A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI

I Tirotta, A Mastropietro, C Gordiglieri, L Gazzera, F Baggi, G Baselli, M Grazia Bruzzone, I Zucca, G Cavallo, G Teraneo, F Baldelli Bombelli, Pierangelo Metrangolo (Corresponding Author), G Resnati (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

65 Citations (Scopus)

Abstract

19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods
Original languageEnglish
Pages (from-to)8524-8527
JournalJournal of the American Chemical Society
Volume136
Issue number24
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

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