Alkylresorcinols in adipose tissue biopsies as biomarkers of whole-grain intake: An exploratory study of responsiveness to advised intake over 12 weeks

H. Wu (Corresponding Author), M. Kolehmainen, H. Mykkänen, K. Poutanen, M. Uusitupa, U. Schwab, A. Wolk, R. Landberg

    Research output: Contribution to journalArticleScientificpeer-review

    8 Citations (Scopus)

    Abstract

    Background/Objectives:Alkylresorcinols (ARs) have been suggested as biomarkers of whole-grain wheat and rye intake. Plasma AR concentrations have a short half-life; hence, long-term biomarkers are needed. This study evaluated the responsiveness of ARs in adipose tissue biopsies as biomarkers after a whole-grain intake intervention.Subjects/Methods:Samples and data of 27 participants from a 12-week randomized parallel-group dietary intervention were available. The participants were replacing their habitual diet with a whole-grain-enriched diet (WGDG) or a refined grain diet (RDG) during the intervention. Blood samples and adipose tissue biopsies were collected at baseline and after 12 weeks, and AR concentrations in the plasma and adipose tissues from the participants were compared against estimated whole-grain intake.Results:AR concentrations in the adipose tissue and plasma did not change after 12 weeks in the WGDG group, as no significant increase in whole-grain intake was observed, but was significantly lower than baseline in the RDG group (P
    Original languageEnglish
    Pages (from-to)1244-1248
    JournalEuropean Journal of Clinical Nutrition
    Volume69
    Issue number11
    DOIs
    Publication statusPublished - 2015
    MoE publication typeA1 Journal article-refereed

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