Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response

Emanuel Schwarz, Johanna Maukonen, Tiina Hyytiäinen, Tuula Kieseppä, Matej Oresic, Sarven Sabunciyan, Outi Mantere, Maria Saarela, Robert Yolken, Jaana Suvisaari

    Research output: Contribution to journalArticleResearchpeer-review

    • 26 Citations

    Abstract

    The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences were associated with response after up to 12 months of treatment. Numbers of Lactobacillus group bacteria were elevated in FEP-patients and significantly correlated with severity along different symptom domains. A subgroup of FEP patients with the strongest microbiota differences also showed poorer response after up to 12 months of treatment. The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission.
    LanguageEnglish
    Pages398-403
    Number of pages6
    JournalSchizophrenia Research
    Volume192
    Issue numberFebruary
    DOIs
    Publication statusPublished - 2018

    Fingerprint

    Microbiota
    Psychotic Disorders
    Lactobacillus
    Mental Disorders
    Therapeutics
    Central Nervous System
    Bacteria

    Keywords

    • schizophrenia
    • microbiome
    • psychosis
    • response

    OKM Publication Types

    • A1 Refereed journal article

    OKM Open Access Status

    • 0 Not Open Access

    Cite this

    Schwarz, Emanuel ; Maukonen, Johanna ; Hyytiäinen, Tiina ; Kieseppä, Tuula ; Oresic, Matej ; Sabunciyan, Sarven ; Mantere, Outi ; Saarela, Maria ; Yolken, Robert ; Suvisaari, Jaana. / Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response. In: Schizophrenia Research. 2018 ; Vol. 192, No. February. pp. 398-403.
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    Schwarz, E, Maukonen, J, Hyytiäinen, T, Kieseppä, T, Oresic, M, Sabunciyan, S, Mantere, O, Saarela, M, Yolken, R & Suvisaari, J 2018, 'Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response' Schizophrenia Research, vol. 192, no. February, pp. 398-403. https://doi.org/10.1016/j.schres.2017.04.017

    Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response. / Schwarz, Emanuel; Maukonen, Johanna; Hyytiäinen, Tiina; Kieseppä, Tuula; Oresic, Matej; Sabunciyan, Sarven; Mantere, Outi; Saarela, Maria; Yolken, Robert; Suvisaari, Jaana.

    In: Schizophrenia Research, Vol. 192, No. February, 2018, p. 398-403.

    Research output: Contribution to journalArticleResearchpeer-review

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    AU - Oresic, Matej

    AU - Sabunciyan, Sarven

    AU - Mantere, Outi

    AU - Saarela, Maria

    AU - Yolken, Robert

    AU - Suvisaari, Jaana

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