Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy

Elisabeth Peeters, Ana Filipa Tavares Da Silva, Maunu M. Toiviainen, Jeroen Van Renterghem, Jurgen Vercruysse, Mikko Juuti

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

Abstract

This study investigated whether Raman and Near Infrared (NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares (PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn't be established. Principal component analysis (PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression (MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties.
Original languageEnglish
Pages (from-to)547-558
JournalAsian Journal of Pharmaceutical Sciences
Volume11
Issue number4
DOIs
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed

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Near-Infrared Spectroscopy
Raman Spectrum Analysis
Tablets
Theophylline
Principal Component Analysis
Least-Squares Analysis
Linear Models
Regression Analysis
Weights and Measures

Keywords

  • continuous production
  • granulation
  • NIR
  • PAT
  • raman
  • tableting

Cite this

Peeters, Elisabeth ; Tavares Da Silva, Ana Filipa ; Toiviainen, Maunu M. ; Van Renterghem, Jeroen ; Vercruysse, Jurgen ; Juuti, Mikko. / Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy. In: Asian Journal of Pharmaceutical Sciences. 2016 ; Vol. 11, No. 4. pp. 547-558.
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Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy. / Peeters, Elisabeth; Tavares Da Silva, Ana Filipa; Toiviainen, Maunu M.; Van Renterghem, Jeroen; Vercruysse, Jurgen; Juuti, Mikko.

In: Asian Journal of Pharmaceutical Sciences, Vol. 11, No. 4, 2016, p. 547-558.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Peeters, Elisabeth

AU - Tavares Da Silva, Ana Filipa

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AU - Vercruysse, Jurgen

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