A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI

I Tirotta, A Mastropietro, C Gordiglieri, L Gazzera, F Baggi, G Baselli, M Grazia Bruzzone, I Zucca, G Cavallo, G Teraneo, F Baldelli Bombelli, Pierangelo Metrangolo (Corresponding Author), G Resnati (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

47 Citations (Scopus)

Abstract

19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods
Original languageEnglish
Pages (from-to)8524-8527
JournalJournal of the American Chemical Society
Volume136
Issue number24
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

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Molecular Probes
Magnetic resonance imaging
Relaxation time
Atoms
Molecules
Water
Fluorine-19 Magnetic Resonance Imaging
Therapeutics

Cite this

Tirotta, I., Mastropietro, A., Gordiglieri, C., Gazzera, L., Baggi, F., Baselli, G., ... Resnati, G. (2014). A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI. Journal of the American Chemical Society, 136(24), 8524-8527. https://doi.org/10.1021/ja503270n
Tirotta, I ; Mastropietro, A ; Gordiglieri, C ; Gazzera, L ; Baggi, F ; Baselli, G ; Grazia Bruzzone, M ; Zucca, I ; Cavallo, G ; Teraneo, G ; Baldelli Bombelli, F ; Metrangolo, Pierangelo ; Resnati, G. / A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI. In: Journal of the American Chemical Society. 2014 ; Vol. 136, No. 24. pp. 8524-8527.
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abstract = "19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods",
author = "I Tirotta and A Mastropietro and C Gordiglieri and L Gazzera and F Baggi and G Baselli and {Grazia Bruzzone}, M and I Zucca and G Cavallo and G Teraneo and {Baldelli Bombelli}, F and Pierangelo Metrangolo and G Resnati",
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Tirotta, I, Mastropietro, A, Gordiglieri, C, Gazzera, L, Baggi, F, Baselli, G, Grazia Bruzzone, M, Zucca, I, Cavallo, G, Teraneo, G, Baldelli Bombelli, F, Metrangolo, P & Resnati, G 2014, 'A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI', Journal of the American Chemical Society, vol. 136, no. 24, pp. 8524-8527. https://doi.org/10.1021/ja503270n

A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI. / Tirotta, I; Mastropietro, A; Gordiglieri, C; Gazzera, L; Baggi, F; Baselli, G; Grazia Bruzzone, M; Zucca, I; Cavallo, G; Teraneo, G; Baldelli Bombelli, F; Metrangolo, Pierangelo (Corresponding Author); Resnati, G (Corresponding Author).

In: Journal of the American Chemical Society, Vol. 136, No. 24, 2014, p. 8524-8527.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI

AU - Tirotta, I

AU - Mastropietro, A

AU - Gordiglieri, C

AU - Gazzera, L

AU - Baggi, F

AU - Baselli, G

AU - Grazia Bruzzone, M

AU - Zucca, I

AU - Cavallo, G

AU - Teraneo, G

AU - Baldelli Bombelli, F

AU - Metrangolo, Pierangelo

AU - Resnati, G

PY - 2014

Y1 - 2014

N2 - 19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods

AB - 19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods

U2 - 10.1021/ja503270n

DO - 10.1021/ja503270n

M3 - Article

VL - 136

SP - 8524

EP - 8527

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 24

ER -

Tirotta I, Mastropietro A, Gordiglieri C, Gazzera L, Baggi F, Baselli G et al. A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI. Journal of the American Chemical Society. 2014;136(24):8524-8527. https://doi.org/10.1021/ja503270n