A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI

I Tirotta, A Mastropietro, C Gordiglieri, L Gazzera, F Baggi, G Baselli, M Grazia Bruzzone, I Zucca, G Cavallo, G Teraneo, F Baldelli Bombelli, Pierangelo Metrangolo (Corresponding Author), G Resnati (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

56 Citations (Scopus)

Abstract

19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods
Original languageEnglish
Pages (from-to)8524-8527
JournalJournal of the American Chemical Society
Volume136
Issue number24
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

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  • Cite this

    Tirotta, I., Mastropietro, A., Gordiglieri, C., Gazzera, L., Baggi, F., Baselli, G., Grazia Bruzzone, M., Zucca, I., Cavallo, G., Teraneo, G., Baldelli Bombelli, F., Metrangolo, P., & Resnati, G. (2014). A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI. Journal of the American Chemical Society, 136(24), 8524-8527. https://doi.org/10.1021/ja503270n