Aqueous starch acetate dispersion as a novel coating material for controlled release products

Maarit Tarvainen (Corresponding Author), Soili Peltonen, Hannu Mikkonen, Minna Elovaara, Minna Tuunainen, Petteri Paronen, Jarkko Ketolainen, Riitta Sutinen

Research output: Contribution to journalArticleScientificpeer-review

44 Citations (Scopus)

Abstract

The aim of this study was to evaluate film-formation properties of a novel, organic solvent-free aqueous dispersion of potato starch acetate (SA; degree of substitution 2.8) and its ability to control drug release from a coated tablet. Initially, film-formation mechanisms and drug permeabilities of both organic solvent and dispersion-based SA free films (prepared by cast or spraying techniques) were investigated. The SA dispersion was suitable for the fluid-bed coating process, forming strong films with complete coalescent polymeric spheres. The model compounds predominantly permeated via the micro-pores of SA free films, which resulted from the leaching of water-soluble excipients from the dispersion. Thus, the permeation rate depended on the film structure rather than the physico-chemical properties of the penetrant. In the case of SA-coated tablet, drug release was sustained when the coating level was increased (from 12% to 20%, stated as a weight gain), and also as lipophilicity of the drug increased. When compared to the reference polymer dispersion (Surelease®), SA coatings showed better mechanical properties against the osmotic pressure caused by a hydrophilic core tablet. These results clearly demonstrate that SA dispersion has high utility as a novel aqueous coating material for controlled release products.

Original languageEnglish
Pages (from-to)179 - 191
Number of pages13
JournalJournal of Controlled Release
Volume96
Issue number1
DOIs
Publication statusPublished - 2004
MoE publication typeA1 Journal article-refereed

Fingerprint

Tablets
Excipients
Osmotic Pressure
Solanum tuberosum
Pharmaceutical Preparations
Weight Gain
Permeability
Polymers
Water
starch acetate
Drug Liberation
ethyl cellulose

Keywords

  • biopolymers

Cite this

Tarvainen, M., Peltonen, S., Mikkonen, H., Elovaara, M., Tuunainen, M., Paronen, P., ... Sutinen, R. (2004). Aqueous starch acetate dispersion as a novel coating material for controlled release products. Journal of Controlled Release, 96(1), 179 - 191. https://doi.org/10.1016/j.jconrel.2004.01.016
Tarvainen, Maarit ; Peltonen, Soili ; Mikkonen, Hannu ; Elovaara, Minna ; Tuunainen, Minna ; Paronen, Petteri ; Ketolainen, Jarkko ; Sutinen, Riitta. / Aqueous starch acetate dispersion as a novel coating material for controlled release products. In: Journal of Controlled Release. 2004 ; Vol. 96, No. 1. pp. 179 - 191.
@article{f6efad8adfb8450fb8c3eb1b4c1ebded,
title = "Aqueous starch acetate dispersion as a novel coating material for controlled release products",
abstract = "The aim of this study was to evaluate film-formation properties of a novel, organic solvent-free aqueous dispersion of potato starch acetate (SA; degree of substitution 2.8) and its ability to control drug release from a coated tablet. Initially, film-formation mechanisms and drug permeabilities of both organic solvent and dispersion-based SA free films (prepared by cast or spraying techniques) were investigated. The SA dispersion was suitable for the fluid-bed coating process, forming strong films with complete coalescent polymeric spheres. The model compounds predominantly permeated via the micro-pores of SA free films, which resulted from the leaching of water-soluble excipients from the dispersion. Thus, the permeation rate depended on the film structure rather than the physico-chemical properties of the penetrant. In the case of SA-coated tablet, drug release was sustained when the coating level was increased (from 12{\%} to 20{\%}, stated as a weight gain), and also as lipophilicity of the drug increased. When compared to the reference polymer dispersion (Surelease{\circledR}), SA coatings showed better mechanical properties against the osmotic pressure caused by a hydrophilic core tablet. These results clearly demonstrate that SA dispersion has high utility as a novel aqueous coating material for controlled release products.",
keywords = "biopolymers",
author = "Maarit Tarvainen and Soili Peltonen and Hannu Mikkonen and Minna Elovaara and Minna Tuunainen and Petteri Paronen and Jarkko Ketolainen and Riitta Sutinen",
year = "2004",
doi = "10.1016/j.jconrel.2004.01.016",
language = "English",
volume = "96",
pages = "179 -- 191",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier",
number = "1",

}

Tarvainen, M, Peltonen, S, Mikkonen, H, Elovaara, M, Tuunainen, M, Paronen, P, Ketolainen, J & Sutinen, R 2004, 'Aqueous starch acetate dispersion as a novel coating material for controlled release products', Journal of Controlled Release, vol. 96, no. 1, pp. 179 - 191. https://doi.org/10.1016/j.jconrel.2004.01.016

Aqueous starch acetate dispersion as a novel coating material for controlled release products. / Tarvainen, Maarit (Corresponding Author); Peltonen, Soili; Mikkonen, Hannu; Elovaara, Minna; Tuunainen, Minna; Paronen, Petteri; Ketolainen, Jarkko; Sutinen, Riitta.

In: Journal of Controlled Release, Vol. 96, No. 1, 2004, p. 179 - 191.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Aqueous starch acetate dispersion as a novel coating material for controlled release products

AU - Tarvainen, Maarit

AU - Peltonen, Soili

AU - Mikkonen, Hannu

AU - Elovaara, Minna

AU - Tuunainen, Minna

AU - Paronen, Petteri

AU - Ketolainen, Jarkko

AU - Sutinen, Riitta

PY - 2004

Y1 - 2004

N2 - The aim of this study was to evaluate film-formation properties of a novel, organic solvent-free aqueous dispersion of potato starch acetate (SA; degree of substitution 2.8) and its ability to control drug release from a coated tablet. Initially, film-formation mechanisms and drug permeabilities of both organic solvent and dispersion-based SA free films (prepared by cast or spraying techniques) were investigated. The SA dispersion was suitable for the fluid-bed coating process, forming strong films with complete coalescent polymeric spheres. The model compounds predominantly permeated via the micro-pores of SA free films, which resulted from the leaching of water-soluble excipients from the dispersion. Thus, the permeation rate depended on the film structure rather than the physico-chemical properties of the penetrant. In the case of SA-coated tablet, drug release was sustained when the coating level was increased (from 12% to 20%, stated as a weight gain), and also as lipophilicity of the drug increased. When compared to the reference polymer dispersion (Surelease®), SA coatings showed better mechanical properties against the osmotic pressure caused by a hydrophilic core tablet. These results clearly demonstrate that SA dispersion has high utility as a novel aqueous coating material for controlled release products.

AB - The aim of this study was to evaluate film-formation properties of a novel, organic solvent-free aqueous dispersion of potato starch acetate (SA; degree of substitution 2.8) and its ability to control drug release from a coated tablet. Initially, film-formation mechanisms and drug permeabilities of both organic solvent and dispersion-based SA free films (prepared by cast or spraying techniques) were investigated. The SA dispersion was suitable for the fluid-bed coating process, forming strong films with complete coalescent polymeric spheres. The model compounds predominantly permeated via the micro-pores of SA free films, which resulted from the leaching of water-soluble excipients from the dispersion. Thus, the permeation rate depended on the film structure rather than the physico-chemical properties of the penetrant. In the case of SA-coated tablet, drug release was sustained when the coating level was increased (from 12% to 20%, stated as a weight gain), and also as lipophilicity of the drug increased. When compared to the reference polymer dispersion (Surelease®), SA coatings showed better mechanical properties against the osmotic pressure caused by a hydrophilic core tablet. These results clearly demonstrate that SA dispersion has high utility as a novel aqueous coating material for controlled release products.

KW - biopolymers

U2 - 10.1016/j.jconrel.2004.01.016

DO - 10.1016/j.jconrel.2004.01.016

M3 - Article

VL - 96

SP - 179

EP - 191

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

IS - 1

ER -