Asymmetric intermolecular hydroamination of unactivated alkenes with simple amines

Alexander L. Reznichenko, Hiep N. Nguyen, Kai C. Hultzsch

Research output: Contribution to journalArticleScientificpeer-review

137 Citations (Scopus)

Abstract

A hard nut to crack: The asymmetric intermolecular Markovnikov addition of simple amines to unactivated alkenes can be achieved utilizing binaphtholate rare-earth-metal catalysts with up to 61% ee and 73% de in the case where R 2 contains a stereogenic center.

Original languageEnglish
Pages (from-to)8984-8987
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number47
DOIs
Publication statusPublished - 15 Nov 2010
MoE publication typeA1 Journal article-refereed

Keywords

  • alkenes
  • amines
  • enantioselectivity
  • intermolecular hydroamination
  • rare-earth metals

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