A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI

I Tirotta; A Mastropietro; C Gordiglieri; L Gazzera; F Baggi; G Baselli; M Grazia Bruzzone; I Zucca; G Cavallo; G Teraneo; F Baldelli Bombelli; Pierangelo Metrangolo; G. Resnati

doi:10.1021/ja503270n

A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI

I Tirotta
, A Mastropietro
, C Gordiglieri
, L Gazzera
, F Baggi
, G Baselli
, M Grazia Bruzzone
, I Zucca
, G Cavallo
, G Teraneo
, F Baldelli Bombelli
, Pierangelo Metrangolo^*
, G. Resnati^*

^*Corresponding author for this work

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Article › Scientific › peer-review

131 Citations (Scopus)

Abstract

19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods

Original language	English
Pages (from-to)	8524-8527
Journal	Journal of the American Chemical Society
Volume	136
Issue number	24
DOIs	https://doi.org/10.1021/ja503270n
Publication status	Published - 2014
MoE publication type	A1 Journal article-refereed

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10.1021/ja503270n

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Tirotta, I., Mastropietro, A., Gordiglieri, C., Gazzera, L., Baggi, F., Baselli, G., Grazia Bruzzone, M., Zucca, I., Cavallo, G., Teraneo, G., Baldelli Bombelli, F., Metrangolo, P., & Resnati, G. (2014). A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI. Journal of the American Chemical Society, 136(24), 8524-8527. https://doi.org/10.1021/ja503270n

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title = "A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI",

abstract = "19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods",

author = "I Tirotta and A Mastropietro and C Gordiglieri and L Gazzera and F Baggi and G Baselli and \{Grazia Bruzzone\}, M and I Zucca and G Cavallo and G Teraneo and \{Baldelli Bombelli\}, F and Pierangelo Metrangolo and G. Resnati",

year = "2014",

doi = "10.1021/ja503270n",

language = "English",

volume = "136",

pages = "8524--8527",

journal = "Journal of the American Chemical Society",

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Tirotta, I, Mastropietro, A, Gordiglieri, C, Gazzera, L, Baggi, F, Baselli, G, Grazia Bruzzone, M, Zucca, I, Cavallo, G, Teraneo, G, Baldelli Bombelli, F, Metrangolo, P & Resnati, G 2014, 'A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI', Journal of the American Chemical Society, vol. 136, no. 24, pp. 8524-8527. https://doi.org/10.1021/ja503270n

TY - JOUR

T1 - A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI

AU - Tirotta, I

AU - Mastropietro, A

AU - Gordiglieri, C

AU - Gazzera, L

AU - Baggi, F

AU - Baselli, G

AU - Grazia Bruzzone, M

AU - Zucca, I

AU - Cavallo, G

AU - Teraneo, G

AU - Baldelli Bombelli, F

AU - Metrangolo, Pierangelo

AU - Resnati, G.

PY - 2014

Y1 - 2014

N2 - 19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods

AB - 19F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo 19F-MRI applications. The molecule, which bears 36 equivalent 19F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods

U2 - 10.1021/ja503270n

DO - 10.1021/ja503270n

M3 - Article

SN - 0002-7863

VL - 136

SP - 8524

EP - 8527

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 24

ER -

A superfluorinated molecular probe for highly sensitive in vivo 19F-MRI

Abstract

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