All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing

K. Misiakos, E. Makarona, I. Raptis, A. Salapatas, A. Psarouli, S. Kakabakos, P. Petrou, M. Hoekman, R. Heideman, R. Stoffer, Kari Tukkiniemi, M. Soppanen, G. Jobst, G. Nounessis, A. Budkowski, J. Rysz

    Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

    1 Citation (Scopus)

    Abstract

    Despite the advances in optical biosensors, the existing technological approaches still face two major challenges: the inherent inability of most sensors to integrate the optical source in the transducer chip, and the need to specifically design the optical transducer per application. In this work, the development of a radical optoelectronic platform is demonstrated based on a monolithic optocoupler array fabricated by standard Si-technology and suitable for multi-analyte detection. The platform has been specifically designed biochemical sensing. In the all-silicon array of transducers, each optocoupler has its own excitation source, while the entire array share a common detector. The light emitting devices (LEDs) are silicon avalanche diodes biased beyond their breakdown voltage and emit in the VIS-NIR part of the spectrum. The LEDs are coupled to individually functionalized optical transducers that converge to a single detector for multiplexed operation. The integrated nature of the basic biosensor scheme and the ability to functionalize each transducer independently allows for the development of miniaturized optical transducers tailored towards multi-analyte tests. The monolithic arrays can be used for a plethora of bio/chemical interactions becoming thus a versatile analytical tool. The platform has been successfully applied in bioassays and binding in a real-time and label-free format and is currently being applied to ultra-sensitive food safety applications.
    Original languageEnglish
    Title of host publicationBio-MEMS and Medical Microdevices
    EditorsAngeliki Tserepi, Manuel Delgado-Restituto, Eleni Makarona
    PublisherInternational Society for Optics and Photonics SPIE
    ISBN (Print)978-081949562-4
    DOIs
    Publication statusPublished - 2013
    MoE publication typeNot Eligible
    EventSPIE Microtechnologies, 2013 - Grenoble, France
    Duration: 24 Apr 201326 Apr 2013

    Publication series

    SeriesProceedings of SPIE
    Volume8765
    ISSN0277-786X

    Conference

    ConferenceSPIE Microtechnologies, 2013
    CountryFrance
    CityGrenoble
    Period24/04/1326/04/13

    Fingerprint

    transducers
    platforms
    silicon
    bioinstrumentation
    avalanche diodes
    bioassay
    detectors
    electrical faults
    food
    format
    safety
    chips
    sensors
    excitation
    interactions

    Keywords

    • integrated interferometers
    • label free detection
    • optical biosensors
    • optocouplers

    Cite this

    Misiakos, K., Makarona, E., Raptis, I., Salapatas, A., Psarouli, A., Kakabakos, S., ... Rysz, J. (2013). All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing. In A. Tserepi, M. Delgado-Restituto, & E. Makarona (Eds.), Bio-MEMS and Medical Microdevices [87650H] International Society for Optics and Photonics SPIE. Proceedings of SPIE, Vol.. 8765 https://doi.org/10.1117/12.2017995
    Misiakos, K. ; Makarona, E. ; Raptis, I. ; Salapatas, A. ; Psarouli, A. ; Kakabakos, S. ; Petrou, P. ; Hoekman, M. ; Heideman, R. ; Stoffer, R. ; Tukkiniemi, Kari ; Soppanen, M. ; Jobst, G. ; Nounessis, G. ; Budkowski, A. ; Rysz, J. / All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing. Bio-MEMS and Medical Microdevices. editor / Angeliki Tserepi ; Manuel Delgado-Restituto ; Eleni Makarona. International Society for Optics and Photonics SPIE, 2013. (Proceedings of SPIE, Vol. 8765).
    @inproceedings{0a93e62bdf06479da9c25951b7dd7d83,
    title = "All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing",
    abstract = "Despite the advances in optical biosensors, the existing technological approaches still face two major challenges: the inherent inability of most sensors to integrate the optical source in the transducer chip, and the need to specifically design the optical transducer per application. In this work, the development of a radical optoelectronic platform is demonstrated based on a monolithic optocoupler array fabricated by standard Si-technology and suitable for multi-analyte detection. The platform has been specifically designed biochemical sensing. In the all-silicon array of transducers, each optocoupler has its own excitation source, while the entire array share a common detector. The light emitting devices (LEDs) are silicon avalanche diodes biased beyond their breakdown voltage and emit in the VIS-NIR part of the spectrum. The LEDs are coupled to individually functionalized optical transducers that converge to a single detector for multiplexed operation. The integrated nature of the basic biosensor scheme and the ability to functionalize each transducer independently allows for the development of miniaturized optical transducers tailored towards multi-analyte tests. The monolithic arrays can be used for a plethora of bio/chemical interactions becoming thus a versatile analytical tool. The platform has been successfully applied in bioassays and binding in a real-time and label-free format and is currently being applied to ultra-sensitive food safety applications.",
    keywords = "integrated interferometers, label free detection, optical biosensors, optocouplers",
    author = "K. Misiakos and E. Makarona and I. Raptis and A. Salapatas and A. Psarouli and S. Kakabakos and P. Petrou and M. Hoekman and R. Heideman and R. Stoffer and Kari Tukkiniemi and M. Soppanen and G. Jobst and G. Nounessis and A. Budkowski and J. Rysz",
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    series = "Proceedings of SPIE",
    publisher = "International Society for Optics and Photonics SPIE",
    editor = "Angeliki Tserepi and Delgado-Restituto, {Manuel } and Eleni Makarona",
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    Misiakos, K, Makarona, E, Raptis, I, Salapatas, A, Psarouli, A, Kakabakos, S, Petrou, P, Hoekman, M, Heideman, R, Stoffer, R, Tukkiniemi, K, Soppanen, M, Jobst, G, Nounessis, G, Budkowski, A & Rysz, J 2013, All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing. in A Tserepi, M Delgado-Restituto & E Makarona (eds), Bio-MEMS and Medical Microdevices., 87650H, International Society for Optics and Photonics SPIE, Proceedings of SPIE, vol. 8765, SPIE Microtechnologies, 2013, Grenoble, France, 24/04/13. https://doi.org/10.1117/12.2017995

    All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing. / Misiakos, K.; Makarona, E.; Raptis, I.; Salapatas, A.; Psarouli, A.; Kakabakos, S.; Petrou, P.; Hoekman, M.; Heideman, R.; Stoffer, R.; Tukkiniemi, Kari; Soppanen, M.; Jobst, G.; Nounessis, G.; Budkowski, A.; Rysz, J.

    Bio-MEMS and Medical Microdevices. ed. / Angeliki Tserepi; Manuel Delgado-Restituto; Eleni Makarona. International Society for Optics and Photonics SPIE, 2013. 87650H (Proceedings of SPIE, Vol. 8765).

    Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

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    AU - Petrou, P.

    AU - Hoekman, M.

    AU - Heideman, R.

    AU - Stoffer, R.

    AU - Tukkiniemi, Kari

    AU - Soppanen, M.

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    AB - Despite the advances in optical biosensors, the existing technological approaches still face two major challenges: the inherent inability of most sensors to integrate the optical source in the transducer chip, and the need to specifically design the optical transducer per application. In this work, the development of a radical optoelectronic platform is demonstrated based on a monolithic optocoupler array fabricated by standard Si-technology and suitable for multi-analyte detection. The platform has been specifically designed biochemical sensing. In the all-silicon array of transducers, each optocoupler has its own excitation source, while the entire array share a common detector. The light emitting devices (LEDs) are silicon avalanche diodes biased beyond their breakdown voltage and emit in the VIS-NIR part of the spectrum. The LEDs are coupled to individually functionalized optical transducers that converge to a single detector for multiplexed operation. The integrated nature of the basic biosensor scheme and the ability to functionalize each transducer independently allows for the development of miniaturized optical transducers tailored towards multi-analyte tests. The monolithic arrays can be used for a plethora of bio/chemical interactions becoming thus a versatile analytical tool. The platform has been successfully applied in bioassays and binding in a real-time and label-free format and is currently being applied to ultra-sensitive food safety applications.

    KW - integrated interferometers

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    Misiakos K, Makarona E, Raptis I, Salapatas A, Psarouli A, Kakabakos S et al. All-silicon monolithic optoelectronic platform for multi-analyte biochemical sensing. In Tserepi A, Delgado-Restituto M, Makarona E, editors, Bio-MEMS and Medical Microdevices. International Society for Optics and Photonics SPIE. 2013. 87650H. (Proceedings of SPIE, Vol. 8765). https://doi.org/10.1117/12.2017995