Association between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals

A Longitudinal Descriptive Cohort Study

Babette L.R. Reijs (Corresponding Author), Stephanie J.B. Vos, Hilkka Soininen, Jyrki Lötjonen, Juha Koikkalainen, Maria Pikkarainen, Anette Hall, Ritva Vanninen, Yawu Liu, Sanna-Kaisa Herukka, Yvonne Freund-Levi, Giovanni B. Frisoni, Lutz Frölich, Flavio Nobili, Marcel Olde Rikkert, Luiza Spiru, Magda Tsolaki, Åsa K. Wallin, Philip Scheltens, Frans Verhey & 1 others Pieter Jelle Visser

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)

Abstract

Background: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear. Objective: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-ß 1-42 (Aß 42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI. Methods: We selected individuals with SCD (n = 111) and MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal MCI studies. CSF Aß 42 and tau concentrations were assessed with ELISA assay and hippocampal volume with multi-atlas segmentation. Lifestyle was assessed by clinical interview at baseline for: social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep. We performed logistic and Cox regression analyses adjusted for study site, age, gender, education, and diagnosis. Prediction for AD-type dementia was performed in individuals with MCI only. Results: Later life lifestyle factors were not associated with AD biomarkers or with conversion to AD-type dementia. AD biomarkers were strongly associated with conversion to AD-type dementia, but these relations were not modulated by lifestyle factors. Apolipoprotein E (APOE) genotype did not influence the results. Conclusions: Later life lifestyle factors had no impact on key AD biomarkers in individuals with SCD and MCI or on conversion to AD-type dementia in MCI.
Original languageEnglish
Pages (from-to)1387-1395
Number of pages9
JournalJournal of Alzheimer's Disease
Volume60
Issue number4
DOIs
Publication statusPublished - 2017
MoE publication typeA1 Journal article-refereed

Fingerprint

Life Style
Alzheimer Disease
Cohort Studies
Biomarkers
Cerebrospinal Fluid
Cognitive Dysfunction
Atlases
Apolipoproteins E
Amyloid
Alcohol Drinking
Dementia
Sleep
Logistic Models
Smoking
Enzyme-Linked Immunosorbent Assay
Genotype
Regression Analysis
Interviews
Education

Keywords

  • alcohol consumption
  • Alzheimer's disease
  • amyloid-ß (1-42)
  • cerebrospinal fluid
  • cognitive reserve
  • exercise
  • hippocampus
  • lifestyle
  • mild cognitive impairment

Cite this

Reijs, B. L. R., Vos, S. J. B., Soininen, H., Lötjonen, J., Koikkalainen, J., Pikkarainen, M., ... Visser, P. J. (2017). Association between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study. Journal of Alzheimer's Disease, 60(4), 1387-1395. https://doi.org/10.3233/JAD-170039
Reijs, Babette L.R. ; Vos, Stephanie J.B. ; Soininen, Hilkka ; Lötjonen, Jyrki ; Koikkalainen, Juha ; Pikkarainen, Maria ; Hall, Anette ; Vanninen, Ritva ; Liu, Yawu ; Herukka, Sanna-Kaisa ; Freund-Levi, Yvonne ; Frisoni, Giovanni B. ; Frölich, Lutz ; Nobili, Flavio ; Rikkert, Marcel Olde ; Spiru, Luiza ; Tsolaki, Magda ; Wallin, Åsa K. ; Scheltens, Philip ; Verhey, Frans ; Visser, Pieter Jelle. / Association between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals : A Longitudinal Descriptive Cohort Study. In: Journal of Alzheimer's Disease. 2017 ; Vol. 60, No. 4. pp. 1387-1395.
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title = "Association between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study",
abstract = "Background: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear. Objective: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-{\ss} 1-42 (A{\ss} 42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI. Methods: We selected individuals with SCD (n = 111) and MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal MCI studies. CSF A{\ss} 42 and tau concentrations were assessed with ELISA assay and hippocampal volume with multi-atlas segmentation. Lifestyle was assessed by clinical interview at baseline for: social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep. We performed logistic and Cox regression analyses adjusted for study site, age, gender, education, and diagnosis. Prediction for AD-type dementia was performed in individuals with MCI only. Results: Later life lifestyle factors were not associated with AD biomarkers or with conversion to AD-type dementia. AD biomarkers were strongly associated with conversion to AD-type dementia, but these relations were not modulated by lifestyle factors. Apolipoprotein E (APOE) genotype did not influence the results. Conclusions: Later life lifestyle factors had no impact on key AD biomarkers in individuals with SCD and MCI or on conversion to AD-type dementia in MCI.",
keywords = "alcohol consumption, Alzheimer's disease, amyloid-{\ss} (1-42), cerebrospinal fluid, cognitive reserve, exercise, hippocampus, lifestyle, mild cognitive impairment",
author = "Reijs, {Babette L.R.} and Vos, {Stephanie J.B.} and Hilkka Soininen and Jyrki L{\"o}tjonen and Juha Koikkalainen and Maria Pikkarainen and Anette Hall and Ritva Vanninen and Yawu Liu and Sanna-Kaisa Herukka and Yvonne Freund-Levi and Frisoni, {Giovanni B.} and Lutz Fr{\"o}lich and Flavio Nobili and Rikkert, {Marcel Olde} and Luiza Spiru and Magda Tsolaki and Wallin, {{\AA}sa K.} and Philip Scheltens and Frans Verhey and Visser, {Pieter Jelle}",
year = "2017",
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pages = "1387--1395",
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Reijs, BLR, Vos, SJB, Soininen, H, Lötjonen, J, Koikkalainen, J, Pikkarainen, M, Hall, A, Vanninen, R, Liu, Y, Herukka, S-K, Freund-Levi, Y, Frisoni, GB, Frölich, L, Nobili, F, Rikkert, MO, Spiru, L, Tsolaki, M, Wallin, ÅK, Scheltens, P, Verhey, F & Visser, PJ 2017, 'Association between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study', Journal of Alzheimer's Disease, vol. 60, no. 4, pp. 1387-1395. https://doi.org/10.3233/JAD-170039

Association between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals : A Longitudinal Descriptive Cohort Study. / Reijs, Babette L.R. (Corresponding Author); Vos, Stephanie J.B.; Soininen, Hilkka; Lötjonen, Jyrki; Koikkalainen, Juha; Pikkarainen, Maria; Hall, Anette; Vanninen, Ritva; Liu, Yawu; Herukka, Sanna-Kaisa; Freund-Levi, Yvonne; Frisoni, Giovanni B.; Frölich, Lutz; Nobili, Flavio; Rikkert, Marcel Olde; Spiru, Luiza; Tsolaki, Magda; Wallin, Åsa K.; Scheltens, Philip; Verhey, Frans; Visser, Pieter Jelle.

In: Journal of Alzheimer's Disease, Vol. 60, No. 4, 2017, p. 1387-1395.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Association between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals

T2 - A Longitudinal Descriptive Cohort Study

AU - Reijs, Babette L.R.

AU - Vos, Stephanie J.B.

AU - Soininen, Hilkka

AU - Lötjonen, Jyrki

AU - Koikkalainen, Juha

AU - Pikkarainen, Maria

AU - Hall, Anette

AU - Vanninen, Ritva

AU - Liu, Yawu

AU - Herukka, Sanna-Kaisa

AU - Freund-Levi, Yvonne

AU - Frisoni, Giovanni B.

AU - Frölich, Lutz

AU - Nobili, Flavio

AU - Rikkert, Marcel Olde

AU - Spiru, Luiza

AU - Tsolaki, Magda

AU - Wallin, Åsa K.

AU - Scheltens, Philip

AU - Verhey, Frans

AU - Visser, Pieter Jelle

PY - 2017

Y1 - 2017

N2 - Background: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear. Objective: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-ß 1-42 (Aß 42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI. Methods: We selected individuals with SCD (n = 111) and MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal MCI studies. CSF Aß 42 and tau concentrations were assessed with ELISA assay and hippocampal volume with multi-atlas segmentation. Lifestyle was assessed by clinical interview at baseline for: social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep. We performed logistic and Cox regression analyses adjusted for study site, age, gender, education, and diagnosis. Prediction for AD-type dementia was performed in individuals with MCI only. Results: Later life lifestyle factors were not associated with AD biomarkers or with conversion to AD-type dementia. AD biomarkers were strongly associated with conversion to AD-type dementia, but these relations were not modulated by lifestyle factors. Apolipoprotein E (APOE) genotype did not influence the results. Conclusions: Later life lifestyle factors had no impact on key AD biomarkers in individuals with SCD and MCI or on conversion to AD-type dementia in MCI.

AB - Background: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear. Objective: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-ß 1-42 (Aß 42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI. Methods: We selected individuals with SCD (n = 111) and MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal MCI studies. CSF Aß 42 and tau concentrations were assessed with ELISA assay and hippocampal volume with multi-atlas segmentation. Lifestyle was assessed by clinical interview at baseline for: social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep. We performed logistic and Cox regression analyses adjusted for study site, age, gender, education, and diagnosis. Prediction for AD-type dementia was performed in individuals with MCI only. Results: Later life lifestyle factors were not associated with AD biomarkers or with conversion to AD-type dementia. AD biomarkers were strongly associated with conversion to AD-type dementia, but these relations were not modulated by lifestyle factors. Apolipoprotein E (APOE) genotype did not influence the results. Conclusions: Later life lifestyle factors had no impact on key AD biomarkers in individuals with SCD and MCI or on conversion to AD-type dementia in MCI.

KW - alcohol consumption

KW - Alzheimer's disease

KW - amyloid-ß (1-42)

KW - cerebrospinal fluid

KW - cognitive reserve

KW - exercise

KW - hippocampus

KW - lifestyle

KW - mild cognitive impairment

UR - http://www.scopus.com/inward/record.url?scp=85033561388&partnerID=8YFLogxK

U2 - 10.3233/JAD-170039

DO - 10.3233/JAD-170039

M3 - Article

VL - 60

SP - 1387

EP - 1395

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 4

ER -