TY - JOUR
T1 - An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome—A SYSDIET Sub-Study
AU - Ulven, Stine M.
AU - Holven, Kirsten B.
AU - Rundblad, Amanda
AU - Myhrstad, Mari C. W.
AU - Leder, Lena
AU - Dahlman, Ingrid
AU - Mello, Vanessa D. De
AU - Schwab, Ursula
AU - Carlberg, Carsten
AU - Pihlajamäki, Jussi
AU - Hermansen, Kjeld
AU - Dragsted, Lars O.
AU - Gunnarsdottir, Ingibjörg
AU - Cloetens, Lieselotte
AU - Åkesson, Björn
AU - Rosqvist, Fredrik
AU - Hukkanen, Janne
AU - Herzig, Karl-heinz
AU - Savolainen, Markku J
AU - Risérus, Ulf
AU - Thorsdottir, Inga
AU - Poutanen, Kaisa S
AU - Arner, Peter
AU - Uusitupa, Matti
AU - Kolehmainen, Marjukka
N1 - Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/12/3
Y1 - 2019/12/3
N2 - A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.
AB - A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.
UR - http://www.scopus.com/inward/record.url?scp=85076023786&partnerID=8YFLogxK
U2 - 10.3390/nu11122932
DO - 10.3390/nu11122932
M3 - Article
C2 - 31816875
SN - 2072-6643
VL - 11
JO - Nutrients
JF - Nutrients
IS - 12
M1 - 2932
ER -
