Aerosol flow reactor method for synthesis of drug nanoparticles

Hannele Eerikäinen, Wiwik Watanabe, Esko I. Kauppinen (Corresponding Author), Petri Ahonen

Research output: Contribution to journalArticleScientificpeer-review

66 Citations (Scopus)

Abstract

An aerosol flow reactor method, a one-step continuous process to produce nanometer-sized drug particles with unimodal size distribution, was developed. This method involves first dissolving the drug material in question into a suitable solvent, which is then followed by atomising the solution as fine droplets into carrier gas. A heated laminar flow reactor tube is used to evaporate the solvent, and solid drug nanoparticles are formed. In this study, the effect of drying temperature on the particle size and morphology was examined. A glucocorticosteroid used for asthma therapy, beclomethasone dipropionate, was selected as an experimental model drug. The geometric number mean particle diameter increases significantly with increasing reactor temperatures due to formation of hollow nanoparticles. Above 160 °C, however, further increase in temperature results in decreasing particle size. The produced nanoparticles are spherical and show smooth surfaces at all studied experimental conditions.
Original languageEnglish
Pages (from-to)357-360
Number of pages4
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume55
Issue number3
DOIs
Publication statusPublished - 2003
MoE publication typeNot Eligible

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Aerosols
Nanoparticles
Particle Size
Pharmaceutical Preparations
Temperature
Beclomethasone
Theoretical Models
Asthma
Gases
Therapeutics

Keywords

  • aerosol particles
  • aerosol flow reactor method
  • aerosols
  • nanoparticles
  • drugs
  • preparation of drug nanoparticles
  • particle size
  • particle size distribution

Cite this

Eerikäinen, Hannele ; Watanabe, Wiwik ; Kauppinen, Esko I. ; Ahonen, Petri. / Aerosol flow reactor method for synthesis of drug nanoparticles. In: European Journal of Pharmaceutics and Biopharmaceutics. 2003 ; Vol. 55, No. 3. pp. 357-360.
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Aerosol flow reactor method for synthesis of drug nanoparticles. / Eerikäinen, Hannele; Watanabe, Wiwik; Kauppinen, Esko I. (Corresponding Author); Ahonen, Petri.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 55, No. 3, 2003, p. 357-360.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Aerosol flow reactor method for synthesis of drug nanoparticles

AU - Eerikäinen, Hannele

AU - Watanabe, Wiwik

AU - Kauppinen, Esko I.

AU - Ahonen, Petri

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AB - An aerosol flow reactor method, a one-step continuous process to produce nanometer-sized drug particles with unimodal size distribution, was developed. This method involves first dissolving the drug material in question into a suitable solvent, which is then followed by atomising the solution as fine droplets into carrier gas. A heated laminar flow reactor tube is used to evaporate the solvent, and solid drug nanoparticles are formed. In this study, the effect of drying temperature on the particle size and morphology was examined. A glucocorticosteroid used for asthma therapy, beclomethasone dipropionate, was selected as an experimental model drug. The geometric number mean particle diameter increases significantly with increasing reactor temperatures due to formation of hollow nanoparticles. Above 160 °C, however, further increase in temperature results in decreasing particle size. The produced nanoparticles are spherical and show smooth surfaces at all studied experimental conditions.

KW - aerosol particles

KW - aerosol flow reactor method

KW - aerosols

KW - nanoparticles

KW - drugs

KW - preparation of drug nanoparticles

KW - particle size

KW - particle size distribution

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