All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing

K. Misiakos, E. Makarona, I. Raptis, A. Salapatas, A. Psarouli, S. Kakabakos, P. Petrou, M. Hoekman, R. Heideman, R. Stoffer, Kari Tukkiniemi, M. Soppanen, G. Jobst, G. Nounessis, A. Budkowski, J. Rysz

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

1 Citation (Scopus)

Abstract

Despite the advances in optical biosensors, the existing technological approaches still face two major challenges: the inherent inability of most sensors to integrate the optical source in the transducer chip, and the need to specifically design the optical transducer per application. In this work, the development of a radical optoelectronic platform is demonstrated based on a monolithic optocoupler array fabricated by standard Si-technology and suitable for multi-analyte detection. The platform has been specifically designed biochemical sensing. In the all-silicon array of transducers, each optocoupler has its own excitation source, while the entire array share a common detector. The light emitting devices (LEDs) are silicon avalanche diodes biased beyond their breakdown voltage and emit in the VIS-NIR part of the spectrum. The LEDs are coupled to individually functionalized optical transducers that converge to a single detector for multiplexed operation. The integrated nature of the basic biosensor scheme and the ability to functionalize each transducer independently allows for the development of miniaturized optical transducers tailored towards multi-analyte tests. The monolithic arrays can be used for a plethora of bio/chemical interactions becoming thus a versatile analytical tool. The platform has been successfully applied in bioassays and binding in a real-time and label-free format and is currently being applied to ultra-sensitive food safety applications.
Original languageEnglish
Title of host publicationBio-MEMS and Medical Microdevices
EditorsAngeliki Tserepi, Manuel Delgado-Restituto, Eleni Makarona
PublisherInternational Society for Optics and Photonics SPIE
ISBN (Print)978-081949562-4
DOIs
Publication statusPublished - 2013
MoE publication typeNot Eligible
EventSPIE Microtechnologies, 2013 - Grenoble, France
Duration: 24 Apr 201326 Apr 2013

Publication series

SeriesProceedings of SPIE
Volume8765
ISSN0277-786X

Conference

ConferenceSPIE Microtechnologies, 2013
CountryFrance
CityGrenoble
Period24/04/1326/04/13

Fingerprint

transducers
platforms
silicon
bioinstrumentation
avalanche diodes
bioassay
detectors
electrical faults
food
format
safety
chips
sensors
excitation
interactions

Keywords

  • integrated interferometers
  • label free detection
  • optical biosensors
  • optocouplers

Cite this

Misiakos, K., Makarona, E., Raptis, I., Salapatas, A., Psarouli, A., Kakabakos, S., ... Rysz, J. (2013). All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing. In A. Tserepi, M. Delgado-Restituto, & E. Makarona (Eds.), Bio-MEMS and Medical Microdevices [87650H] International Society for Optics and Photonics SPIE. Proceedings of SPIE, Vol.. 8765 https://doi.org/10.1117/12.2017995
Misiakos, K. ; Makarona, E. ; Raptis, I. ; Salapatas, A. ; Psarouli, A. ; Kakabakos, S. ; Petrou, P. ; Hoekman, M. ; Heideman, R. ; Stoffer, R. ; Tukkiniemi, Kari ; Soppanen, M. ; Jobst, G. ; Nounessis, G. ; Budkowski, A. ; Rysz, J. / All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing. Bio-MEMS and Medical Microdevices. editor / Angeliki Tserepi ; Manuel Delgado-Restituto ; Eleni Makarona. International Society for Optics and Photonics SPIE, 2013. (Proceedings of SPIE, Vol. 8765).
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author = "K. Misiakos and E. Makarona and I. Raptis and A. Salapatas and A. Psarouli and S. Kakabakos and P. Petrou and M. Hoekman and R. Heideman and R. Stoffer and Kari Tukkiniemi and M. Soppanen and G. Jobst and G. Nounessis and A. Budkowski and J. Rysz",
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Misiakos, K, Makarona, E, Raptis, I, Salapatas, A, Psarouli, A, Kakabakos, S, Petrou, P, Hoekman, M, Heideman, R, Stoffer, R, Tukkiniemi, K, Soppanen, M, Jobst, G, Nounessis, G, Budkowski, A & Rysz, J 2013, All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing. in A Tserepi, M Delgado-Restituto & E Makarona (eds), Bio-MEMS and Medical Microdevices., 87650H, International Society for Optics and Photonics SPIE, Proceedings of SPIE, vol. 8765, SPIE Microtechnologies, 2013, Grenoble, France, 24/04/13. https://doi.org/10.1117/12.2017995

All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing. / Misiakos, K.; Makarona, E.; Raptis, I.; Salapatas, A.; Psarouli, A.; Kakabakos, S.; Petrou, P.; Hoekman, M.; Heideman, R.; Stoffer, R.; Tukkiniemi, Kari; Soppanen, M.; Jobst, G.; Nounessis, G.; Budkowski, A.; Rysz, J.

Bio-MEMS and Medical Microdevices. ed. / Angeliki Tserepi; Manuel Delgado-Restituto; Eleni Makarona. International Society for Optics and Photonics SPIE, 2013. 87650H (Proceedings of SPIE, Vol. 8765).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

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Misiakos K, Makarona E, Raptis I, Salapatas A, Psarouli A, Kakabakos S et al. All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing. In Tserepi A, Delgado-Restituto M, Makarona E, editors, Bio-MEMS and Medical Microdevices. International Society for Optics and Photonics SPIE. 2013. 87650H. (Proceedings of SPIE, Vol. 8765). https://doi.org/10.1117/12.2017995