Antibody-based bio-nanotube membranes for enantiomeric drug separations

Sang Bok Lee, David T. Mitchell, Lacramioara Trobin, Tarja Nevanen, Hans Söderlund, Charles Martin (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

566 Citations (Scopus)

Abstract

Synthetic bio-nanotube membranes were developed and used to separate two enantiomers of a chiral drug. These membranes are based on alumina films that have cylindrical pores with monodisperse nanoscopic diameters (for example, 20 nanometers).
Silica nanotubes were chemically synthesized within the pores of these films, and an antibody that selectively binds one of the enantiomers of the drug was attached to the inner walls of the silica nanotubes.
These membranes selectively transport the enantiomer that specifically binds to the antibody, relative to the enantiomer that has lower affinity for the antibody.
The solvent dimethyl sulfoxide was used to tune the antibody binding affinity. The enantiomeric selectivity coefficient increases as the inside diameter of the silica nanotubes decreases.
Original languageEnglish
Pages (from-to)2198-2200
JournalScience
Volume296
Issue number5576
DOIs
Publication statusPublished - 2002
MoE publication typeNot Eligible

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Enantiomers
Nanotubes
Silicon Dioxide
Membranes
Antibodies
Pharmaceutical Preparations
Aluminum Oxide
Dimethyl Sulfoxide

Keywords

  • nanotubes

Cite this

Lee, S. B., Mitchell, D. T., Trobin, L., Nevanen, T., Söderlund, H., & Martin, C. (2002). Antibody-based bio-nanotube membranes for enantiomeric drug separations. Science, 296(5576), 2198-2200. https://doi.org/10.1126/science.1071396
Lee, Sang Bok ; Mitchell, David T. ; Trobin, Lacramioara ; Nevanen, Tarja ; Söderlund, Hans ; Martin, Charles. / Antibody-based bio-nanotube membranes for enantiomeric drug separations. In: Science. 2002 ; Vol. 296, No. 5576. pp. 2198-2200.
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Lee, SB, Mitchell, DT, Trobin, L, Nevanen, T, Söderlund, H & Martin, C 2002, 'Antibody-based bio-nanotube membranes for enantiomeric drug separations', Science, vol. 296, no. 5576, pp. 2198-2200. https://doi.org/10.1126/science.1071396

Antibody-based bio-nanotube membranes for enantiomeric drug separations. / Lee, Sang Bok; Mitchell, David T.; Trobin, Lacramioara; Nevanen, Tarja; Söderlund, Hans; Martin, Charles (Corresponding Author).

In: Science, Vol. 296, No. 5576, 2002, p. 2198-2200.

Research output: Contribution to journalArticleScientificpeer-review

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