Advantages of NIR radiation use for optical determination of skin horny layer thickness with embedded TiO2 nanoparticles during tape stripping procedure

Alexey P. Popov, A. V. Priezzhev, J. Lademann, Risto Myllylä

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Abstract

The tape stripping technique is an experimental method frequently used for reconstruction of the in-depth distribution of various topically administered substances within the horny layer of human skin, e.g., compounds contained in sunscreens. Titanium dioxide (TiO2) nanoparticles (25-200 nm in diameter) are one such compound. Optical techniques which apply blue light are found to be suitable for reconstruction. However, the presence of particles affects the light propagation within the skin and therefore causes incorrect determination of strip thickness, leading to an improper reconstructed distribution of nanoparticle concentration revealed from the experimental data. This study evaluates the errors emerging from the use of blue (400 nm) and NIR (800 nm) radiation and finds the use of longer wavelength light more advantageous. Particles of different diameters are considered, and it is revealed that the application of small particles (25-60 nm) results in the lowest rate of error.

Original languageEnglish
Pages (from-to)751-757
JournalLaser Physics
Volume16
Issue number5
DOIs
Publication statusPublished - 1 May 2006
MoE publication typeA1 Journal article-refereed

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