Asymmetric intermolecular hydroamination of unactivated alkenes with simple amines

Alexander L. Reznichenko; Hiep N. Nguyen; Kai C. Hultzsch

doi:10.1002/anie.201004570

Asymmetric intermolecular hydroamination of unactivated alkenes with simple amines

Alexander L. Reznichenko, Hiep N. Nguyen, Kai C. Hultzsch

Not published at VTT

Rutgers - The State University of New Jersey

Research output: Contribution to journal › Article › Scientific › peer-review

167 Citations (Scopus)

Abstract

A hard nut to crack: The asymmetric intermolecular Markovnikov addition of simple amines to unactivated alkenes can be achieved utilizing binaphtholate rare-earth-metal catalysts with up to 61% ee and 73% de in the case where R ² contains a stereogenic center.

Original language	English
Pages (from-to)	8984-8987
Number of pages	4
Journal	Angewandte Chemie: International Edition
Volume	49
Issue number	47
DOIs	https://doi.org/10.1002/anie.201004570
Publication status	Published - 15 Nov 2010
MoE publication type	A1 Journal article-refereed

Keywords

alkenes
amines
enantioselectivity
intermolecular hydroamination
rare-earth metals

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10.1002/anie.201004570

Cite this

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title = "Asymmetric intermolecular hydroamination of unactivated alkenes with simple amines",

abstract = "A hard nut to crack: The asymmetric intermolecular Markovnikov addition of simple amines to unactivated alkenes can be achieved utilizing binaphtholate rare-earth-metal catalysts with up to 61% ee and 73% de in the case where R 2 contains a stereogenic center.",

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AU - Nguyen, Hiep N.

AU - Hultzsch, Kai C.

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KW - alkenes

KW - amines

KW - enantioselectivity

KW - intermolecular hydroamination

KW - rare-earth metals

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JO - Angewandte Chemie: International Edition

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Asymmetric intermolecular hydroamination of unactivated alkenes with simple amines

Abstract

Keywords

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