Alfentanil inhibits muscle fasciculations caused by suxamethonium in children and in young adults

A. Yli-Hankala, T. Randell, Timo Varpula, L. Lindgren

Research output: Contribution to journalArticleScientificpeer-review

6 Citations (Scopus)

Abstract

The effect of alfentanil on suxamethonium‐induced muscle fasciculations was studied in a double‐blind study in 34 children (mean age 6.8 years) and in 30 adults (mean age 20 years). After pretreatment with either alfentanil 50 μg kg‐1 or saline, each patient was anaesthetized with a sleep dose of thiopental followed by suxamethonium 1.5 mg kg‐1 for endotracheal intubation. Compared to the control groups, alfentanil significantly decreased the intensity of visible muscle fasciculations caused by suxamethonium. In children, the duration of muscle fasciculations was shorter in the alfentanil than in the control group. In adults, the intensity rather than the duration of fasciculations was attenuated by alfentanil. The inhibition of fasciculations caused by alfentanil was also demonstrated in children in the surface electromyogram recorded on the biceps. There was no circulatory response to endotracheal intubation in the groups pretreated with alfentanil.

Original languageEnglish
Pages (from-to)588-591
Number of pages4
JournalActa Anaesthesiologica Scandinavica
Volume36
Issue number6
DOIs
Publication statusPublished - 1992
MoE publication typeA1 Journal article-refereed

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