All-Silicon Spectrally Resolved Interferometric Circuit for Multiplexed Diagnostics: A Monolithic Lab-on-a-Chip Integrating All Active and Passive Components

Konstantinos Misiakos, Eleni Makarona, Marcel Hoekman, Romanos Fyrogenis, Kari Tukkiniemi, Gerhard Jobst, Panagiota Sotirios Petrou, Sotirios Elias Kakabakos, Alexandros Salapatas, Dimitrios Goustouridis, Mikko Harjanne, Paivi Heimala, Ioannis Raptis (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Despite the tremendous advances in micro- and nanoelectronics and the fast-pacing advances in photonic circuit designs, seamless monolithic integration of electronic and photonic components on single chips still remains elusive. In this work, a radically designed silicon-based chip that monolithically integrates in a 37 mm2 footprint 10 interferometric optical sensors along with their respective optical sources, spectral analyzers, and photodetector arrays is presented. The chip is fabricated with mainstream CMOS-compatible fabrication techniques and employs optical devices operating in the visible/infrared spectrum and waveguides with a critical dimension of 1.0 μm. In addition, it exploits the newly introduced detection principle of broad-band Mach-Zehnder interferometry that surpasses the stringent requirement for external monochromatic sources and inherent limitations of traditional interferometry and introduces alternative designs of on-chip spectral analyzers and mode-filtering components, aspiring thus to become a novel lab-on-a-chip that can address the needs of next-generation analytical systems. Apart from the conceptual design, novel photonic features, fabrication steps, and out-of-the-box system development that circumvents the need for fluidic interfacing and employs only electrical interconnects, the present work tests the potential of the fully spectroscopic chip for analytical applications through real-time monitoring of immunochemical reactions and demonstrates limits of detection for antimouse IgG antibody and CRP of 60 and 8 pM, respectively.

Original languageEnglish
Pages (from-to)1694-1705
Number of pages12
JournalACS Photonics
Volume6
Issue number7
DOIs
Publication statusPublished - 13 Jun 2019
MoE publication typeA1 Journal article-refereed

Fingerprint

Optics and Photonics
Lab-on-a-chip
Silicon
Interferometry
Photonics
chips
Networks (circuits)
silicon
Fabrication
Optical Devices
Nanoelectronics
Optical sensors
Fluidics
photonics
Optical devices
Photodetectors
Conceptual design
Antibodies
Microelectronics
Mach number

Keywords

  • Broad-band interferometry
  • Lab-on-chip
  • Optical biosensing
  • Photonic circuit
  • Photonics-microelectronic integration

Cite this

Misiakos, Konstantinos ; Makarona, Eleni ; Hoekman, Marcel ; Fyrogenis, Romanos ; Tukkiniemi, Kari ; Jobst, Gerhard ; Petrou, Panagiota Sotirios ; Kakabakos, Sotirios Elias ; Salapatas, Alexandros ; Goustouridis, Dimitrios ; Harjanne, Mikko ; Heimala, Paivi ; Raptis, Ioannis. / All-Silicon Spectrally Resolved Interferometric Circuit for Multiplexed Diagnostics : A Monolithic Lab-on-a-Chip Integrating All Active and Passive Components. In: ACS Photonics. 2019 ; Vol. 6, No. 7. pp. 1694-1705.
@article{7751927f7d524e7283f742922045988f,
title = "All-Silicon Spectrally Resolved Interferometric Circuit for Multiplexed Diagnostics: A Monolithic Lab-on-a-Chip Integrating All Active and Passive Components",
abstract = "Despite the tremendous advances in micro- and nanoelectronics and the fast-pacing advances in photonic circuit designs, seamless monolithic integration of electronic and photonic components on single chips still remains elusive. In this work, a radically designed silicon-based chip that monolithically integrates in a 37 mm2 footprint 10 interferometric optical sensors along with their respective optical sources, spectral analyzers, and photodetector arrays is presented. The chip is fabricated with mainstream CMOS-compatible fabrication techniques and employs optical devices operating in the visible/infrared spectrum and waveguides with a critical dimension of 1.0 μm. In addition, it exploits the newly introduced detection principle of broad-band Mach-Zehnder interferometry that surpasses the stringent requirement for external monochromatic sources and inherent limitations of traditional interferometry and introduces alternative designs of on-chip spectral analyzers and mode-filtering components, aspiring thus to become a novel lab-on-a-chip that can address the needs of next-generation analytical systems. Apart from the conceptual design, novel photonic features, fabrication steps, and out-of-the-box system development that circumvents the need for fluidic interfacing and employs only electrical interconnects, the present work tests the potential of the fully spectroscopic chip for analytical applications through real-time monitoring of immunochemical reactions and demonstrates limits of detection for antimouse IgG antibody and CRP of 60 and 8 pM, respectively.",
keywords = "Broad-band interferometry, Lab-on-chip, Optical biosensing, Photonic circuit, Photonics-microelectronic integration",
author = "Konstantinos Misiakos and Eleni Makarona and Marcel Hoekman and Romanos Fyrogenis and Kari Tukkiniemi and Gerhard Jobst and Petrou, {Panagiota Sotirios} and Kakabakos, {Sotirios Elias} and Alexandros Salapatas and Dimitrios Goustouridis and Mikko Harjanne and Paivi Heimala and Ioannis Raptis",
year = "2019",
month = "6",
day = "13",
doi = "10.1021/acsphotonics.9b00235",
language = "English",
volume = "6",
pages = "1694--1705",
journal = "ACS Photonics",
issn = "2330-4022",
publisher = "American Chemical Society ACS",
number = "7",

}

Misiakos, K, Makarona, E, Hoekman, M, Fyrogenis, R, Tukkiniemi, K, Jobst, G, Petrou, PS, Kakabakos, SE, Salapatas, A, Goustouridis, D, Harjanne, M, Heimala, P & Raptis, I 2019, 'All-Silicon Spectrally Resolved Interferometric Circuit for Multiplexed Diagnostics: A Monolithic Lab-on-a-Chip Integrating All Active and Passive Components', ACS Photonics, vol. 6, no. 7, pp. 1694-1705. https://doi.org/10.1021/acsphotonics.9b00235

All-Silicon Spectrally Resolved Interferometric Circuit for Multiplexed Diagnostics : A Monolithic Lab-on-a-Chip Integrating All Active and Passive Components. / Misiakos, Konstantinos; Makarona, Eleni; Hoekman, Marcel; Fyrogenis, Romanos; Tukkiniemi, Kari; Jobst, Gerhard; Petrou, Panagiota Sotirios; Kakabakos, Sotirios Elias; Salapatas, Alexandros; Goustouridis, Dimitrios; Harjanne, Mikko; Heimala, Paivi; Raptis, Ioannis (Corresponding Author).

In: ACS Photonics, Vol. 6, No. 7, 13.06.2019, p. 1694-1705.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - All-Silicon Spectrally Resolved Interferometric Circuit for Multiplexed Diagnostics

T2 - A Monolithic Lab-on-a-Chip Integrating All Active and Passive Components

AU - Misiakos, Konstantinos

AU - Makarona, Eleni

AU - Hoekman, Marcel

AU - Fyrogenis, Romanos

AU - Tukkiniemi, Kari

AU - Jobst, Gerhard

AU - Petrou, Panagiota Sotirios

AU - Kakabakos, Sotirios Elias

AU - Salapatas, Alexandros

AU - Goustouridis, Dimitrios

AU - Harjanne, Mikko

AU - Heimala, Paivi

AU - Raptis, Ioannis

PY - 2019/6/13

Y1 - 2019/6/13

N2 - Despite the tremendous advances in micro- and nanoelectronics and the fast-pacing advances in photonic circuit designs, seamless monolithic integration of electronic and photonic components on single chips still remains elusive. In this work, a radically designed silicon-based chip that monolithically integrates in a 37 mm2 footprint 10 interferometric optical sensors along with their respective optical sources, spectral analyzers, and photodetector arrays is presented. The chip is fabricated with mainstream CMOS-compatible fabrication techniques and employs optical devices operating in the visible/infrared spectrum and waveguides with a critical dimension of 1.0 μm. In addition, it exploits the newly introduced detection principle of broad-band Mach-Zehnder interferometry that surpasses the stringent requirement for external monochromatic sources and inherent limitations of traditional interferometry and introduces alternative designs of on-chip spectral analyzers and mode-filtering components, aspiring thus to become a novel lab-on-a-chip that can address the needs of next-generation analytical systems. Apart from the conceptual design, novel photonic features, fabrication steps, and out-of-the-box system development that circumvents the need for fluidic interfacing and employs only electrical interconnects, the present work tests the potential of the fully spectroscopic chip for analytical applications through real-time monitoring of immunochemical reactions and demonstrates limits of detection for antimouse IgG antibody and CRP of 60 and 8 pM, respectively.

AB - Despite the tremendous advances in micro- and nanoelectronics and the fast-pacing advances in photonic circuit designs, seamless monolithic integration of electronic and photonic components on single chips still remains elusive. In this work, a radically designed silicon-based chip that monolithically integrates in a 37 mm2 footprint 10 interferometric optical sensors along with their respective optical sources, spectral analyzers, and photodetector arrays is presented. The chip is fabricated with mainstream CMOS-compatible fabrication techniques and employs optical devices operating in the visible/infrared spectrum and waveguides with a critical dimension of 1.0 μm. In addition, it exploits the newly introduced detection principle of broad-band Mach-Zehnder interferometry that surpasses the stringent requirement for external monochromatic sources and inherent limitations of traditional interferometry and introduces alternative designs of on-chip spectral analyzers and mode-filtering components, aspiring thus to become a novel lab-on-a-chip that can address the needs of next-generation analytical systems. Apart from the conceptual design, novel photonic features, fabrication steps, and out-of-the-box system development that circumvents the need for fluidic interfacing and employs only electrical interconnects, the present work tests the potential of the fully spectroscopic chip for analytical applications through real-time monitoring of immunochemical reactions and demonstrates limits of detection for antimouse IgG antibody and CRP of 60 and 8 pM, respectively.

KW - Broad-band interferometry

KW - Lab-on-chip

KW - Optical biosensing

KW - Photonic circuit

KW - Photonics-microelectronic integration

UR - http://www.scopus.com/inward/record.url?scp=85072944856&partnerID=8YFLogxK

U2 - 10.1021/acsphotonics.9b00235

DO - 10.1021/acsphotonics.9b00235

M3 - Article

AN - SCOPUS:85072944856

VL - 6

SP - 1694

EP - 1705

JO - ACS Photonics

JF - ACS Photonics

SN - 2330-4022

IS - 7

ER -