Application of lipidomics and metabolomics to the study of adipose tissue

Ismo Mattila; Tuulikki Seppänen-Laakso; Tapani Suortti; Matej Oresic

doi:10.1007/978-1-59745-245-8_9

Application of lipidomics and metabolomics to the study of adipose tissue

Ismo Mattila, Tuulikki Seppänen-Laakso, Tapani Suortti, Matej Oresic

Research output: Chapter in Book/Report/Conference proceeding › Chapter or book article › Scientific › peer-review

13 Citations (Scopus)

Abstract

Role of specific reactive lipids as well as amino acids in control of insulin signalling in adipose tissue is well recognized. Since it is practically impossible to measure the levels of all metabolites in the biological sample simultaneously with a single analytical platform, we utilize multiple platforms to study the lipids and metabolites of relevance to adipose tissue metabolism and insulin signalling. Two screening platforms cover a broad range of lipid molecular species (UPLC/MS based lipidomics platform) as well as organic acids and sterols (GCxGC-TOF platform). A targeted platform for amino acids (UPLC) is also applied.

Original language	English
Title of host publication	Adipose Tissue Protocols
Editors	Kaiping Yang
Place of Publication	Totowa, NJ, USA
Publisher	Springer
Pages	123-130
ISBN (Electronic)	978-1-59745-245-8
ISBN (Print)	978-1-58829-916-1
DOIs	https://doi.org/10.1007/978-1-59745-245-8_9
Publication status	Published - 2008
MoE publication type	A3 Part of a book or another research book

Keywords

Metabolomics
lipidomics
branched chain amino acids
liquid chromatography
gas chromatography
mass spectrometry
insulin resistance

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10.1007/978-1-59745-245-8_9

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abstract = "Role of specific reactive lipids as well as amino acids in control of insulin signalling in adipose tissue is well recognized. Since it is practically impossible to measure the levels of all metabolites in the biological sample simultaneously with a single analytical platform, we utilize multiple platforms to study the lipids and metabolites of relevance to adipose tissue metabolism and insulin signalling. Two screening platforms cover a broad range of lipid molecular species (UPLC/MS based lipidomics platform) as well as organic acids and sterols (GCxGC-TOF platform). A targeted platform for amino acids (UPLC) is also applied.",

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AU - Mattila, Ismo

AU - Seppänen-Laakso, Tuulikki

AU - Suortti, Tapani

AU - Oresic, Matej

N1 - HUO: NT Health-effects CA2: TK401

PY - 2008

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N2 - Role of specific reactive lipids as well as amino acids in control of insulin signalling in adipose tissue is well recognized. Since it is practically impossible to measure the levels of all metabolites in the biological sample simultaneously with a single analytical platform, we utilize multiple platforms to study the lipids and metabolites of relevance to adipose tissue metabolism and insulin signalling. Two screening platforms cover a broad range of lipid molecular species (UPLC/MS based lipidomics platform) as well as organic acids and sterols (GCxGC-TOF platform). A targeted platform for amino acids (UPLC) is also applied.

AB - Role of specific reactive lipids as well as amino acids in control of insulin signalling in adipose tissue is well recognized. Since it is practically impossible to measure the levels of all metabolites in the biological sample simultaneously with a single analytical platform, we utilize multiple platforms to study the lipids and metabolites of relevance to adipose tissue metabolism and insulin signalling. Two screening platforms cover a broad range of lipid molecular species (UPLC/MS based lipidomics platform) as well as organic acids and sterols (GCxGC-TOF platform). A targeted platform for amino acids (UPLC) is also applied.

KW - Metabolomics

KW - lipidomics

KW - branched chain amino acids

KW - liquid chromatography

KW - gas chromatography

KW - mass spectrometry

KW - insulin resistance

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DO - 10.1007/978-1-59745-245-8_9

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BT - Adipose Tissue Protocols

A2 - Yang, Kaiping

PB - Springer

CY - Totowa, NJ, USA

ER -

Application of lipidomics and metabolomics to the study of adipose tissue

Abstract

Keywords

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