Alignment of 3-dimensional cardiac structures in O-15-labeled water PET emission images with mutual information

A. Juslin (Corresponding Author), Jyrki Lötjönen, S.V. Nesterov, K. Kalliokoski, J. Knuuti, U. Ruotsalainen

    Research output: Contribution to journalArticleScientificpeer-review

    4 Citations (Scopus)

    Abstract

    Background
    The aim of this study was to develop a method to correct the heart position between two oxygen 15-labeled water cardiac positron emission tomography (PET) image sets to be able to use the equivalent regions of interest for the quantification of the perfusion values in the same myocardial segments.

    Methods and Results
    Independent component analysis was applied to the dynamic image sets (simulated phantom and 6 rest-pharmacologic stress and 10 rest-rest image sets of healthy female volunteers) acquired at different time points to separate the cardiac structures (ventricles and myocardium). The separated component images from independent component analysis from the 2 studies of the same individual were aligned with a normalized mutual information-based registration method. The alignment parameters were applied to position the regions of interest in the floating image sets for calculation of the myocardial blood flow values. In the rest case the mean myocardial blood flow value was 0.76 ± 0.12 mL · g±1 · min±1 for the manual method and 0.79 ± 0.10 mL · g±1 · min±1 for the proposed method (by use of the right ventricle component in the alignment), and in the stress case these values were 3.39 ± 0.70 mL · g±1 · min±1 and 4.01 ± 0.71 mL · g±1 · min±1, respectively. No statistically significant difference was found between the methods.

    Conclusion
    In the tests with the phantom and patient images the alignment of cardiac structures was shown to be successful. The alignment could be done without the use of information from the myocardial compartment.
    Original languageEnglish
    Pages (from-to)82-91
    JournalJournal of Nuclear Cardiology
    Volume14
    Issue number1
    DOIs
    Publication statusPublished - 2007
    MoE publication typeA1 Journal article-refereed

    Fingerprint

    Positron-Emission Tomography
    Water
    Heart Ventricles
    Myocardium
    Healthy Volunteers
    Perfusion
    Oxygen

    Keywords

    • positron emission tomography
    • tomography
    • PET
    • myocardial perfusion
    • registration
    • mutual information
    • independent component analysis

    Cite this

    Juslin, A. ; Lötjönen, Jyrki ; Nesterov, S.V. ; Kalliokoski, K. ; Knuuti, J. ; Ruotsalainen, U. / Alignment of 3-dimensional cardiac structures in O-15-labeled water PET emission images with mutual information. In: Journal of Nuclear Cardiology. 2007 ; Vol. 14, No. 1. pp. 82-91.
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    title = "Alignment of 3-dimensional cardiac structures in O-15-labeled water PET emission images with mutual information",
    abstract = "BackgroundThe aim of this study was to develop a method to correct the heart position between two oxygen 15-labeled water cardiac positron emission tomography (PET) image sets to be able to use the equivalent regions of interest for the quantification of the perfusion values in the same myocardial segments.Methods and ResultsIndependent component analysis was applied to the dynamic image sets (simulated phantom and 6 rest-pharmacologic stress and 10 rest-rest image sets of healthy female volunteers) acquired at different time points to separate the cardiac structures (ventricles and myocardium). The separated component images from independent component analysis from the 2 studies of the same individual were aligned with a normalized mutual information-based registration method. The alignment parameters were applied to position the regions of interest in the floating image sets for calculation of the myocardial blood flow values. In the rest case the mean myocardial blood flow value was 0.76 ± 0.12 mL · g±1 · min±1 for the manual method and 0.79 ± 0.10 mL · g±1 · min±1 for the proposed method (by use of the right ventricle component in the alignment), and in the stress case these values were 3.39 ± 0.70 mL · g±1 · min±1 and 4.01 ± 0.71 mL · g±1 · min±1, respectively. No statistically significant difference was found between the methods.ConclusionIn the tests with the phantom and patient images the alignment of cardiac structures was shown to be successful. The alignment could be done without the use of information from the myocardial compartment.",
    keywords = "positron emission tomography, tomography, PET, myocardial perfusion, registration, mutual information, independent component analysis",
    author = "A. Juslin and Jyrki L{\"o}tj{\"o}nen and S.V. Nesterov and K. Kalliokoski and J. Knuuti and U. Ruotsalainen",
    year = "2007",
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    Alignment of 3-dimensional cardiac structures in O-15-labeled water PET emission images with mutual information. / Juslin, A. (Corresponding Author); Lötjönen, Jyrki; Nesterov, S.V.; Kalliokoski, K.; Knuuti, J.; Ruotsalainen, U.

    In: Journal of Nuclear Cardiology, Vol. 14, No. 1, 2007, p. 82-91.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - Alignment of 3-dimensional cardiac structures in O-15-labeled water PET emission images with mutual information

    AU - Juslin, A.

    AU - Lötjönen, Jyrki

    AU - Nesterov, S.V.

    AU - Kalliokoski, K.

    AU - Knuuti, J.

    AU - Ruotsalainen, U.

    PY - 2007

    Y1 - 2007

    N2 - BackgroundThe aim of this study was to develop a method to correct the heart position between two oxygen 15-labeled water cardiac positron emission tomography (PET) image sets to be able to use the equivalent regions of interest for the quantification of the perfusion values in the same myocardial segments.Methods and ResultsIndependent component analysis was applied to the dynamic image sets (simulated phantom and 6 rest-pharmacologic stress and 10 rest-rest image sets of healthy female volunteers) acquired at different time points to separate the cardiac structures (ventricles and myocardium). The separated component images from independent component analysis from the 2 studies of the same individual were aligned with a normalized mutual information-based registration method. The alignment parameters were applied to position the regions of interest in the floating image sets for calculation of the myocardial blood flow values. In the rest case the mean myocardial blood flow value was 0.76 ± 0.12 mL · g±1 · min±1 for the manual method and 0.79 ± 0.10 mL · g±1 · min±1 for the proposed method (by use of the right ventricle component in the alignment), and in the stress case these values were 3.39 ± 0.70 mL · g±1 · min±1 and 4.01 ± 0.71 mL · g±1 · min±1, respectively. No statistically significant difference was found between the methods.ConclusionIn the tests with the phantom and patient images the alignment of cardiac structures was shown to be successful. The alignment could be done without the use of information from the myocardial compartment.

    AB - BackgroundThe aim of this study was to develop a method to correct the heart position between two oxygen 15-labeled water cardiac positron emission tomography (PET) image sets to be able to use the equivalent regions of interest for the quantification of the perfusion values in the same myocardial segments.Methods and ResultsIndependent component analysis was applied to the dynamic image sets (simulated phantom and 6 rest-pharmacologic stress and 10 rest-rest image sets of healthy female volunteers) acquired at different time points to separate the cardiac structures (ventricles and myocardium). The separated component images from independent component analysis from the 2 studies of the same individual were aligned with a normalized mutual information-based registration method. The alignment parameters were applied to position the regions of interest in the floating image sets for calculation of the myocardial blood flow values. In the rest case the mean myocardial blood flow value was 0.76 ± 0.12 mL · g±1 · min±1 for the manual method and 0.79 ± 0.10 mL · g±1 · min±1 for the proposed method (by use of the right ventricle component in the alignment), and in the stress case these values were 3.39 ± 0.70 mL · g±1 · min±1 and 4.01 ± 0.71 mL · g±1 · min±1, respectively. No statistically significant difference was found between the methods.ConclusionIn the tests with the phantom and patient images the alignment of cardiac structures was shown to be successful. The alignment could be done without the use of information from the myocardial compartment.

    KW - positron emission tomography

    KW - tomography

    KW - PET

    KW - myocardial perfusion

    KW - registration

    KW - mutual information

    KW - independent component analysis

    U2 - 10.1016/j.nuclcard.2006.10.020

    DO - 10.1016/j.nuclcard.2006.10.020

    M3 - Article

    VL - 14

    SP - 82

    EP - 91

    JO - Journal of Nuclear Cardiology

    JF - Journal of Nuclear Cardiology

    SN - 1071-3581

    IS - 1

    ER -