Application of lipidomics and metabolomics to the study of adipose tissue

Ismo Mattila, Tuulikki Seppänen-Laakso, Tapani Suortti, Matej Oresic

    Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

    13 Citations (Scopus)


    Role of specific reactive lipids as well as amino acids in control of insulin signalling in adipose tissue is well recognized. Since it is practically impossible to measure the levels of all metabolites in the biological sample simultaneously with a single analytical platform, we utilize multiple platforms to study the lipids and metabolites of relevance to adipose tissue metabolism and insulin signalling. Two screening platforms cover a broad range of lipid molecular species (UPLC/MS based lipidomics platform) as well as organic acids and sterols (GCxGC-TOF platform). A targeted platform for amino acids (UPLC) is also applied.
    Original languageEnglish
    Title of host publicationAdipose Tissue Protocols
    EditorsKaiping Yang
    Place of PublicationTotowa, NJ, USA
    ISBN (Electronic)978-1-59745-245-8
    ISBN (Print)978-1-58829-916-1
    Publication statusPublished - 2008
    MoE publication typeA3 Part of a book or another research book


    • Metabolomics
    • lipidomics
    • branched chain amino acids
    • liquid chromatography
    • gas chromatography
    • mass spectrometry
    • insulin resistance


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