Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response

Emanuel Schwarz; Johanna Maukonen; Tiina Hyytiäinen; Tuula Kieseppä; Matej Oresic; Sarven Sabunciyan; Outi Mantere; Maria Saarela; Robert Yolken; Jaana Suvisaari

doi:10.1016/j.schres.2017.04.017

Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response

Emanuel Schwarz, Johanna Maukonen, Tiina Hyytiäinen, Tuula Kieseppä, Matej Oresic, Sarven Sabunciyan, Outi Mantere, Maria Saarela, Robert Yolken, Jaana Suvisaari

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255 Citations (Scopus)

Abstract

The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences were associated with response after up to 12 months of treatment. Numbers of Lactobacillus group bacteria were elevated in FEP-patients and significantly correlated with severity along different symptom domains. A subgroup of FEP patients with the strongest microbiota differences also showed poorer response after up to 12 months of treatment. The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission.

Original language	English
Pages (from-to)	398-403
Journal	Schizophrenia Research
Volume	192
Issue number	February
DOIs	https://doi.org/10.1016/j.schres.2017.04.017
Publication status	Published - 2018
MoE publication type	A1 Journal article-refereed

Keywords

schizophrenia
microbiome
psychosis
response

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10.1016/j.schres.2017.04.017

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Schwarz, E., Maukonen, J., Hyytiäinen, T., Kieseppä, T., Oresic, M., Sabunciyan, S., Mantere, O., Saarela, M., Yolken, R., & Suvisaari, J. (2018). Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response. Schizophrenia Research, 192(February), 398-403. https://doi.org/10.1016/j.schres.2017.04.017

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title = "Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response",

abstract = "The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences were associated with response after up to 12 months of treatment. Numbers of Lactobacillus group bacteria were elevated in FEP-patients and significantly correlated with severity along different symptom domains. A subgroup of FEP patients with the strongest microbiota differences also showed poorer response after up to 12 months of treatment. The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission.",

keywords = "schizophrenia, microbiome, psychosis, response",

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Schwarz, E, Maukonen, J, Hyytiäinen, T, Kieseppä, T, Oresic, M, Sabunciyan, S, Mantere, O, Saarela, M, Yolken, R & Suvisaari, J 2018, 'Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response', Schizophrenia Research, vol. 192, no. February, pp. 398-403. https://doi.org/10.1016/j.schres.2017.04.017

TY - JOUR

T1 - Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response

AU - Schwarz, Emanuel

AU - Maukonen, Johanna

AU - Hyytiäinen, Tiina

AU - Kieseppä, Tuula

AU - Oresic, Matej

AU - Sabunciyan, Sarven

AU - Mantere, Outi

AU - Saarela, Maria

AU - Yolken, Robert

AU - Suvisaari, Jaana

PY - 2018

Y1 - 2018

N2 - The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences were associated with response after up to 12 months of treatment. Numbers of Lactobacillus group bacteria were elevated in FEP-patients and significantly correlated with severity along different symptom domains. A subgroup of FEP patients with the strongest microbiota differences also showed poorer response after up to 12 months of treatment. The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission.

AB - The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences were associated with response after up to 12 months of treatment. Numbers of Lactobacillus group bacteria were elevated in FEP-patients and significantly correlated with severity along different symptom domains. A subgroup of FEP patients with the strongest microbiota differences also showed poorer response after up to 12 months of treatment. The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission.

KW - schizophrenia

KW - microbiome

KW - psychosis

KW - response

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U2 - 10.1016/j.schres.2017.04.017

DO - 10.1016/j.schres.2017.04.017

M3 - Article

SN - 0920-9964

VL - 192

SP - 398

EP - 403

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - February

ER -

Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response

Abstract

Keywords

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