Applications of a new subspace clustering algorithm (COSA) in medical systems biology

Doris Damian, Matej Orešič (Corresponding Author), Elwin Verheij, Jacqueline Meulman, Jerome Friedman, Aram Adourian, Nicole Morel, Age Smilde, Jan van der Greef (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)


A novel clustering approach named Clustering Objects on Subsets of Attributes (COSA) has been proposed (Friedman and Meulman, (2004). Clustering objects on subsets of attributes. J. R. Statist. Soc. B 66, 1–25.) for unsupervised analysis of complex data sets. We demonstrate its usefulness in medical systems biology studies. Examples of metabolomics analyses are described as well as the unsupervised clustering based on the study of disease pathology and intervention effects in rats and humans. In comparison to principal components analysis and hierarchical clustering based on Euclidean distance, COSA shows an enhanced capability to trace partial similarities in groups of objects enabling a new discovery approach in systems biology as well as offering a unique approach to reveal common denominators of complex multi-factorial diseases in animal and human studies.
Original languageEnglish
Pages (from-to)69-77
Issue number1
Publication statusPublished - 2007
MoE publication typeA1 Journal article-refereed


  • COSA
  • subspace clustering
  • metabolomics
  • lipidomics
  • biomarkers
  • translational research
  • metabolic syndrome
  • Zucker rats
  • ZDF rats


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