Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention

Keyphrases

• Tumor Stroma 100%
• Tumor Microenvironment 100%
• Therapeutic Intervention 100%
• Microtissue 100%
• Functional Target 100%
• Cancer-associated Fibroblasts 100%
• Automated Tracking 100%
• Fibroblasts 40%
• Motility 40%
• Cell Culture 20%
• Prostate Cancer 20%
• Extracellular Matrix 20%
• Tumor Growth 20%
• Prostate Cancer Cells 20%
• Tumor 20%
• Tumor Cells 20%
• Tumor Invasion 20%
• Invasiveness 20%
• Cancer Targeting 20%
• Living Cells 20%
• In Vitro Model 20%
• Complex Cell 20%
• Morphological Changes 20%
• Paracrine Function 20%
• Three-dimensional Culture 20%
• Complex Phenotypes 20%
• Tumor Cancer 20%
• Target Validation 20%
• Physical Impacts 20%
• Live Measurements 20%
• Automated pipeline 20%
• Tumor Histology 20%
• Biochemical Perturbation 20%
• Computational Support 20%
• Tumor Organoids 20%
• Three-dimensional Cell Culture 20%
• Focal Adhesion Kinase Inhibitor 20%

Medicine and Dentistry

• Neoplasm 100%
• Cancer Associated Fibroblast 100%
• Stroma 100%
• Tumor Microenvironment 100%
• In Vitro 40%
• Prostate Cancer 40%
• Cell Culture 40%
• Fibroblast 40%
• Morphology 20%
• Cancer Cell 20%
• Tumor Cell 20%
• Organoid 20%
• Tumor Progression 20%
• Extracellular Matrix 20%
• Tumor Invasion 20%
• Tumor Histology 20%
• Tumor Model 20%
• Cytometry 20%
• Focal Adhesion Kinase Inhibitor 20%
• Malignant Neoplasm 20%

INIS

• morphology 100%
• tumors 100%
• interventions 100%
• cancer 80%
• fibroblasts 70%
• growth 20%
• in vitro 20%
• cell cultures 20%
• prostate 20%
• interactions 10%
• dynamics 10%
• pipelines 10%
• tracks 10%
• adhesion 10%
• validation 10%
• matrices 10%
• units 10%
• perturbations 10%
• phenotype 10%
• kinases 10%
• tumor cells 10%
• organoids 10%
• histology 10%
• live time 10%
• morphological changes 10%