Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species

Liangxiong Xu, Ping Wu, Jinghua Xue, Istvan Molnar, Xiaoyi Wei (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

21 Citations (Scopus)

Abstract

Eight new β-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N-P (1-3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4′-hydroxymonocillin IV (7), and 4′-methoxymonocillin IV (8), along with nine known RALs (9-17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature a novel 6/11/5 ring system, and 3 is the first 5′-keto RAL. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6 exhibit cytotoxicity against MCF-7, A549, and HeLa cells, and compounds 5 and 7 display antifungal activity against Peronophythora litchii.

Original languageEnglish
Pages (from-to)2215-2223
Number of pages9
JournalJournal of Natural Products
Volume80
Issue number8
DOIs
Publication statusPublished - 25 Aug 2017
MoE publication typeA1 Journal article-refereed

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