Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy

Elisabeth Peeters, Ana Filipa Tavares Da Silva, Maunu M. Toiviainen, Jeroen Van Renterghem, Jurgen Vercruysse, Mikko Juuti

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This study investigated whether Raman and Near Infrared (NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares (PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn't be established. Principal component analysis (PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression (MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties.
Original languageEnglish
Pages (from-to)547-558
JournalAsian Journal of Pharmaceutical Sciences
Issue number4
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed



  • continuous production
  • granulation
  • NIR
  • PAT
  • raman
  • tableting

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