TY - JOUR
T1 - Aqueous starch acetate dispersion as a novel coating material for controlled release products
AU - Tarvainen, Maarit
AU - Peltonen, Soili
AU - Mikkonen, Hannu
AU - Elovaara, Minna
AU - Tuunainen, Minna
AU - Paronen, Petteri
AU - Ketolainen, Jarkko
AU - Sutinen, Riitta
PY - 2004
Y1 - 2004
N2 - The aim of
this study was to evaluate film-formation properties of a novel, organic
solvent-free aqueous dispersion of potato starch acetate (SA; degree of substitution 2.8) and its ability to control drug release from a coated tablet. Initially, film-formation mechanisms and drug permeabilities of both organic solvent
and dispersion-based SA free films (prepared by cast or spraying
techniques) were investigated. The SA dispersion was suitable for the
fluid-bed coating process,
forming strong films with complete coalescent polymeric spheres. The
model compounds predominantly permeated via the micro-pores of SA free
films, which resulted from the leaching of water-soluble excipients from the dispersion. Thus, the permeation rate
depended on the film structure rather than the physico-chemical
properties of the penetrant. In the case of SA-coated tablet, drug
release was sustained when the coating level was increased (from 12% to
20%, stated as a weight gain), and also as lipophilicity of the drug increased. When compared to the reference polymer dispersion (Surelease®), SA coatings showed better mechanical properties against the osmotic pressure caused by a hydrophilic core tablet. These results clearly demonstrate that SA dispersion has high utility as a novel aqueous coating material for controlled release products.
AB - The aim of
this study was to evaluate film-formation properties of a novel, organic
solvent-free aqueous dispersion of potato starch acetate (SA; degree of substitution 2.8) and its ability to control drug release from a coated tablet. Initially, film-formation mechanisms and drug permeabilities of both organic solvent
and dispersion-based SA free films (prepared by cast or spraying
techniques) were investigated. The SA dispersion was suitable for the
fluid-bed coating process,
forming strong films with complete coalescent polymeric spheres. The
model compounds predominantly permeated via the micro-pores of SA free
films, which resulted from the leaching of water-soluble excipients from the dispersion. Thus, the permeation rate
depended on the film structure rather than the physico-chemical
properties of the penetrant. In the case of SA-coated tablet, drug
release was sustained when the coating level was increased (from 12% to
20%, stated as a weight gain), and also as lipophilicity of the drug increased. When compared to the reference polymer dispersion (Surelease®), SA coatings showed better mechanical properties against the osmotic pressure caused by a hydrophilic core tablet. These results clearly demonstrate that SA dispersion has high utility as a novel aqueous coating material for controlled release products.
KW - biopolymers
U2 - 10.1016/j.jconrel.2004.01.016
DO - 10.1016/j.jconrel.2004.01.016
M3 - Article
SN - 0168-3659
VL - 96
SP - 179
EP - 191
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 1
ER -