Active implant for optoacoustic natural sound enhancement

S. Mohrdiek, M. Fretz, R. Jose James, G. Spinola Durante, T. Burch, A. Kral, A. Rettenmaier, R. Milani, M. Putkonen, W. Noell, M. Ortsiefer, A. Daly, V. Vinciguerra, C. Garnham, D. Shah

    Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

    Abstract

    This paper summarizes the results of an EU project called ACTION: ACTive Implant for Optoacoustic Natural sound enhancement. The project is based on a recent discovery that relatively low levels of pulsed infrared laser light are capable of triggering activity in hair cells of the partially hearing (hearing impaired) cochlea and vestibule. The aim here is the development of a self-contained, smart, highly miniaturized system to provide optoacoustic stimuli directly from an array of miniature light sources in the cochlea. Optoacoustic compound action potentials (oaCAP) are generated by the light source fully inserted into the unmodified cochlea. Previously, the same could only be achieved with external light sources connected to a fiber optic light guide. This feat is achieved by integrating custom made VCSEL arrays at a wavelength of about 1550 nm onto small flexible substrates. The laser light is collimated by a specially designed silicon-based ultra-thin lens (165 um thick) to get the energy density required for the generation of oaCAP signals. A dramatic miniaturization of the packaging technology is also required. A long term biocompatible and hermetic sapphire housing with a size of less than a 1 cubic millimeter and miniature Pt/PtIr feedthroughs is developed, using a low temperature laser assisted process for sealing. A biofouling thin film protection layer is developed to avoid fibrinogen and cell growth on the system.
    Original languageEnglish
    Title of host publicationOptogenetics and Optical Manipulation
    EditorsE. Duco Jansen, Nitish V. Thakor, Samarendra K. Mohanty, Nitish V. Thakor
    PublisherInternational Society for Optics and Photonics SPIE
    Volume10052
    ISBN (Electronic)9781510605459
    ISBN (Print)978-1-5106-0545-9
    DOIs
    Publication statusPublished - 1 Jan 2017
    MoE publication typeA4 Article in a conference publication
    EventOptogenetics and Optical Manipulation, Progress in Biomedical Optics and Imaging - San Francisco, United States
    Duration: 28 Jan 201729 Jan 2017

    Publication series

    SeriesProceedings of SPIE
    Volume10052
    ISSN0277-786X

    Conference

    ConferenceOptogenetics and Optical Manipulation, Progress in Biomedical Optics and Imaging
    Abbreviated titleSPIE BIOS
    CountryUnited States
    CitySan Francisco
    Period28/01/1729/01/17

    Fingerprint

    cochlea
    Photoacoustic effect
    light sources
    Acoustic waves
    hearing
    Light sources
    Light
    acoustics
    augmentation
    Cochlea
    vestibules
    Audition
    fibrinogen
    Lasers
    hair
    sealing
    miniaturization
    Biofouling
    packaging
    infrared lasers

    Keywords

    • biocompatible
    • cochlea
    • hearing loss
    • hermeticity
    • laser
    • miniature package
    • optical stimulation
    • optoacoustic effect
    • Biocompatible

    Cite this

    Mohrdiek, S., Fretz, M., Jose James, R., Spinola Durante, G., Burch, T., Kral, A., ... Shah, D. (2017). Active implant for optoacoustic natural sound enhancement. In E. D. Jansen, N. V. Thakor, S. K. Mohanty, & N. V. Thakor (Eds.), Optogenetics and Optical Manipulation (Vol. 10052). [100520K] International Society for Optics and Photonics SPIE. Proceedings of SPIE, Vol.. 10052 https://doi.org/10.1117/12.2251912
    Mohrdiek, S. ; Fretz, M. ; Jose James, R. ; Spinola Durante, G. ; Burch, T. ; Kral, A. ; Rettenmaier, A. ; Milani, R. ; Putkonen, M. ; Noell, W. ; Ortsiefer, M. ; Daly, A. ; Vinciguerra, V. ; Garnham, C. ; Shah, D. / Active implant for optoacoustic natural sound enhancement. Optogenetics and Optical Manipulation. editor / E. Duco Jansen ; Nitish V. Thakor ; Samarendra K. Mohanty ; Nitish V. Thakor. Vol. 10052 International Society for Optics and Photonics SPIE, 2017. (Proceedings of SPIE, Vol. 10052).
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    title = "Active implant for optoacoustic natural sound enhancement",
    abstract = "This paper summarizes the results of an EU project called ACTION: ACTive Implant for Optoacoustic Natural sound enhancement. The project is based on a recent discovery that relatively low levels of pulsed infrared laser light are capable of triggering activity in hair cells of the partially hearing (hearing impaired) cochlea and vestibule. The aim here is the development of a self-contained, smart, highly miniaturized system to provide optoacoustic stimuli directly from an array of miniature light sources in the cochlea. Optoacoustic compound action potentials (oaCAP) are generated by the light source fully inserted into the unmodified cochlea. Previously, the same could only be achieved with external light sources connected to a fiber optic light guide. This feat is achieved by integrating custom made VCSEL arrays at a wavelength of about 1550 nm onto small flexible substrates. The laser light is collimated by a specially designed silicon-based ultra-thin lens (165 um thick) to get the energy density required for the generation of oaCAP signals. A dramatic miniaturization of the packaging technology is also required. A long term biocompatible and hermetic sapphire housing with a size of less than a 1 cubic millimeter and miniature Pt/PtIr feedthroughs is developed, using a low temperature laser assisted process for sealing. A biofouling thin film protection layer is developed to avoid fibrinogen and cell growth on the system.",
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    author = "S. Mohrdiek and M. Fretz and {Jose James}, R. and {Spinola Durante}, G. and T. Burch and A. Kral and A. Rettenmaier and R. Milani and M. Putkonen and W. Noell and M. Ortsiefer and A. Daly and V. Vinciguerra and C. Garnham and D. Shah",
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    Mohrdiek, S, Fretz, M, Jose James, R, Spinola Durante, G, Burch, T, Kral, A, Rettenmaier, A, Milani, R, Putkonen, M, Noell, W, Ortsiefer, M, Daly, A, Vinciguerra, V, Garnham, C & Shah, D 2017, Active implant for optoacoustic natural sound enhancement. in ED Jansen, NV Thakor, SK Mohanty & NV Thakor (eds), Optogenetics and Optical Manipulation. vol. 10052, 100520K, International Society for Optics and Photonics SPIE, Proceedings of SPIE, vol. 10052, Optogenetics and Optical Manipulation, Progress in Biomedical Optics and Imaging, San Francisco, United States, 28/01/17. https://doi.org/10.1117/12.2251912

    Active implant for optoacoustic natural sound enhancement. / Mohrdiek, S.; Fretz, M.; Jose James, R.; Spinola Durante, G.; Burch, T.; Kral, A.; Rettenmaier, A.; Milani, R.; Putkonen, M.; Noell, W.; Ortsiefer, M.; Daly, A.; Vinciguerra, V.; Garnham, C.; Shah, D.

    Optogenetics and Optical Manipulation. ed. / E. Duco Jansen; Nitish V. Thakor; Samarendra K. Mohanty; Nitish V. Thakor. Vol. 10052 International Society for Optics and Photonics SPIE, 2017. 100520K (Proceedings of SPIE, Vol. 10052).

    Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

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    Mohrdiek S, Fretz M, Jose James R, Spinola Durante G, Burch T, Kral A et al. Active implant for optoacoustic natural sound enhancement. In Jansen ED, Thakor NV, Mohanty SK, Thakor NV, editors, Optogenetics and Optical Manipulation. Vol. 10052. International Society for Optics and Photonics SPIE. 2017. 100520K. (Proceedings of SPIE, Vol. 10052). https://doi.org/10.1117/12.2251912