All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing

K. Misiakos, E. Makarona, I. Raptis, A. Salapatas, A. Psarouli, S. Kakabakos, P. Petrou, M. Hoekman, R. Heideman, R. Stoffer, Kari Tukkiniemi, M. Soppanen, G. Jobst, G. Nounessis, A. Budkowski, J. Rysz

    Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

    1 Citation (Scopus)


    Despite the advances in optical biosensors, the existing technological approaches still face two major challenges: the inherent inability of most sensors to integrate the optical source in the transducer chip, and the need to specifically design the optical transducer per application. In this work, the development of a radical optoelectronic platform is demonstrated based on a monolithic optocoupler array fabricated by standard Si-technology and suitable for multi-analyte detection. The platform has been specifically designed biochemical sensing. In the all-silicon array of transducers, each optocoupler has its own excitation source, while the entire array share a common detector. The light emitting devices (LEDs) are silicon avalanche diodes biased beyond their breakdown voltage and emit in the VIS-NIR part of the spectrum. The LEDs are coupled to individually functionalized optical transducers that converge to a single detector for multiplexed operation. The integrated nature of the basic biosensor scheme and the ability to functionalize each transducer independently allows for the development of miniaturized optical transducers tailored towards multi-analyte tests. The monolithic arrays can be used for a plethora of bio/chemical interactions becoming thus a versatile analytical tool. The platform has been successfully applied in bioassays and binding in a real-time and label-free format and is currently being applied to ultra-sensitive food safety applications.
    Original languageEnglish
    Title of host publicationBio-MEMS and Medical Microdevices
    EditorsAngeliki Tserepi, Manuel Delgado-Restituto, Eleni Makarona
    PublisherInternational Society for Optics and Photonics SPIE
    ISBN (Print)978-0-8194-9562-4
    Publication statusPublished - 2013
    MoE publication typeA4 Article in a conference publication
    EventSPIE Microtechnologies, 2013 - Grenoble, France
    Duration: 24 Apr 201326 Apr 2013

    Publication series

    SeriesProceedings of SPIE


    ConferenceSPIE Microtechnologies, 2013


    • integrated interferometers
    • label free detection
    • optical biosensors
    • optocouplers


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