Alignment of 3-dimensional cardiac structures in O-15-labeled water PET emission images with mutual information

Anu Juslin (Corresponding Author), Jyrki Lötjönen, Sergey V. Nesterov, Kari Kalliokoski, Juhani Knuuti, Ulla Ruotsalainen

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Abstract

Background
The aim of this study was to develop a method to correct the heart position between two oxygen 15-labeled water cardiac positron emission tomography (PET) image sets to be able to use the equivalent regions of interest for the quantification of the perfusion values in the same myocardial segments.

Methods and Results
Independent component analysis was applied to the dynamic image sets (simulated phantom and 6 rest-pharmacologic stress and 10 rest-rest image sets of healthy female volunteers) acquired at different time points to separate the cardiac structures (ventricles and myocardium). The separated component images from independent component analysis from the 2 studies of the same individual were aligned with a normalized mutual information-based registration method. The alignment parameters were applied to position the regions of interest in the floating image sets for calculation of the myocardial blood flow values. In the rest case the mean myocardial blood flow value was 0.76 ± 0.12 mL · g±1 · min±1 for the manual method and 0.79 ± 0.10 mL · g±1 · min±1 for the proposed method (by use of the right ventricle component in the alignment), and in the stress case these values were 3.39 ± 0.70 mL · g±1 · min±1 and 4.01 ± 0.71 mL · g±1 · min±1, respectively. No statistically significant difference was found between the methods.

Conclusion
In the tests with the phantom and patient images the alignment of cardiac structures was shown to be successful. The alignment could be done without the use of information from the myocardial compartment.
Original languageEnglish
Pages (from-to)82-91
JournalJournal of Nuclear Cardiology
Volume14
Issue number1
DOIs
Publication statusPublished - 2007
MoE publication typeA1 Journal article-refereed

Fingerprint

Positron-Emission Tomography
Water
Heart Ventricles
Myocardium
Healthy Volunteers
Perfusion
Oxygen

Keywords

  • positron emission tomography
  • tomography
  • PET
  • myocardial perfusion
  • registration
  • mutual information
  • independent component analysis

Cite this

Juslin, Anu ; Lötjönen, Jyrki ; Nesterov, Sergey V. ; Kalliokoski, Kari ; Knuuti, Juhani ; Ruotsalainen, Ulla. / Alignment of 3-dimensional cardiac structures in O-15-labeled water PET emission images with mutual information. In: Journal of Nuclear Cardiology. 2007 ; Vol. 14, No. 1. pp. 82-91.
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abstract = "BackgroundThe aim of this study was to develop a method to correct the heart position between two oxygen 15-labeled water cardiac positron emission tomography (PET) image sets to be able to use the equivalent regions of interest for the quantification of the perfusion values in the same myocardial segments.Methods and ResultsIndependent component analysis was applied to the dynamic image sets (simulated phantom and 6 rest-pharmacologic stress and 10 rest-rest image sets of healthy female volunteers) acquired at different time points to separate the cardiac structures (ventricles and myocardium). The separated component images from independent component analysis from the 2 studies of the same individual were aligned with a normalized mutual information-based registration method. The alignment parameters were applied to position the regions of interest in the floating image sets for calculation of the myocardial blood flow values. In the rest case the mean myocardial blood flow value was 0.76 ± 0.12 mL · g±1 · min±1 for the manual method and 0.79 ± 0.10 mL · g±1 · min±1 for the proposed method (by use of the right ventricle component in the alignment), and in the stress case these values were 3.39 ± 0.70 mL · g±1 · min±1 and 4.01 ± 0.71 mL · g±1 · min±1, respectively. No statistically significant difference was found between the methods.ConclusionIn the tests with the phantom and patient images the alignment of cardiac structures was shown to be successful. The alignment could be done without the use of information from the myocardial compartment.",
keywords = "positron emission tomography, tomography, PET, myocardial perfusion, registration, mutual information, independent component analysis",
author = "Anu Juslin and Jyrki L{\"o}tj{\"o}nen and Nesterov, {Sergey V.} and Kari Kalliokoski and Juhani Knuuti and Ulla Ruotsalainen",
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Alignment of 3-dimensional cardiac structures in O-15-labeled water PET emission images with mutual information. / Juslin, Anu (Corresponding Author); Lötjönen, Jyrki; Nesterov, Sergey V.; Kalliokoski, Kari; Knuuti, Juhani; Ruotsalainen, Ulla.

In: Journal of Nuclear Cardiology, Vol. 14, No. 1, 2007, p. 82-91.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Alignment of 3-dimensional cardiac structures in O-15-labeled water PET emission images with mutual information

AU - Juslin, Anu

AU - Lötjönen, Jyrki

AU - Nesterov, Sergey V.

AU - Kalliokoski, Kari

AU - Knuuti, Juhani

AU - Ruotsalainen, Ulla

PY - 2007

Y1 - 2007

N2 - BackgroundThe aim of this study was to develop a method to correct the heart position between two oxygen 15-labeled water cardiac positron emission tomography (PET) image sets to be able to use the equivalent regions of interest for the quantification of the perfusion values in the same myocardial segments.Methods and ResultsIndependent component analysis was applied to the dynamic image sets (simulated phantom and 6 rest-pharmacologic stress and 10 rest-rest image sets of healthy female volunteers) acquired at different time points to separate the cardiac structures (ventricles and myocardium). The separated component images from independent component analysis from the 2 studies of the same individual were aligned with a normalized mutual information-based registration method. The alignment parameters were applied to position the regions of interest in the floating image sets for calculation of the myocardial blood flow values. In the rest case the mean myocardial blood flow value was 0.76 ± 0.12 mL · g±1 · min±1 for the manual method and 0.79 ± 0.10 mL · g±1 · min±1 for the proposed method (by use of the right ventricle component in the alignment), and in the stress case these values were 3.39 ± 0.70 mL · g±1 · min±1 and 4.01 ± 0.71 mL · g±1 · min±1, respectively. No statistically significant difference was found between the methods.ConclusionIn the tests with the phantom and patient images the alignment of cardiac structures was shown to be successful. The alignment could be done without the use of information from the myocardial compartment.

AB - BackgroundThe aim of this study was to develop a method to correct the heart position between two oxygen 15-labeled water cardiac positron emission tomography (PET) image sets to be able to use the equivalent regions of interest for the quantification of the perfusion values in the same myocardial segments.Methods and ResultsIndependent component analysis was applied to the dynamic image sets (simulated phantom and 6 rest-pharmacologic stress and 10 rest-rest image sets of healthy female volunteers) acquired at different time points to separate the cardiac structures (ventricles and myocardium). The separated component images from independent component analysis from the 2 studies of the same individual were aligned with a normalized mutual information-based registration method. The alignment parameters were applied to position the regions of interest in the floating image sets for calculation of the myocardial blood flow values. In the rest case the mean myocardial blood flow value was 0.76 ± 0.12 mL · g±1 · min±1 for the manual method and 0.79 ± 0.10 mL · g±1 · min±1 for the proposed method (by use of the right ventricle component in the alignment), and in the stress case these values were 3.39 ± 0.70 mL · g±1 · min±1 and 4.01 ± 0.71 mL · g±1 · min±1, respectively. No statistically significant difference was found between the methods.ConclusionIn the tests with the phantom and patient images the alignment of cardiac structures was shown to be successful. The alignment could be done without the use of information from the myocardial compartment.

KW - positron emission tomography

KW - tomography

KW - PET

KW - myocardial perfusion

KW - registration

KW - mutual information

KW - independent component analysis

U2 - 10.1016/j.nuclcard.2006.10.020

DO - 10.1016/j.nuclcard.2006.10.020

M3 - Article

VL - 14

SP - 82

EP - 91

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

IS - 1

ER -