An international dosimetry exchange for boron neutron capture therapy, Part I: Absorbed dose measurements

P. J. Binns, K. J. Riley, O. K. Harling, W. S. Kiger, P. M. Munck Af Rosenschöld, V. Giusti, J. Capala, K. Sköld, I. Auterinen, T. Serén, P. Kotiluoto, J. Uusi-Simola, M. Marek, L. Viererbl, F. Spurny

    Research output: Contribution to journalArticleScientificpeer-review

    23 Citations (Scopus)

    Abstract

    An international collaboration was organized to undertake a dosimetry exchange to enable the future combination of clinical data from different centers conducting neutron capture therapy trials. As a first step (Part I) the dosimetry group from the Americas, represented by MIT, visited the clinical centers at Studsvik (Sweden), VTT Espoo (Finland), and the Nuclear Research Institute (NRI) at Rez (Czech Republic). A combined VTT/NRI group reciprocated with a visit to MIT. Each participant performed a series of dosimetry measurements under equivalent irradiation conditions using methods appropriate to their clinical protocols. This entailed in-air measurements and dose versus depth measurements in a large water phantom. Thermal neutron flux as well as fast neutron and photon absorbed dose rates were measured. Satisfactory agreement in determining absorbed dose within the experimental uncertainties was obtained between the different groups although the measurement uncertainties are large, ranging between 3% and 30% depending upon the dose component and the depth of measurement. To improve the precision in the specification of absorbed dose amongst the participants, the individually measured dose components were normalized to the results from a single method. Assuming a boron concentration of 15 μg g-1 that is typical of concentrations realized clinically with the boron delivery compound boronophenylalanine-fructose, systematic discrepancies in the specification of the total biologically weighted dose of up to 10% were apparent between the different groups. The results from these measurements will be used in future to normalize treatment plan calculations between the different clinical dosimetry protocols as Part II of this study.

    Original languageEnglish
    Pages (from-to)3729-3736
    Number of pages8
    JournalMedical Physics
    Volume32
    Issue number12
    DOIs
    Publication statusPublished - 1 Jan 2005
    MoE publication typeA1 Journal article-refereed

    Fingerprint

    Boron Neutron Capture Therapy
    Clinical Protocols
    Uncertainty
    Neutron Capture Therapy
    Boron Compounds
    Fast Neutrons
    Boron
    Czech Republic
    Neutrons
    Finland
    Fructose
    Photons
    Sweden
    Hot Temperature
    Air
    Water
    Therapeutics

    Keywords

    • BNCT
    • Dosimetry intercomparison
    • Thermal neutrons

    Cite this

    Binns, P. J., Riley, K. J., Harling, O. K., Kiger, W. S., Munck Af Rosenschöld, P. M., Giusti, V., ... Spurny, F. (2005). An international dosimetry exchange for boron neutron capture therapy, Part I: Absorbed dose measurements. Medical Physics, 32(12), 3729-3736. https://doi.org/10.1118/1.2132572
    Binns, P. J. ; Riley, K. J. ; Harling, O. K. ; Kiger, W. S. ; Munck Af Rosenschöld, P. M. ; Giusti, V. ; Capala, J. ; Sköld, K. ; Auterinen, I. ; Serén, T. ; Kotiluoto, P. ; Uusi-Simola, J. ; Marek, M. ; Viererbl, L. ; Spurny, F. / An international dosimetry exchange for boron neutron capture therapy, Part I : Absorbed dose measurements. In: Medical Physics. 2005 ; Vol. 32, No. 12. pp. 3729-3736.
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    Binns, PJ, Riley, KJ, Harling, OK, Kiger, WS, Munck Af Rosenschöld, PM, Giusti, V, Capala, J, Sköld, K, Auterinen, I, Serén, T, Kotiluoto, P, Uusi-Simola, J, Marek, M, Viererbl, L & Spurny, F 2005, 'An international dosimetry exchange for boron neutron capture therapy, Part I: Absorbed dose measurements', Medical Physics, vol. 32, no. 12, pp. 3729-3736. https://doi.org/10.1118/1.2132572

    An international dosimetry exchange for boron neutron capture therapy, Part I : Absorbed dose measurements. / Binns, P. J.; Riley, K. J.; Harling, O. K.; Kiger, W. S.; Munck Af Rosenschöld, P. M.; Giusti, V.; Capala, J.; Sköld, K.; Auterinen, I.; Serén, T.; Kotiluoto, P.; Uusi-Simola, J.; Marek, M.; Viererbl, L.; Spurny, F.

    In: Medical Physics, Vol. 32, No. 12, 01.01.2005, p. 3729-3736.

    Research output: Contribution to journalArticleScientificpeer-review

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    AU - Binns, P. J.

    AU - Riley, K. J.

    AU - Harling, O. K.

    AU - Kiger, W. S.

    AU - Munck Af Rosenschöld, P. M.

    AU - Giusti, V.

    AU - Capala, J.

    AU - Sköld, K.

    AU - Auterinen, I.

    AU - Serén, T.

    AU - Kotiluoto, P.

    AU - Uusi-Simola, J.

    AU - Marek, M.

    AU - Viererbl, L.

    AU - Spurny, F.

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    Binns PJ, Riley KJ, Harling OK, Kiger WS, Munck Af Rosenschöld PM, Giusti V et al. An international dosimetry exchange for boron neutron capture therapy, Part I: Absorbed dose measurements. Medical Physics. 2005 Jan 1;32(12):3729-3736. https://doi.org/10.1118/1.2132572