Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1244-1248 |
| Journal | European Journal of Clinical Nutrition |
| Volume | 69 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2015 |
| MoE publication type | A1 Journal article-refereed |
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Alkylresorcinols in adipose tissue biopsies as biomarkers of whole-grain intake: An exploratory study of responsiveness to advised intake over 12 weeks. / Wu, H. (Corresponding Author); Kolehmainen, M.; Mykkänen, H.; Poutanen, K.; Uusitupa, M.; Schwab, U.; Wolk, A.; Landberg, R.
In: European Journal of Clinical Nutrition, Vol. 69, No. 11, 2015, p. 1244-1248.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Alkylresorcinols in adipose tissue biopsies as biomarkers of whole-grain intake: An exploratory study of responsiveness to advised intake over 12 weeks
AU - Wu, H.
AU - Kolehmainen, M.
AU - Mykkänen, H.
AU - Poutanen, K.
AU - Uusitupa, M.
AU - Schwab, U.
AU - Wolk, A.
AU - Landberg, R.
PY - 2015
Y1 - 2015
N2 - Background/Objectives:Alkylresorcinols (ARs) have been suggested as biomarkers of whole-grain wheat and rye intake. Plasma AR concentrations have a short half-life; hence, long-term biomarkers are needed. This study evaluated the responsiveness of ARs in adipose tissue biopsies as biomarkers after a whole-grain intake intervention.Subjects/Methods:Samples and data of 27 participants from a 12-week randomized parallel-group dietary intervention were available. The participants were replacing their habitual diet with a whole-grain-enriched diet (WGDG) or a refined grain diet (RDG) during the intervention. Blood samples and adipose tissue biopsies were collected at baseline and after 12 weeks, and AR concentrations in the plasma and adipose tissues from the participants were compared against estimated whole-grain intake.Results:AR concentrations in the adipose tissue and plasma did not change after 12 weeks in the WGDG group, as no significant increase in whole-grain intake was observed, but was significantly lower than baseline in the RDG group (P
AB - Background/Objectives:Alkylresorcinols (ARs) have been suggested as biomarkers of whole-grain wheat and rye intake. Plasma AR concentrations have a short half-life; hence, long-term biomarkers are needed. This study evaluated the responsiveness of ARs in adipose tissue biopsies as biomarkers after a whole-grain intake intervention.Subjects/Methods:Samples and data of 27 participants from a 12-week randomized parallel-group dietary intervention were available. The participants were replacing their habitual diet with a whole-grain-enriched diet (WGDG) or a refined grain diet (RDG) during the intervention. Blood samples and adipose tissue biopsies were collected at baseline and after 12 weeks, and AR concentrations in the plasma and adipose tissues from the participants were compared against estimated whole-grain intake.Results:AR concentrations in the adipose tissue and plasma did not change after 12 weeks in the WGDG group, as no significant increase in whole-grain intake was observed, but was significantly lower than baseline in the RDG group (P
U2 - 10.1038/ejcn.2015.138
DO - 10.1038/ejcn.2015.138
M3 - Article
VL - 69
SP - 1244
EP - 1248
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
SN - 0954-3007
IS - 11
ER -