutic agents in vivo. Herein we
report a superfluorinated molecular probe, herein called
PERFECTA, possessing excellent cellular compatibility,
and whose spectral properties, relaxation times, and
sensitivity are promising for in vivo 19F-MRI
applications. The molecule, which bears 36 equivalent 19F
atoms and shows a single intense resonance peak, is
easily synthesized via a simple one-step reaction and is
formulated in water with high stability using trivial
reagents and methods
U2 - 10.1021/ja503270n
DO - 10.1021/ja503270n
M3 - Article
SN - 0002-7863
VL - 136
SP - 8524
EP - 8527
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 24
ER -