TY - JOUR
T1 - Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species
AU - Xu, Liangxiong
AU - Wu, Ping
AU - Xue, Jinghua
AU - Molnar, Istvan
AU - Wei, Xiaoyi
N1 - Funding Information:
We thank Prof. T.-H. Li, Guangdong Institute of Microbiology, for morphological authentication of the producing fungus, Ms. A. Sun, South China Sea Institute of Oceanology, Chinese Academy of Sciences, for HRESIMS measurements, Ms. Y.-Y. Chen, School of Pharmaceutical Science, Sun Yat-Sen University, for X-ray diffraction analysis, Prof. L. Du from Chemistry Department, Nebraska University−Lincoln, NE, USA, and Prof. R.-Q. Pan from South China Agricultural University for the test fungi. This work was supported by grants from the National Science Foundation of China (Nos. 81172942 to X.W., 30901856 to L.X.), the U.S. National Institutes of Health (NIGMS R01GM114418-01A1 to I.M.), and the Guangzhou Science Technology and Innovation Commission (No. 201604020048 to L.X.).
Publisher Copyright:
© 2017 The American Chemical Society and American Society of Pharmacognosy.
PY - 2017/8/25
Y1 - 2017/8/25
N2 - Eight new β-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N-P (1-3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4′-hydroxymonocillin IV (7), and 4′-methoxymonocillin IV (8), along with nine known RALs (9-17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature a novel 6/11/5 ring system, and 3 is the first 5′-keto RAL. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6 exhibit cytotoxicity against MCF-7, A549, and HeLa cells, and compounds 5 and 7 display antifungal activity against Peronophythora litchii.
AB - Eight new β-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N-P (1-3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4′-hydroxymonocillin IV (7), and 4′-methoxymonocillin IV (8), along with nine known RALs (9-17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature a novel 6/11/5 ring system, and 3 is the first 5′-keto RAL. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6 exhibit cytotoxicity against MCF-7, A549, and HeLa cells, and compounds 5 and 7 display antifungal activity against Peronophythora litchii.
UR - http://www.scopus.com/inward/record.url?scp=85028321071&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.7b00066
DO - 10.1021/acs.jnatprod.7b00066
M3 - Article
C2 - 28749671
AN - SCOPUS:85028321071
SN - 0163-3864
VL - 80
SP - 2215
EP - 2223
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 8
ER -