Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(β-dribofuranosyl) benzimidazole enhance metabolic stability in vitro and in vivo

Keyphrases

• Metabolic Stability 100%
• Bromo 100%
• Stability in Vitro 100%
• Benzimidazole 100%
• Amino Acid Ester Prodrug 100%
• L-Asp 21%
• Metabolic Enzymes 15%
• Prodrug 15%
• Human Cytomegalovirus 15%
• Metabolism 10%
• Ester Bond 10%
• Antiviral Activity 10%
• Amino Acid Prodrug 10%
• Modular Approach 5%
• Potent Inhibitor 5%
• Cytotoxicity 5%
• Bond Cleavage 5%
• Rate Limiting 5%
• Rapid Absorption 5%
• Selective Inhibitor 5%
• In Vitro Metabolism 5%
• Oral Administration 5%
• Metabolite Formation 5%
• Clinical Utility 5%
• Prodrug Activation 5%
• N-glycosidic Bond 5%
• Promoiety 5%
• In Vitro Stability 5%
• In Vivo Efficacy 5%
• Bonding Stability 5%
• Systemic Exposure 5%
• Glycosidic Bond Stability 5%
• Stability Profile 5%
• In Vivo Assessment 5%
• Caco-2 Cell Uptake 5%
• In Vivo Pharmacokinetics 5%
• Cytomegalovirus Replication 5%
• In Vivo Delivery 5%
• Concentrations-time Profiles 5%
• Plaque Formation 5%
• Pharmacokinetic Equivalence 5%

INIS

• stability 100%
• esters 100%
• in vitro 100%
• in vivo 100%
• amino acids 100%
• benzimidazoles 100%
• enzymes 15%
• humans 15%
• metabolism 15%
• administration 10%
• comparative evaluations 5%
• assessments 5%
• concentration 5%
• inhibition 5%
• mice 5%
• uptake 5%
• toxicity 5%
• delivery 5%
• drugs 5%
• metabolites 5%
• absorption 5%
• half-life 5%
• cleavage 5%
• utilities 5%
• oral administration 5%
• plaque formation 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Prodrug 100%
• Amino Acid 100%
• Benzimidazole 100%
• Human Cytomegalovirus 15%
• Antiviral Activity 10%
• Bond Cleavage 5%
• Glycosidic Bond 5%
• Cytotoxicity 5%
• Pharmacokinetics 5%