TY - JOUR
T1 - Association between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals
T2 - A Longitudinal Descriptive Cohort Study
AU - Reijs, Babette L.R.
AU - Vos, Stephanie J.B.
AU - Soininen, Hilkka
AU - Lötjonen, Jyrki
AU - Koikkalainen, Juha
AU - Pikkarainen, Maria
AU - Hall, Anette
AU - Vanninen, Ritva
AU - Liu, Yawu
AU - Herukka, Sanna-Kaisa
AU - Freund-Levi, Yvonne
AU - Frisoni, Giovanni B.
AU - Frölich, Lutz
AU - Nobili, Flavio
AU - Rikkert, Marcel Olde
AU - Spiru, Luiza
AU - Tsolaki, Magda
AU - Wallin, Åsa K.
AU - Scheltens, Philip
AU - Verhey, Frans
AU - Visser, Pieter Jelle
PY - 2017
Y1 - 2017
N2 - Background: Lifestyle factors have been associated with
the risk of dementia, but the association with
Alzheimer's disease (AD) remains unclear. Objective: To
examine the association between later life lifestyle
factors and AD biomarkers (i.e., amyloid-ß 1-42 (Aß 42)
and tau in cerebrospinal fluid (CSF), and hippocampal
volume) in individuals with subjective cognitive decline
(SCD) and mild cognitive impairment (MCI). In addition,
to examine the effect of later life lifestyle factors on
developing AD-type dementia in individuals with MCI.
Methods: We selected individuals with SCD (n = 111) and
MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal
MCI studies. CSF Aß 42 and tau concentrations were
assessed with ELISA assay and hippocampal volume with
multi-atlas segmentation. Lifestyle was assessed by
clinical interview at baseline for: social activity,
physical activity, cognitive activity, smoking, alcohol
consumption, and sleep. We performed logistic and Cox
regression analyses adjusted for study site, age, gender,
education, and diagnosis. Prediction for AD-type dementia
was performed in individuals with MCI only. Results:
Later life lifestyle factors were not associated with AD
biomarkers or with conversion to AD-type dementia. AD
biomarkers were strongly associated with conversion to
AD-type dementia, but these relations were not modulated
by lifestyle factors. Apolipoprotein E (APOE) genotype
did not influence the results. Conclusions: Later life
lifestyle factors had no impact on key AD biomarkers in
individuals with SCD and MCI or on conversion to AD-type
dementia in MCI.
AB - Background: Lifestyle factors have been associated with
the risk of dementia, but the association with
Alzheimer's disease (AD) remains unclear. Objective: To
examine the association between later life lifestyle
factors and AD biomarkers (i.e., amyloid-ß 1-42 (Aß 42)
and tau in cerebrospinal fluid (CSF), and hippocampal
volume) in individuals with subjective cognitive decline
(SCD) and mild cognitive impairment (MCI). In addition,
to examine the effect of later life lifestyle factors on
developing AD-type dementia in individuals with MCI.
Methods: We selected individuals with SCD (n = 111) and
MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal
MCI studies. CSF Aß 42 and tau concentrations were
assessed with ELISA assay and hippocampal volume with
multi-atlas segmentation. Lifestyle was assessed by
clinical interview at baseline for: social activity,
physical activity, cognitive activity, smoking, alcohol
consumption, and sleep. We performed logistic and Cox
regression analyses adjusted for study site, age, gender,
education, and diagnosis. Prediction for AD-type dementia
was performed in individuals with MCI only. Results:
Later life lifestyle factors were not associated with AD
biomarkers or with conversion to AD-type dementia. AD
biomarkers were strongly associated with conversion to
AD-type dementia, but these relations were not modulated
by lifestyle factors. Apolipoprotein E (APOE) genotype
did not influence the results. Conclusions: Later life
lifestyle factors had no impact on key AD biomarkers in
individuals with SCD and MCI or on conversion to AD-type
dementia in MCI.
KW - alcohol consumption
KW - Alzheimer's disease
KW - amyloid-ß (1-42)
KW - cerebrospinal fluid
KW - cognitive reserve
KW - exercise
KW - hippocampus
KW - lifestyle
KW - mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=85033561388&partnerID=8YFLogxK
U2 - 10.3233/JAD-170039
DO - 10.3233/JAD-170039
M3 - Article
SN - 1387-2877
VL - 60
SP - 1387
EP - 1395
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 4
ER -