Allocation of rhodamine-loaded nanocapsules from blood circulatory system to adjacent tissues assessed in vivo by fluorescence spectroscopy

Yana Tarakanchikova (Corresponding Author), Olga Stelmashchuk, Evgeniya Seryogina, Gennadii Piavchenko, Evgeny Zherebtsov, Andrey Dunaev, Alexey Popov, Igor Meglinski

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Abstract

Modern fluorescent modalities play an important role in the functional diagnostic of various physiological processes in living tissues. Utilizing the fluorescence spectroscopy approach we observe the circulation of fluorescent-labelled nanocapsules with rhodamine tetramethylrhodamine in a microcirculatory blood system. The measurements were conducted transcutaneously on the surface of healthy Wistar rat thighs in vivo. The administration of the preparation capsule suspension with a rhodamine concentration of 5 mg kg-1 of the animal weight resulted in a two-fold increase of fluorescence intensity relative to the baseline level. The dissemination of nanocapsules in the adjacent tissues via the circulatory system was observed and assessed quantitatively. The approach can be used for the transdermal assessment of rhodamine-loaded capsules in vivo.

Original languageEnglish
Article number105601
JournalLaser Physics Letters
Volume15
Issue number10
DOIs
Publication statusPublished - Oct 2018
MoE publication typeA1 Journal article-refereed

Keywords

  • blood microcirculation
  • drug delivery
  • fluorescence spectroscopy
  • fluorescent-labelled particles
  • Nanocomposite polymeric capsules
  • optical measurements in vivo

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    Tarakanchikova, Y., Stelmashchuk, O., Seryogina, E., Piavchenko, G., Zherebtsov, E., Dunaev, A., Popov, A., & Meglinski, I. (2018). Allocation of rhodamine-loaded nanocapsules from blood circulatory system to adjacent tissues assessed in vivo by fluorescence spectroscopy. Laser Physics Letters, 15(10), [105601]. https://doi.org/10.1088/1612-202X/aad857