Abstract
| Original language | English |
|---|---|
| Title of host publication | Bio-MEMS and Medical Microdevices |
| Editors | Angeliki Tserepi, Manuel Delgado-Restituto, Eleni Makarona |
| Publisher | International Society for Optics and Photonics SPIE |
| ISBN (Print) | 978-081949562-4 |
| DOIs | |
| Publication status | Published - 2013 |
| MoE publication type | Not Eligible |
| Event | SPIE Microtechnologies, 2013 - Grenoble, France Duration: 24 Apr 2013 → 26 Apr 2013 |
Publication series
| Series | Proceedings of SPIE |
|---|---|
| Volume | 8765 |
| ISSN | 0277-786X |
Conference
| Conference | SPIE Microtechnologies, 2013 |
|---|---|
| Country | France |
| City | Grenoble |
| Period | 24/04/13 → 26/04/13 |
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Keywords
- integrated interferometers
- label free detection
- optical biosensors
- optocouplers
Cite this
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All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing. / Misiakos, K.; Makarona, E.; Raptis, I.; Salapatas, A.; Psarouli, A.; Kakabakos, S.; Petrou, P.; Hoekman, M.; Heideman, R.; Stoffer, R.; Tukkiniemi, Kari; Soppanen, M.; Jobst, G.; Nounessis, G.; Budkowski, A.; Rysz, J.
Bio-MEMS and Medical Microdevices. ed. / Angeliki Tserepi; Manuel Delgado-Restituto; Eleni Makarona. International Society for Optics and Photonics SPIE, 2013. 87650H (Proceedings of SPIE, Vol. 8765).Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review
TY - GEN
T1 - All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing
AU - Misiakos, K.
AU - Makarona, E.
AU - Raptis, I.
AU - Salapatas, A.
AU - Psarouli, A.
AU - Kakabakos, S.
AU - Petrou, P.
AU - Hoekman, M.
AU - Heideman, R.
AU - Stoffer, R.
AU - Tukkiniemi, Kari
AU - Soppanen, M.
AU - Jobst, G.
AU - Nounessis, G.
AU - Budkowski, A.
AU - Rysz, J.
PY - 2013
Y1 - 2013
N2 - Despite the advances in optical biosensors, the existing technological approaches still face two major challenges: the inherent inability of most sensors to integrate the optical source in the transducer chip, and the need to specifically design the optical transducer per application. In this work, the development of a radical optoelectronic platform is demonstrated based on a monolithic optocoupler array fabricated by standard Si-technology and suitable for multi-analyte detection. The platform has been specifically designed biochemical sensing. In the all-silicon array of transducers, each optocoupler has its own excitation source, while the entire array share a common detector. The light emitting devices (LEDs) are silicon avalanche diodes biased beyond their breakdown voltage and emit in the VIS-NIR part of the spectrum. The LEDs are coupled to individually functionalized optical transducers that converge to a single detector for multiplexed operation. The integrated nature of the basic biosensor scheme and the ability to functionalize each transducer independently allows for the development of miniaturized optical transducers tailored towards multi-analyte tests. The monolithic arrays can be used for a plethora of bio/chemical interactions becoming thus a versatile analytical tool. The platform has been successfully applied in bioassays and binding in a real-time and label-free format and is currently being applied to ultra-sensitive food safety applications.
AB - Despite the advances in optical biosensors, the existing technological approaches still face two major challenges: the inherent inability of most sensors to integrate the optical source in the transducer chip, and the need to specifically design the optical transducer per application. In this work, the development of a radical optoelectronic platform is demonstrated based on a monolithic optocoupler array fabricated by standard Si-technology and suitable for multi-analyte detection. The platform has been specifically designed biochemical sensing. In the all-silicon array of transducers, each optocoupler has its own excitation source, while the entire array share a common detector. The light emitting devices (LEDs) are silicon avalanche diodes biased beyond their breakdown voltage and emit in the VIS-NIR part of the spectrum. The LEDs are coupled to individually functionalized optical transducers that converge to a single detector for multiplexed operation. The integrated nature of the basic biosensor scheme and the ability to functionalize each transducer independently allows for the development of miniaturized optical transducers tailored towards multi-analyte tests. The monolithic arrays can be used for a plethora of bio/chemical interactions becoming thus a versatile analytical tool. The platform has been successfully applied in bioassays and binding in a real-time and label-free format and is currently being applied to ultra-sensitive food safety applications.
KW - integrated interferometers
KW - label free detection
KW - optical biosensors
KW - optocouplers
U2 - 10.1117/12.2017995
DO - 10.1117/12.2017995
M3 - Conference article in proceedings
SN - 978-081949562-4
T3 - Proceedings of SPIE
BT - Bio-MEMS and Medical Microdevices
A2 - Tserepi, Angeliki
A2 - Delgado-Restituto, Manuel
A2 - Makarona, Eleni
PB - International Society for Optics and Photonics SPIE
ER -