Automatic statistical shape analysis of cerebral asymmetry in 3D T1-weighted magnetic resonance images at vertex-level: Application to neuroleptic-naïve schizophrenia

Antonietta Pepe (Corresponding Author), Lu Zhao, Juha Koikkalainen, Jarmo Hietala, Ulla Ruotsalainen, Jussi Tohka

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Abstract

The study of the structural asymmetries in the human brain can assist the early diagnosis and progression of various neuropsychiatric disorders, and give insights into the biological bases of several cognitive deficits. The high inter-subject variability in cortical morphology complicates the detection of abnormal asymmetries especially if only small samples are available. This work introduces a novel automatic method for the local (vertex-level) statistical shape analysis of gross cerebral hemispheric surface asymmetries which is robust to the individual cortical variations. After segmentation of the cerebral hemispheric volumes from three-dimensional (3D) T1-weighted magnetic resonance images (MRI) and their spatial normalization to a common space, the right hemispheric masks were reflected to match with the left ones. Cerebral hemispheric surfaces were extracted using a deformable model-based algorithm which extracted the salient morphological features while establishing the point correspondence between the surfaces. The interhemispheric asymmetry, quantified by customized measures of asymmetry, was evaluated in a few thousands of corresponding surface vertices and tested for statistical significance.

The developed method was tested on scans obtained from a small sample of healthy volunteers and first-episode neuroleptic-naïve schizophrenics. A significant main effect of the disease on the local interhemispheric asymmetry was observed, both in females and males, at the frontal and temporal lobes, the latter being often linked to the cognitive, auditory, and memory deficits in schizophrenia. The findings of this study, although need further testing in larger samples, partially replicate previous studies supporting the hypothesis of schizophrenia as a neurodevelopmental disorder.
Original languageEnglish
Pages (from-to)676-687
JournalMagnetic Resonance Imaging
Volume31
Issue number5
DOIs
Publication statusPublished - 2013
MoE publication typeA1 Journal article-refereed

Fingerprint

Magnetic resonance
Antipsychotic Agents
Schizophrenia
Magnetic Resonance Spectroscopy
Memory Disorders
Frontal Lobe
Temporal Lobe
Masks
Early Diagnosis
Healthy Volunteers
Brain
Data storage equipment
Testing
Neurodevelopmental Disorders

Keywords

  • automatic
  • neuroleptic-naïve schizophrenia
  • atatistical shape asymmetry

Cite this

Pepe, Antonietta ; Zhao, Lu ; Koikkalainen, Juha ; Hietala, Jarmo ; Ruotsalainen, Ulla ; Tohka, Jussi. / Automatic statistical shape analysis of cerebral asymmetry in 3D T1-weighted magnetic resonance images at vertex-level : Application to neuroleptic-naïve schizophrenia. In: Magnetic Resonance Imaging. 2013 ; Vol. 31, No. 5. pp. 676-687.
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Automatic statistical shape analysis of cerebral asymmetry in 3D T1-weighted magnetic resonance images at vertex-level : Application to neuroleptic-naïve schizophrenia. / Pepe, Antonietta (Corresponding Author); Zhao, Lu; Koikkalainen, Juha; Hietala, Jarmo; Ruotsalainen, Ulla; Tohka, Jussi.

In: Magnetic Resonance Imaging, Vol. 31, No. 5, 2013, p. 676-687.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Tohka, Jussi

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AB - The study of the structural asymmetries in the human brain can assist the early diagnosis and progression of various neuropsychiatric disorders, and give insights into the biological bases of several cognitive deficits. The high inter-subject variability in cortical morphology complicates the detection of abnormal asymmetries especially if only small samples are available. This work introduces a novel automatic method for the local (vertex-level) statistical shape analysis of gross cerebral hemispheric surface asymmetries which is robust to the individual cortical variations. After segmentation of the cerebral hemispheric volumes from three-dimensional (3D) T1-weighted magnetic resonance images (MRI) and their spatial normalization to a common space, the right hemispheric masks were reflected to match with the left ones. Cerebral hemispheric surfaces were extracted using a deformable model-based algorithm which extracted the salient morphological features while establishing the point correspondence between the surfaces. The interhemispheric asymmetry, quantified by customized measures of asymmetry, was evaluated in a few thousands of corresponding surface vertices and tested for statistical significance.The developed method was tested on scans obtained from a small sample of healthy volunteers and first-episode neuroleptic-naïve schizophrenics. A significant main effect of the disease on the local interhemispheric asymmetry was observed, both in females and males, at the frontal and temporal lobes, the latter being often linked to the cognitive, auditory, and memory deficits in schizophrenia. The findings of this study, although need further testing in larger samples, partially replicate previous studies supporting the hypothesis of schizophrenia as a neurodevelopmental disorder.

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