Application of lipidomics and metabolomics to the study of adipose tissue

Ismo Mattila, Tuulikki Seppänen-Laakso, Tapani Suortti, Matej Oresic

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

13 Citations (Scopus)

Abstract

Role of specific reactive lipids as well as amino acids in control of insulin signalling in adipose tissue is well recognized. Since it is practically impossible to measure the levels of all metabolites in the biological sample simultaneously with a single analytical platform, we utilize multiple platforms to study the lipids and metabolites of relevance to adipose tissue metabolism and insulin signalling. Two screening platforms cover a broad range of lipid molecular species (UPLC/MS based lipidomics platform) as well as organic acids and sterols (GCxGC-TOF platform). A targeted platform for amino acids (UPLC) is also applied.
Original languageEnglish
Title of host publicationAdipose Tissue Protocols
EditorsKaiping Yang
Place of PublicationTotowa, NJ, USA
PublisherSpringer
Pages123-130
ISBN (Electronic)978-1-59745-245-8
ISBN (Print)978-1-58829-916-1
DOIs
Publication statusPublished - 2008
MoE publication typeA3 Part of a book or another research book

Fingerprint

Tissue
Metabolites
Lipids
Insulin
Amino Acids
Organic acids
Sterols
Metabolism
Screening
Metabolomics

Keywords

  • Metabolomics
  • lipidomics
  • branched chain amino acids
  • liquid chromatography
  • gas chromatography
  • mass spectrometry
  • insulin resistance

Cite this

Mattila, I., Seppänen-Laakso, T., Suortti, T., & Oresic, M. (2008). Application of lipidomics and metabolomics to the study of adipose tissue. In K. Yang (Ed.), Adipose Tissue Protocols (pp. 123-130). Totowa, NJ, USA: Springer. https://doi.org/10.1007/978-1-59745-245-8_9
Mattila, Ismo ; Seppänen-Laakso, Tuulikki ; Suortti, Tapani ; Oresic, Matej. / Application of lipidomics and metabolomics to the study of adipose tissue. Adipose Tissue Protocols. editor / Kaiping Yang. Totowa, NJ, USA : Springer, 2008. pp. 123-130
@inbook{e253e22f58ff4f4e99f88d6357f41460,
title = "Application of lipidomics and metabolomics to the study of adipose tissue",
abstract = "Role of specific reactive lipids as well as amino acids in control of insulin signalling in adipose tissue is well recognized. Since it is practically impossible to measure the levels of all metabolites in the biological sample simultaneously with a single analytical platform, we utilize multiple platforms to study the lipids and metabolites of relevance to adipose tissue metabolism and insulin signalling. Two screening platforms cover a broad range of lipid molecular species (UPLC/MS based lipidomics platform) as well as organic acids and sterols (GCxGC-TOF platform). A targeted platform for amino acids (UPLC) is also applied.",
keywords = "Metabolomics, lipidomics, branched chain amino acids, liquid chromatography, gas chromatography, mass spectrometry, insulin resistance",
author = "Ismo Mattila and Tuulikki Sepp{\"a}nen-Laakso and Tapani Suortti and Matej Oresic",
note = "HUO: NT Health-effects CA2: TK401",
year = "2008",
doi = "10.1007/978-1-59745-245-8_9",
language = "English",
isbn = "978-1-58829-916-1",
pages = "123--130",
editor = "Kaiping Yang",
booktitle = "Adipose Tissue Protocols",
publisher = "Springer",
address = "Germany",

}

Mattila, I, Seppänen-Laakso, T, Suortti, T & Oresic, M 2008, Application of lipidomics and metabolomics to the study of adipose tissue. in K Yang (ed.), Adipose Tissue Protocols. Springer, Totowa, NJ, USA, pp. 123-130. https://doi.org/10.1007/978-1-59745-245-8_9

Application of lipidomics and metabolomics to the study of adipose tissue. / Mattila, Ismo; Seppänen-Laakso, Tuulikki; Suortti, Tapani; Oresic, Matej.

Adipose Tissue Protocols. ed. / Kaiping Yang. Totowa, NJ, USA : Springer, 2008. p. 123-130.

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

TY - CHAP

T1 - Application of lipidomics and metabolomics to the study of adipose tissue

AU - Mattila, Ismo

AU - Seppänen-Laakso, Tuulikki

AU - Suortti, Tapani

AU - Oresic, Matej

N1 - HUO: NT Health-effects CA2: TK401

PY - 2008

Y1 - 2008

N2 - Role of specific reactive lipids as well as amino acids in control of insulin signalling in adipose tissue is well recognized. Since it is practically impossible to measure the levels of all metabolites in the biological sample simultaneously with a single analytical platform, we utilize multiple platforms to study the lipids and metabolites of relevance to adipose tissue metabolism and insulin signalling. Two screening platforms cover a broad range of lipid molecular species (UPLC/MS based lipidomics platform) as well as organic acids and sterols (GCxGC-TOF platform). A targeted platform for amino acids (UPLC) is also applied.

AB - Role of specific reactive lipids as well as amino acids in control of insulin signalling in adipose tissue is well recognized. Since it is practically impossible to measure the levels of all metabolites in the biological sample simultaneously with a single analytical platform, we utilize multiple platforms to study the lipids and metabolites of relevance to adipose tissue metabolism and insulin signalling. Two screening platforms cover a broad range of lipid molecular species (UPLC/MS based lipidomics platform) as well as organic acids and sterols (GCxGC-TOF platform). A targeted platform for amino acids (UPLC) is also applied.

KW - Metabolomics

KW - lipidomics

KW - branched chain amino acids

KW - liquid chromatography

KW - gas chromatography

KW - mass spectrometry

KW - insulin resistance

U2 - 10.1007/978-1-59745-245-8_9

DO - 10.1007/978-1-59745-245-8_9

M3 - Chapter or book article

SN - 978-1-58829-916-1

SP - 123

EP - 130

BT - Adipose Tissue Protocols

A2 - Yang, Kaiping

PB - Springer

CY - Totowa, NJ, USA

ER -

Mattila I, Seppänen-Laakso T, Suortti T, Oresic M. Application of lipidomics and metabolomics to the study of adipose tissue. In Yang K, editor, Adipose Tissue Protocols. Totowa, NJ, USA: Springer. 2008. p. 123-130 https://doi.org/10.1007/978-1-59745-245-8_9