Application of lipidomics and metabolomics to the study of adipose tissue

Ismo Mattila, Tuulikki Seppänen-Laakso, Tapani Suortti, Matej Oresic

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

13 Citations (Scopus)

Abstract

Role of specific reactive lipids as well as amino acids in control of insulin signalling in adipose tissue is well recognized. Since it is practically impossible to measure the levels of all metabolites in the biological sample simultaneously with a single analytical platform, we utilize multiple platforms to study the lipids and metabolites of relevance to adipose tissue metabolism and insulin signalling. Two screening platforms cover a broad range of lipid molecular species (UPLC/MS based lipidomics platform) as well as organic acids and sterols (GCxGC-TOF platform). A targeted platform for amino acids (UPLC) is also applied.
Original languageEnglish
Title of host publicationAdipose Tissue Protocols
EditorsKaiping Yang
Place of PublicationTotowa, NJ, USA
PublisherSpringer
Pages123-130
ISBN (Electronic)978-1-59745-245-8
ISBN (Print)978-1-58829-916-1
DOIs
Publication statusPublished - 2008
MoE publication typeA3 Part of a book or another research book

Keywords

  • Metabolomics
  • lipidomics
  • branched chain amino acids
  • liquid chromatography
  • gas chromatography
  • mass spectrometry
  • insulin resistance

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