Adhesion force measurement of a DPI size pharmaceutical particle by colloid probe atomic force microscopy

M. Tsukada (Corresponding Author), R. Irie, Y. Yonemochi, R. Noda, H. Kamiya, W. Watanabe, Esko I. Kauppinen

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

The method to determine the adhesion characteristics of fine drug particles for dry powder inhalation (DPI) was established using a colloid probe which mounted a 1–3 μm drug particle on a commercial atomic force microscope (AFM) cantilever. A new preparation system of colloid probes for fine particles smaller than 2.5 μm in diameter was developed with the aid of a micromanipulator and a video microscope. Using this colloid probe, adhesion force distribution between a spherical polycrystalline drug particle and a plate of lactose monohydrate representing for DPI carrier materials or stainless steel for device wall materials was measured. Atmospheric humidity as well as the material and surface roughness of a target plate affected the determined adhesion force. With increasing surface roughness of a lactose plate, the adhesion force between a drug particle and the plate distributed more widely and their mean value decreased. Adhesion force increased meaningfully with atmospheric humidity. Adhesion force for stainless steel was higher than that for lactose.

Original languageEnglish
Pages (from-to)262 - 269
Number of pages8
JournalPowder Technology
Volume141
Issue number3
DOIs
Publication statusPublished - 2004
MoE publication typeA1 Journal article-refereed

Fingerprint

Force measurement
Colloids
Powders
Drug products
Particles (particulate matter)
Atomic force microscopy
Adhesion
Lactose
Pharmaceutical Preparations
Stainless Steel
Atmospheric humidity
Microscopes
Stainless steel
Surface roughness
Micromanipulators

Keywords

  • colloid probe
  • AFM
  • atomic force microscope
  • dry powder inhalation
  • drug particle adhesion
  • lactose carrier
  • adhesion
  • adhesion force measurement

Cite this

Tsukada, M., Irie, R., Yonemochi, Y., Noda, R., Kamiya, H., Watanabe, W., & Kauppinen, E. I. (2004). Adhesion force measurement of a DPI size pharmaceutical particle by colloid probe atomic force microscopy. Powder Technology, 141(3), 262 - 269. https://doi.org/10.1016/j.powtec.2004.03.008
Tsukada, M. ; Irie, R. ; Yonemochi, Y. ; Noda, R. ; Kamiya, H. ; Watanabe, W. ; Kauppinen, Esko I. / Adhesion force measurement of a DPI size pharmaceutical particle by colloid probe atomic force microscopy. In: Powder Technology. 2004 ; Vol. 141, No. 3. pp. 262 - 269.
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Tsukada, M, Irie, R, Yonemochi, Y, Noda, R, Kamiya, H, Watanabe, W & Kauppinen, EI 2004, 'Adhesion force measurement of a DPI size pharmaceutical particle by colloid probe atomic force microscopy', Powder Technology, vol. 141, no. 3, pp. 262 - 269. https://doi.org/10.1016/j.powtec.2004.03.008

Adhesion force measurement of a DPI size pharmaceutical particle by colloid probe atomic force microscopy. / Tsukada, M. (Corresponding Author); Irie, R.; Yonemochi, Y.; Noda, R.; Kamiya, H.; Watanabe, W.; Kauppinen, Esko I.

In: Powder Technology, Vol. 141, No. 3, 2004, p. 262 - 269.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Tsukada, M.

AU - Irie, R.

AU - Yonemochi, Y.

AU - Noda, R.

AU - Kamiya, H.

AU - Watanabe, W.

AU - Kauppinen, Esko I.

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AB - The method to determine the adhesion characteristics of fine drug particles for dry powder inhalation (DPI) was established using a colloid probe which mounted a 1–3 μm drug particle on a commercial atomic force microscope (AFM) cantilever. A new preparation system of colloid probes for fine particles smaller than 2.5 μm in diameter was developed with the aid of a micromanipulator and a video microscope. Using this colloid probe, adhesion force distribution between a spherical polycrystalline drug particle and a plate of lactose monohydrate representing for DPI carrier materials or stainless steel for device wall materials was measured. Atmospheric humidity as well as the material and surface roughness of a target plate affected the determined adhesion force. With increasing surface roughness of a lactose plate, the adhesion force between a drug particle and the plate distributed more widely and their mean value decreased. Adhesion force increased meaningfully with atmospheric humidity. Adhesion force for stainless steel was higher than that for lactose.

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