Abstract
Background/Objectives:Alkylresorcinols (ARs) have been
suggested as biomarkers of whole-grain wheat and rye
intake. Plasma AR concentrations have a short half-life;
hence, long-term biomarkers are needed. This study
evaluated the responsiveness of ARs in adipose tissue
biopsies as biomarkers after a whole-grain intake
intervention.Subjects/Methods:Samples and data of 27
participants from a 12-week randomized parallel-group
dietary intervention were available. The participants
were replacing their habitual diet with a
whole-grain-enriched diet (WGDG) or a refined grain diet
(RDG) during the intervention. Blood samples and adipose
tissue biopsies were collected at baseline and after 12
weeks, and AR concentrations in the plasma and adipose
tissues from the participants were compared against
estimated whole-grain intake.Results:AR concentrations in
the adipose tissue and plasma did not change after 12
weeks in the WGDG group, as no significant increase in
whole-grain intake was observed, but was significantly
lower than baseline in the RDG group (P
| Original language | English |
|---|---|
| Pages (from-to) | 1244-1248 |
| Journal | European Journal of Clinical Nutrition |
| Volume | 69 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2015 |
| MoE publication type | A1 Journal article-refereed |
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Wu, H., Kolehmainen, M., Mykkänen, H., Poutanen, K., Uusitupa, M., Schwab, U., Wolk, A., & Landberg, R. (2015). Alkylresorcinols in adipose tissue biopsies as biomarkers of whole-grain intake: An exploratory study of responsiveness to advised intake over 12 weeks. European Journal of Clinical Nutrition, 69(11), 1244-1248. https://doi.org/10.1038/ejcn.2015.138